What is new in ARDS. Geoff Bellingan. Medical Director University College Hospital
|
|
- Laurence Banks
- 7 years ago
- Views:
Transcription
1 What is new in ARDS Geoff Bellingan Medical Director University College Hospital
2
3 ARDS: Pathophysiology INJURY EXUDATION & INFLAMMATION FIBROPROLIFERATION SURVIVE DIE
4 A TOP investigator studies the problem
5 Fibroproliferative activity of BAL within 24 hours of ARDS 70% 32% that of 10% serum
6 N-PCP A BETTER PREDICTOR OF OUTCOME. WITHIN 24 h OF DIAGNOSIS Survivors Nonsurvivors p Value (n= 28) (n= 16) BAL 1.24 ( ) 3.1 ( ) N-PCP-III, U/ml* APACHE II 17.5 ± ± score SAPS II 32.7 ± ± score PaO 2 /FIO ± ± Lung injury 3.1 ± ± score
7 Haematoxylin/Eosin: Early
8 Martius Scarlet Blue: Early
9 ACE : D allele as a risk factor for ARDS Genotype and allele frequency Genotype % Allele II ID DD p I D p ARDS n= CABG Control n= ICU Control n= Population Control n=
10 Small differences in genotype make big differences to phenotype
11
12 ARDS: Treatment
13 Early CPAP Can prevent evolution of ALI in haematologic malignancy 20 x 20 and only 4 vs 16 ventilated in those with early CPAP Ranieri et al ICM 2010
14 ECMO NICE (interventional procedure guidance 39 April 2011) Evidence on safety for severe ARDS is adequate but shows risk of serious side effects Evidence on efficacy inadequate to draw firm conclusions Should only be used with special arrangements for clinical governance, consent and research
15 ECMO RCT of 180 patients ECMO/conventional = death/severe disability in 37% vs. 53% (no information on 3 pts) RR 0.69 CI Non-randomised comparison of 245 patients ECMO/conventional = survival of 55% vs. 61% Non-randomised comparison of 150 patients ECMO/conventional = survival of 53% vs. 71%
16 ECMO developed DIC 1 in 68 perforated vessel 8% injuries in rupture of ECMO tubing Anecdotal reports of air embolus, mechanical failure, sepsis and MOF
17 High Frequency Oscillation (HFO) Oscar Trial HTA funded UK mechanical ventilation tiral normal 6 mls/kg <30 cm H20 vs High Frequency Oscillation recruitment currently at well over 550 pts
18 Pharmacological treatments????
19 ARDS: successful treatments cisatracurium paralysis improves survival in early ARDS - ACURASYS trial. Papazian et al NEJM 340 patients - ARDS within 48 hours 90-day mortality 31.6% vs 40.7%, P=0.04. Confined to those with P/F ratio of <16. More ventilator-free time, less other organ failure Muscle weakness similar. May work by facilitating lung-protective ventilation.
20 ARDS: other drugs Beta2 Agonists Despite the promise of BALTI 1, with significantly higher recruitment, the BALTI 2 trial demonstrated an increased mortality? The exact cause unclear but appeared related to tachydysrhythmia and metabolic acidosis. The American inhaled beta agonist trial also showed no treatment benefit (trend to harm)
21 ARDS: other drugs Sildenafil Pulmonary hypertension and right heart failure reduces pulmonary artery pressure but does not improve oxygenation in ARDS. Also note the PAP was reduced 25 to 22 so not massive Cornet et al ICM 2010
22 ARDS: other drugs Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction The HARP-2 Trial. Evidence that statins may be beneficial in ALI: A trend to lower mortality in patients receiving statins during their ICU stay. A small randomised, placebo-controlled proof of concept study showed simvastatin improved pulmonary organ dysfunction, reduced inflammation and well tolerated in ALI. Recruiting now in UK and Ireland Chief Investigators: Professor Danny McAuley (UK) Professor John Laffey (ROI)
23 ARDS: other drugs Interferon Beta Boosting endothelial CD73 and reducing lung leak The Faron Trial Chief Investigator: Geoff Bellingan
24 Traumakine (FP-1201) in ALI/ARDS Prevents a major cause of ALI development (vascular leakage): Inactivating pro-inflammatory purines ATP/ADP and Enhanced production of adenosine, reduced vascular leakage (JEM 1998:188:1433) An enhancer of fluid clearance (activation of lung epithelial cells) (PNAS 2007:104:4083) A suppressor of activated T cells (inhibition of inflammation) (JEM 2007:204:1257)
25
26 Traumakine Acceptance of Orphan Drug status in Europe Completed UK phase I/II ALI/ARDS study (37 patients). Proof-of-concept clinical efficacy data, MXA and CD73 dose response Mortality of 8% (3/37) Room temperature stabile formulation. Preparing for pan-european phase II/III trial.
