LIFE SCIENCE INITIATIVES FOR TOMORROW S INNOVATIONS A FUTURE ALIVE WITH OPPORTUNITIES. Business Sweden

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1 LIFE SCIENCE INITIATIVES FOR TOMORROW S INNOVATIONS A FUTURE ALIVE WITH OPPORTUNITIES

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3 INDEX LIFE SCIENCE INITIATIVES FOR TOMORROW S INNOVATIONS CONTENT Introduction - A future full of opportunities 5 Stockholm/Uppsala - Excellence in healthcare and medical science 6 Gothenburg - Pioneering progress in biomaterials in western Sweden 7 Malmö/Lund - A 21st century knowledge center 8 Umeå - Leadership in antibiotics, plant science and sports medicine 9 About 10 BUSINESS SWEDEN, BUSINESS UNIT HEALTH CARE AND LIFE SCIENCE, IN COOPERATION WITH: Stockholm/Uppsala, Stockholm Business Region Development: Gothenburg, Business Region Göteborg: Malmö/Lund, Invest in Skåne: Umeå, Västerbotten Investment Agency:

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5 INTRODUCTION 5 A FUTURE FULL OF OPPORTUNITIES A GLOBAL LEADER IN A GLOBAL MARKET Sweden is northern Europe s largest and most dynamic life science region with world class companies, internationally acclaimed science, and a proud track record of investments in the innovations of tomorrow. Sweden hosts regional clusters with unrivalled expertise in their fields. Exciting opportunities abound in an environment dedicated to medical innovation, drug discovery and pharmaceutical commercialisation. AT THE PINNACLE OF ACHIEVEMENT Sweden s success rests on an unswerving commitment to excellence in R&D and drug discovery. Per capita spending on life science research is the highest in Europe. Swedish universities possess world class expertise in areas ranging from cancer and diabetes research to medical devices and stem cell therapies. Specialist fields include drug discovery in infections and metabolic diseases, immunology and neuroscience, as well as advanced tools for diagnostics and bioproduction. Sweden is renowned for its high quality clinical trials, biobanks and registers including the world s largest twin register. RESEARCH AND BUSINESS HAND IN HAND A focus on proximity to patients means basic research is often integrated with clinical research, a major advantage when developing new therapies and treatments. A unique model of close collaboration between industry, academia and clinical practitioners has fostered the growth of world leading pharmaceuticals companies like Astra, now a part of AstraZeneca, and Pharmacia, now a part of Pfizer. EXCEPTIONAL ENVIRONMENT Sweden has exceptional assets for modern research. Studies of how genetic and environmental factors affect health can probably be conducted more accurately than anywhere else thanks to an extensive network of national health registers and databanks. The stem cell regulatory framework is one of the most research-friendly in the world. CENTRES OF REGIONAL EXCELLENCE As Swedish life sciences embrace a new era, the sector is buzzing with potential for investors and partners across multiple areas. Numerous groundbreaking projects are ongoing at regional level. When completed, the New Karolinska Solna University Hospital, will combine with a downtown knowledge centre to strengthen the capital s position as a world leading life science cluster. In Lund in southern Sweden, the European Spallation Source (ESS) is under construction. This will be a major European research facility for materials research a venture that will attract top scientists, experts and companies from around the globe. Gothenburg is striving for international leadership in regenerative medicine biomaterials and stem cells while, in the north, Umeå is a global research leader in infectious disease treatment and sports medicine. WELCOME TO SWEDEN NORTHERN EUROPE S NUMBER ONE LIFE SCIENCE REGION

