American Society of Cytopathology Core Curriculum in Molecular Biology

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "American Society of Cytopathology Core Curriculum in Molecular Biology"

Transcription

1 American Society of Cytopathology Core Curriculum in Molecular Biology

2 American Society of Cytopathology Core Curriculum in Molecular Biology Chapter 7 Circulating Tumor Cells Circulating Tumor Cells: Overview Kara Hansing, SCT(ASCP) CM Jill L. Caudill, MEd, SCT(ASCP) CM Mayo School of Health Sciences Rochester, Minnesota

3 Cancer Physiology Although tumors can develop from any tissue, cancers originating from epithelial cells make up about 85% of all cancers Cancer has the ability to spread or metastasize from a primary site to other parts of the body Metastases are generally associated with a poor prognosis

4 Metastasis Cancer spreads in three ways: By local extension from the tumor to the surrounding tissues Through the lymphatic system to lymph nodes Through the bloodstream to distant sites

5 The Question Is there clinical utility in identifying the presence of circulating tumor cells in the blood?

6 Concept of Circulating Tumor Cells The concept is not new Tumor cells identified in the blood stream of cancer patients as early as Circulating Cancer Cell Cooperative (CCCC) Slide seminar conference Acta Cytologica (1965) 9: 21 49

7 Techniques for Identification of CTCs CellSearch (Veridex, Warren, NJ) Currently the only FDA approved method for clinical use CTC chip microfluid platform FAST using fiber optic arrays ISET based on cellular size MACS immunobeads Oncoquick utilizes cellular density

8 Introduction to CellSearch The CellSearch System is designed to identify metastatic cancer cells circulating in the blood stream Technology can theoretically be applied to epithelial tumors of the breast, prostate, colon, lung, ovary, pancreas, and head & neck Current FDA approval covers testing for metastatic breast, prostate and colon cancers only

9 The Potential Effect on Follow Up Care Currently: Follow up appointments every 4 6 months (decreasing in frequency as cancer free intervals lengthen) Physical exams and/or lab or imaging tests are utilized to identify recurrences If symptoms or physical exam findings suggest recurrence, tumor marker studies, blood tests, scans, x rays and/or biopsies may be ordered

10 Limitations of Current Follow Up Care Brought Cancer recurrence/metastasis may not always be detected during follow up visits Efficacy of therapy is complicated to assess High disagreement rate for scoring radiographic images Painful and expensive for patient

11 Role of CellSearch in Follow-up Care After Primary Treatment Simple blood test Information provided can assist in management of patients with metastatic breast cancer (i.e. monitoring therapy, predicting progression, and evaluating prognosis) CellSearch is a diagnostic test and not a screening test for breast cancer!

12 Role of CellSearch in Follow-up Care After Primary Treatment Brought Benefits Simple blood draw is relatively painless test Less expensive than traditional imaging tests More robust and reproducible assay than radiography Highly sensitive test that can detect 1 tumor cell in a tube (7.5 ml) of blood Clinical studies have shown that having 5 or more CTCs per 7.5 ml of blood predicts shorter progression free survival and overall survival earlier than traditional imaging method systems

13 CellSearch System Overview Brought Review monitor Autoprep system Cell save preservative tube Analyzer Magnest

14 CellSearch Technology Uses a combination of immunomagnetic labeling and immunofluorescent identification of the tumor cells See the CellSearch video for a more complete description of the process:

15 CellSearch Technology Cells are magnetized Tumor cells labeled with a cytokeratin Inflammatory cells labeled with CD45/LCA 4' 6 Diamidino 2 phenylindole (DAPI) counterstain for the nuclei A magnet is used to pull cells onto a surface for scanning

16 CellSearch Technology Brought Sample or control in Magnest is scanned using 4 different filters Software analyzes the data for each frame (~175), selects events which meet the size and intensity profile, and compiles images for final classification by user

17 CellSearch Technology Brought Events are classified as a tumor cells if morphological features and staining patterns are consistent with that of an epithelial cell

18 References Alberts B, et al. (2002) Molecular Biology of the Cell, 4 th ed. New York: Garland Publishing. Cristofanilli M, Budd T, Ellis M, et al. Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer. N Engl J Med. 2004; 351: Veridex

Metastatic Cancer: Questions and Answers. Key Points

Metastatic Cancer: Questions and Answers. Key Points CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Metastatic Cancer: Questions

More information

OBJECTIVES By the end of this segment, the community participant will be able to:

OBJECTIVES By the end of this segment, the community participant will be able to: Cancer 101: Cancer Diagnosis and Staging Linda U. Krebs, RN, PhD, AOCN, FAAN OCEAN Native Navigators and the Cancer Continuum (NNACC) (NCMHD R24MD002811) Cancer 101: Diagnosis & Staging (Watanabe-Galloway