27
ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) S. Agarwal, MD, S. Kache MD
ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) S. Agarwal, MD, S. Kache MD Definition ARDS is a clinical syndrome of lung injury with hypoxic respiratory failure caused by intense pulmonary inflammation that
More informationThe Berlin definition of Severe ARDS includes assessment of which of the following?
2013 ACS Critical Care Update ARDS, Ventilators MCQs August, 2013 (Berlin Definition of ARDS Question 1) The Berlin definition of Severe ARDS includes assessment of which of the following? A. Oxygenation:
More informationESCMID Online Lecture Library. by author
Do statins improve outcomes of patients with sepsis and pneumonia? Jordi Carratalà Department of Infectious Diseases Statins for sepsis & community-acquired pneumonia Sepsis and CAP are major healthcare
More informationVasopressors. Judith Hellman, M.D. Associate Professor Anesthesia and Perioperative Care University of California, San Francisco
Vasopressors Judith Hellman, M.D. Associate Professor Anesthesia and Perioperative Care University of California, San Francisco Overview Define shock states Review drugs commonly used to treat hypotension
More informationThe Initial and 24 h (After the Patient Rehabilitation) Deficit of Arterial Blood Gases as Predictors of Patients Outcome
Biomedical & Pharmacology Journal Vol. 6(2), 259-264 (2013) The Initial and 24 h (After the Patient Rehabilitation) Deficit of Arterial Blood Gases as Predictors of Patients Outcome Vadod Norouzi 1, Ali
More informationProtocols for Early Extubation After Cardiothoracic Surgery
Protocols for Early Extubation After Cardiothoracic Surgery AATS / STS CT Critical Care Symposium April 27, 2014 Toronto, Ontario Nevin M. Katz, M.D. Johns Hopkins University Foundation for the Advancement
More informationYear in Review 2012 Intensive Care. J.G. van der Hoeven j.vanderhoeven@ic.umcn.nl or hahoe@mac.com www.intensivistenopleiding.nl
Year in Review 2012 Intensive Care J.G. van der Hoeven j.vanderhoeven@ic.umcn.nl or hahoe@mac.com www.intensivistenopleiding.nl ARDS Difficult weaning Fluid therapy Sepsis Subjects Berlin definition Bilateral
More informationOmega-3 fatty acids improve the diagnosis-related clinical outcome. Critical Care Medicine April 2006;34(4):972-9
Omega-3 fatty acids improve the diagnosis-related clinical outcome 1 Critical Care Medicine April 2006;34(4):972-9 Volume 34(4), April 2006, pp 972-979 Heller, Axel R. MD, PhD; Rössler, Susann; Litz, Rainer
More informationThe term acute respiratory distress syndrome (ARDS) was first coined in 1967
AACN Advanced Critical Care Volume 26, Number 3, pp. 185-191 2015 AACN Earnest Alexander, PharmD, and Gregory M. Susla, PharmD Department Editors Pharmacological Treatments for Acute Respiratory Distress
More informationThe Sepsis Puzzle: Identification, Monitoring and Early Goal Directed Therapy
The Sepsis Puzzle: Identification, Monitoring and Early Goal Directed Therapy Cindy Goodrich RN, MS, CCRN Content Description Sepsis is caused by widespread tissue injury and systemic inflammation resulting
More informationSeries 1 Case Studies Adverse Events that Represent Unanticipated Problems: Reporting Required
Welcome! This document contains three (3) series of Case Study examples that will demonstrate all four OHSU reporting categories (#1 4) as well as examples of events that are considered not reportable.
More informationNon-Invasive Positive Pressure Ventilation in Heart Failure Patients: For Who, Wy & When?
