ÖZGEÇMİŞ. Tıp Fakültesi, Temel Bilimler Bölümü, Tibbi Biyoloji ve Genetik A.D. İncirli caddesi no:11, Bakırköy, 34217, İstanbul

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1 ÖZGEÇMİŞ Adı Soyadı : Veli Cengiz Özalp Doğum Tarihi: Adres : İstanbul Kemerburgaz Üniversitesi Tıp Fakültesi, Temel Bilimler Bölümü, Tibbi Biyoloji ve Genetik A.D. İncirli caddesi no:11, Bakırköy, 34217, İstanbul Tel : / 5214 Fax : Öğrenim Durumu: 2012 Doçentlik YÖK, Biyoloji 2000 Doktora. Biyoloji Bölümü, Orta Doğu Teknik Üniversitesi 1993 Yüksek Lisans Biyoloji Bölümü, Orta Doğu Teknik Üniversitesi 1990 Lisans Biyoloji Bölümü, Orta Doğu Teknik Üniversitesi Akademik Görevler: İstanbul Kemerburgaz Üniversitesi Doç. Dr., Tibbi Biyoloji ve Genetik A.D., Temel Bilimler Bölümü, Tıp Fakültesi, 2013-Devam ediyor Orta Doğu Teknik Üniversitesi Misafir Araştırmacı, TÜBİTAK geri dönüş bursu, Biyoloji Bölümü, Araş. Gör., Biyoloji Bölümü, University of Basque Country, UPV, San Sebastian, İspanya Dr. Araş. Gör., Department of Chemistry, POLYMAT (Institute for Polymer Materials),

2 University of Southern Denmark, Odense, Danimarka Dr. Araş. Gör., Department of Biochemistry and Molecular Biology, University of Rovira i Virgili, Tarragona, İspanya Dr. Araş. Gör., Department of Chemical Engineering, University Illinois at Urbana-Champaign, USA Dr. Araş. Gör., Department of Molecular and Integrative Physiology, School of Molecular and Cellular Biology, University of Burgundy, Dijon, Fransa Dr. Araş. Gör., Phytobiology, Bilkent Üniversitesi Dr. Araş. Gör., Moleküler Biyoloji ve Genetik Bölümü, Texas Tech University, Lubbock, USA Araş. Gör., Department of Biotechnology, Verilen lisans ve lisansüstü düzeydeki dersler: Akademik Yıl Dönem Dersin Adı Sonbahar MED311 Genitoürineri sistems, Genetik, İstanbul Kemerburgaz Üniversitesi, Tıp Fakültesi ; İlkbahar MED122 Organ ve Doku Sistemleri II-Genetik, İstanbul Kemerburgaz Üniversitesi, Tıp Fakültesi ; ; Sonbahar MED121 Organ ve Doku Sistemleri I-Tıbbi Biyoloji, İstanbul Kemerburgaz Üniversitesi, Tıp Fakültesi ; ; Sonbahar MED111 Temel Tıp Bilimlerine Giriş-Tıbbi biyoloji, İstanbul Kemerburgaz Üniversitesi, Tıp Fakültesi

3 YAYINLAR A. SCI/E indeksine giren dergilerde yayımlanan makaleler: A50. Borsa, B.A., Tuna, B.G., Hernandez, F.J., Hernandez, L.I., Bayramoglu, G., Arica, M.Y. and Ozalp, V.C Staphylococcus aureus detection in blood samples by silica nanoparticle-oligonucleotides conjugates. Biosensors and Bioelectronics. 86: A49. Borsa, B.A., Aldag, M.A., Yilmaz, M., Dalar, Z.G., Ozalp, V.C Comparison of a Novel Test (ODAK Brucella Coombs Gel Test) with Commonly Used Serological Tests in Human Brucellosis. Clinical Laboratory, DOI: /Clin.Lab A48. Ozalp, V.C., Cam, D., Hernandez, F.J., Hernandez, L.I., Schäfer, T., and Oktem, H.A Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes. Analyst. 141: A47. Bayramoglu, G., Arica, M.Y., Genc, A., Ozalp, V.C., Ince, A., Bicak, N A facile and efficient method of enzyme immobilization on silica particles via Michael acceptor film coatings: immobilized catalase in a plug flow reactor. Bioprocess and Biosystems Engineering. 39 (6): A46. Ozalp, V.C., Bayramoglu, G., Arica, M.Y Magnetic silica nanoparticle Taq polymerase hybrids for multiple uses in polymerase chain reaction. RSC Advances. 5: A45. Bayramoglu, G., Tekinay, T., Ozalp, V.C., Arica, M.Y Fibrous polymer grafted magnetic chitosan beads with strong poly(cation-exchange) groups for single step purification of lysozyme. Journal of Chromatography B. 990: A44. Kavruk, M., Celikbicak, O., Ozalp, V.C., Borsa, B.A., Hernandez, F.J., Bayramoglu, G., Salih, B., Arica, M.Y Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens. Chemical Communications. 51: A43. Ozalp, V.C., Kavruk, M., Dilek, O., Bayrac, A.T Aptamers: Molecular Tools for Medical Diagnosis. Current Topics in Medicinal Chemistry. 15 (12): A42.Schafer, T. and Ozalp, V.C DNA-aptamer gating membranes. Chemical Communications. 51 (25):