More information

Us TOO University Presents: Understanding Diagnostic Testing

Us TOO University Presents: Understanding Diagnostic Testing Us TOO University Presents: Understanding Diagnostic Testing for Prostate Cancer Patients Today s speaker is Manish Bhandari, MD Program moderator is Pam Barrett, Us TOO International Made possible by

More information

Fact Sheet: Molecular Imaging and Cancer

Fact Sheet: Molecular Imaging and Cancer Fact Sheet: Molecular Imaging and Cancer Cancer causes one in every four deaths in the United States, second only to heart disease. According to the American Cancer Society, an estimated 1.48 million new

More information

Frequently Asked Questions About Ovarian Cancer

Frequently Asked Questions About Ovarian Cancer Media Contact: Gerri Gomez Howard Cell: 303-748-3933 gerri@gomezhowardgroup.com Frequently Asked Questions About Ovarian Cancer What is ovarian cancer? Ovarian cancer is a cancer that forms in tissues

More information

The TV Series. www.healthybodyhealthymind.com INFORMATION TELEVISION NETWORK

The TV Series. www.healthybodyhealthymind.com INFORMATION TELEVISION NETWORK The TV Series www.healthybodyhealthymind.com Produced By: INFORMATION TELEVISION NETWORK ONE PARK PLACE 621 NW 53RD ST BOCA RATON, FL 33428 1-800-INFO-ITV www.itvisus.com 2005 Information Television Network.

More information

Introduction Breast cancer is cancer that starts in the cells of the breast. Breast cancer happens mainly in women. But men can get it too.

Introduction Breast cancer is cancer that starts in the cells of the breast. Breast cancer happens mainly in women. But men can get it too. Male Breast Cancer Introduction Breast cancer is cancer that starts in the cells of the breast. Breast cancer happens mainly in women. But men can get it too. Many people do not know that men can get breast

More information

Gallbladder cancer is a disease in which malignant (cancer) cells form in the tissues of the gallbladder.

Gallbladder cancer is a disease in which malignant (cancer) cells form in the tissues of the gallbladder. Gallbladder cancer Gallbladder cancer is a disease in which malignant (cancer) cells form in the tissues of the gallbladder. Gallbladder cancer is a rare disease in which malignant (cancer) cells are found

More information

Smoking and misuse of certain pain medicines can affect the risk of developing renal cell cancer.

Smoking and misuse of certain pain medicines can affect the risk of developing renal cell cancer. Renal cell cancer Renal cell cancer is a disease in which malignant (cancer) cells form in tubules of the kidney. Renal cell cancer (also called kidney cancer or renal adenocarcinoma) is a disease in which

More information

Cancer Diagnosis and Staging

Cancer Diagnosis and Staging Cancer diagnosis and Staging Module 4 Cancer Diagnosis and Staging Target Audience: Community members Staff of Indian health programs, including Community Health Representatives Contents of Learning Module:

More information

Understanding Metastatic Disease

Understanding Metastatic Disease Supported by an unrestricted educational grant from Pfizer Understanding Metastatic Disease Metastatic disease or metastases are phrases that mean the same as Secondary cancer. This means that the cancer

More information

UICC World Cancer Congress. Cancer Staging and Quality of Care

UICC World Cancer Congress. Cancer Staging and Quality of Care UICC World Cancer Congress August 27 30, 2012, Montreal CANCER STAGE: A neglected cornerstone of Cancer Control Cancer Staging and Quality of Care Christian Wittekind Institut für Pathologie UKL 1 Agenda!

More information

Mesothelioma. 1995-2013, The Patient Education Institute, Inc. www.x-plain.com ocft0101 Last reviewed: 03/21/2013 1

Mesothelioma. 1995-2013, The Patient Education Institute, Inc. www.x-plain.com ocft0101 Last reviewed: 03/21/2013 1 Mesothelioma Introduction Mesothelioma is a type of cancer. It starts in the tissue that lines your lungs, stomach, heart, and other organs. This tissue is called mesothelium. Most people who get this

More information

Small cell lung cancer

Small cell lung cancer Small cell lung cancer Small cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung. The lungs are a pair of cone-shaped breathing organs that are found within

More information

See page 6 of this form for definitions / instructions to assist you in completing Question 1.

See page 6 of this form for definitions / instructions to assist you in completing Question 1. Pre-PET Form Comment to Clinician: You have requested an F-18 Fluoride PET scan, a test for which the Centers for Medicare and Medicaid Services (CMS) requires pre- and post-pet information from the referring

More information

Extrahepatic bile duct cancer is a rare disease in which malignant (cancer) cells form in the part of bile duct that is outside the liver.