REUNIÃO CONJUNTA DOS GRUPOS DE ESTUDO DE CUIDADOS INTENSIVOS CARDÍACOS E DE FISIOPATOLOGIA DO ESFORÇO E REABILITAÇÃO CARDÍACA O L H Ã O 2 7 e 2 8 d e J a n e i r o 2 0 1 2 Non-Invasive Positive Pressure
More informationPaddy McMaster Consultant in Paediatric Intensive Care University Hospital of North Staffordshire Stoke on Trent UK
Paddy McMaster Consultant in Paediatric Intensive Care University Hospital of North Staffordshire Stoke on Trent UK Haemofiltration Plasmafiltration In sepsis / SIRS Excluded: not sepsis, subgroup analysis
More informationIrish Association for Emergency Medicine (IAEM) submission to the National COPD Strategy
31 st Irish Association for Emergency Medicine (IAEM) submission to the National COPD Strategy 1 Introduction Chronic obstructive pulmonary disease (COPD) is an important disease for patients, the health
More informationYear in review: mechanical ventilation
Year in review: mechanical ventilation Leo Heunks, MD, PhD Pulmonary and Critical Care Physician Dept of Critical Care Intensivisten dagen 2013 Disclosures Maquet (NAVA catheters, travel fee, speakers
More informationAcute Respiratory Distress Syndrome - Pipeline Review, H1 2016
Report Information More information from: https://www.wis eguyreports.com/reports/389452 Acute Respiratory Distress Syndrome - Pipeline Review, H1 2016 Report / Search Code: WGR389452 Publish Date: 29
More informationComparison of the Rate of Improvement in Gas Exchange between Two High Frequency Ventilators in a Newborn Piglet Lung Injury Model
Comparison of the Rate of Improvement in Gas Exchange between Two High Frequency Ventilators in a Newborn Piglet Lung Injury Model Kurt Gillette, MD, San Antonio Military Medical Center Background: High
More information5/30/2014 OBJECTIVES THE ROLE OF A RESPIRATORY THERAPIST IN THE DELIVERY ROOM. Disclosure
THE ROLE OF A RESPIRATORY THERAPIST IN THE DELIVERY ROOM Ona Fofah, MD FAAP Assistant Professor of Pediatrics Director, Division of Neonatology Department of Pediatrics Rutgers- NJMS, Newark OBJECTIVES
More informationCatheter insertion of a new aortic valve to treat aortic stenosis
Issue date March 2012 Understanding NICE guidance Information for people who use NHS services NICE interventional procedures guidance advises the NHS on when and how new procedures can be used in clinical
More informationSE5h, Sepsis Education.pdf. Surviving Sepsis
Surviving Sepsis 1 Scope and Impact of the Problem: Severe sepsis is a major healthcare problem that affects millions of people around the world each year with an extremely high mortality rate of 30 to
More informationImportance of Protocols in the Decision to Use Noninvasive Ventilation
Importance of Protocols in the Decision to Use Noninvasive Ventilation Janice L. Zimmerman, M.D. Weill Cornell Medical College The Methodist Hospital Houston, Texas Objectives Review application of protocols
More informationJournal Club: Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy by the AIM-HIGH Investigators
Journal Club: Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy by the AIM-HIGH Investigators Shaikha Al Naimi Doctor of Pharmacy Student College of Pharmacy Qatar University
More informationType II Pulmonary Hypertension: Pulmonary Hypertension due to Left Heart Disease
Heart Failure Center Hadassah University Hospital Type II Pulmonary Hypertension: Pulmonary Hypertension due to Left Heart Disease Israel Gotsman MD The Heart Failure Center, Heart Institute Hadassah University
More informationFrom AARC Protocol Committee; Subcommittee Adult Critical Care Version 1.0a (Sept., 2003), Subcommittee Chair, Susan P. Pilbeam
AARC - ADULT MECHANICAL VENTILATOR PROTOCOLS 1. Guidelines for Using Ventilator Protocols 2. Definition of Modes and Suggestions for Use of Modes 3. Adult Respiratory Ventilator Protocol - Guidelines for
More informationCommon Ventilator Management Issues
Common Ventilator Management Issues William Janssen, M.D. Assistant Professor of Medicine National Jewish Health University of Colorado Denver Health Sciences Center You have just admitted a 28 year-old
More informationVersion History. Previous Versions. Drugs for MS.Drug facts box fingolimod Version 1.0 Author
Version History Policy Title Drugs for MS.Drug facts box fingolimod Version 1.0 Author West Midlands Commissioning Support Unit Publication Date Jan 2013 Review Date Supersedes/New (Further fields as required
More informationELSO GUIDELINES FOR TRAINING AND CONTINUING EDUCATION OF ECMO SPECIALISTS
ELSO GUIDELINES FOR TRAINING AND CONTINUING EDUCATION OF ECMO SPECIALISTS PURPOSE The "" is a document developed by the Extracorporeal Life Support Organization (ELSO) as a reference for current and future
More informationCo-morbiditeit associeert met respiratoire aandoeningen louter omwille van de leeftijd. COPD patiënten hebben veel meer kans op longkanker dan rokers
Academisch centrum huisartsgeneeskunde Pneumologie Juni 2012 Prof W Janssens Co-morbiditeit associeert met respiratoire aandoeningen louter omwille van de leeftijd. COPD patiënten hebben veel meer kans
