Evidence for Treatment
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1 Evidence for Treatment Mr. Duy Thai Orthopaedic Surgeon, Northern Health, Western Health
2 Conflict of Interest None
3 a condition characterized by functional restriction of both active and passive shoulder motion for which radiographs of the glenohumeral joint are essentially unremarkable ASES Consensus definition, 2012
4 Frozen shoulder (Codman 1934) Broad, descriptive term Includes: Post traumatic Post Surgical Cuff pathology Adhesive capsulitis (Neviaser JS 1945) A specific pathologic entity Primary Secondary Associations with Diabetes and other systemic disorders
5 Diagnostic criteria 1. Insidious onset 2. Painful restriction of active and passive elevation < True shoulder pain 4. External rotation < 50% of opposite site 5. Night pain 6. Normal radiographs Zuckerman et.al, JSES 1994
6 Natural History I Stage II Stage III Stage IV Reeves, Scand J Rheum, 1975
7 I II III IV Clinical Pain Pain + ROM ROM Progressive improvement in ROM Arthroscopic Diffuse synovitis Diffuse, thickened synovitis Histology Hypertrophic, hypervascular synovitis, inflammatory cell infiltrates Hypervascular synovitis, capsular fibroplasia Cytokine soup: TGFß, TNF, IL-1, IL-6, PDGF, VEGF, MMP3 Thickened capsule, diminished volume Synovium not hypervascular, dense scar formation in capsule Adapted from Hannafin et.al, CORR
8 Treatment 1. Relieve pain 2. Improve range of motion 3. Shorten natural history of symptom resolution
9 Treatment should be based on a clinical assessment of what Stage the patient is in Not on symptom duration Duration of each stage highly variable overlap All treatment modalities need to have ongoing physiotherapy interventions
10 I Stage II Reeves, Scand J Rheum, 1975
11 Oral vs Intra Articular steroids JSES 2010 Study Design Population size Stage of disease Level 1 RCT n=40 Stage II Comments 40mg triamcinolone + 0.5% bupivicaine, 3 injections (4 weeks apart) Vs Reducing dose of Prednisolone over 25 days from 40mg Conclusion Injections superior at all stages of review up to 1 year
12 Retrospective, Small numbers Stage 1 vs Stage 2 injections Stage 1 improved quicker 6 weeks recovery of ROM Stage 2 7 months HSSJ, 2007
13 JSES 2012 n=191 Prospective RCT Minimum 3mo symptom duration Primary Adhesive capsulitis 2% lignocaine + 40mg triamcinolone Single injection Best outcome at 2 weeks Effects wear off at 16 weeks Intra articular = subacromial JSES 2011 n=71 Prospective RCT Minimum 6 wk symptom duration 2% lignocaine + 40mg triamcinolone At 3 wks GH injection better relief of pain than SA At 6 and 12 wks same effect
14 Stage I and II Adhesive Capsulitis Oral steroids should not be used Subacromial injections can be as effective as glenohumeral joint injections Easier to perform No need for radiology Injections improve pain and functional scores in the short term JBJS Am, 2011
15 Stage III Reeves, Scand J Rheum, 1975
16 Stage III: Treatment options Steroid injections Hydrodilatation Manipulation under anaesthesia Surgical release
17 BMC Musculoskeletal Disorders 2008 RCT n=76 Minimum 3mo symptom duration 15mg Bupivicaine + 20mg triamcinolone (3 injections 2wk apart) vs Hydrodilation (20mls) Review at 6 weeks Improvement in SPADI and ROM for both Both groups the same JSES 2009 RCT n=53 Median duration of symptoms 16 weeks 40mg triamciniolone+2% lignocaine (3 injections 6 wk apart) vs MUA Most effect within 3 weeks, then plateau off Both group equal efficacy
18 RCT n=46 Minimum 3mo duration of symptoms MUA + arthoscopic release vs intra articular injection (2% lignocaine and depo medrol) Arthroylsis achieved better outcome sooner (at 6 weeks) compared with injection (at 12 weeks) Int Orthopaedics, 2012
19 JBJS Am, 2012
20 My Approach If patient is seen in Stage I or II Subacromial injection of 2% lignocaine + 40mg Depo Nisolone in rooms Allows initial assessment of response Refer to physiotherapy Review at 6 weeks to assess response If poor response, refer for fluoroscopic guided injection to Glenohumeral joint Reassess at 4 6 mo If poor response, consider arthroscopic capsular release
21 My Approach If patient is in Stage III Duration of symptoms often > 6 months Discuss with patient options low yield with further injections Recommend arthroscopic capsular release ± subacromial decompression
22
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24 Question: 60yo female. RHD. Well controlled type 2 Diabetes. 9 months of painful, stiff right shoulder. Pain better now, but unable to reach up and comb hair. IR to back pocket. Active and passive ROM same. Normal xrays and US. Treatment? A. Skillful neglect B. Steroid (intra articular or subacromial) C. Hydrodilation D. MUA E. Arthroscopic capsular release
25 References Zuckerman, JD et.al; Frozen shoulder: a consensus definition; J Shoulder Elbow Surg (2011) 20, Neviaser, RJ et.al; Adhesive Capsulitis of the Shoulder; J Am Acad Orthop Surg 2011;19: Le Lievre, HMJ et.al, Long-Term Outcomes After Arthroscopic Capsular Release for Idiopathic Adhesive Capsulitis, J Bone Joint Surg Am. 2012;94: De Carli, A et.al; Shoulder adhesive capsulitis: manipulation and arthroscopic arthrolysis or intraarticular steroid injections?; International Orthopaedics (SICOT) (2012) 36: Jacobs, LG et.al; Manipulation or intra-articular steroids in the management of adhesive capsulitis of the shoulder? A prospective randomized trial; J Shoulder Elbow Surg (2009) 18, Tveitå, EK et.al; Hydrodilatation, corticosteroids and adhesive capsulitis: A randomized controlled trial; BMC Musculoskeletal Disorders 2008, 9:53 Marx, RG et.al; Intra-articular Corticosteroid Injection for the Treatment of Idiopathic Adhesive Capsulitis of the Shoulder; HSSJ (2007) 3: Lorbch, O et.al; Nonoperative management of adhesive capsulitis of the shoulder: Oral cortisone application versus intra-articular cortisone injections; J Shoulder Elbow Surg (2010) 19, Hanafin, JA et.al; Adhesive Capsulitis A Treatment Approach; CORR 2000:372; Reeves B: The natural history of the frozen shoulder syndrome. Scand J Rheumatol, 4: , 1975.
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