4 A41. G. Bayramoglu, A. Akbulut, V. C. Ozalp, M. Y. Arica Immobilized lipase on micro-porous biosilica for enzymatic transesterification of algal oil. Chemical Engineering Research and Design. 95: A40. G. Bayramoglu, V. C. Ozalp, M. Yilmaz, B. Salih, M. Y. Arica Lysozyme specific aptamer immobilized MCM-41 silicate for single-step purification and quartz crystal microbalance (QCM)-based determination of lysozyme from chicken egg white. Microporous and Mesoporous Materials. 207: A39. Ozalp, VC., Bayramoglu, G., Erdem, Z., Arica, MY Pathogen detection in complex samples by quartz crystal microbalance sensor coupled to aptamer functionalized core-shell type magnetic separation. Analytica Chimica Acta. 853: A38. Machado, IB, Ozalp, VC, Rezabal, E and Schäfer, T Molecular Recognition by a DNA-Aptamer Molecular Beacon in a Protic Ionic Liquid Solution. Chemistry-A European Journal. 20 (37): A37. Frank J. Hernandez, Luiza I. Hernandez, Murat Kavruk, Yakup M. Arıca, Gülay Bayramoğlu, Baris A. Borsa, Hüseyin A. Öktem, Thomas Schäfer and Veli C. Özalp NanoKeepers: stimuli responsive nanocapsules for programmed specific targeting and drug delivery. Chemical Communications. 50, A36. Senyurt O, Eyidoğan F, Yılmaz R, Oz MT, Ozalp VC, Arıca Y, Oktem HA Development of a paper type tyrosinase biosensor for detection of phenolic compounds. Biotechnology and Applied Biochemistry. 62 (1): A35. Bayramoglu, G., Gozen, D., Ersoy, G., Ozalp, VC, Akcali, K.C., Arica, MY Examination of fabrication conditions of acrylate-based hydrogel formulations for doxorubicin release and efficacy test for hepatocellular carcinoma cell. Journal of Biomaterials Science, Polymer Edition, 25 (7): A34. Bayramoglu, G., Ozalp, VC, Arica, MY Preparation and characterization of mixed-mode magnetic adsorbent with p-amino-benzamidine ligand: Operated in a magnetically stabilized fluidized bed reactor for purification of trypsin from bovine pancreas. Process Biochemistry, 49 (3): A33. Bayramoglu, G., Ozalp, VC, Arica, MY Magnetic Polymeric Beads Functionalized with Different Mixed-Mode Ligands for Reversible Immobilization of Trypsin. Industrial & Engineering Chemistry Research, 53 (1): A32. Ozalp VC, Bayramoglu G, Kavruk, M., Keskin, B., Öktem, HA, and Arica MY Pathogen detection by core-shell type aptamer-magnetic pre-concentration coupled to real-time PCR. Analytical Biochemistry 447:

