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1 Nerium International: St. Louis 16

2 Discovering novel small molecule therapeutics to modulate signal transduction imbalances.

3 Signum Biosciences Founders Dr. Jeffry B. Stock PROFESSOR, PRINCETON UNIVERSITY Maxwell Stock PRESIDENT & CEO, SIGNUM BIOSCIENCES 1. Dr. Stock joined the faculty of Princeton University in Elected Fellow, American Academy of Microbiology Winner of The Humboldt Prize Elected Fellow, American Association for the Advancement of Science (AAAS) peer reviewed publications in top scientific journals. 3. Co-founded Signum Biosciences in 2003 with his son, Maxwell Stock CEO of Signum Biosciences. 4. In 1998 Dr. Stock and Max began to work together at Princeton University to apply the results of these scientific breakthroughs toward the development of products with direct applications for human health.

4 Signum Biosciences History Signum Biosciences was founded in 2003 based on Dr. Stock s work on signal transduction at Princeton University. Biosciences developed new technology platforms in CNS and Dermatology. Signum Dermalogix was spun-out from Biosciences in Dermatologically focused, centered on developing novel Rx and cosmetic products. Signum Nutralogix was spun-out from Biosciences Dedicated to developing dietary supplements for brain health and overall health.

5 Signum s Core Technology Creating Innovations in Neuroscience & Dermatology to Combat Aging

6 Brain Aging vs Skin Aging: More Similar Than You Think 1. If you are wondering how your brain is aging, just look in the mirror. New research draws a link between aging of skin and aging of the brain. DR. DOUGLAS FIELDS Neurobiologist and author of The Other Brain, January Research has discovered that aging neurons follow exactly the same rules of senescence (biological aging) as do skin cells (fibroblasts). DR. THOMAS VON ZGLINICKI Newcastle University, Aging Cell Scientists convert human skin cells directly into brain cells. DR. ANDREW YOO Washington University, Neuron 2014

7 Signum is Dedicated to Brain and Skin Aging Signum s research and development have yielded novel anti-aging agents that can protect our brain and skin. Common causes of premature aging of our brain and skin cells: 1. Chronic inflammation 2. Oxidative stress 3. DNA damage Signum has developed proprietary molecules and extracts that are: 1. Anti-inflammatory 2. Anti-oxidant 3. Modulate cell signaling

8 Signum s Technology is Patent Protected Signum s patents in both anti-aging of the skin and anti-aging of the brain have been exclusively licensed to Nerium International! Licensed Patents: 1. Isoprenyl compounds and methods thereof US B2 2. Compositions and methods for enhancing cognitive function US B2

9 Why Nerium International? 1. Perfect marriage with Real Science, Real Results. 2. Developing novel products that work and are affordable 3. Bringing innovative research to consumers faster than anyone 4. A family business with a set of core values in alignment with our own

10 Neuroscience

11 Brain Health is Important

12 EHT A Novel Brain Health Supplement Eicosanoyl-5-hydroxytryptamide is a unique mixture of bioactive molecules found in coffee that was identified using our patented screening technology.

13 The Problem: Aging of the Brain

14 The Discovery of Eicosanoyl-5-hydroxytryptamide 1. Evidence shows that coffee reduces the risk of brain health decline. 2. After 20 years of research, Dr. Stock of Princeton University and Signum Biosciences discovered the specific bioactive molecules in coffee that s responsible for this benefit. 3. Developed a patented decaffeinated coffee extract enriched for high levels of Eicosanoyl-5-hydroxytryptamide found in EHT Age-Defying. 4. Awarded a global patent for this patented coffee extract.

15 What is Eicosanoyl-5-hydroxytryptamide 1. Starting with a coffee bean extract, our scientists screened for PP2A activity. 2. Several botanical extraction process iterations and refinements were performed resulting in the identification of our patented coffee extract. 3. Together with vitamin B6, B12, vitamin D and magnesium, and our proprietary coffee extract, EHT Age Defying supplement provides protection for our brains.

16 Eicosanoyl-5-hydroxytryptamide How it works Eicosanoyl-5-hydroxytryptamide targets microtubules in neurons 1. Microtubules are conveyer belts inside the neuron. 2. They move nutrients, neuro-transmitters, and organelles like mitochondria. 3. They also serve as a cytoskeletal role in the neuron.

17 Eicosanoyl-5-hydroxytryptamide How it works Eicosanoyl-5-hydroxytryptamide protects and stabilizes tau protein

18 Disintegration of Microtubules in Brain Cells

19 The Centrality of PP2A in Neuronal Function Significance of Protein Phosphatase 2A (PP2A)

20 Neuroscience Journals & Conferences Eicosanoyl-5-hydroxytryptamide has been presented at the following conferences: 1. ICAD 2. Neuroscience Annual Meeting 3. International Conference of Alzheimer s Drug Discovery 4. Protein Phosphatases Conference 5. Inge Grunde-Iqbal Symposium on Tau Therapeutics 6. AAN American Academy of Neurobiology 7. Experimental Biology Conference (April 2016) Eicosanoyl-5-hydroxytryptamide has been published in the following journals: 1. Neurobiology of Aging 2. Neurotherapeutics 3. Journal of Neuroscience

21 Benefits of Nerium Age-Defying Supplement: EHT

22 Research Pipeline for Mind, Body & Face Developing new anti-aging technology distributed exclusively through Nerium International

23 Thank You

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