Extrahepatic bile duct cancer is a rare disease in which malignant (cancer) cells form in the part of bile duct that is outside the liver. EXTRAHEPATIC BILE DUCT CANCER General Information Extrahepatic bile duct cancer is a rare disease in which malignant (cancer) cells form in the part of bile duct that is outside the liver. A network of

More information

An Update on Lung Cancer Diagnosis

An Update on Lung Cancer Diagnosis An Update on Lung Cancer Diagnosis Dr Michael Fanning MBBS FRACGP FRACP RESPIRATORY AND SLEEP PHYSICIAN Mater Medical Centre Outline Risk factors for lung cancer Screening for lung cancer Radiologic follow-up

More information

Kidney Cancer OVERVIEW

Kidney Cancer OVERVIEW Kidney Cancer OVERVIEW Kidney cancer is the third most common genitourinary cancer in adults. There are approximately 54,000 new cancer cases each year in the United States, and the incidence of kidney

More information

Liver Cancer What is the liver? What is liver cancer?

Liver Cancer What is the liver? What is liver cancer? Liver Cancer What is the liver? The liver is the largest internal organ in the body and is important in digesting food. The liver performs many other functions, including collecting and filtering blood

More information

Intestinal Cancer. Intestinal cancer is rare. But eating a high-fat diet or having certain digestive diseases can raise a person s risk.

Intestinal Cancer. Intestinal cancer is rare. But eating a high-fat diet or having certain digestive diseases can raise a person s risk. Intestinal Cancer Introduction This reference summary discusses cancer of the small intestines, not cancer of the colon. Intestinal cancer starts in the cells of the small intestine. The small intestine

More information

Diagnosis and Prognosis of Pancreatic Cancer

Diagnosis and Prognosis of Pancreatic Cancer Main Page Risk Factors Reducing Your Risk Screening Symptoms Diagnosis Treatment Overview Chemotherapy Radiation Therapy Surgical Procedures Lifestyle Changes Managing Side Effects Talking to Your Doctor

More information

PET Scans in the Head and Neck. Diagnostic imaging

PET Scans in the Head and Neck. Diagnostic imaging PET Scans in the Head and Neck Joseph C. Sniezek, MD FACS Head and Neck Surgery Tripler Army Medical Center Diagnostic imaging 1. Anatomic information -x-ray -CT -MRI -Ultrasound 2. Physiologic/Metabolic

More information

Adjuvant Therapy for Breast Cancer: Questions and Answers

Adjuvant Therapy for Breast Cancer: Questions and Answers CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Adjuvant Therapy for Breast

More information

Gestational Trophoblastic Tumors

Gestational Trophoblastic Tumors 32 Gestational Trophoblastic Tumors C58.9 Placenta SUMMARY OF CHANGES Gestational trophoblastic tumors are effectively treated with chemotherapy even when widely metastatic so that traditional anatomic

More information

Guide to Understanding Breast Cancer

Guide to Understanding Breast Cancer An estimated 220,000 women in the United States are diagnosed with breast cancer each year, and one in eight will be diagnosed during their lifetime. While breast cancer is a serious disease, most patients

More information

Questions to Ask As You Learn More About Kidney Cancer

Questions to Ask As You Learn More About Kidney Cancer Questions to Ask As You Learn More About Kidney Cancer Now that you have been diagnosed with kidney cancer, it is important for you to understand your condition and your treatment options. Many patients

More information

Molecular Imaging and Prostate Cancer

Molecular Imaging and Prostate Cancer Molecular Imaging and Prostate Cancer Prostate cancer is the second leading cause of cancer death in American men, behind only lung cancer. Based on rates from 2004 2006, the National Cancer Institute

More information

Diagnosis and Prognosis of Thyroid Cancer

Diagnosis and Prognosis of Thyroid Cancer Main Page Risk Factors Reducing Your Risk Screening Symptoms Diagnosis Treatment Overview Chemotherapy Radiation Therapy Surgical Procedures Medications Lifestyle Changes Living With Thyroid Cancer Talking

More information

Report series: General cancer information

Report series: General cancer information Fighting cancer with information Report series: General cancer information Eastern Cancer Registration and Information Centre ECRIC report series: General cancer information Cancer is a general term for

More information

Registrar s Guide to Chapter 1, AJCC Seventh Edition

Registrar s Guide to Chapter 1, AJCC Seventh Edition Registrar s Guide to Chapter 1, AJCC Seventh Edition Donna M. Gress, RHIT, CTR Validating science. Improving patient care. This presentation was supported by the Cooperative Agreement Number DP13-1310

More information

Colon and Rectal Cancer

Colon and Rectal Cancer Colon and Rectal Cancer What is colon or rectal cancer? Colon or rectal cancer is the growth of abnormal cells in your large intestine, which is also called the large bowel. The colon is the last 5 feet

