World-leading expertise in Gene and Cell Therapy
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1 Worldleading expertise in Gene and Cell Therapy Jefferies Healthcare Conference New York, June 2015
2 Disclaimer The information contained in this presentation is being supplied and communicated to you on a confidential basis solely for your information and may not be reproduced, further distributed to any other person or published, in whole or in part, for any purpose. For the purpose of this disclaimer, presentation means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed during Cohort 2 the presentation Dose meetings or any presentation Administration to which this 3 document months (UPDRS) relates. 6 months (UPDRS) 1 year (UPDRS) 2 years (UPDRS) Although 1, n=3 reasonable care 1x has been taken to Original ensure that the facts stated Mean 27% in this presentation Mean are 30% accurate and Mean that the 29% opinions expressed are fair and reasonable, the contents of this presentation have not been formally Max. verified up to 30% by Oxford BioMedica plc (the Company ) or any other Max. person. up to 30% Accordingly, no representation or warranty, expressed or implied, is made as to the fairness, accuracy, completeness or correctness of the information and opinions contained 2, n=3 in this presentation, 2x and no reliance Original should be placed on Mean such 28% information or opinions. Mean 34% Further, the Mean information 29% in this presentation is not Max. up 53% complete and may be changed. Neither the Company nor any of its respective members, directors, officers or employees nor any other person accepts any liability whatsoever for any loss howsoever arising from any use of such information or opinions or otherwise arising in connection with this presentation. This presentation does not constitute an offer to sell or a solicitation of offers to buy Ordinary Shares in the Company (the Securities ). The Securities have not been registered under the US Securities Act of 1933, as amended (the Securities Act ), or qualified for sale under the law of any state or other jurisdiction of the United States of America and may not be offered or sold in the United States of America except pursuant to such registration or an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act. Neither the United States Securities and Exchange Commission nor any securities regulatory body of any state or other jurisdiction of the United States of America, nor any securities regulatory body of any other country or political subdivision thereof, has approved or disapproved of this presentation or the securities discussed herein or passed on the accuracy or adequacy of the contents of this presentation. Any representation to the contrary is unlawful. This presentation is being communicated only to U.S. persons that are qualified institutional buyers within the meaning of Rule 144A under the Securities Act or institutions that are accredited investors within the meaning of Rule 501 under the Securities Act. This presentation may contain forwardlooking statements that reflect the Company's current expectations regarding future events, its liquidity and results of operations and its future working capital requirements. Forwardlooking statements involve risks and uncertainties. Actual events could differ materially from those projected herein and depend on a number of factors, including the success of the Company's development strategies, the successful and timely completion of clinical studies, securing satisfactory licensing agreements for products, the ability of the Company to obtain additional financing for its operations and the market conditions affecting the availability and terms of such financing. By participating in this presentation you agree to be bound by the foregoing restrictions and the other terms of this disclaimer. 2
3 Oxford BioMedica an overview 1, n=3 1x Original Mean 27% Product Mean 34% Development + Proprietary gene and cell therapy pipeline + OXB Solutions Lentiviral vector manufacture and process development IP Ownership Lentiviral vector patents and knowhow A leading gene and cell therapy company 3
4 Corporate history and financing Spun out of Oxford University in , n=3 1x Original Mean 27% Mean 34% London Stock Exchange (Ticker OXB.L) Market capitalisation $405m (May 25, 2015) $22m cash at December 31, 2014, plus $50m loan facility 4
5 Gene therapy & cell therapy In vivo Ex vivo ProSavin (Parkinson s disease) Lentivector manufacturing for CTL019 1, n=3 1x Original Mean 27% Mean 34% RetinoStat (Wet AMD) 5
6 Lentiviral vector advantages over AAV 1. Larger therapeutic payloads 2. Permanent modification of dividing cells such as Tcells or 1, n=3 1x Original Mean 27% stem cells Mean 34% Potential for one shot treatment giving longterm or permanent efficacy 6
