DISILANOL C+ Body and Face Anti-Aging Anti-Wrinkle Firming Soothing

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1 Body and Face Anti-Aging Anti-Wrinkle Firming Soothing

2 is a member of the silanol family. As such, it is composed of an organic silicium core which is responsible for its skin-care benefits. Silicium is a structural component of the skin. As a result, treatment with helps the skin to recover from the age-induced loss in silicium. The skin will therefore be restructured for global benefits. has firming properties, improves skin hydration, and soothes the skin. All these benefits make of the perfect global active for anti-aging, and body-care products. HO CH3 Si CH3 Dimethylsilanol, the organic silicium core OH

3 Higher fibroblast number due to an optimized cross-communication Cross-communication between the different skin compartments is a crucial factor for skin health as different cell types are capable of supporting the proliferation and the activity of cells from another skin compartment. Fibroblast proliferation (% ) %.3%.5% FIRMING EPIDERMIS Keratinocytes stimulate fibroblast proliferation DERMIS Aged keratinocytes from the epidermis lose their ability to support fibroblast (dermis cells) proliferation. Treatment with improves keratinocyte s ability to support fibroblast proliferation in vitro. Stimulation of fibroblast activity Because of aging, all skin cell metabolism tend to decrease. As a result their activity will be impaired. Because fibroblasts produce fewer collagen with age (as shown using an aged fibroblast model (serum (FCS)-deprived cell medium), skin will become less dense, less resistant and less elastic. Treatment with increases the amount of collagen produced by aged fibroblasts in vitro. Collagen production (% of control) 1 5 1% FCS 2% FCS (.8%) Because of silicium s interactions with structure proteins such as collagen fibers, elastin fibers and GAGs, is capable of restructuring the skin. The skin is therefore rejuvenated, firmer and denser. Wrinkle depth (% of control) 1 5 Young skin Anti-wrinkle Mature skin Before After Before After Width (mm) ANTI-AGING Length (mm) Depth (µm) Long lasting benefits The architecture of aged skin tends to collapse. It is destructured and its capacity to be properly hydrated drops. Because of the silanol-induced skin restructuration, long lasting efficacy is achieved as shown with moisturization (one of the silanols characteristic properties). Hydration index (a.u.) (.12%) Placebo Time (h) Higher number of fibroblasts for higher collagen concentration Collagen booster effect for a denser, more resistant and more elastic skin has strong anti-wrinkle properties is therefore capable of increasing skin hydration for a longer period hence providing long lasting benefits protection SOOTHING, a potent anti-oxydant has strong anti-inflammation properties OH released (a.u.) Time (min) Control In vitro, is shown to scavenge a majority of chemically-generated hydroxyl radicals (OH ) Skin is protected and its cell activity is insured Free radicals are responsible for most signs of aging. They are generated by different kind of stress such as sunrays exposure, and they are responsible for many skin cell alterations: DNA mutations, membrane brittleness, impaired metabolism for lower activity Hydroxyl radicals (OH ) are described as the most reactive radicals. As such, they are the most likely to have a noxious effect on skin. Il-1 released (pg/ml) Control UV-B + Hydrocortisone (.1%) + (.15%) Because skin is better organized, all skin cells are in a better environment and, as a result, not only will they be able to have an enhanced activity, but they will also be capable of defending themselves against any kind of stress in a most effective way. Treatment with provides the skin with strong restructuring and anti-inflammation effects for higher skin cell resistance and soothing benefits

4 INCI name : Silanediol salicylate (and) tromethamine (and) methyl-2-propanediol ANALYTICAL COMPOSITION Silanediol salicylate 24,5 % including silicium 3 % Tromethamine 13 % Methyl-2-propanediol sq 1 % PHYSICO-CHEMICAL CHARACTERISTICS Limpid to slightly opalescent, colorless to yellowish liquid. Slight characteristic smell ph of 3% solution in water: 5.5 Miscible with water, alcohol and glycol. PRESERVATIVE SYSTEM No preservative. TOLERANCE STUDIES At usage concentration, is perfectly tolerated. Pure, is not a skin irritant but it is however irritant for the eyes. Formulation Suitable for every type of formulation (cream, gel, lotion ) and does not have any known incompatibility. It is recommended to incorporate at the end of the formulation process and at a ph between 4 and 7. Recommended usage dose:.5 to.5%. AVAILABILITY is available in 5 and 3kg drums. EXSYMOL S.A.M. - 4 avenue Albert II - MC 98 MONACO Tél. : Fax : mail : -

5 A3_144GB134A EXSYMOL S.A.M. - 4 avenue Albert II - MC 98 MONACO Tél. : Fax : Internet :

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