More information

RCC. RENAL CELL CARCINOMA the most common form of kidney cancer UNDERSTANDINGRCC

RCC. RENAL CELL CARCINOMA the most common form of kidney cancer UNDERSTANDINGRCC RCC RENAL CELL CARCINOMA the most common form of kidney cancer UNDERSTANDINGRCC RENAL CELL CARCINOMA ABOUT THIS GUIDE This guide will: Help you understand renal cell carcinoma (RCC) Provide information

More information

Louisa Fleure. Advanced Prostate Cancer Clinical Nurse Specialist. Guys and St Thomas NHS Trust

Louisa Fleure. Advanced Prostate Cancer Clinical Nurse Specialist. Guys and St Thomas NHS Trust Louisa Fleure Advanced Prostate Cancer Clinical Nurse Specialist Guys and St Thomas NHS Trust The classification of advanced prostate cancer The incidence of patients presenting with, or developing advanced

More information

Small Intestine Cancer

Small Intestine Cancer Small Intestine Cancer What is the Small Intestine? The small intestine, also called the small bowel, is part of the body s gastrointestinal tract or digestive system. Its jobs are to: Break down food

More information

Follow-Up Care for Breast Cancer

Follow-Up Care for Breast Cancer A Patient s Guide Follow-Up Care for Breast Cancer Recommendations of the American Society of Clinical Oncology The American Society of Clinical Oncology (ASCO) is a nonprofit organization which represents

More information

Liver Cancer And Tumours

Liver Cancer And Tumours Liver Cancer And Tumours What causes liver cancer? Many factors may play a role in the development of cancer. Because the liver filters blood from all parts of the body, cancer cells from elsewhere can

More information

WHEN PROSTATE CANCER RETURNS: ADVANCED PROSTATE CANCER. How Will I Know If My Prostate Cancer Returns?

WHEN PROSTATE CANCER RETURNS: ADVANCED PROSTATE CANCER. How Will I Know If My Prostate Cancer Returns? WHEN PROSTATE CANCER RETURNS: ADVANCED PROSTATE CANCER (The following information is based on the general experiences of many prostate cancer patients. Your experience may be different.) How Will I Know

More information

Hodgkin Lymphoma Understanding your diagnosis

Hodgkin Lymphoma Understanding your diagnosis Hodgkin Lymphoma Understanding your diagnosis Let s Make Cancer History 1 888 939-3333 cancer.ca Hodgkin Lymphoma Understanding your diagnosis When you first hear that you have cancer you may feel alone

More information

Breast Cancer. Sometimes cells keep dividing and growing without normal controls, causing an abnormal growth called a tumor.

Breast Cancer. Sometimes cells keep dividing and growing without normal controls, causing an abnormal growth called a tumor. Breast Cancer Introduction Cancer of the breast is the most common form of cancer that affects women but is no longer the leading cause of cancer deaths. About 1 out of 8 women are diagnosed with breast

More information

Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer

Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer J.-L. Zhang, Q. Yao, J.-H. Chen,Y. Wang, H. Wang, Q. Fan, R. Ling, J. Yi and L. Wang Xijing Hospital Vascular Endocrine

More information

Post-PET Restaging Cancer Form National Oncologic PET Registry

Post-PET Restaging Cancer Form National Oncologic PET Registry Post-PET Restaging Cancer Form National Oncologic PET Registry Facility ID #: Registry Case Number: Patient Name: Your patient had a PET scan on: mm/dd/yyyy. The PET scan was done for restaging of (cancer

More information

The lungs What is lung cancer? How common is it? Risks & symptoms Diagnosis & treatment options

The lungs What is lung cancer? How common is it? Risks & symptoms Diagnosis & treatment options Why We re Here The lungs What is lung cancer? How common is it? Risks & symptoms Diagnosis & treatment options What Are Lungs? What Do They Do? 1 Located in the chest Allow you to breathe Provide oxygen

More information

Ef#icient Isolation and Accurate In Situ Analysis of Circulating Tumor Cells Using Detachable Beads and a High- Pore- Density Filter

Ef#icient Isolation and Accurate In Situ Analysis of Circulating Tumor Cells Using Detachable Beads and a High- Pore- Density Filter Ef#icient Isolation and Accurate In Situ Analysis of Circulating Tumor Cells Using Detachable Beads and a High- Pore- Density Filter Hun Joo Lee, Jin Ho Oh, Jin Mi Oh, Jong- Myeon Park, Jeong- Gun Lee,

More information

Understanding. Pancreatic Cancer

Understanding. Pancreatic Cancer Understanding Pancreatic Cancer Understanding Pancreatic Cancer The Pancreas The pancreas is an organ that is about 6 inches long. It s located deep in your belly between your stomach and backbone. Your

More information

TNM staging and prognosis. Alexandru Eniu, MD, PhD Medical Oncologist Department of Breast Tumors Cancer Institute Ion Chiricuţă Cluj-Napoca, Romania

TNM staging and prognosis. Alexandru Eniu, MD, PhD Medical Oncologist Department of Breast Tumors Cancer Institute Ion Chiricuţă Cluj-Napoca, Romania TNM staging and prognosis Alexandru Eniu, MD, PhD Medical Oncologist Department of Breast Tumors Cancer Institute Ion Chiricuţă Cluj-Napoca, Romania The Basics of TNM Staging Premises: Cancers of the same

More information

Follow-up care plan after treatment for breast cancer. A guide for General Practitioners

Follow-up care plan after treatment for breast cancer. A guide for General Practitioners Follow-up care plan after treatment for breast cancer A guide for General Practitioners This leaflet provides information for GPs on the follow-up care required by women who had breast cancer. It is for

More information

Lymph Nodes and Cancer What is the lymph system?

