Smart Systems for Medical Devices

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1 Smart Systems for Medical Devices FP6 & FP7 supported Gold Nuggets portfolio

2 COWIN activities COWIN is an European initiative dedicated to facilitate access to Smart Systems in using advanced technologies. We offer industrial companies free support in: Extracting gold nuggets technologies fitting with their innovative projects Generating added-value projects with advanced technologies to capture innovation in smart systems Optimizing their access to key partners with key competencies for the success of their innovative projects And getting access to financing for such projects reusing extracted from the European Commission portfolio

3 Smart systems for Medical Devices Smart systems technologies are currently revolutionizing the Healthcare industry. New therapy strategies, genetic disease treatment, intelligent drug delivery solutions, smart medical imaging and surgical tools are healthcare improvements promised to future generations. Smart systems are key solutions to solve societal challenges and to improve quality of patients treatment and life. First commercialized products based on smart systems technologies have already seduced their customers and demonstrated their added-value, as illustrated hereafter.

4 Example of success stories Surgical robots using Smart Systems to assist surgeons for minimally invasive surgery. Product launch: 1999 Volume > 700 robots shipped Respimat soft Mist inhaler for pulmonary diseases Product launch: 2004 Revenues for inhalers: >100M$ in 2011 Infrared Thermopile sensors for body temperature via ears First success in Medical Devices pave the way to follow-up products generations using smart systems technology.

5 Added-value of Smart Systems technology Smart systems for Medical devices allow the use of miniaturized implantable devices providing minimally invasive solutions. Smart Systems give opportunity to use communicating solutions between sensors and recorders or data centers to exchange information (in-line with trends in e-health and telemedicine). Medical devices using Smart Systems technologies allow: 1) More efficient patient monitoring (at the hospital, at home,.) 2) More efficient therapeutic treatment

6 A real business opportunity Based on such added-value, Smart systems technology for Life Science application represents today a growing market driven both by products becoming standards and emerging solutions. Data extracted from Yole Développement BIOMEMS 2010 report

7 Gold Nuggets portfolio

8 Portfolio of advanced key technologies COWIN builds-up portfolio of added-value technologies enable to answer market needs in medical devices. Our Gold nuggets portfolio includes especially: Innovative drug delivery solution: through oral cavity Imagery guided drug delivery treatment Neurostimulation and Neural recording: Implantable and smart electrodes arrays Telemetry controlled implanted micro-electrodes Bi-directionnal electrodes for neurostimulation and recording Motion Analysis solution for gesture monitoring: Gait Trainer Solution Unobtrusive Audio & Bio-feedback Module Other technologies are available under request

9 Drug Delivery portfolio Technologies from COWIN portfolio targeting drug delivery applications have been developed to solve industry key specifications in term of reliability, safety and ease to use.

10 Advanced technologies for drug delivery Main Gold Nuggets: Intra-oral drug delivery solution Continuous drug delivery for a better bio-availability Applications: Treatment for chronicle diseases & drug addiction Status: existing prototype with preclinical test + protocol validated for specific molecules (L-DOPA ethyl ester) Intra-oral drug delivery Imagery MRI-guided drug delivery solutions Magnetic propulsion of nano-capsules for drug delivery Added-value: better control to address the target therapeutic Applications: Local treatment in a targeted way for human cancer In-line with current innovation in medical imagery Status: Prototype available and need to adapt the development to a specific solution Nanocapsule based drug delivery Other technologies are available under request

11 Neurosciences portfolio Technologies from COWIN portfolio targeting Neurology applications are inline with requirements for patient home monitoring or minimally invasive neuro-surgery.

12 Advanced technologies for Neurostimulation Main Gold Nuggets: Telemetry controlled implanted micro-electrodes Implanted micro-electrodes on the Vagus Nerve for recording and stimulation on the nerve Applications: Stimulation for epilepsy and possible use for other neurological disorders (Parkinson, ) Products entered in pre-production Bi-directionnal multichannel electrodes for neurostimulation and recording Implantable multichannel polyimide based micro-electrodes to stimulate and to collect signal from the nerves Applications: relief of phantom limb pain for amputees, spinal cord injuries, trauma Fully developed systems for concept demonstration. Successful in-vitro and in-vivo experiments with small and large animals ISO certified cytotoxicity testing. Neurostimulator and implanted electrodes Electrode for Neuroscientific use

13 Advanced technologies for Neural Recording Main Gold Nuggets: Implantable and smart electrodes arrays Neural probe able to pinpoint neural activity at the cellular level without mechanical repositioning of the electrode. Applications: Research in the Neuro-electrophysiology, awake free behavioral animal studies, suitable for acute and chronic experiments. Acute and chronic active probes are available products for R&D applications Probe lengths available from 1mm till 4cm tall. 50µm thin active probe CMOS-MEMS integrated technology Courtesy of ATLAS Neuroengineering

14 Motion Analysis portfolio Technologies from COWIN portfolio targeting remote gait and motion analysis for fall prevention and mobility monitoring of patients (elderly, orthopaedics, prosthesis).

15 Advanced technologies for remote motion analysis (1/2) Main Gold Nuggets: Gait Trainer Solution Non invasive Motion sensing and gesture analysis based on inertial sensors Fast Response (10 time faster than existing solutions) Easy to use by therapists or nurses Applications : Prosthesis, Orthopaedic Clinics for rehabilitation, Elderly people for fall prevention Inertial Sensor Platform Biofeedback based portable device for elderly mobility in home environment Lightweight & Wireless audio-biofeedback system based on body sensors network, stereo headset and software mobile device Optimized for unobtrusiveness and ease of use by elderly people, Ubiquitous use, Modular Architecture (interoperability, versatility) Experimental set-up

16 Robot and instrumentation portfolio Technologies from COWIN portfolio targeting tools and instrumentation for medical applications and surgical procedure assistance.

17 Advanced technologies for remote motion analysis Main Gold Nuggets: SPRINT Robot: robot for single port minimally invasive surgery High degrees of freedom for single port procedures Minimally invasive tool 3D full HD vision system Applications : Laparoscopic surgery Status: Proof of concept prototype Sprint robot arms Magnetically guided minimally invasive vision system Magnetic levitation robot guided by an external magnet Applications: laparoscopic surgery, single port surgery, colonoscopy, infusion systems Status: Several proof of concept prototypes developed and tested MIM camera

18 COme to WIN

19 How we are working We are constantly identifying attractive and advanced technologies You just have to express your field of interest and the type of technologies you are looking for We can exchange NDA if you wish We will then identify for you advanced technologies fitting with your needs and expectations We organize One-on-One meetings to create synergies and assess collaborations opportunities

20 COWIN services Individual support A team of experts in smart systems will work with you to support your innovation in its way to market; Services and tools designed to fit with your needs will be offered to you Strong collaboration to make your technology a real business case To meet and set-up collaboration with prospects and key partners To be ready to overcome main challenges and barriers for commercial exploitation To use at best the COWIN s services

21 Contact us now Geraldine Andrieux-Gustin COWIN s Project Coordinator Yole Développement

22 COWIN at a glance