Orthomyxoviridae Avian Influenza

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1 Avian Flu Reported in 2003 Orthomyxoviridae Avian Influenza Dr. Suresh Mittal VPB 560 Disease reported present Disease reported absent Data unavailable or incomplete Outbreaks in Asia H5N1 in Asia - late 2003 and early 2004 Cambodia, China, Indonesia, Japan, Laos, South Korea, Thailand and Vietnam At that time, more than 100 million birds either died from the disease or were culled. Dec An outbreak of bird flu in Hong Kong kills six people and sickens another 12. To remove the source of the virus, authorities destroy about 1.5 million chickens. The outbreak is caused by the avian influenza strain known as H5N1, the same virus behind the current crisis in Asia. Human Cases - December 2003 to March human cases of confirmed H5N1 influenza in Thailand and 23 in Vietnam, including 23 deaths. March 1999 Two children in Hong Kong are diagnosed with avian influenza caused by the strain H9N2, a milder strain than H5N1. Both patients recover and no other cases in Hong Kong are confirmed. Mainland China reports several additional cases caused by H9N2 during the same time frame. Feb Two cases of bird flu caused by H5N1 are reported among members of a family in Hong Kong who had recently traveled to China. One person recovers, while the other dies. Another family member dies after contracting a respiratory illness in China, but no testing is done to confirm the cause of death. 1

2 March 2003 An outbreak of bird flu in the Netherlands kills a veterinarian and sickens more than 80 other people, mostly poultry workers and their families. The illnesses are caused by another strain of the avian influenza virus, known as H7N7, which results in mostly eye infections and some respiratory symptoms. Jan. 11 Japan says 6,000 chickens have died of avian influenza on a farm, and says it is the first time the disease has been confirmed in the country. Dec A child in Hong Kong is diagnosed with bird flu caused by the H9N2 strain. The child is hospitalized and later recovers. Meanwhile, South Korea confirms an outbreak of the H5N1 virus at a chicken farm near Seoul and begins a mass cull of poultry as the virus rapidly spreads across the country. Jan Vietnam announces that bird flu caused by the H5N1 strain has been found on many of its poultry farms. Students get their feet sterilized as they come out of a blocked area to go to school in the town of Kokonoe, Oita prefecture - Japan TOKYO, Feb. 19, 2004 Jan. 25 Indonesia discovers an outbreak of avian influenza among chickens but has no evidence that the disease has spread to humans. Pakistan says two million chickens have died of a mild form of bird flu, caused bythe H7N7 and H9N2 strains. A worker checks chickens Tuesday at Indonesia's biggest slaughte rhouse, located in Parung on the outskirts of Jakarta A chicken with the bird flu virus tries to escape from a bonfire of burning chickens Friday, Feb. 6, 2004, in the village of Bolangan, in Bali, Indonesia. Jan. 26 Thailand confirms the death of a six-year-old boy, the nation s first human death from bird flu. Feb. 1 China s state television reports five more areas with suspected cases of bird flu in poultry, bringing to 11 the total number of such outbreaks. The WHO says two sisters have died in Vietnam after contracting bird flu and they may have caught the virus from their brother, who had also died. Workers from the Thai livestock department catch chickens during the destruction at a farm in Song Peenong district, Supanburi province, Thailand, Jan. 23, Worker sprays chemical at empty cages at a poultry market in Bangkok in Jan

3 Feb. 1 China s state television reports five more areas with suspected cases of bird flu in poultry, bringing to 11 the total number of such outbreaks. The WHO says two sisters have died in Vietnam after contracting bird flu and they may have caught the virus from their brother, who had also died. Feb. 2 An 18-year-old dies of bird flu in Ho Chi Minh City, bringing to nine the fatalities in Vietnam. A Thai woman dies of bird flu, raising that country s toll from the virus to three. The total number of fatalities stands at 12. Feb. 3 Indonesia finds the H5N1 strain of bird flu in its poultry flocks. A sevenyear-old Thai boy dies, becoming the country s fourth confirmed death from the disease. The total number of fatalities stands at 13. Bangkok Health Department workers trap and recover pigeons at Sanam LuangPark Friday, Feb. 6, 2004, in downtown Bangkok. Officials were checking for pigeons infected with bird flu. Outbreaks in North America with Transmission to Humans An official from the Agri-Food and Veterinary Authority inspects chickens imported from Malaysia at the Tuas entry point to Singapore, Jan. 30, H7N3 in Canada Feb poultry farm workers 9,000 birds destroyed H7N2 in New York Nov patient admitted to hospital. No source of infection determined. Outbreaks in North America Among Poultry H5N2 in Poultry in Texas - Feb H2N2 in Pennsylvania - Feb H7N2 in Poultry in Maryland - March 2004 H7N2 in Poultry in Delaware and Live Bird Markets in New Jersey Feb ,800 birds were destroyed. Avian influenza: Edema & cyanosis of comb & wattle 3

4 Highly Pathogenic Avian Influenza (Fowl Plague) Cyanotic, swollen comb and wattles (Image kindly provided by PIADC FADD School) Affected chicken (Image kindly provided by PIADC FADD School) Edematous comb (Image kindly provided by PIADC FADD School) Hemorrhages on leg (Image kindly provided by PIADC FADD School) Hemorrhages on leg (Image kindly provided by PIADC FADD School) Avian influenza: Bloody cloaca 4

5 Avian influenza: Hemorrhage in trachea Avian influenza: Hemorrhage on heart Avian influenza: Hemorrhage in proventriculus Avian influenza: Hemorrhage on the serosal covering of abdominal organs Avian influenza: Hemorrhage on mesentery of small intestine Avian influenza: Hemorrhage in intestine 5

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