Lymph Nodes and Cancer What is the lymph system? Lymph Nodes and Cancer What is the lymph system? Our bodies have a network of lymph vessels and lymph nodes. (Lymph is pronounced limf.) This network is a part of the body s immune system. It collects

More information

Metastatic Renal Cell Carcinoma: Staging and Prognosis of Three Separate Cases.

Metastatic Renal Cell Carcinoma: Staging and Prognosis of Three Separate Cases. Metastatic Renal Cell Carcinoma: Staging and Prognosis of Three Separate Cases. Abstract This paper describes the staging, imaging, treatment, and prognosis of renal cell carcinoma. Three case studies

More information

Tumour Markers. What are Tumour Markers? How Are Tumour Markers Used?

Tumour Markers. What are Tumour Markers? How Are Tumour Markers Used? Dr. Anthony C.H. YING What are? Tumour markers are substances that can be found in the body when cancer is present. They are usually found in the blood or urine. They can be products of cancer cells or

More information

Newsletter. WntResearch AB, Medeon Science Park, Per Albin Hanssons väg 41, 205 12 Malmö, Sweden. Primary Objective:

Newsletter. WntResearch AB, Medeon Science Park, Per Albin Hanssons väg 41, 205 12 Malmö, Sweden. Primary Objective: Newsletter This resume of the results from the phase 1 study with Foxy-5 is based on clinical and laboratory data from the study, and these data have now been locked into the database. The full report

More information

The Center for Prostate Cancer. Personalized Treatment. Clinical Excellence.

The Center for Prostate Cancer. Personalized Treatment. Clinical Excellence. The Center for Prostate Cancer Personalized Treatment. Clinical Excellence. The Center for Prostate Cancer Leaders in Prostate Cancer Treatment and Research The Center for Prostate Cancer at the North

More information

METASTASES TO THE BONE

METASTASES TO THE BONE RADIATION THERAPY FOR METASTASES TO THE BONE Facts to Help Patients Make an Informed Decision TARGETING CANCER CARE AMERICAN SOCIETY FOR RADIATION ONCOLOGY WHAT ARE BONE METASTASES? Cancer that starts

More information

What is Prosigna? Indications for Use

What is Prosigna? Indications for Use What is Prosigna? The Prosigna Breast Cancer Prognostic Gene Signature Assay is currently the only FDA-cleared test that provides a risk category and numerical score to assess a patient's risk of distant

More information

Prostate Cancer. Treatments as unique as you are

Prostate Cancer. Treatments as unique as you are Prostate Cancer Treatments as unique as you are UCLA Prostate Cancer Program Prostate cancer is the second most common cancer among men. The UCLA Prostate Cancer Program brings together the elements essential

More information

X-Plain Breast Cancer Reference Summary

X-Plain Breast Cancer Reference Summary X-Plain Breast Cancer Reference Summary The risk of breast cancer among Asian Americans living in the U.S. is relatively low compared to caucasian women. However, there is concern that the risk of breast

More information

Metastatic Breast Cancer...

Metastatic Breast Cancer... DIAGNOSIS: Metastatic Breast Cancer... What Does It Mean For You? A diagnosis of metastatic breast cancer can be frightening. It raises many questions and reminds us of days past when cancer was such a

More information

NCT Preliminary Report: Phase I Dose Escalating Study to Evaluate the Safety,

NCT Preliminary Report: Phase I Dose Escalating Study to Evaluate the Safety, NCT02020291 Preliminary Report: Phase I Dose Escalating Study to Evaluate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profiles of Foxy-5 in Patients with Metastatic Breast, Colon or Prostate

More information

A SAFE, NON-INVASIVE TREATMENT OPTION: GAMMA KNIFE PERFEXION

A SAFE, NON-INVASIVE TREATMENT OPTION: GAMMA KNIFE PERFEXION A SAFE, NON-INVASIVE TREATMENT OPTION: GAMMA KNIFE PERFEXION Not actually a knife, the Gamma Knife Perfexion is an advanced radiosurgery device which uses extremely precise beams of radiation to treat

More information

Joseph Wagner, Ph.D. Chief Executive Officer OncoCyte Corporation

Joseph Wagner, Ph.D. Chief Executive Officer OncoCyte Corporation Joseph Wagner, Ph.D. Chief Executive Officer OncoCyte Corporation Forward Looking Statements The matters discussed in this presentation include forward looking statements which are subject to various risks,

More information

Lung Cancer: Diagnosis, Staging and Treatment

Lung Cancer: Diagnosis, Staging and Treatment PATIENT EDUCATION patienteducation.osumc.edu Lung Cancer: Diagnosis, Staging and Treatment Cancer starts in our cells. Cells are the building blocks of our tissues. Tissues make up the organs of the body.

