Research and Development in the Czech Republic. Mr. Jiri Krechl Head of R&D Support Department

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1 Research and Development in the Czech Republic Mr. Jiri Krechl Head of R&D Support Department

2 CZECHINVEST Investment and Business Development Agency Ministry of Industry and Trade CzechInvest Investment and Business Development Agency Source: CzechInvest, 2014 mission to support foreign direct investment to develop local companies to implement business-development programs to improve the business environment

3 Structure of Presentation Basic figures about Czech R&D Life Sciences Universities in the Czech Republic R&D funding in the Czech Republic Centers of Excellence and Regional R&D Centers Biomedicine R&D Infrastructure

4 Basic Figures State expenditure: USD 1.24 bln Approx FTEs in R&D (12,2 per 1000 FTEs) 0,68% of scientific papers in the world 24% of R&D workplaces, 37% of employees and 33,4% of total expenditures located in Prague Source: SCImago Journal & Country Rank 2012, Czech Statistical Office 2014

5 R&D Basic Indicators GERD in absolute numbers and as a portion of GDP (%) before and after adopting ESA 2010 standard Source: Czech Statistical Office, 2014

6 R&D International Comparison GERD as a portion of GDP (%) in 2007 and 2012 Source: Czech Statistical Office 2014

7 Map of Main Life Sciences Universities Jan Evangelista Purkyne University Faculty of Medicine, Charles University, Hradec Kralove Charles University University of Pardubice University of Ostrava Czech Technical University Institute of Chemical Technology Masaryk University Palacky University University of South Bohemia Mendel University University of Veterinary and Pharmaceutical Sciences Source: CzechInvest

8 Key National Sources of R&D Funding Czech Science Foundation Project-based funding of basic research High priority given to international collaboration Technology Agency Project-based funding of applied research and experimental development Different programmes support development of new technologies, their verification in practice, collaboration between academia and industry etc.

9 EU Sources of R&D Funding EU Structural Funds OP Enterprise and Innovation for Competitiveness Administered by CzechInvest Main programmes being Innovation, Potential and Application OP Research, Development and Education Administered by Ministry of Education, Youth and Sports Mainly Priority Axis 1: Enhancing capacities for quality research

10 EU Sources of R&D Funding Horizon 2020 The EU Framework Programme for R&D Running from 2014 to 2020 with a budget of just over 70 billion Major simplification through a single set of rules and a market-driven approach International cooperation as an important priority Czech institutions actively seeking partnerships in research consortia

11 Closed Operational Program Research and Development for Innovations Operational program funded by EU Period Purpose is to strengthen the country's competitiveness and growth orientation towards a knowledge economy Total budget over 2,1 billion EUR 48 R&D centers were supported (all outside of Prague) Source: Ministry of Education, Youth and Sport

12 Map of projects funded from OP Research and Development for Innovations Source: CzechInvest

13 Map of core Biotechnology / Biomedicine R&D Centers Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University Institute of Molecular and Translational Medicine St. Anne s University Hospital Brno - International Clinical Research Center Central European Institute of Technology Regional Centre for Applied Molecular Oncology Source: CzechInvest

14 Map of Biotechnology / Biomedicine related R&D Centers Extreme Light Infrastructure Centre of the Region Haná for Biotechnological and Agricultural Research Center of Algal Biotechnology Trebon Source: CzechInvest

15 Biotechnology / Biomedicine R&D Infrastructure from Basic to Applied Research Cancer research - cancer progression, metastasis, resistance to therapy, genetic and epigenetic defects in cancer etc. Applied molecular oncology molecular imaging, tissue and cell imaging, biomarkers discovery and evaluation, molecular therapy etc. Clinical applications and commercial outputs - diagnostic methods for personalized medicine, clinical trials etc. Source: RECAMO

16 Biotechnology / Biomedicine R&D Infrastructure Basic Research Programme Examples Functional Genomics, Cellular Biology and Virology Translational Medicine, Molecular Basis of Diseases and Molecular Targets Structural Biology, Molecular Medicine, Brain and Mind Research, Nanotechnology Protein Biochemistry and Proteomics, Chemical Biology Cardiovascular and Metabolic Disorders, Neuroepidemiology Source: CzechInvest

17 Biotechnology / Biomedicine R&D Infrastructure Applied Research Programme Examples Applications in Molecular, Biomedical, Material Sciences; X-ray Sources Driven by Ultrashort Laser Pulses Biomaterials and Tissue Engineering, Structural Biology and Protein Engineering Molecular Biomarker Discovery and Evaluation, Molecular Targets of Therapy and Drug Discovery Biomarkers - Identification and Validation, Chemical Biology and Experimental Therapeutics Source: CzechInvest

18 Biotechnology / Biomedicine R&D Infrastructure Valid Patent Examples Novel saponin compounds, methods of preparation thereof, use thereof and pharmaceutical compositions European patent Unique holographic microscope Czech, European and US patent Anti-tumor triterpenoids substituted with nitrogen Czech patent Source: CzechInvest

19 Biotechnology / Biomedicine R&D Infrastructure Core Facilities Examples Czech Centre for Phenogenomics, Centre for Molecular Structures, Centre for Imaging Methods Nanobiotechnology Core Facility, Cryo-electron Microscopy and Tomography, Genomics Core Facility, Bioimaging Centre Center of Biomolecular and Cellular Engineering, Clinical Pharmacology Unit, Integrated Center of Cellular Therapy and Regenerative Medicine Source: CzechInvest

20 Thank you for your attention.

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