5 A31. Ozalp VC,Pinto, A., Nikulina, E., Chuvilin, A. and Schäfer, T In situ Monitoring of DNA-Aptavalve Gating Function on Mesoporous Silica Nanoparticles. Particle & Particle Systems Characterization 31 (1): A30. Ozalp VC, Bayramoglu G, Arica MY, Oktem HA Design of a core-shell type immuno-magnetic separation system and multiplex PCR for rapid detection of pathogens from food samples. Applied Microbiology and Biotechnology. 97(21): A29. Schrøder TD, Ozalp VC, Lunding A, Jernshøj KD, Olsen LF An experimental study of the regulation of glycolytic oscillations in yeast. FEBS Journal. 280 (23): A28. Bayramoglu, G., Ozalp, VC, Arica, MY Adsorption and separation of immunoglobulins by novel affinity core shell beads decorated with Protein L and l- histidine. Journal of Chromatography B. 396: 1-9. A27. Ozalp, V.C., Zeydanlı, U.S., Lunding, A., Kavruk, M., Oz, M.T., Eyidoğan, F., Olsen, L.F., Oktem, H.A Nanoparticle Embedded Enzymes for Improved Lateral Flow Sensors. Analyst. 138 (15): A26. Kavruk, M., Ozalp, V.C., Oktem, H.A Portable bioactive paper-based biosensor for quantification of pesticides. Journal of Analytical Methods in Chemistry. Volume 2013 (2013), Article ID , 8 pages. A25. Ozalp, V.C., Bilecen, K., Kavruk, M., Oktem, H.A Antimicrobial aptamers for detection and inhibition of microbial pathogen growth. Future Microbiology. 8(3): A24. Hernandez, F.J., Hernandez, L.I., Pinto, A., Schäfer, T., Özalp, V.C Targeting Cancer Cells with Controlled Release Nanocapsules based on Single Aptamer. Chemical Communications. 49, A23. Serrano-Santos, M. B., E. Llobet, Ozalp, V.C., Schafer, T "Characterization of Structural Changes in Aptamer Films for Controlled Release Nanodevices." Chemical Communications. 48 (81): A22. Ytting, C.K., Fuglsang, A.T., Hiltunen, K., Kastaniotis, A.J., Ozalp, V.C., Nielsen, L.J., and Olsen, L.F Measurements of intracellular ATP provide new insight into the regulation of glycolysis in the yeast Saccharomyces cerevisiae. Integrative Biology. 4(1): A21. Ozalp, V.C Dual Polarization Interferometry for Quantification of Small Molecules Using Aptamers. Analytical and Bioanalytical Chemistry. 402(2):

6 A20. Ozalp, V.C Acoustic Quantification of ATP Using Quartz Crystal Microbalance with Dissipation. Analyst. 136 (23): A19. Ozalp, V.C. and Schafer, T Aptamer-based Switchable Nanovalves for Stimuli- Responsive Drug Delivery. Chemistry-A European Journal. 17(36): A18. Ozalp, V. C., Nielsen, L. J., Olsen, L. F An Aptamer-based Nanobiosensor for Real-Time Measurements of ATP Dynamics. ChemBioChem. 11(18): A17. Ozalp, V. C., Pedersen, T. R., Nielsen, L. J., Olsen, L. F Time-Resolved Measurements of Intracellular ATP in the Yeast Saccharomyces cerevisiae Using A New Type of Nanobiosensor. Journal of Biological Chemistry. 285(48): A16. Nielsen, L. J., Olsen, L. F., Ozalp, V. C Aptamers Embedded in Polyacrylamide Nanoparticles: A Tool for in Vivo Metabolite Sensing. ACS Nano. 4 (8): A15. Nasef H, Ozalp VC, Beni V, O'Sullivan CK Melting temperature of surfacetethered DNA. Analytical Biochemistry, 406 (1): A14. Nasef H, Beni V, Ozalp VC, O'Sullivan CK Cystic fibrosis: a label-free detection approach based on thermally modulated electrochemical impedance spectroscopy. Analytical and Bioanalytical Chemistry. 396(7): A13. Naqvi, S. M. S., Raza, S. Q., Hyder, M. Z., Ozalp, C. V., Oktem, H. A., Yucel, M Sub-cellular distribution of two salt-induced peptides in roots of Oryza sativa L. var Nonabokra. African Journal of Biotechnology, 8 (18): A12. Pinto, A., Bermudo Redondo, M. C., Ozalp, V. C., O Sullivan, C. K Real-time apta-pcr for fold improvement in detection limit. Molecular Biosystems. 5 (5): A11. Hernandez, F. J., Dondapati, S. J., Ozalp, V. C., Pinto, A., O'Sullivan, C. K., Klar, T. A., Katakis, I Label free optical sensor for Avidin based on single gold nanoparticles functionalized with aptamers. Journal of Biophotonics, 2 (4): A10. Ozalp, V.C., Nygren, A.O.H., and C.K. O Sullivan Fluorescent Resonance Energy Transfer (FRET) Based Detection of Multiplex Ligation-dependent Probe Amplification assay (MLPA) Product. Molecular Biosystems. 4 (9): A9. Mairal, T., Ozalp, C., Lozano, P., Mir, M., Katakis, I. and O Sullivan, C Aptamer-based Analytical Applications. Analytical and Bioanalytical Chemistry. 390 (4): A8. Oktem, H. A., Bayramoglu, G., Ozalp, V. C., Arica, M. Y Single-Step Purification of Recombinant Thermus aquaticus DNA Polymerase Using DNA- Aptamer Immobilized Novel Affinity Magnetic Beads. Biotechnology Progress, 23 (1):