More information

Breast Cancer Follow-Up

Breast Cancer Follow-Up Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer Breast Cancer Follow-Up Breast Cancer Follow-Up Version 2002: Thomssen / Scharl Version 2003 2009: Bauerfeind / Bischoff /

More information

Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available.

Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available. Thymus Cancer Introduction Thymus cancer is a rare cancer. It starts in the small organ that lies in the upper chest under the breastbone. The thymus makes white blood cells that protect the body against

More information

Lung Cancer: Diagnosis, Staging and Treatment

Lung Cancer: Diagnosis, Staging and Treatment PATIENT EDUCATION patienteducation.osumc.edu Lung Cancer: Diagnosis, Staging and Treatment Cancer begins in our cells. Cells are the building blocks of our tissues. Tissues make up the organs of the body.

More information

Pathology Department

Pathology Department Banha University Faculty of Medicine Pathology Department Third Year Student's Guide and Activity Book Student's Name: Student's Number: Group: 00-0 - 0 - Course Specifications University : Benha Faculty

More information

Florida Breast Health Specialists Breast Cancer Information and Facts

Florida Breast Health Specialists Breast Cancer Information and Facts Definition Breast cancer is a cancer that starts in the tissues of the breast. There are two main types of breast cancer: Ductal carcinoma starts in the tubes (ducts) that move milk from the breast to

More information

Colon cancer is a disease in which malignant (cancer) cells form in the tissues of the colon.

Colon cancer is a disease in which malignant (cancer) cells form in the tissues of the colon. Colon cancer Colon cancer is a disease in which malignant (cancer) cells form in the tissues of the colon. The colon is part of the body s digestive system. The digestive system removes and processes nutrients

More information

Cancer of the Cervix

Cancer of the Cervix Cancer of the Cervix WOMENCARE A Healthy Woman is a Powerful Woman (407) 898-1500 A woman's cervix (the opening of the uterus) is lined with cells. Cancer of the cervix occurs when those cells change,

More information

Changes in Breast Cancer Reports After Second Opinion. Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain

Changes in Breast Cancer Reports After Second Opinion. Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain Changes in Breast Cancer Reports After Second Opinion Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain Second Opinion in Breast Pathology Usually requested when a patient is referred

More information

Thyroid Cancer. This reference summary will help you better understand what thyroid cancer is and what treatment options are available.

Thyroid Cancer. This reference summary will help you better understand what thyroid cancer is and what treatment options are available. Thyroid Cancer Introduction The thyroid is a gland in the neck. Thyroid cancer is a common type of cancer. It accounts for 1% to 5% of cancer cases worldwide. As medical technology advances, more cases

More information

TNM Staging Fact Sheet

TNM Staging Fact Sheet TNM Staging Fact Sheet Jan 2010 This document provides answers to some of the frequently asked questions posed by physicians, health information management professionals, and cancer program administrators,

More information

PANCREATIC CANCER. Two different categories of cancer can affect the pancreas: Exocine and Endocrine cancers

PANCREATIC CANCER. Two different categories of cancer can affect the pancreas: Exocine and Endocrine cancers PANCREATIC CANCER INTRODUCTION More than 42,000 Americans develop cancer of the pancreas each year; it is the fourth leading cause of cancer-related death in the United States. Two different categories

More information

Treating Prostate Cancer

Treating Prostate Cancer Treating Prostate Cancer A Guide for Men With Localized Prostate Cancer Most men have time to learn about all the options for treating their prostate cancer. You have time to talk with your family and

More information

October 2012 Pulmonary Case of the Month: Hemoptysis from an Uncommon Cause. Lewis J. Wesselius, MD

October 2012 Pulmonary Case of the Month: Hemoptysis from an Uncommon Cause. Lewis J. Wesselius, MD October 2012 Pulmonary Case of the Month: Hemoptysis from an Uncommon Cause Lewis J. Wesselius, MD Department of Pulmonary Medicine Mayo Clinic Arizona Scottsdale, AZ History of Present Illness A 39 year

More information

General Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014

General Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014 General Rules SEER Summary Stage 2000 Linda Mulvihill Public Health Advisor NCRA Annual Meeting May 2014 National Center for Chronic Disease Prevention and Health Promotion Division of Cancer Prevention