7 Oxford BioMedica s unique capabilities Slide for large image Proprietary analytics Analytical development Lentiviral vector IP OXB Solutions Process development Cell/Vector engineering Manufacturing capacity One stop shop 7
8 Oxford BioMedica s business model Product pipeline + OXB process development 1, n=3 1x Original Mean 27% Development Solutions IP Ownership + Mean 34% Lentiviral vector Lentiviral vector Proprietary gene manufacture and patents and know 3, n=3 and cell therapy 2x Enhanced Mean 26% how Revenues Manufacturing and process development Licence fees Milestones Royalties 8
9 Product Portfolio Oxford BioMedica 2011, all rights reserved 9
10 Portfolio of pipeline assets (excluding those already outlicensed) Lentiviral vector TECHNOLOGY Product Indication Stage Next inflection 1, n=3 1x Original Mean 27% OPHTHALMOLOGY RetinoStat Wet AMD Phase I follow up stage Mean 34% (primary end point met) Est. date Phase I CSR 2015 EncorStat Corneal graft rejection Phase I/II preparation FPI Phase I/II 2016 GlaucomaGT Chronic glaucoma Preclinical End preclinical 2016 CNS ProSavin OXB102 Parkinson s disease Phase I/II complete Phase I/II preparation FPI Phase I/II 2016 MoNuDin Motor neuron disease Research End preclinical 2015 NEW IDEAS 5T4 TECHNOLOGY Investigating several therapy areas where Lenti based vectors have an advantage over AAV due to payload capacity Exploring possibilities to enter cell therapy field in our own right e.g. CART 5T4 ONCOLOGY TroVax Cancer (multiple) 3 x Phase II ongoing End Phase II 2015/16 CART 5T4 Cancer (multiple) Preclinical End preclinical 2016 TBD TBD 10
11 Licences to OXB s IP and products 1, n=3 Company 1x Products Original Terms Mean 27% Lenti based vector IP & Knowhow Novartis CTL019/ Other CART $10m Max. up to upfront 53% Mean 34% Estimated launch date 2017 Multi billion $ GSK Up to 6 rare orphan diseases Undisclosed royalties Products Sanofi StarGen Undisclosed development milestones and royalties 5T4 Tumour antigen Estimated Peak Yr Sales Not disclosed TBD $10m $50m per product 2021 $500m Sanofi UshStat 2021 $90m IP Pfizer 5T4 antibody Undisclosed 2023 >$300m IP ImaginAb 5T4 imaging diagnostic PrimeBoost Undisclosed 2024 $10m IP Bavarian Nordic PROSTVAC TM Undisclosed 2017 $60m 11
12 Gamechanging Novartis contract Nonexclusive licence to OXB s IP 1, n=3 1x Original Mean 27% Initial 3 year manufacturing contract for clinical supply for NVS CTL019 Mean 34% programme potential to extend Process development collaboration Financial terms include $14m up front, including an equity investment and IP licence Undisclosed royalties on CTL019 and other CART products Up to $76m over 3 year manufacturing and process development 2014 Transforming cash flows 12
13 Expanding facilities Windrush Court Corporate Headquarters & Laboratories Harrow House (GMP1/GMP2/GMP3) Fill & Finish API manufacturing facility Yarnton (GMP4) API manufacturing facility 13
14 Financial position Cash at end m 1, n=3 1x Original Mean 27% $50m loan facility secured May 2015 Mean 34% $25m drawn down 3m AMSCI loan repaid and facility terminated Capital expenditure across 2015/2016 expected to be in the region of 20m Manufacturing and process development revenues set to grow in 2015, reducing underlying operational cash burn 14
15 Upcoming potential value driving news flow 2015 Further IP licences/manufacturing/process development contracts 1, n=3 1x RetinoStat Original decision Mean regarding 27% Mean Phase 30% II Mean indication 29% and development pathway Mean 34% Identification of new product development candidates TroVax Phase II studies initial results 2016 MoNuDin preclinical results FPI OXB102 clinical programme FPI EncorStat clinical programme StarGen /UshStat development milestones GlaucomaGT preclinical results CART 5T4 preclinical results Plus updates from Novartis on CTL019 programme from time to time 15
16 In summary Whollyowned highvalue clinical pipeline for value generation Three gene therapy product candidates in Phase I/II development Three investigatorled Phase II TroVax studies 1, n=3 1x Original Mean 27% Outlicensed clinical programmes Mean 34% Two ophthalmology in vivo Phase I/II products licensed to Sanofi Two outlicensed 5T4 antibody technology phase I studies Further innovative product development opportunities for value creation Including CART 5T4 Lentiviral vector IP recognised by Novartis, GSK Significant revenue potential from manufacturing and process development offsets cash burn 16
17 Contact us Oxford BioMedica plc 1, Windrush n=3 Court 1x Original Mean 27% Tim Watts, CFO Transport Way Oxford OX4 6LT United Kingdom John Dawson, CEO Tel: +44 (0) Mean 34%
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