More informationYour Life Your Health Cariodmetabolic Risk Syndrome Part VII Inflammation chronic, low-grade By James L. Holly, MD The Examiner January 25, 2007
Your Life Your Health Cariodmetabolic Risk Syndrome Part VII Inflammation chronic, low-grade By James L. Holly, MD The Examiner January 25, 2007 The cardiometabolic risk syndrome is increasingly recognized
More information4.1b(i) Composition of Enteral Nutrition: Fish Oils, Borage Oils and Antioxidants* April 2013
4.1b(i) Composition of Enteral Nutrition: Fish Oils, Borage Oils and Antioxidants* April 2013 2013 Recommendation: Based on 2 level 1 studies and 5 level 2 studies, the use of an enteral formula with fish
More informationExtracorporeal Life Support Organization (ELSO) Guidelines for Neonatal Respiratory Failure
Extracorporeal Life Support Organization (ELSO) Guidelines for Neonatal Respiratory Failure Introduction This neonatal respiratory failure guideline is a supplement to ELSO s General Guidelines for all
More informationMedical management of CHF: A New Class of Medication. Al Timothy, M.D. Cardiovascular Institute of the South
Medical management of CHF: A New Class of Medication Al Timothy, M.D. Cardiovascular Institute of the South Disclosures Speakers Bureau for Amgen Background Chronic systolic congestive heart failure remains
More informationService delivery interventions
Service delivery interventions S A S H A S H E P P E R D D E P A R T M E N T O F P U B L I C H E A L T H, U N I V E R S I T Y O F O X F O R D CO- C O O R D I N A T I N G E D I T O R C O C H R A N E E P
More informationDietary treatment of cachexia challenges of nutritional research in cancer patients
Dietary treatment of cachexia challenges of nutritional research in cancer patients Trude R. Balstad 4th International Seminar of the PRC and EAPC RN, Amsterdam 2014 Outline Cancer cachexia Dietary treatment
More informationInflammatory or cardiogenic lung edema? It does matter!
Inflammatory or cardiogenic lung edema? It does matter! Dr Xavier MONNET Medical Intensive Care Unit Bicêtre Hospital FRANCE Conflict of interest Inflammatory or cardiogenic lung edema? It does matter!
More informationVersion History. Previous Versions. for secondary progressive MS (SPMS) Policy Title. Drugs for MS.Drug facts box Interferon beta 1b
Version History Policy Title Drugs for MS.Drug facts box Interferon beta 1b for secondary progressive MS (SPMS) Version 1.0 Author West Midlands Commissioning Support Unit Publication Date Jan 2013 Review
More informationCARDIO/PULMONARY MEDICINE FOR PRIMARY CARE. Las Vegas, Nevada Bellagio March 4 6, 2016. Participating Faculty
CARDIO/PULMONARY MEDICINE FOR PRIMARY CARE Las Vegas, Nevada Bellagio March 4 6, 2016 Participating Faculty Friday, March 4th: 7:30 am - 8:00 am Registration and Hot Breakfast 8:00 am - 9:00 am Pulmonary
More informationNIV in non CPE, non-copd, non-neuromuscular patients
NIV in non CPE, non-copd, non-neuromuscular patients Giorgio Iotti Anestesia e Rianimazione 2 Pavia Italia Missioni ECMOteam Pavia 2009/2011 18 4 2 Trasporto con ECMO senza ECMO ALI/ARDS Immunocompetent
More informationPulmonary Diseases. Lung Disease: Pathophysiology, Medical and Exercise Programming. Overview of Pathophysiology
Lung Disease: Pathophysiology, Medical and Exercise Programming Overview of Pathophysiology Ventilatory Impairments Increased airway resistance Reduced compliance Increased work of breathing Ventilatory
More informationAntioxidantien - ein Irrweg? REDOXS & OMEGA Studie
www.lknoe.a AKE Herbsttagung 2013 St. Wolfgang Antioxidantien - ein Irrweg? REDOXS & OMEGA Studie Friedrich Längle Chirurgische Abteilung REDOX A Randomized Trial of Glutamine and Antioxidants in Critically
More informationPatient Blood Management Guidelines: Module 4. Critical Care
Patient Blood Management Guidelines: Module 4 Critical Care National Blood Authority, 2012. With the exception of any logos and registered trademarks, and where otherwise noted, all material presented
More informationPrevention of Acute COPD exacerbations
December 3, 2015 Prevention of Acute COPD exacerbations George Pyrgos MD 1 Disclosures No funding received for this presentation I have previously conducted clinical trials with Boehringer Ingelheim. Principal
More informationNATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE. Health Technology Appraisal. Drugs for the treatment of pulmonary arterial hypertension
NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE Health Technology Appraisal Drugs for the treatment of Remit / Appraisal objective: Final scope To appraise the clinical and cost effectiveness of
More informationACLS PHARMACOLOGY 2011 Guidelines
ACLS PHARMACOLOGY 2011 Guidelines ADENOSINE Narrow complex tachycardias or wide complex tachycardias that may be supraventricular in nature. It is effective in treating 90% of the reentry arrhythmias.