More information

9. Discuss guidelines for follow-up post-thyroidectomy for cancer (labs/tests) HH

9. Discuss guidelines for follow-up post-thyroidectomy for cancer (labs/tests) HH 9. Discuss guidelines for follow-up post-thyroidectomy for cancer (labs/tests) HH Differentiated thyroid cancer expresses the TSH receptor on the cell membrane and responds to TSH stimulation by increasing

More information

THYROID CANCER. I. Introduction

THYROID CANCER. I. Introduction THYROID CANCER I. Introduction There are over 11,000 new cases of thyroid cancer each year in the US. Females are more likely to have thyroid cancer than men by a ratio of 3:1, and it is more common in

More information

Recruiting now. Could you help by joining this study?

Recruiting now. Could you help by joining this study? Non-Small Cell Lung Cancer Recruiting now AstraZeneca is looking for men and women with locally advanced or metastatic non-small cell lung cancer (NSCLC) to join ATLANTIC, a clinical study to help investigate

More information

An Introduction to Cancer and Basic Cancer Vocabulary

An Introduction to Cancer and Basic Cancer Vocabulary An Introduction to Cancer and Basic Cancer Vocabulary Marc B. Garnick, MD Beth Israel Deaconess Medical Center Harvard Medical School, Boston Medical Director Cancer Programs Northeast Hospital Corporation,

More information

Detection and staging of recurrent prostate cancer is still one of the important clinical problems in prostate cancer. A rise in PSA or biochemical

Detection and staging of recurrent prostate cancer is still one of the important clinical problems in prostate cancer. A rise in PSA or biochemical Summary. 111 Detection and staging of recurrent prostate cancer is still one of the important clinical problems in prostate cancer. A rise in PSA or biochemical recurrence (BCR) is the first sign of recurrent

More information

Patient information factsheet

Patient information factsheet Sentinel lymph node biopsy This factsheet has been designed to give you information about having a sentinel lymph node biopsy (SLNB) and the care you will receive before, during and after the operation.

More information

SIGNPOSTS. Along the Pathway of Prostate Cancer. Understanding Diagnostic Tests and Procedures to Monitor Prostate Cancer

SIGNPOSTS. Along the Pathway of Prostate Cancer. Understanding Diagnostic Tests and Procedures to Monitor Prostate Cancer SIGNPOSTS Along the Pathway of Prostate Cancer Understanding Diagnostic Tests and Procedures to Monitor Prostate Cancer Your journey is unique like you. Signposts along the pathway can show you where you

More information

Analysis of Prostate Cancer at Easter Connecticut Health Network Using Cancer Registry Data

Analysis of Prostate Cancer at Easter Connecticut Health Network Using Cancer Registry Data The 2014 Cancer Program Annual Public Reporting of Outcomes/Annual Site Analysis Statistical Data from 2013 More than 70 percent of all newly diagnosed cancer patients are treated in the more than 1,500

More information

HERC Coverage Guidance Advanced Imaging for Staging of Prostate Cancer Disposition of Public Comments

HERC Coverage Guidance Advanced Imaging for Staging of Prostate Cancer Disposition of Public Comments Table of Contents Commenters... 1 Public Comments... 2 References Provided by Commenters... 6 Commenters Identification Stakeholder A Medical Imaging & Technology Alliance (MITA), Arlington, VA [Submitted

More information

Testicular Cancer. This reference summary will help you better understand what testicular cancer is and what treatment options are available.

Testicular Cancer. This reference summary will help you better understand what testicular cancer is and what treatment options are available. Testicular Cancer Introduction Testicles, or testes, make male hormones and sperm. The testicles are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. You can get cancer

More information

QUESTIONS FOR YOUR LUNG CANCER CARE TEAM

QUESTIONS FOR YOUR LUNG CANCER CARE TEAM What should I ask my doctor? Thinking about lung cancer brings up many questions. Sometimes it is difficult to keep all of your questions straight. Many patients have topics in mind they want to discuss

More information

RESEARCH EDUCATE ADVOCATE. Just Diagnosed with Melanoma Now What?

RESEARCH EDUCATE ADVOCATE. Just Diagnosed with Melanoma Now What? RESEARCH EDUCATE ADVOCATE Just Diagnosed with Melanoma Now What? INTRODUCTION If you are reading this, you have undergone a biopsy (either of a skin lesion or a lymph node) or have had other tests in which

More information

DOES HYPERFRACTIONATED RADIOTHERAPY CHANGE THE OUTCOME OF HEAD AND NECK CANCER? A TRIAL COMPARING CONVENTIONAL WITH HYPERFRACTIONATED RADIOTHERAPY

