Supplementary Online Content. Krogh C, Fischer TK, Skotte L. Familial aggregation and heritability of pyloric stenosis. JAMA. 2010;303(23):
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1 Supplementry Online Content Krogh C, Fischer TK, Skotte L. Fmilil ggregtion nd heritbility of pyloric stenosis. JAMA. 2010;303(23): etble 1. Components of Vrince nd Model Fit Sttistics in Four Heritbility Models for Pyloric Stenosis in Twins etble 2. Risk Rtios (RRs) of Pyloric Stenosis According to Fmily History by Type of Reltive etble 3. Rte Rtios (RRs) of Pyloric Stenosis According to Fmily History by Type of Reltive With n Extended Cse Definition etble 4. Rte Rtios (RRs) of Pyloric Stenosis According to Fmily History by Type of Reltive for Children Born Before nd After 1990 etble 5. Rte Rtios (RRs) of Pyloric Stenosis According to Fmily History by Type of Reltive for Children Born Before nd After 1996 etble 6. Rte Rtios (RRs) of Pyloric Stenosis According to Fmily History by Type of Reltive With Additionl Adjustment for Number of Older Reltives This supplementry mteril hs been provided by the uthors to give reders dditionl informtion bout their work.
2 etble 1. Components of Vrince nd Model Fit Sttistics in Four Heritbility Models for Pyloric Stenosis in Twins Components of Vrince 1 Goodness of Fit Model 2 Additive genetic ( 2) ADE 0.87 ( ) ACE 0.71 ( ) Dominnt genetic (d 2 ) 0.00 ( ) Shred environment (c 2 ) ( ) CE ( ) Non-shred environment (e 2 ) ( ) 0.14 ( ) 0.34 ( ) AIC 3 χ 2 (d.f.) (3) (3) (4) AE 5, (4) ( ) ( ) 1 Proportion of totl vrince (95% Confidence intervl) 2 A=dditive genetic component, D=dominnt genetic component, C=shred environmentl component, E=non-shred environmentl component 3 AIC, Akike s informtion crition. 4 Test for CE vs ACE: χ 2 =7.72, d.f.=1, p= Test for AE vs ACE: χ 2 =0.37, d.f.=1, p= Best fitting model.
3 etble 2. Risk Rtios (RRs) of Pyloric Stenosis According to Fmily History by Type of Reltive Siblings Hlf-Siblings Cousins Hlf-Cousins Children without Children 956, ,582 1,053, ,126 ffected reltive Cses 1, , Children with Children 1,745 1,109 6,290 1,213 ffected reltive Cses RR (95% CI) 19.6( ) 4.26 ( ) 3.10 ( ) 1.59 ( ) Abbrevitions: RR, risk rtio; CI, confidence intervl. Risk rtios nd 95% CI were estimted by log-liner binomil regression.
4 etble 3. Rte Rtios (RRs) of Pyloric Stenosis According to Fmily History by Type of Reltive With n Extended Cse Definition Siblings Hlf-Siblings Cousins Hlf-Cousins Children without Person-yers 934, ,632 1,023, ,491 ffected reltive Cses 1, , Children with Person-yers 2,004 1,271 7,289 1,389 ffected reltive Cses RR b (95% CI) 17.8 ( ) 4.54 ( ) 2.34 ( ) 1.00 ( ) The extended cse definition is wider cse definition, llowing for not only children with n opertion code but lso children with only dignosis code for pyloric stenosis. b RR djusted for sex, ge nd period.
5 etble 4. Rte Rtios (RRs) of Pyloric Stenosis According to Fmily History by Type of Reltive for Children Born Before nd After 1990 Siblings Hlf-Siblings Cousins Hlf-Cousins Before 1990 Children without Person-yers 343, , ,137 18,853 ffected reltive Cses Children with Person-yers , ffected reltive Cses RR (95% CI) 16.3 ( ) 4.55 ( ) 1.54 ( ) - b After 1990 Children without Person-yers 590, , , ,938 ffected reltive Cses Children with Person-yers 1, ,995 1,060 ffected reltive Cses RR (95% CI) 22.1 ( ) 5.16 ( ) 3.91 ( ) 1.96 ( ) RR djusted for sex, ge nd period. b It ws not possible to estimte the RR due to no cses with ffected hlf-cousins in tht time period.
6 etble 5. Rte Rtios (RRs) of Pyloric Stenosis According to Fmily History by Type of Reltive for Children Born Before nd After 1996 Siblings Hlf-Siblings Cousins Hlf-Cousins Before 1996 Children without Person-yers 534, , ,377 52,284 ffected reltive Cses Children with Person-yers 1, , ffected reltive Cses RR (95% CI) 16.7 ( ) 4.09 ( ) 2.14 ( ) 1.04 ( ) After 1996 Children without Person-yers 400, , , ,507 ffected reltive Cses Children with Person-yers , ffected reltive Cses RR (95% CI) 27.4 ( ) 6.97 ( ) 5.30 ( ) 2.16 ( ) RR djusted for sex, ge nd period.
7 etble 6. Rte Rtios (RRs) of Pyloric Stenosis According to Fmily History by Type of Reltive With Additionl Adjustment for Number of Older Reltives Siblings Hlf-Siblings Cousins Hlf-Cousins Children without Person-yers 934, ,939 1,024, ,791 ffected reltive Cses 1, , Children with Person-yers 1,675 1,076 6,144 1,167 ffected reltive Cses RR (95% CI) 18.7 ( ) 5.01 ( ) 3.15 ( ) 1.61 ( ) RR djusted for sex, ge, period nd dditionlly for number of older reltives.
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