More informationOverall Goals/Objectives - Surgical Critical Care Residency Program The goal of the Pediatric Surgical Critical Care Residency program is to provide
Overall Goals/Objectives - Surgical Critical Care Residency Program The goal of the Pediatric Surgical Critical Care Residency program is to provide advanced proficiency in the care and management of critically
More informationApplying the 2016 ASPEN/ SCCM Critical Care Guidelines to Your Practice. Susan Brantley, MS, RD, LDN
Applying the 2016 ASPEN/ SCCM Critical Care Guidelines to Your Practice Susan Brantley, MS, RD, LDN Objectives: Upon completion of this presentation, participants should be able to: 1. Distinguish the
More informationScottish Medicines Consortium
Scottish Medicines Consortium sildenafil citrate 20mg tablets (Revatio ) No. (235/06) Pfizer New indication 6 January 2006 The Scottish Medicines Consortium (SMC) has completed its assessment of the above
More information3100B Clinical Training Program. 3100B HFOV VIASYS Healthcare
3100B Clinical Training Program 3100B HFOV VIASYS Healthcare HFOV at Alveolar Level Nieman,, G, SUNY 1999 Who DO We Treat? Only Pathology studied to date has been ARDS Questions about management of adults
More informationOptimal fluid therapy in 2013. Eric Hoste Department of Intensive Care Medicine Ghent University Hospital Ghent University
Optimal fluid therapy in 2013 Eric Hoste Department of Intensive Care Medicine Ghent University Hospital Ghent University EGDT: fluids are good & prevent AKI Lin et al, Shock 2006 EGDT and AKI Prowle et
More informationGruppo di lavoro: Malattie Tromboemboliche
Gruppo di lavoro: Malattie Tromboemboliche 2381 Soluble Recombinant Thrombomodulin Ameliorates Hematological Malignancy-Induced Disseminated Intravascular Coagulation More Promptly Than Conventional Anticoagulant
More informationPharmacy Policy Bulletin
Pharmacy Policy Bulletin Title: Policy #: Pulmonary Arterial Hypertensive (PAH) agents Rx.01.83 Application of pharmacy policy is determined by benefits and contracts. Benefits may vary based on product
More informationAppendix G - Identification and Selection of Studies
FINAL Emergency framework for rationing of blood for massively bleeding patients during a red phase of a Appendix G - Identification and Selection of Studies Inclusion/Exclusion Criteria We included studies
More informationVASOPRESSOR AGENTS IN SEPTIC SHOCK
VASOPRESSOR AGENTS IN SEPTIC SHOCK Daniel De Backer Head Dept Intensive Care, CHIREC hospitals, Belgium Professor of Intensive Care, Université Libre de Bruxelles President European Society of Intensive
More informationResuscitation in congenital heart disease. Peter C. Laussen MBBS FCICM Department Critical Care Medicine Hospital for Sick Children Toronto
Resuscitation in congenital heart disease Peter C. Laussen MBBS FCICM Department Critical Care Medicine Hospital for Sick Children Toronto Evolution of Congenital Heart Disease Extraordinary success: Overall
More informationSubject: Severe Sepsis/Septic Shock Published Date: August 9, 2013 Scope: Hospital Wide Original Creation Date: August 9, 2013
Stony Brook Medicine Severe Sepsis/Septic Shock Recognition and Treatment Protocols Subject: Severe Sepsis/Septic Shock Published Date: August 9, 2013 Scope: Hospital Wide Original Creation Date: August
More informationObjectives COPD. Chronic Obstructive Pulmonary Disease (COPD) 4/19/2011
Objectives Discuss assessment findings and treatment for: Chronic Obstructive Pulmonary Disease Bronchitis Emphysema Asthma Anaphylaxis Other respiratory issues Provide some definitions Chronic Obstructive
More informationSafe Zone: CV PIP < 26; HFOV: MAP < 16; HFJV: MAP < 16 Dopamine infusion up to 20 mcg/kg/min Epinephrine infusion up to 0.1 mcg /kg/min.