6 LIFE SCIENCE INITIATIVES 6 EXCELLENCE IN HEALTHCARE AND MEDICAL SCIENCE STOCKHOLM/UPPSALA The Stockholm-Uppsala region hosts more than 550 life science companies and 300 major research projects employing over 23,000 people, making it one of the largest life science clusters in Europe. In Stockholm, large investments within life science are being made to create a world leading hub for research and development a leading life science arena with first-class research infrastructure. LIFE SCIENCE INITIATIVES FOR TOMORROW S INNOVATIONS NEW KNOWLEDGE CENTRE LEADS THE WAY Major investments are currently under way in Stockholm to develop a 21st century center of excellence a vibrant knowledge cluster grouping academic institutions, life science companies, healthcare providers and international research projects. This is made under the common trademark Stockholm Life. EUROPE S MOST MODERN HOSPITAL Scheduled for completion in 2016, the new Karolinska Solna University Hospital will be Europe s most modern hospital and is the world s largest public-private partnership within healthcare. The hospital will be a hub for national university medical education and reinforce the Stockholm-Uppsala region as a leading biomedical center. The goal is rapid knowledge transfer, resulting in higher quality healthcare for each patient. Adjacent to the hospital, a new city district is being built to serve as a knowledge center for life science Stockholm Life. Within walking distance, Stockholm Life includes three universities with diverse fields of knowhow and a strong recruitment base Karolinska Institutet, Europe s highest ranked university in clinical medicine and pharmacology, Stockholm University, and KTH Royal Institute of Technology. The universities are together with Uppsala University partners in the science for life laboratory SciLife Lab a national resource center offering high-throughput services and research in biomedicine focused on large scale genomics and proteomics, bioinformatics and bio imaging. Another national initiative is U-CAN, a bio-bank project for tumor and blood samples from different types of cancer. The material is collected before, during and after therapy to make it possible to study the effect of therapy on the tumor. This is run by Uppsala-Umeå Comprehensive Cancer Consortium. SEVEN REASONS FOR STOCKHOLM/UPPSALA The New Karolinska Solna University Hospital. Europe s most modern hospital, opens in 2016 SciLifeLab a leading hub for research in molecular biosciences and medicine Stockholm Life a new downtown knowledge center for life science in Europe Uppsala Umeå Comprehensive Cancer Consortium, U-CAN Access to knowledge capital through biobanks and registers World leading research in multiple therapeutic areas: oncology, neuroscience, inflammation, metabolics and regenerative medicine The life science cluster, located next to one of the world s strongest ICT clusters, drives research and innovation in e- and m-health

7 LIFE SCIENCE INITIATIVES 7 PIONEERING PROGRESS IN BIOMATERIALS IN WESTERN SWEDEN GOTHENBURG Western Sweden (Gothenburg) has a long tradition of industry and trade. Its port, the largest in Scandinavia, has attracted companies from all around the world. With 50 percent of Scandinavia s industrial capacity, it is the home to companies such as AstraZeneca, SCA, Implants, Mölnlycke HC, Getinge, Nobel Biocare and SKF, among others. Western Sweden s strength is the combination of industrial knowledge and interdisciplinary clinical research. LONG-TRACK RECORD OF INNOVATION Gothenburg has an openness to collaboration between academia and industry, and a great track record of success. If it is the region that gave rise to blockbuster medicines including Losec/ Prilosec/ Nexium, Seloken, Dicumarol, Plendil, the Cholera vaccine, along with drugs such as Brilinta and Abilify. The former was developed in collaboration with Professor Arvid Carlsson, who won the Nobel Prize in 2000 for his work on the dopamine system. LEADERS IN BIOMATERIALS AND REGENERATIVE MEDICINE One of Gothenburg s key areas of expertise is biomaterials and implants. This focus was driven by research from Professor Per-Ingvar Brånemark of the University of Gothenburg, who discovered and developed the science of osseo-integration, a key breakthrough in orthopedics and dentistry. Gothenburg has become a key international hub for R&D, design and production of the next generation biomaterials including smart textiles, being used as grafts, bandages or to measure pulse and the immune system. Stem cells and regenerative medicine is another well developed arena, with companies such as Vitrolife, Cellectricon, Novahep and Cellectis. Unique surgical operations and research have been carried out by the researchers at the Sahlgrenska Academy. 2012, for the first time ever, a vein grown from human stem cells was transplanted and the first mother-daughter uterus transplant was carried out. STRONG IN CLINICAL AND TRANSLATIONAL RESEARCH The region is at the forefront of clinical and translational medicine and has become the leading centre for clinical trials in Sweden. Organisations such as Medtech West and Gothia Forum serve as meeting places and centralised banks of knowledge on clinical and biomedical research in Western Sweden. The Sahlgrenska University Hospital is the most important partner and stakeholder. It is the largest healthcare unit and the largest emergency care hospital in Northern Europe. The hospital is the only one in Scandinavia with a complete transplantation programme for all organ transplants for both children and adults. Construction of the hospital s new Centre for Imaging and Intervention is expected to be completed in SEVEN REASONS FOR WEST SWEDEN (GOTHENBURG) Proven track record of success in innovation World leader in biomaterials and orthopedic implants: The BIOMATCELL VINN Excellence Centre of Biomaterials and Cell Therapy at the University of Gothenburg World leader in transplantation and regenerative medicine Interdisciplinary approach to biomedical research and development Largest healthcare unit in Northern Europe Expertise and infrastructure in the area of imaging and visualisation Among the fastest growing regions within medical devices and surgical equipment