7 A7. Ozalp, C., Szczesna-Skorupa, E., Kemper, B Identification of Membrane- Contacting Loops of the Catalytic Domain of Cytochrome P450 2C2 by Tryptophan Fluorescence Scanning. Biochemistry, 45 (14): A6. Ozalp, C., Szczesna-Skorupa, E., Kemper, B Bimolecular Fragment Complementation Analysis of Cytochrome P450 2C2, 2E1 and NADPH-Cytochrome P450 Reductase Molecular Interactions in Living Cells. Drug Metabolism and Disposition, 33(9): A5. Bhalla, S., Ozalp, C., Fang, S., Xiang, L., Kemper, J. K Ligand-activated Pregnane X Receptor Interferes with HNF-4 Signaling by Targeting a Common Coactivator PGC-1. Journal of Biological Chemistry, Oct 2004; 279: A4. Daniel Reisen, Nathalie Leborgne-Castel, Cengiz Özalp, François Chaumont and Francis Marty Expression of a cauliflower tonoplast aquaporin tagged with GFP in tobacco suspension cells correlates with an increase in cell size. Plant Molecular Biology. 52 (2): A3. Ozalp, VC., Naqvi, SMS, Öktem, HA., Yücel, M Photosystem II and Cellular Membrane Stability Evaluation in Hexaploid Wheat Seedlings under Salt Stress Conditions. Journal of Plant Nutrition, 23 (2): A2. Naqvi, SMS, Ozalp, VC., Öktem, HA., Yücel, M Salt-induced Synthesis of New Proteins in the Roots of Rice Varieties. Journal of Plant Nutrition, 18(6): A1. Naqvi, SMS., Ozalp, VC., Öktem, HA., Yücel, M Two-dimensional Electrophoresis with a Different Approach to Isoelectric Focusing. Analyst, 119: Uluslararası hakemli dergilerde yayımlanan makaleler 1. Hernandez, F.J. and Ozalp, V.C Garaphene and Other Nanomaterial-based Electrochemical Aptasensors. Biosensors, 2 (1): Ozalp, V.C., Eyidogan, F., Oktem, H.A Aptamer-Gated Nanoparticles for Smart Drug Delivery. Pharmaceuticals. 4(8): B. Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler : B1 B2 Ozalp, VC. Nanoparticle-antibiotic with aptamers. 2nd International Congress on Biosensors, Workshop on Aptamers and Biosensors, 2015, June in İzmir, Turkey e-abstract book- Dilek O, Ozalp, VC. Aptamer-gated silica nanoparticles synthesized via click chemistry. ASCB/IFCB Meeting Location: Philadelphia, Dec MOLECULAR BIOLOGY OF THE CELL Volume: 25 Meeting Abstract: P671

