PROGRAM FOR THE CONFERENCE. Frontiers in Cancer Research and Therapy. Karolinska Institutet, Nobel Forum, March 5-6, 2015

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1 Photo: Science Photo Library PROGRAM FOR THE CONFERENCE F 2015 Frontiers in Cancer Research and Therapy Karolinska Institutet, Nobel Forum, March 5-6, 2015

2 5 MARCH 2015, THURSDAY, NOBEL FORUM KAROLINSKA INSTITUTET, SOLNA WELCOME NOTE Dan Grandér, Chair of Department of Oncology-Pathology SESSION 1: TUMOR MICROENVIRONMENT Charlotte Rolny and Lisa Westerberg 9:00 9:30 KARI ALITALO University of Helsinki, Finland Combinatorial targeting of angiogenic pathways 9:30 10:00 DOUGLAS HANAHAN École Polytechnique Fédérale de Lausanne, Switzerland Case studies in therapeutic targeting hallmarks of cancer 10:00 10:30 CHRISTER BETSHOLTZ Uppsala University, Sweden Organ (and tumor) specific characteristics of vascular cells. Can they be targeted? COFFEE BREAK 11:15 11:45 EMILY WANG Beckman Research Institute of City of Hope, USA Cancer-host crosstalk: Extracellular micrornas in breast cancer 11:45 12:15 LARS HOLMGREN Cell-cell interactions in tissue morphogenesis and cancer 12:15 12:45 BRIAN RUFFELL Oregon Health & Science University, USA Intratumoral Dendritic Cells and Chemotherapy LUNCH & POSTER SESSION SESSION 2: POST-TRANSCRIPTIONAL PROGRAMS IN CANCER Ola Larsson and Veronica Höiom 14:00 14:30 PETER BITTERMAN University of Minnesota, USA Translation factor eif4e functions as an upstream driver and a downstream effector in oncogenesis 14:30 15:00 JERRY PELLETIER McGill University, Canada eif4f - A tumor cell vulnerability in Multiple Myeloma 15:00 15:30 STEPHAN VAGNER Institut Curie, France mrna translation and resistance to anti-cancer targeted therapies

3 5 MARCH 2015, THURSDAY, NOBEL FORUM KAROLINSKA INSTITUTET, SOLNA COFFEE BREAK 16:00 16:30 HILA GINGOLD Weizmann Institute of Science, Israel Translation in proliferation and differentiation - how cancer hijacks the apparatus? 16:30 17:00 POUL SORENSEN University of British Columbia, Canada Selective mrna translation and the tumor cell stress response

4 6 MARCH 2015, NOBEL FORUM KAROLINSKA INSTITUTET, SOLNA :30-9:00 MORNING COFFEE SESSION 3: CANCER THERAPIES Andreas Lundqvist and Svetlana Bajalica Lagercrantz 9:00 9:30 LAURENCE COOPER MD Anderson Cancer Center, USA The First-in-Human Application of Sleeping Beauty System for Non-Viral Genetic Modification of T cells 9:30 10:00 SANDRA DEMARIA New York University, USA Individualized in situ vaccination by radiation and immunotherapy 10:00 10:30 CAROLA RIES Roche Innovation Center Penzberg, Germany Depletion of tumor-associated macrophages as a novel strategy for cancer therapy COFFEE BREAK 11:00 11:30 PATRIK ERNFORS Targeting vulnerability in glioblastoma 11:30 12:00 PETTER WOLL University of Oxford, UK Fate mapping of rare and distinct cancer stem cells in myelodysplastic syndromes 12:00 12:30 THOMAS HELLEDAY Targeting DNA repair: from PARP to MTH1 inhibitors LUNCH & POSTER SESSION SESSION 3: CANCER THERAPIES, CONTINUING Theodoros Foukakis 13:30 14:00 MARIANNE FARNEBO Roles of WRAP53 and noncoding RNA in DNA repair 14:00 14:30 PIERRE SONVEAUX Université catholique de Louvain, Belgium Mitochondria in cancer metastasis: license to drive COFFEE BREAK

5 6 MARCH 2015, NOBEL FORUM KAROLINSKA INSTITUTET, SOLNA SESSION 4: CANCER BIOMARKERS Theodoros Foukakis 15:00-15:30 Nicholas Navin MD Anderson Cancer Center, USA Investigating Clonal Evolution in Breast Cancer with Single Cell Genomics 15:30-16:00 Janne Lehtiö Connecting breast cancer genotype with molecular phenotype by proteogenomics 16:00-16:30 Closing words and Department awards Dan Grandér, Chair of Department of Oncology-Pathology

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