Congenital Diaphragmatic Hernia: Management Guidelines 5-2006 Issued By: Division of Neonatology Reviewed: Effective Date: Categories: Chronicity Document Congenital Diaphragmatic Hernia: Management Guidelines
More informationAcknowledgements. PAH in Children: Natural History. The Sildenafil Saga
The Sildenafil Saga David L. Wessel, MD Executive Vice President Chief Medical Officer Ikaria Distinguished Professor of Critical Care Children s National Medical Center Washington, DC, USA Acknowledgements
More informationRecommendations: Other Supportive Therapy of Severe Sepsis*
Recommendations: Other Supportive Therapy of Severe Sepsis* K. Blood Product Administration 1. Once tissue hypoperfusion has resolved and in the absence of extenuating circumstances, such as myocardial
More informationKING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTRE (GEN. ORG.) NURSING AFFAIRS. Scope of Service PEDIATRIC INTENSIVE CARE UNIT (PICU)
PICU-Jan.2012 Page 1 of 7 Number of Beds: 18 Nurse Patient Ratio: 1:1-2 : The Pediatric Intensive Care Unit (PICU) provides 24 hour intensive nursing care for patients aged neonate through adolescence.
More informationPressure Ulcers in the ICU Incidence, Risk Factors & Prevention
Congress of the Critical Care Society of South Africa Sun City, 10-12 July 2015 Pressure Ulcers in the ICU Incidence, Risk Factors & Prevention Stijn BLOT Dept. of Internal Medicine Faculty of Medicine
More informationBig data size isn t enough! Irene Petersen, PhD Primary Care & Population Health
Big data size isn t enough! Irene Petersen, PhD Primary Care & Population Health Introduction Reader (Statistics and Epidemiology) Research team epidemiologists/statisticians/phd students Primary care
More informationPulmonary Hypertension in Sickle Cell Disease. Jorge Ramos Hematology Fellows Conference June 28, 2013
Pulmonary Hypertension in Sickle Cell Disease Jorge Ramos Hematology Fellows Conference June 28, 2013 Patient Presentation 28F with SCD, genotype SS. Presented to UWMC ER with 1 month progressive DOE and
More informationNew and Emerging Immunotherapies for Multiple Sclerosis: Oral Agents
New and Emerging Immunotherapies for Multiple Sclerosis: Oral Agents William Tyor, M.D. Chief, Neurology Atlanta VA Medical Center Professor, Department of Neurology Emory University School of Medicine
More informationSeptic Shock: Pharmacologic Agents for Hemodynamic Support. Nathan E Cope, PharmD PGY2 Critical Care Pharmacy Resident
Septic Shock: Pharmacologic Agents for Hemodynamic Support Nathan E Cope, PharmD PGY2 Critical Care Pharmacy Resident Objectives Define septic shock and briefly review pathophysiology Outline receptor
More informationPlumbing 101:! TXA and EMS! Jay H. Reich, MD FACEP! EMS Medical Director! City of Kansas City, Missouri/Kansas City Fire Department!
Plumbing 101:! TXA and EMS! Jay H. Reich, MD FACEP! EMS Medical Director! City of Kansas City, Missouri/Kansas City Fire Department! EMS Section Chief! Department of Emergency Medicine! University of Missouri-Kansas
More informationU.S. Food and Drug Administration
U.S. Food and Drug Administration Notice: Archived Document The content in this document is provided on the FDA s website for reference purposes only. It was current when produced, but is no longer maintained
More informationFFR CT : Clinical studies
FFR CT : Clinical studies Bjarne Nørgaard Department Cardiology B Aarhus University Hospital Skejby, Denmark Disclosures: Research grants: Edwards and Siemens Coronary CTA: High diagnostic sensitivity
More informationAtrial Fibrillation Management Across the Spectrum of Illness
Disclosures Atrial Fibrillation Management Across the Spectrum of Illness NONE Barbara Birriel, MSN, ACNP-BC, FCCM The Pennsylvania State University Objectives AF Discuss the pathophysiology, diagnosis,
More informationAdvantages and disadvantages of CRRT in ARF patients. Norbert Lameire Renal Division University Hospital Ghent, Belgium
Advantages and disadvantages of CRRT in ARF patients Norbert Lameire Renal Division University Hospital Ghent, Belgium Alexandria, 17/2/2005 Indications for RRT in critically ill ARF patients Renal Replacement
More informationAre mental health nurses equipped with the knowledge to effectively manage the physical health of their service users?
Are mental health nurses equipped with the knowledge to effectively manage the physical health of their service users? Dr Hussain Al-Zubaidi George Eliot Hospital Trust Dr Shahnaz Hassan Coventry and Warwickshire
More informationPulmonary interstitium. Interstitial Lung Disease. Interstitial lung disease. Interstitial lung disease. Causes.
Pulmonary interstitium Interstitial Lung Disease Alveolar lining cells (types 1 and 2) Thin elastin-rich connective component containing capillary blood vessels Interstitial lung disease Increase in interstitial
More informationProstate cancer OLD PROBLEMS AND NEW DIRECTIONS. Liam Bourke PhD Mres BSc (Hons) FRSPH Queen Mary University of London l.bourke@qmul.ac.