DOES HYPERFRACTIONATED RADIOTHERAPY CHANGE THE OUTCOME OF HEAD AND NECK CANCER? A TRIAL COMPARING CONVENTIONAL WITH HYPERFRACTIONATED RADIOTHERAPY Medical Joumal of the Islamic Republic of Iran Volume 18 Number 3 Fall 1383 November 2004 DOES HYPERFRACTIONATED RADIOTHERAPY CHANGE THE OUTCOME OF HEAD AND NECK CANCER? A TRIAL COMPARING CONVENTIONAL

More information

A912: Kidney, Renal cell carcinoma

A912: Kidney, Renal cell carcinoma A912: Kidney, Renal cell carcinoma General facts of kidney cancer Renal cell carcinoma, a form of kidney cancer that involves cancerous changes in the cells of the renal tubule, is the most common type

More information

AFTER DIAGNOSIS: PROSTATE CANCER Understanding Your Treatment Options

AFTER DIAGNOSIS: PROSTATE CANCER Understanding Your Treatment Options AFTER DIAGNOSIS: PROSTATE CANCER Understanding Your Treatment Options INTRODUCTION This booklet describes how prostate cancer develops, how it affects the body and the current treatment methods. Although

More information

What is Cancer? Cancer is a genetic disease: Cancer typically involves a change in gene expression/function:

What is Cancer? Cancer is a genetic disease: Cancer typically involves a change in gene expression/function: Cancer is a genetic disease: Inherited cancer Sporadic cancer What is Cancer? Cancer typically involves a change in gene expression/function: Qualitative change Quantitative change Any cancer causing genetic

More information

These rare variants often act aggressively and may respond differently to therapy than the more common prostate adenocarcinoma.

These rare variants often act aggressively and may respond differently to therapy than the more common prostate adenocarcinoma. Prostate Cancer OVERVIEW Prostate cancer is the second most common cancer diagnosed among American men, accounting for nearly 200,000 new cancer cases in the United States each year. Greater than 65% of

More information

Hodgkin Lymphoma Disease Specific Biology and Treatment Options. John Kuruvilla

Hodgkin Lymphoma Disease Specific Biology and Treatment Options. John Kuruvilla Hodgkin Lymphoma Disease Specific Biology and Treatment Options John Kuruvilla My Disclaimer This is where I work Objectives Pathobiology what makes HL different Diagnosis Staging Treatment Philosophy

More information

Cancer Staging. Introduction. Overview

Cancer Staging. Introduction. Overview Many Hearts Many Minds One Goal Volume 2 Number 3 May 2005 Cancer Staging bt Maureen MacIntyre, Director, Surveillance and Epidemiology Unit, Cancer Care Nova Scotia and Dr. Eva Grunfeld, Clinician Scientist

More information

ALLIED HEALTH. Clinical Practice Acute care Neuro-rehab Out-patient Management Education Research Consultation

ALLIED HEALTH. Clinical Practice Acute care Neuro-rehab Out-patient Management Education Research Consultation ALLIED HEALTH Physical & Occupational Therapy, Cytotechnology, Dental Hygiene, Health Information Management, Medical Technology What can I do with these degrees? PHYSICAL THERAPY Physical therapy involves

More information

Contact Maryann Verrillo Diane Shnitzler (703) 691-1805. Interventional Radiology Treatments for Kidney Cancer

Contact Maryann Verrillo Diane Shnitzler (703) 691-1805. Interventional Radiology Treatments for Kidney Cancer Interventional Radiology Treatments for Kidney Cancer FACT SHEET Contact Maryann Verrillo Diane Shnitzler (703) 691-1805 Kidney cancer is the eighth most common cancer in men and the tenth in women. 1

More information

Follow-Up Care for Endometrial (Uterus) Cancer after Discharge from the Cancer Center

Follow-Up Care for Endometrial (Uterus) Cancer after Discharge from the Cancer Center Follow-Up Care for Endometrial (Uterus) Cancer after Discharge from the Cancer Center Disclaimer This is general information developed by The Ottawa Hospital. It is not intended to replace the advice of

More information

One out of every two men and one out of every three women will have some type of cancer at some point during their lifetime. 3

One out of every two men and one out of every three women will have some type of cancer at some point during their lifetime. 3 1. What is cancer? 2. What causes cancer?. What causes cancer? 3. Can cancer be prevented? The Facts One out of every two men and one out of every three women will have some type of cancer at some point

More information

Science Highlights. To PSA or not to PSA: That is the Question.

Science Highlights. To PSA or not to PSA: That is the Question. Science Highlights June 2012 by Ann A. Kiessling, PhD at the To PSA or not to PSA: That is the Question. The current raucous debate over the commonly used PSA blood test to screen for prostate cancer,

More information

PSA Screening for Prostate Cancer Information for Care Providers

PSA Screening for Prostate Cancer Information for Care Providers All men should know they are having a PSA test and be informed of the implications prior to testing. This booklet was created to help primary care providers offer men information about the risks and benefits

More information