8 LIFE SCIENCE INITIATIVES 8 A 21ST CENTURY KNOWLEDGE CENTRE MALMÖ/LUND Skåne, in southern Sweden, is one of Europe s most important arenas for life science enterprise and research, with four universities and an array of world class research institutions. The region is at the heart of the cross-border Medicon Valley life science cluster, which employs 40,000 people in pharmaceuticals, biotech and medical technology. Ready access to top international scientific expertise and a rich pipeline of new, exciting products foster a discoveryoriented climate for life sciences that is second to none in northern Europe. DYNAMIC INNOVATION ENVIRONMENT Close cooperation between hospitals, universities, public research institutions and private business supports a uniquely fertile environment for life science projects and joint ventures. A wealth of exciting programmes and initiatives drives innovation across areas like nano science, biomarkers in cancer medicine, regenerative stem cell therapies, and diabetes treatments. ESS AND MAX IV THE FUTURE ARRIVES Skåne will serve a research community of 16,000 scientists when two unique projects are put into operation in the next 5-10 years. The university city of Lund is the designated location for the future European Spallation Source (ESS), a scientific research centre being built by 17 European countries that will house the world s most powerful neutron source. ESS will stand alongside MAX IV, a planned next-generation synchrotron light source that when completed, will be the powerful laser in the world. Together, ESS and MAX IV will form a world leading centre for materials research, offering unprecedented access to research competencies for the life science and medical industries. MEDICON VILLAGE: A DEDICATED LIFE SCIENCE HUB IN LUND Medicon Village creates an environment where research, innovation and entrepreneurship work together to create value for people s health and well-being. Together with the medical research centres Biomedical Centre (BMC) in Lund and the Clinical Research Centre (CRC) in Malmö, as well as the developing research facilities ESS and the MAX IV laboratory, Medicon Village is establishing an infrastructure of world class. This provides a huge lift to, and enhances the attractiveness of, the entire region. SEVEN REASONS FOR MALMÖ/LUND Lund University: largest university in the Nordics with outstanding research within diabetes, nanoscience and nanotechnology, biomarkers in cancer medicine, regenerative stem cell therapy and neuroscience (Parkinson s disease), and inhalation Research, innovation and business under one roof at Medicon Village next to Ideon Science Park the oldest and largest science park in Scandinavia The Swedish side of Medicon Valley and just 20 minutes away from Copenhagen 300+ Life Science players offering world-class products and services from discovery to commercialisation Leadership in gene therapy, medical implants, drug development, genomics and proteomics, diagnostics and renal care EXODIAB one of the best and largest biobanks in diabetes research worldwide European Spallation Source, the world s most powerful neutron source, and the MAX IV Lab, the world s strongest laser, under construction in Skåne