Prostate cancer OLD PROBLEMS AND NEW DIRECTIONS Liam Bourke PhD Mres BSc (Hons) FRSPH Queen Mary University of London l.bourke@qmul.ac.uk What s this talk about? OLD PROBLEMS: Advancing prostate cancer
More informationCirrhosis and HCV. Jonathan Israel M.D.
Cirrhosis and HCV Jonathan Israel M.D. Outline Relationship of fibrosis and cirrhosisprevalence and epidemiology. Sequelae of cirrhosis Diagnosis of cirrhosis Effect of cirrhosis on efficacy of treatment
More informationUnderstanding the Pain Trajectory During Treadmill Testing in Peripheral Artery Disease
Understanding the Pain Trajectory During Treadmill Testing in Peripheral Artery Disease Diane Treat-Jacobson, PhD, RN, FAHA, FAAN Susan J. Henly, PhD, RN Ulf G. Bronas, PhD, ATC, ATR Arthur S. Leon, MD,
More informationSurgical Site Infection Prevention
Surgical Site Infection Prevention 1 Objectives 1. Discuss risk factors for SSI 2. Describe evidence-based best practices for SSI prevention 3. State principles of antibiotic prophylaxis 4. Discuss novel
More informationThe Global Alliance against Chronic Respiratory Diseases
The Global Alliance against Chronic Respiratory Diseases Pulmonary hypertension Dr Marc Humbert What is the burden of pulmonary hypertension? The true burden of pulmonary hypertension is currently unknown
More informationInfluenza (Flu) Influenza is a viral infection that may affect both the upper and lower respiratory tracts. There are three types of flu virus:
Respiratory Disorders Bio 375 Pathophysiology General Manifestations of Respiratory Disease Sneezing is a reflex response to irritation in the upper respiratory tract and is associated with inflammation
More informationManagement of Infants with BPD: Evidence-Based or Eminence-Based?
Management of Infants with BPD: Evidence-Based or Eminence-Based? Steven M. Donn, MD, FAAP Professor of Pediatrics Division of Neonatal-Perinatal Medicine C.S. Mott Children s Hospital University of Michigan
More informationSTAGES OF SHOCK. IRREVERSIBLE SHOCK Heart deteriorates until it can no longer pump and death occurs.
STAGES OF SHOCK SHOCK : A profound disturbance of circulation and metabolism, which leads to inadequate perfusion of all organs which are needed to maintain life. COMPENSATED NONPROGRESSIVE SHOCK 30 sec
More informationLothian Guideline for Domiciliary Oxygen Therapy Service for COPD
Lothian Guideline for Domiciliary Oxygen Therapy Service for COPD This document describes the standard for clinical assessment, prescription, optimal management and follow-up of patients receiving domiciliary
More informationAPPENDIX B SAMPLE PEDIATRIC CRITICAL CARE NURSE PRACTITIONER GOALS AND OBJECTIVES
APPENDIX B SAMPLE PEDIATRIC CRITICAL CARE NURSE PRACTITIONER GOALS AND OBJECTIVES The critical care nurse practitioner orientation is an individualized process based on one s previous experiences and should
More informationSTROKE OCCURRENCE SYMPTOMS OF STROKE
STROKE OCCURRENCE SYMPTOMS OF STROKE The symptoms of stroke depend on what part of the brain is affected and how large an area is involved. A stroke is a sudden event accompanied by one or more of the
More informationMANAGEMENT OF LIPID DISORDERS: IMPLICATIONS OF THE NEW GUIDELINES
MANAGEMENT OF LIPID DISORDERS: IMPLICATIONS OF THE NEW GUIDELINES Robert B. Baron MD MS Professor and Associate Dean UCSF School of Medicine Declaration of full disclosure: No conflict of interest EXPLAINING
More information240- PROBLEM SET INSERTION OF SWAN-GANZ SYSTEMIC VASCULAR RESISTANCE. Blood pressure = f(cardiac output and peripheral resistance)
240- PROBLEM SET INSERTION OF SWAN-GANZ 50 kg Pig Rt Jugular 0 cm Rt Atrium 10 cm Rt ventricle 15 cm Wedge 20-25 cm SYSTEMIC VASCULAR RESISTANCE Blood pressure = f(cardiac output and peripheral resistance)
More informationChi Squared and Fisher's Exact Tests. Observed vs Expected Distributions
BMS 617 Statistical Techniques for the Biomedical Sciences Lecture 11: Chi-Squared and Fisher's Exact Tests Chi Squared and Fisher's Exact Tests This lecture presents two similarly structured tests, Chi-squared
More informationUnderstanding Hypoventilation and Its Treatment by Susan Agrawal
www.complexchild.com Understanding Hypoventilation and Its Treatment by Susan Agrawal Most of us have a general understanding of what the term hyperventilation means, since hyperventilation, also called
More informationSeverity scores in ICU
Severity scores in ICU DM seminar Dr.Vamsi Krishna Mootha Dept of Pulmonary medicine, PGIMER Introduction Severity of illness scoring systems are developed to evaluate delivery of care and provide prediction
More informationHepatitis C. David Mutimer Queen Elizabeth Hospital Liver Unit Birmingham. Substance Misuse Treatment in the West Midlands. How can we reduce harm?