8 B3 B4 B5 B6 B7 B8 B9 B10 B11 Aptavalves for Stimulus-Responsive Hybrid Nanodevices, Third International Conference on Multifunctional, Hybrid and Nanomaterials Hybrid Materials 2013, 3-7 March 2013 in Sorrento, Italy. Schäfer, T. and V.C. Özalp "Small-molecule Stimulus Responsive Membrane with Reversible Gating Function", 8 th European Congress of Chemical Engineering and 1 st European Congress of Applied Biotechnology (ECCE/ECAB), Berlin, Germany, September 25-29, Machado, I., Serrano Santos, M.B., Özalp, V.C. and Schäfer, T. "Investigation of the applicability of oligonucleic acids as biomolecular recognition sites in stimuliresponsive membranes", 8 th European Congress of Chemical Engineering and 1 st European Congress of Applied Biotechnology (ECCE/ECAB), Berlin, Germany, September 25-29, Schäfer, T. and V.C. Özalp "Small-Molecule Stimulus Responsive Membrane with Reversible Gating Function", International Congress on Membranes and Membrane Processes (ICOM), Amsterdam, The Netherlands, July 23-29, Machado, I., Serrano Santos, M.B., Özalp, V.C. and Schäfer, T. "Stimuli- Responsive Membranes Based on Oligonucleic Acids as Biomolecular Recognition Sites", International Congress on Membranes and Membrane Processes (ICOM), Amsterdam, The Netherlands, July 23-29, Schäfer, T. and Özalp, V.C. "Stimulus-Responsive Membrane with Reversible Gating Function upon Small Molecule Recognition", Meeting of the North American Membrane Society (NAMS), Las Vegas, June 4-6, Machado, I., Serrano Santos, M.B., Özalp, V.C. and Schäfer, T. "Oligonucleic Acids as Biomolecular Recognition Sites for the Design of Stimuli-Responsive Membranes", Meeting of the North American Membrane Society (NAMS), Las Vegas, June 4-6, Veli Cengiz Ozalp, Lise Junker Nielsen, Lars Folke Olsen. Aptamer embedded polyacrylamide nanoparticles used as nanosensors for metabolite detection in vivo. Nanoparticles 2009, Micro and Nano Encapsulations, July 2009, Berlin, Germany. Schäfer, T., Schäfer, M., Özalp, C. "Exploring the Potential of Oligonucleic Acids ( Aptamers ) for Designing Stimuli-Responsive Membranes", Euromembrane 2009, Montpellier, France, September 7-10, B12 A.Pinto, M.Svobodova, M.C. Bermudo, P. Nadal Polo, C.V.Ozalp, C.K.O Sullivan. Towards the aptamers meadiated detection of wheat high molecular weight glutenin. XIV. Trobado Transfronterera sobre Sensores i Biosensors (XIV. Cross-Border Meeting on Sensors and Biosensors), Banyul Sur Mer, France, B13 P. Nadal Polo, V. Cengiz Ozalp, N. Canela, I. Katakis, C. K. O Sullivan. Preparation of aptamers against lupine potential allergens. XIV. Trobado Transfronterera sobre Sensores i Biosensors (XIV. Cross-Border Meeting on Sensors and Biosensors), Banyul Sur Mer, France, 2009.

9 B14 Laureyn, W., Liu, C., O'Sullivan, C.K., Ozalp, V.C., Nilsson, O., Fermer, C., Drese, K.S., Roeser, T., Ritzi, M.,Hauch, S., Albert, W., Borgen, E., Nygren, A.O.H. Lab-on-chip for the isolation and characterization of circulating tumor cells (2007) 2007 NSTI Nanotechnology Conference and Trade Show, Santa Clara, California, U.S.A. - NSTI Nanotech 2007, Technical Proceedings, 2, pp C. Yazılan uluslararası kitaplarda bölümler : C1. Schafer, T. and Ozalp, V.C. Oligonucleic acids ( Aptamers ) for Designing Stimuliresponsive Membranes in Responsive Membranes and Materials. (Editors: Wickramasinghe, R., Daunert, S. and Schafer, T.), John Wiley Publishing, C2. Ozalp, V.C. and Schafer, T. Aptamer-Nanoparticle Bioconjugates for Drug Delivery, in Nanoparticles. (Editor: Hashimi, A.), Intech publishing, C3. Hernandez, F.J., Kavruk, M., Hernandez, L.I., Ozalp, V.C. Nanocapsules in biomedicine: promises and challenges, in Advanced Theranostics Materials, Advance Materials Series (Editor: A. Tiwari), John Wiley & Sons, (ISBN). C4. Yi Long, Franziska Pfeiffer, Günter Mayer, Tine Daa Schrøder, Veli Cengiz Özalp, and Lars Folke Olsen. Selection of Aptamers for Metabolite Sensing and Construction of Optical Nanosensors in Nucleic Acid Aptamers (Editor: G. Mayer), Springer, (ISBN). D. Ulusal hakemli dergilerde yayımlanan makaleler : D1. Gundoguş, N., Sayilir, C., Ozalp, VC., Ozkan, F., Yücel, M., Criss, EW Effects of Polyamine Stimulated Casein Kinase II from Rat Brain on Cellular Oncogene Activities. Turkish Journal of Medical Sciences, 23: D2. Oktem, HA., Ozkan, F., Ozalp, VC., Yücel, M Agrobacterium mediated Gene Transfer. Turkish Journal of Botany, Vol.18, F. Diğer yayınlar : F1. Patent; Nucleic acid nanobiosensors. Inventors: Lars Folke Olsen, Cengiz Ozalp, Lise Junker Nielsen, University of Southern Denmark. Publication No.:WO/2011/003424, Publication Date: F2. Patent; Aptamer-gated nanoparticles for lateral flow assays. Ozalp, V.C., Oktem, H.A., Hernandez, F.J., Hernandez, L.I., Schafer, T. Publication No.: WO , Publication Date: Atıflar