R508 A NEW NON-TOXIC DRUG TREATMENT THAT KILLS CANCER

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1 WE NEED YOUR HELP TESTING R508 A NEW NON-TOXIC DRUG TREATMENT THAT KILLS CANCER WE NEED $25,000 FOR CURRENT TESTING OF THIS POWERFUL NEW CANCER TREATMENT

2 TABLE OF CONTENTS WHAT YOU NEED TO KNOW ABOUT R508 IN 90 SECONDS OR LESS.. 3 THE SCIENCE: R508 KILLS CANCER BY BLOCKING A PROTEIN THAT CANCER CELLS NEED TO SURVIVE R508 ELIMINATES CANCER IN MICE WITH NO TOXIC SIDE EFFECTS 5 R508 IS LIKELY TO KILL CANCER CELLS IN HUMANS. 6 LABORATORY TESTS: R508 IS HIGHLY EFFECTIVE AGAINST MELANOMA EVEN WITH A SINGLE DOSE 7 R508 IS HIGHLY EFFECTIVE AGAINST MANY TYPES OF CANCER... 8 THE NEXT STEP: TESTING R508 IN DOGS WITH CANCER TAX-DEDUCTIBLE DONATIONS.. 10 Page 2 of 10

3 WHAT YOU NEED TO KNOW ABOUT R508 IN 90 SECONDS OR LESS (science details on following pages) WHAT IS R508? R508 is a new drug that kills cancer by blocking a protein that cancer cells need to survive. R508 was developed after 25 years of meticulous research by Dr. Sanjay Awasthi. WHO IS DR. SANJAY AWASTHI? Sanjay Awasthi, MD, is a biochemist and cancer doctor at the prestigious City of Hope Beckman Research Institute. Dr. Awasthi s research is so important it s been cited over 8,000 times by other scientists. And Dr. Awasthi isn t just a dedicated scientist; he s a compassionate oncologist who s personally treated thousands of cancer patients. IS R508 TOXIC? No. R508 is not a chemo drug. It won t make you sick to your stomach and it won t cause your hair to fall out. WHAT TYPES OF CANCERS CAN R508 TREAT? R508 has completely eliminated melanoma and neuroblastoma as well as cancers of the prostate, lung, breast, colon, pancreas and kidney in laboratory mice. WHAT COMES NEXT? Our next step is to humanely test R508 on beloved pet dogs with deadly cancers. Of course we will conduct our potentially lifesaving pet trials at licensed veterinary hospitals, under the supervision of dedicated veterinarians, and with the last hope permission of their loving owners. Successful tests in dogs will save the lives of man s best friends and help advance R508 toward human trials that just might save you or a family member in the future. HOW YOU CAN HELP Thanks to many concerned supporters, we have received initial funds to get us to this fantastic scientific breakthrough, but we need your help. Just about everyone you know has someone in their family who has had, or is currently suffering with, some form of cancer. You can help stop this needless misery! With your donations to the amazing City of Hope Cancer Research Hospital, our continuing research has the possibility of stopping many of these deadly cancers in the very near future. Please make a contribution to help us raise $25,000. Every dollar counts. Page 3 of 10

4 R508 KILLS CANCER BY BLOCKING A PROTEIN THAT CANCER CELLS NEED TO SURVIVE R508 was designed by Dr. Awasthi based on his research of a cancer protein called Rlip (aka RLIP76 or RALBP1). 1 R508 is a highly-effective anticancer agent that kills cancer cells rather than just stopping their growth. R508 specifically blocks the formation of Rlip protein in cancer cells. As Rlip declines, cancer cells die. R508 has no adverse effects on normal cells, yet it very effectively kills all major types of cancers in mice. Cancer cell Cytoplasm Cancer cell CANCER CELLS Cytoplasm Nucleus Nucleus R508 Rlip RNA Ribosome Rlip RNA X Ribosome Rlip gene (DNA) Cancer Cell Survival Growth Metastasis Resistance to Treatment Rlip protein Rlip protein causes cancers to grow, metastasize and become resistant to treatment Rlip gene (DNA) Cancer Cell Death Rlip protein R508 blocks Rlip CANCER CELLS DIE R508 is nontoxic in mice and causes no negative side effects. Unlike most chemotherapy drugs which increase the risk of diabetes and hyperlipidemia, R508 reduces blood glucose, cholesterol and triglycerides in mice. 1 Sanjay Awasthi, Sharad S. Singhal, Yogesh C. Awasthi, Bryan Martin, Jung-Hee Woo, C. Casey Cunningham, and Arthur E. Frankel, RLIP76 and Cancer, Clinical Cancer Research (July 15, 2008); Rit Vatsyayan, Poorna Shandra Rao Lelsani, Sanjay Awasthi, Sharad S. Singhal, RLIP76: A versatile transporter and an emerging target for cancer therapy, Biochemical Pharmacology (June 15, 2010). Page 4 of 10

