cystatin C cystatin C

Transcription

1 [1,2] (USRDS) 2005 ( ) 2001 (National Kidney Foundation, NKF) K-DOQI (1) (glomerular filtration rate, GFR) 3 (2) 60 ml/min/1.73m 2 3 [3-5] ( 1) 113 (serum creatinine) (Ketoacidosis) (degradation) trimethoprim cimetidine (creatinine clearance, CCr) [6,7] cystatin C Cystatin C 13 cystatin C cystatin C cystatin C cystatin C CRP cystatin C cystatin C ( )

2 1. Cockcroft-Gault (140-Age) Weight Ccr(ml/min) 72 Scr ( 0.85 if female) Ccr Scr mg/dl Age year Weight kg 2. Abbreviated MDRD Study Estimated GFR (ml/min/1.73m2) = 186 (Scr) (Age) ( if female) ( if black) = 175 (Standarized Scr) (Age) ( if female) ( if black) 2005( ) 7 3. Schwartz 4. Counahan-Barratt GFR= 0.55 Height (cm) Scr (mg dl) 5. GFR= Height (cm) Scr (mg dl) 1. cystatin C [8-12] (inulin) ( 99m Tc-DTPA 51 Cr-EDTA iohexol 125 I-iothalamate ) ( 1)

3 1. K-DOQI GFR(mL/min/1.73m 2 ) Cockcroft-Gault MDRD(Modification of Diet in Renal Disease) study ( 1) Cockcroft-Gault ml/min [7,13,14] Cockcroft-Gault 140 ( ) ( ) Cockcroft-Gault Cockcroft-Gault Cockcroft-Gault Cockcroft-Gault MDRD Study ( ) [7,15,16] MDRD Study Cockcroft-Gault ( ) [17-19] MDRD Study GFR 90 ml/min/1.73m 2 Cockcroft-Gault [20-22] MDRD Study [23] ( MDRD Study abbreviated MDRD Study MDRD Study Schwartz Counahan-Barratt ( 1) Schwartz Counahan-Barratt

4 Schwartz % % % % % 7.4% 1 2.2% 2 2.8% 3 1.5% 4 0.9% 14.2% 91 (26.2%) % % % % % 14% 8.5% ( ) 0.3% ( ) 0.3% ( ) 7.9% ( ) 5.2% ( ) 1.2% 8.5% 24% % 71.4% 25% 8% 1.6 [24] ( ) ( ) 24 [7,23] ( 38.7%) ( 30.3%) ( 6.2%) ( 1.8%) ( 1.1%)

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