An Unusual Presentation of Pulmonary Sarcoidosis. Emily Barsky, Harvard Medical School, Year IV Gillian Lieberman, MD
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1 An Unusual Presentation of Pulmonary Sarcoidosis Emily Barsky, Harvard Medical School, Year IV Gillian Lieberman, MD
2 Our Patient: Ms. WS 35F with asthma, recurrent pneumonia, and remote history of intravenous drug use who presents with sudden onset right-sided chest pain and shortness of breath Woke from sleep with sharp, stabbing chest pain Seen in emergency department one week prior for chest pain, fevers, productive cough Diagnosed with multifocal pneumonia and sent home with course of levofloxacin 2
3 Our Patient: History Review of Systems: Lesions on face and bilateral upper extremities for several months. Review of systems otherwise negative Past Medical History: Asthma, diabetes, recurrent pneumonia Family History: No family history of pulmonary disease, cancer, autoimmune disease Social history: From Puerto Rico, moved to US in 1995, no recent travel. Lives in East Boston, homeless in past. Has positive TB contacts and prison contacts. Positive history of intravenous drug use but none in last 8 years, social alcohol use, 5 pack-year past smoking history. Negative HIV test 1-2 mos ago, no prior PPD. 3
4 Our Patient: Physical Exam Afebrile, HR 123, BP 114/60, Sp02 97% on 2L 02 Pulmonary: No breath sounds on right Cardiac: No murmur Skin: Erythematous, violacious plaques with scale on forehead, nose and at tattoo sites on upper extremities bilaterally CXR was obtained given the patient s acute dyspnea, chest pain, and hypoxia 4
5 Our Patient: Initial AP CXR What are the findings? Image source: MGH, CAS 5
6 Our Patient: Right Tension Pneumothorax Pneumothorax Mediastinal Shift? Possible lucency Collapsed lung tissue Mild rib splaying Depression of R hemidiaphragm Image source: MGH, CAS 6
7 Pneumothorax: Types SIMPLE Small volume lung collapse (generally <30%) Patient remains relatively asymptomatic Signs on CXR: White visceral line, marking lung/ pleural air interface; straight or convex towards chest wall No pulmonary vasculature visible beyond this line No mediastinal shift or occasionally mediastinal shift TOWARDS defect Image source: O Connor AS, Morgan WE. Radiological Review of Pneumothorax. BMJ. 2005;330: TENSION CLINICAL diagnosis patient is symptomatic usually only occurs with large pneumothoraces One-way valve: air enters pleural space on inspiration but can t exit on expiration--> pressure in pleural space builds up--> pleural pressure exceeds atmospheric pressure--> further lung compression--> respiratory failure In extreme cases, can lead to cardiovascular collapse (impaired venous return to inferior and superior vena cava) Signs on CXR: Visceral pleural line with lack of pulmonary vasculature beyond that point Mediastinal shift AWAY from defect (once pleural pressure sufficiently high) +/- depression/inversion of ipsilateral hemidiaphragm +/- splaying of ipsilateral ribs 7
8 Pneumothorax: Classification Primary Spontaneous Pneumothorax Spontaneous rupture of a pleural bleb Often occurs in thin, tall men Tends to recur Risk factors: Smoking Male gender Family history Marfan s Secondary Spontaneous Pneumothorax Usually due to underlying lung disease. Can occur with any lung disease, but most commonly: Chronic Obstructive Pulmonary Disease (70%) Cystic Fibrosis Mycobacterium Tuberculosis Pneumocystis Carinii Pneumonia Interstitial Lung Disease 8
9 Pneumothorax: Management Small pneumothorax: If <30% hemithorax involvement and if clinically stable --> observe closely Supplemental oxygen (hastens reabsorption) Usually spontaneously resolve, occasionally requires needle aspiration Large pneumothorax: If >30% hemithorax involvement or clinically unstable --> requires treatment Needle aspiration, chest tube placement (thoracostomy) Tension pneumothorax: Requires emergent chest tube placement If with severe hemodynamic or respiratory compromise, can first decompress with subcutaneous needle, then place chest tube What was done for our patient? Given the tension pneumothorax, a chest tube was placed immediately 9
10 Our Patient: After Chest Tube Placement AP View 1. Chest tube 2. Small residual R pneumothorax 3. Subcutaneous emphysema Image source: MGH, CAS 10
11 Our Patient: Work-Up But why did our patient have a pneumothorax? Let s first look at her CXR from the week prior. 11
