Posttraumatic Therapy

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1 1498 Posttraumatic Therapy PTSD ASD PTSD PTSD PTSD g GABA

2 1499 posttraumatic stress disorder PTSD Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision DSM IV TR A B C D 4 A A1 A2 PTSD B C D PTSD 1 B 3 C 2 D PTSD PTSD 7 4 PTSD PTSD 6 PTSD PTSD 3 PTSD PTSD PTSD 1 PTSD 3 PTSD PTSD 3 PTSD PTSD 6 acute stress disorder ASD ASD PTSD PTSD ASD ASD PTSD PTSD PTSD PTSD PTSD PTSD PTSD PTSD PTSD PTSD PTSD

3 1500 PTSD PTSD PTSD PTSD PTSD PTSD PTSD ASD PTSD PTSD PTSD PTSD 1 debriefing therapy PTSD 2 3 PTSD PTSD PTSD PTSD propranolol PTSD PTSD exposure therapy PTSD PTSD 3 1

4 Flooding in vivo prolonged exposure PE PE 7 10 in vivoptsd PE 50 PTSD Foa Meadows PTSD anxiety management techniques cognitive therapy automatic systems of meaning PTSD cognitive processing therapy CPT CPT PTSD PTSD CPT PTSD CPT PTSD

5 1502 PTSD stuck point CPT CPT PE CPT PTSD 5 eye movement desensitization reprocessing EMDR PEEMDR PTSD EMDR relaxation therapy CPT EMDR PTSD PTSD PTSD PTSD PTSD PTSD PE CPT PTSD PTSD CPT PE PTSD PTSD PTSD PTSD PTSD PTSD PE PTSD PTSD PTSD

6 1503 PTSD PTSD 1 PTSD PTSD PTSD selective serotonin reuptake inhibitor SSRI SSRI fluoxetine sertraline paroxetine citalopram SSRI PTSD sertraline PTSD 30 tricyclic antidepressant PTSD PTSD monoamine oxidase inhibitor MAOI SSRI PTSD MAO MAOI PTSD MAO MAOI MAOI PTSD trazodone mirtazapine amitriptyline g A GABA A 2 D2 2 5 HT2 a1 a2 PTSD PTSD

7 1504 PTSD PTSD Propranolol b clonidine antiadrenergic agentptsd PTSD propranolol a1 Prazosin PTSD carbamazepine valproic acid PTSD Topiramate GABA GABA A GABA PTSD PTSD PTSD PTSD corticotrophin releasing hormone CRH CRH CRH CRH PTSD Y neuropeptide Y NPY PTSD NPY CRH NPY NPY PTSD NPY PTSD NPY NPY NPY PTSD GABA A GABA PTSD N D N methyl D aspartate NMDA PTSD D PTSD PTSD PTSD PTSD

8 PTSD PTSD Albucher, R. C. and Liberzon, I Psychopharmacological treatment in PTSD: a critical review. Journal of Psychiatric Research 36, Armony, J. L. and LeDoux, J. E How the brain processes emotional information. Annals of the New York Academy of Science 281, Cloitre, M., Koenen, K. C., Cohen, L. R. and Han, H Skills training in affective and interpersonal regulation followed by exposure: a phase-based treatment for PTSD related to childhood abuse. Journal of Consulting and Clinical Psychology 70, Ehlers, A. and Clark, D Early psychological interventions for adult survivors of trauma: a review. Biological Psychiatry 53, Foa, E. B. and Meadows, E. A Psychosocial treatments for posttraumatic stress disorder. A critical review. Annual Reviews of Psychology 48, Hien, D. A., Cohen, L. R., Miele, G. M., Litt, L. C. and Capstick, C Promising treatments for women with comorbid PTSD and substance use disorders. American Journal of Psychiatry 16, Marmar, C. R., Neylan, T. C. and Schoenfeld, F. B New directions in the pharmacotherapy of posttraumatic stress disorder. Psychiatric Quarterly 73, Morgan, C. A., III, Rasmusson, A. M., Wang, S., et al Neuropeptide Yand subjective distress in humans exposed to acute stress: replication and extension of a previous report. Biological Psychiatry 52, Najavits, L. M., Weiss, R. D., Shaw, S. R. and Muenz, L. R Seeking safety : outcome of a new cognitivebehavioral psychotherapy for women with posttraumatic stress disorder and substance dependence. Journal of Traumatic Stress 11, Nishith, P., Nixon, R. D. and Resick, P. A Resolution of trauma-related guilt following treatment of PTSD in female rape victims: a result of cognitive processing therapy targeting comorbid depression? Journal of Affective Disorders 86, Pitman, R. K., Sanders, K. M., Zusman, R. M., et al Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biological Psychiatry 51, Rasmusson, A., Pinna, G., Weisman, D., et al Decreased CSF allopregnanolone levels in women with PTSD correlate negatively with reexperiencing symptoms. Society of Biological Psychiatry, poster presentation. May 19 21, 2005, Atlanta, GA. Resick, P. A., Nishith, P., Weaver, T. I., Astin, M. C. and Feuer, C. A A comparison of cognitive processing therapy with prolonged exposure and a waiting condition for the treatment of chronic posttraumatic stress disorder in female rape victims. Journal of Consulting and Clinical Psychology 70, Ressler, K., J., Rothbaum, B. O., Tannenbaum, L., et al Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Archives of General Psychiatry 61, Taylor, S., Thordarson, D. S., Maxfield, L., et al Comparative efficacy, speed, and adverse effects of three PTSD treatments: exposure therapy, EMDR, and relaxation training. Journal of Consulting and Clinical Psychology 71,

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