5 % surviving cancer free R508 ELIMINATES CANCER IN MICE WITH NO TOXIC SIDE EFFECTS R508 Treatment Eliminated Cancer in 100% of p53 Knockout Mice 100% 50% 0% All R508-treated mice survived All untreated mice died of cancer by 22 weeks time to death (weeks) RESULTS NEVER PREVIOUSLY ACHIEVED BY ANY TREATMENT untreated R508 treated R508-treated Untreated Whether or not we get cancer depends upon a very important gene called p53. It protects our DNA and prevents healthy cells from becoming cancer cells. The ability to suppress cancer has earned p53 the title, Guardian of the Genome. 2 R508 is so effective that it even stops cancer in mice that are completely missing the p53 gene (called p53 Knockout mice). These mice always get cancer by the age of six months because they have no p53 gene to protect them. Despite their genetic vulnerability, R508 keeps these mice cancer free with no toxic side effects. R508 development has been funded by the National Institutes of Health for the past 2 decades. The mechanism of action has been painstakingly demonstrated in over 100 scientific publications by Dr. Awasthi in high-impact journals. 2 Anna Mandinova and Sam Lee, Guardian of the Genome: p53 The Gene That Cracked the Cancer Code, Science Magazine (April 2015). Page 5 of 10

6 508 IS LIKELY TO STOP CANCER IN HUMANS Many cancer treatments are successful in mice, but fail when used on human cancer patients. Dr. Awasthi s research indicates that R508 is likely to work in humans because: R508 blocks the Rlip protein that cancer cells need to survive Rlip protein increases similarly in both mouse and human cancer cells Laboratory studies show nearly identical (98%) function of Rlip in cultured mouse cancer cells and cultured human cancer cells Cancer cell Cytoplasm Nucleus Rlip gene (DNA) Rlip RNA Ribosome Rlip protein The Rlip protein in mice and humans is structurally nearly identical. Cancer Cell Rlip protein causes cancers Survival to grow, metastasize and become Growth resistant to treatment Metastasis Resistance to Treatment Blocking Rlip with R508 should kill human cancer just as effectively as it kills cancer in mice. 3 3 Only clinical testing in human cancer patients can conclusively determine if R508 is an effective cancer treatment for humans. Page 6 of 10

7 R508 IS HIGHLY EFFECTIVE AGAINST MELANOMA EVEN WITH A SINGLE DOSE Before Treatment Tumors Grow Rapidly Without R508 Treatment After One Dose of R508 Tumors Shrink Rapidly After a Single Dose of R508 Time (days) Shown here is the striking efficacy of a single-dose treatment of R508 in a highly resistant animal malignancy model of the p53 knockout mouse Page 7 of 10

8 Melanoma Prostate Cancer Kidney Cancer Pancreatic Cancer Colon Cancer Breast Cancer Neuroblastoma Lung Cancer Percent Change in Cancer Size R508 IS HIGHLY EFFECTIVE AGAINST MANY TYPES OF CANCER RED: GREEN: UNTREATED MICE MICE TREATED WITH R % 200% Un-treated Treated with R508 After 30 days 100% Cancers in untreated mice increased by % In mice treated with R508, lung and colon cancers were 100% eliminated and other cancers decreased by an average of 89% 0% -100% After just 30 days, 8 types of cancers treated with R508 were either completely eliminated or nearly gone while untreated cancers continued to grow. Page 8 of 10

9 THE NEXT STEP: TESTING R508 IN DOGS WITH CANCER Pet dogs with cancer will be treated with R508 to provide further evidence that it can work in humans. Research supporting relationships between human and dog cancers continue to grow. We ve learned that the genetic alterations influencing cancer growth in humans is similar in dogs. 4 And scientists have shown that cancers in pet dogs and humans share many features, including appearance, biological behavior and, most importantly, response to treatments. 5 We will partner with highly-experienced veterinarians at licensed animal hospitals to humanely treat dogs with deadly cancers. Clinical trials in dogs are similar to those done in humans, with safety protections in place to minimize harm. 6 If we re successful, we ll save the lives of pets that otherwise would have died from cancer. We ll use this achievement to broaden the use of R508 and make the treatment widely available to veterinary clinics and, of course, to advance R508 closer to human trials. Pet dogs may be humans best friends in a new arena of life: cancer treatment, said University of Illinois veterinary clinical medicine professor Timothy Fan. Physiological similarities between dogs and humans, and conserved genetics between some dog and human cancers, can allow pet dogs to serve as useful models for studying new cancer drugs. 7 Veterinary clinical medicine professor Timothy Fan recently tested an anticancer drug in pet dogs with lymphoma and osteosarcoma. There is heterogeneity in the human population and in dogs. So I would argue that if your drug agent produces positive results in dogs, that would give me greater confidence that those findings would be translatable to people. 8 A successful test of R508 in dogs will save the lives of man s best friends and provide compelling evidence of its likely effectiveness in humans. 9 4 Melissa Paoloni and Chand Khanna, Comparative Oncology Today, Veterinary Clinic of North America: Small Animal Practice (November 2007). 5 Melissa Paoloni and Chand Khanna, Translation of new cancer treatments from pet dogs to humans, Nature Reviews Cancer (February 2008). 6 Human and canine lymphomas share molecular similarities, first large-scale comparison shows, UNC healthcare & UNC School of Medicine (June 2013). 7 Diana Yates, Drug trials in pet dogs with cancer may speed advances in human oncology, University of Illinois Life Sciences (June 16, 2015). 8 Ibid. 9 Only clinical testing in human cancer patients can conclusively determine if R508 is an effective cancer treatment for humans. Page 9 of 10

10 TAX-DEDUCTIBLE DONATIONS* Tax-deductible donations are payable to CITY OF HOPE. On the memo line of the check please write:. Send checks to: Philanthropy City of Hope Comprehensive Cancer Center 1500 E. Duarte Road Duarte, CA *City of Hope is a 501(c)3 not-for-profit charitable organization. EIN: CONTACT: Fred Powers Page 10 of 10

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