12 Our Patient: Prior CXR Blurring of diaphragms R>L suggesting bibasilar atelectasis vs infiltrates Ill-defined areas of opacification throughout both lung fields PA plain film from one week PTA o?lucency Image source: MGH, CAS 12
13 Our Patient: Prior CXR Cont d Focal area of opacity in anterior lung, but difficult to ascertain which side it is on ED Conclusion one week prior: Multifocal pneumonia Lateral view Regardless, still no clear cause for tension pneumothorax So let s do a CT Image source: MGH, CAS 13
14 Our Patient: Chest CT without Contrast Residual pneumothorax Subcutaneous emphysema Cavitary lesion in RLL Lung nodule Probable Atelectasis Axial Image Image source: MGH, CAS 14
15 Our Patient: Coronal and Sagital Reconstructions RLL Cavity Chest tube Subcutaneous emphysema Minor fissure Major fissure RLL nodule Image source: MGH, CAS 15
16 Our Patient: Lung Nodules 1.1 cm nodule in RLL Sub-cm LLL nodule Image source: MGH, CAS 16
17 Our Patient: Bronchial Thickening This is an axial cut superior to the location of the cavitary lesion Notice the bronchial and peribronchial thickening on the right, as well as the micronodules and nodular opacities Image source: MGH, CAS 17
18 Our Patient: Lymphadenopathy Coronal Reconstruction, Soft Tissue Window o The soft tissue window allows for visualization of the mediastinum and detection of lymphadenopathy o While the absence of contrast renders it suboptimal, there is fullness suggestive of mediastinal, hilar, and subcarinal lymphadenopathy Image source: MGH, CAS 18
19 Our Patient: Summary of Findings RLL cavitary lesion Multiple nodules and micronodules Bronchial and peribronchial thickening Mediastinal, hilar and subcarinal adenopathy However, her diagnosis is still unclear 19
20 Cavitary Lung Lesions: Differential Infection Abscess (especially anaerobes, Nocardia, S. aureus, Klebsiella) Mycobacterium (TB, nontuberculous) Fungi Septic emboli- endocarditis Rheumatologic/Vasculitis Most commonly Wegener s Others (rarely): Sarcoidosis, SLE, RA 20
21 Cavitary Lung Lesions: Differential Cont d Neoplasm Primary Especially squamous cell carcinoma Others: lymphoma, Kaposi s Sarcoma Metastatic (i.e. osteosarcoma) Misc Empyema, pulmonary embolism, Langerhan s cell histiocytosis, bronchiolitis obliterans organizing pneumonia 21
22 Our Patient: Work-up Cont d Given significant TB risk factors, induced sputum x 3 --> negative for acid fast bacilli Bronchoscopy with bronchoalveolar lavage --> no organisms But what about the skin findings? 22
23 Companion Patient #1: Skin Lesions in Tattoo Derm performed skin biopsy Path: granulomatous dermatitis Skin lesions in a similar patient Image source: Lodha S, Sanchez M, et al. Sarcoidosis of the Skin: A Review for the Pulmonologist. Chest. 2009;136(2) Image source:hatwin KE, Roddie ME. Pulmonary sarcoidosis: the great pretender. Clinical Radiology Aug;65(8) Our patient s diagnosis? Sarcoidosis +/- lung superinfection Skin biopsy in a similar patient 23
24 Sarcoidosis Systemic granulomatous disease of unknown etiology affecting multiple organ systems Epidemiology: Usually presents between ages Organ system involvement: Lung >90% Skin 25% (varied presentations) Occular 20-50% (i.e. uveitis) Liver (hepatitis ) 50-80% Other organs systems: musculoskeletal (myositis, polyarthritis), reticuloendothelial (lymphadenopathy, hepatosplenomegaly), cardiac (arrhythmias), renal (focal segmental glomerulosclerosis, membranous nephropathy, crescentic), neurologic 24
25 Sarcoidosis Cont d Signs and symptoms: Up to 50% asymptomatic, diagnosed on routine CXR 1/3 have nonspecific symptoms (fever, malaise, fatigue, weight loss, decreased exercise tolerance) Organ specific symptoms (i.e. cough, chest pain, dyspnea in the case of pulmonary sarcoid) Diagnosis: 1. Clinical and radiologic features consistent with disease 2. Noncaseating granulomas on histology (transbronchial lung, skin, or lymph node biopsy most commonly) 3. Exclusion of other similar diseases 25
26 Pulmonary Sarcoidosis: Stages Stage 0: Normal CXR Stage 1: Bilateral hilar adenopathy Stage 2: Bilateral hilar adenopathy and reticular opacities/infiltrates (upper zones>lower zones) Stage 3: Reticular opacities/infiltrates, resolved hilar adenopathy Stage 4: Fibrosis (irreversible) Stage I Stage III Stage IV Image source: Wu JJ, Schiff KR. Sarcoidosis. Am Fam Physician Jul 15;70(2):
27 Pulmonary Sarcoidosis: Companion Patient #2 Early Stage Notice the bilateral hilar adenopathy typical of early stage sarcoidosis Also notice the reticulonodular opacities, most prominent in the RUL PA Plain film PACS, BIDMC 27