Hepatitis C David Mutimer Queen Elizabeth Hospital Liver Unit Birmingham Substance Misuse Treatment in the West Midlands. How can we reduce harm? Birmingham October 19 th 2007 infection HCV Natural History
More informationCLINICAL TRIALS SHOULD YOU PARTICIPATE? by Gwen L. Nichols, MD
CLINICAL TRIALS SHOULD YOU PARTICIPATE? by Gwen L. Nichols, MD Gwen L. Nichols, M.D., is currently the Oncology Site Head of the Roche Translational Clinical Research Center at Hoffman- LaRoche. In this
More information1. Phosphodiesterase Type 5 Enzyme Inhibitors: Sildenafil (Revatio), Tadalafil (Adcirca)
This policy has been developed through review of medical literature, consideration of medical necessity, generally accepted medical practice standards, and approved by the IEHP Pharmacy and Therapeutic
More informationJ of Evolution of Med and Dent Sci/ eissn- 2278-4802, pissn- 2278-4748/ Vol. 3/ Issue 65/Nov 27, 2014 Page 13575
EFFECT OF BREATHING EXERCISES ON BIOPHYSIOLOGICAL PARAMETERS AND QUALITY OF LIFE OF PATIENTS WITH COPD AT A TERTIARY CARE CENTRE Sudin Koshy 1, Rugma Pillai S 2 HOW TO CITE THIS ARTICLE: Sudin Koshy, Rugma
More informationUsing 'Big Data' to Estimate Benefits and Harms of Healthcare Interventions
Using 'Big Data' to Estimate Benefits and Harms of Healthcare Interventions Experience with ICES and CNODES DAVID HENRY, PROFESSOR OF HEALTH SYSTEMS DATA, UNIVERSITY OF TORONTO, SENIOR SCIENTIST, INSTITUTE
More informationIdiopathic Pulmonary Fibrosis (IPF) Research
Idiopathic Pulmonary Fibrosis (IPF): Why Early Referral is Critical Even if Your Patient is Not Eligible for a Clinical Trial Idiopathic Pulmonary Fibrosis (IPF) Research Management of IPF requires a confident
More informationDabigatran etexilate for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism ERRATUM
Dabigatran etexilate for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism ERRATUM This report was commissioned by the NIHR HTA Programme as project number 12/78
More informationMarilyn Borkgren-Okonek, APN, CCNS, RN, MS Suburban Lung Associates, S.C. Elk Grove Village, IL
Marilyn Borkgren-Okonek, APN, CCNS, RN, MS Suburban Lung Associates, S.C. Elk Grove Village, IL www.goldcopd.com GLOBAL INITIATIVE FOR CHRONIC OBSTRUCTIVE LUNG DISEASE GLOBAL STRATEGY FOR DIAGNOSIS, MANAGEMENT
More informationDoes Selenium protect against lung cancer? Do Selenium supplements reduce the incidence of lung cancer in healthy individuals?
Does Selenium protect against lung cancer? Do Selenium supplements reduce the incidence of lung cancer in healthy individuals? Alexander Blakes and Eleanor Brunt October 2014 The question Mr Wilson s father
More informationLIVER FUNCTION TESTS AND STATINS
LIVER FUNCTION TESTS AND STATINS Philippe J. Zamor and Mark W. Russo Current Opinion in Cardiology 2011,26:338 341 SUMMARY Purpose of review: To discuss recent data on statins in patients with elevated
More informationMalignant Mesothelioma State of the Art
Malignant Mesothelioma State of the Art Paul Baas The Netherlands Cancer Institute August 12, 2011, Carlsbad, CA Summary Diagnosis; epithelial type subdivided Pleiomorphic vs other Staging: IASLC-IMIG
More informationNHS. Surgical repair of vaginal wall prolapse using mesh. National Institute for Health and Clinical Excellence. 1 Guidance.
Issue date: June 2008 NHS National Institute for Health and Clinical Excellence Surgical repair of vaginal wall prolapse using mesh 1 Guidance 1.1 The evidence suggests that surgical repair of vaginal
More information