9 LIFE SCIENCE INITIATIVES 9 LEADERSHIP IN ANTIBIOTICS, PLANT SCIENCE AND SPORTS MEDICINE UMEÅ Umeå is a thriving hotspot for life science knowledge and innovation in northern Sweden. The success of the cluster is founded on an understanding of the importance of close collaborations across several fields.the Umeå region hosts a dynamic cluster of life science companies and academic research groups. The city of 115,000 is served by one of Sweden s top universities and offers exceptionally productive conditions for biotech and pharma companies, many of which are international leaders in their fields. TRIO OF WORLD LEADERS PLANT SCIENCE EXPERTISE More than 3,000 people work in life science business and research projects in Umeå. The region is world leading in infection control, plant science and sports medicine, but also excels in metabolic and neurological diseases, and diagnostics. INFECTION CONTROL At the Umeå Centre for Microbial Research (UCMR ), 200 active scientists in the fields of medicine, molecular biology, chemistry and physics, work together to develop a new generation of treatments for infectious diseases. These new approaches include targeting secretion systems, quorum sensing and biofilm formation in bacteria. The biotech cluster in Umeå, which includes Umeå University, Umeå University Hospital and a business incubator facility that provides seed financing, is an ideal partner for new drug development. The Umeå Plant Science Center combines expertise in experimental plant biology from both Umeå University and the Swedish Agricultural University. The scientific edge lies in genome programmes on poplar and Norway spruce, and the insight of commercially important tree genes. The results from the genome research are successfully applied on eucalyptus forestry and the commercialisation is spearheaded by SweTree technologies. TREATING SPORTS INJURIES Sports medicine is an area where Umeå has cutting edge expertise. Top athletes and recreational sportspeople from around the globe are treated at the Sports Medicine Umeå Clinic. The clinic works with Umeå University to develop pioneering therapies and rehabilitation programs for exercise-related injuries. SEVEN REASONS FOR UMEÅ Northern Sweden s academic and financial center Umeå University top institution with 35,000 students Umeå Centre for Microbial Research international pioneer in antibiotic development Umeå Plant Science Centre hub for experimental plant biology and research commercialisation Internationally renowned clinic for sports injury treatment and rehabilitation University Hospital of Umeå large medical establishment with excellent infrastructure for clinical trials Biotech incubator offers seed financing, business development and infrastructure for spin-offs

10 ABOUT US 10 BUSINESS SWEDEN WE STRENGTHEN SWEDEN AS AN ATTRACTIVE BUSINESS PARTNER s aim is to strengthen and promote Sweden as an attractive, innovative and competetive business partner. facilitates for foreign companies to invest in Sweden. We support international actors who are interested in gaining access to new markets or technologies, establishing new operations or expanding their business. We work with different scenarios and investment perspectives: from start-ups, mergers and acquisitions to partnerships and knowledge transfer. Sweden s innovation-friendly climate offers excellent investment opportunities in manufacturing, transport, science, technology, health care, music, design, tourism and other industries. An important part is also to support Swedish companies in reaching export markets with their products, services and ideas and to create business opportunities for smalland medium-sized enterprises to grow internationally. The support consists of advice on among all industry facts, business contacts, market analysis and international procurement, skills development for companies, events, and targeted campaigns. is owned by the Swedish government and the industry, represented by the Ministry for Foreign Affairs and the Swedish Foreign Trade Association. The shared ownership provides access to contacts and networks at all levels. OUR SUCCESS RESTS ON OUR EXPERIENCED EMPLOYEES COLLECTIVE EXPERTISE ACCORDING TO THE TRADITIONAL SWEDISH MODEL: POLITICS, NETWORKING, COMMUNICATION AND DIPLOMACY COMBINED WITH A RESPONSIBLE AND SOUND BUSINESS DEVELOPMENT. OUR SERVICES FOR INTERNATIONAL INVESTORS Strategic investment advice and tailored business information We have in-depth knowledge of industries where Sweden enjoys specific strengths. Knowledge of Industry and market dynamics is key when establishing a business or initiating collaborations in a new country. We offer customized advice and information based on your specific needs Matchmaking and introduction to investment opportunities Our sector specialists act as matchmakers and work closely with your company to help identify potential opportunities in Sweden that could strengthen your global business Meeting arrangements in Sweden Based on your needs we can assist in arranging relevant meetings throughout Sweden Information about how to establish and run a business We summarize information on business rules and regulations. Even though Sweden is a highly transparent society with very helpful government agencies it is not always easy to know where to find relevant information - we will assist you in doing so Network access - introductions to public and private companies and Organisations We have extensive knowledge of relevant government agencies and well established networks of business service providers that can assist you further in getting your business up and running. Tell us what you need and we find it for you

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12 CONTACT INFO BUSINESS SWEDEN Box 240, SE Stockholm, Sweden World Trade Center, Klarabergsviadukten 70 T F CARL MORATH Senior Investment Advisor, Business Unit Health Care & Life Science T M

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