28 Pulmonary Sarcoidosis: Companion Patient #3 PA Plain Film Late Stage Coronal CT View Extensive mediastinal and hilar lymph node calcification Upper lobe volume lose secondary to fibrosis Mass-like area of fibrosis Traction bronchiectasis PACS, BIDMC 28
29 Pulmonary Sarcoidosis: Other Radiological Findings Nodules (multiple, often subpleural) Bronchial wall thickening Focal ground glass Bronchovascular beading Apical cysts Honeycombing Parenchymal masses or consolidation Others: traction bronchiectasis, cavitation, pleural disease 29
30 Pulmonary Sarcoidosis: Treatment and Prognosis Treatment: Corticosteroids, cytotoxic agents, immunomodulators Prognosis: Depends on host characteristics, organ involvement, disease extent Spontaneous resolution in: Stage 1: 90% of patients Stage 2: 70% of patients Stage 3: 20% of patients Permanent functional impairment in 20-25% 30
31 Sarcoidosis: Role of Imaging CXR Initial CXR with staging, prognostic power Suboptimal for evaluating parenchymal abnormalities High Resolution CT Less prognostic power than CXR Excellent for evaluating parenchymal abnormalities Functional Imaging: Can identify occult lesions, guide therapy for potential areas of reversible disease PET/CT (FDG)- wave of the future? excellent sensitivity, but significant radiation 31
32 Functional Imaging of Sarcoidosis: FDG PET Disseminated Sarcoidosis R paratracheal, bilateral hilar and mediastinal lymph nodes Spleen Pelvic lymph nodes R apical lung nodule Confirms splenic lesion Images from: Balan A, Hoey ET et al. Multi-technique imaging of sarcoidosis. Clinical Radiology 2010 Sep;65(9):
33 Functional Imaging: Companion Patient #4 Significant hilar, mediastinal, paratrachial, and cardiac involvement Image courtesy of Dr. Kevin Donohoe 33
34 Our Patient: Outcome Our patient was thought to have presumed sarcoidosis, with an ATYPICAL presentation (cavitary lung lesion and lung nodules, as well as more typical mediastinal and hilar lymphadenopathy), with probable superinfection Chest tube was removed after several days and lung remained inflated Patient was treated with empiric course of broad spectrum antibiotics for pulmonary superinfection Outpatient follow-up was scheduled after completion of antibiotic course, with repeat CT to look for resolution of cavitary lesion and to better evaluate underlying lung parenchyma The patient will likely start treatment for sarcoidosis at that time 34
35 Summary I Pneumothorax There are two types of pneumothorax: simple and tension. Tension pneumothorax can lead to respiratory and hemodynamic compromise and is a surgical emergency requiring immediate chest tube placement When a patient presents with a primary spontaneous pneumothorax, consider further imaging to investigate the etiology Cavitary lung lesions There is a broad differential for cavitary lung lesions including infection, septic emboli, rheumatologic disease, and malignancy Sarcoidosis can present with a cavitary lung lesion in rare instances 35
36 Summary II Sarcoidosis Sarcoidosis is a systemic granulomatous disease, which most commonly affects the respiratory system Pulmonary sarcoidosis has four stages of disease Common pulmonary manifestations include hilar adenopathy and/or reticular opacities in early stages, and fibrosis in end stage disease However, there are numerous other less common manifestations of pulmonary sarcoidosis (i.e. cavitation) Imaging plays an important role in diagnosing, staging, and prognosticating for pulmonary sarcoidosis 36
37 Acknowledgements Mai-Lan Ho, MD Marc Camacho, MD Kevin Donohoe, MD Pamela Mok, MD Jennifer Son, MD Iva Petkovska, MD Gillian Lieberman, MD Larry Barbaras Emily Hanson 37
38 Bibliography Balan A, Hoey ET, et al. Multi-technique imaging of sarcoidosis. Clinical Radiology Sep;65(9): Coker RK. Management strategies for pulmonary sarcoidosis. Ther Clin Risk Manag Jun;5(3): Gadkowski LB, Stout JE. Cavitary pulmonary disease. Clin Microbiol Rev April;21(2); Hatwin KE, Roddie ME, et al. Pulmonary sarcoidosis: the great pretender. Clinical Radiology Aug;65(8) Hours S, Nunes H, et al. Pulmonary cavitary sarcoidosis. Medicine May;87(3): Mackie B, Humphrey DA, et al. Atypical sarcoidosis: a case report and literature review. Am J Med Sci. 2006;331(5): O'Connor AR, Morgan WE. Radiological review of pneumothorax. BMJ June; 330(7506): Wu JJ, Schiff KR. Sarcoidosis. Am Fam Physician Jul;70(2):
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