Projects at the Danish Research Centre for Magnetic Resonance
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1 Projects at the Danish Research Centre for Magnetic Resonance Five projects involving MRI presented by Bettina Hornbøll (biologist) and Lars G. Hanson (physicist) Hvidovre Hospital
2 Magnetic Resonance Imaging, MRI Magnetic Resonance Imaging Nuclei in body are aligned so the patient becomes magnetic. Radiowaves are used to the make magnetic needle swing. Radiowave signal from oscillating dipole is detected.
3 MR-basics, measurement and analysis projects The following 5 projects are described in detail at BSc/MSc-project: Using MR-scanning to image macromolecules in the brain. Supervisors: Lars G. Hanson, Lise Vejby Søgaard, Xingchen Wu, Ellen Garde BSc/MSc-project: Measurement of the magnetization of Carbon13 used for MRI Supervisors: Lars G. Hanson, Lise Vejby Søgaard, Peter Magnusson.
4 Brain mapping and structural analysis BSc/MSc-project: Investigating acute changes in brain structure in response to experimentally induced changes in serotonergic function Supervisors: Hartwig Siebner, Arnold Skimminge, Julian Macoveanu, William Baaré MSc-project: How do acute changes in the central serotonergic system modify the functional cross-talk within functional brain networks? Supervisors: Julian Macoveanu, Hartwig Siebner, Olaf Paulson, Bettina Hornbøll MSc/BSc-project: Changes in brain function in healthy individuals who are at risk for depression Supervisors: Julian Macoveanu, Hartwig Siebner, Lars Kessing, Bettina Hornbøll Interdisciplinarity: Supervisors are MDs, psychologist, biologist, engineers and physicists.
5 Project: Indirect MR imaging of macromolecules Only small mobile molecules give MR signal, most notably water. Macromolecules can be indirectly imaged due to chemical exchange of hydrogen. Important in research and drug development for Multiple Sclerosis. Relies of analysis of images acquired with and without saturation of bound protons using radiowaves: Magnetization Transfer Imaging Project: Implementation of MTI at the DRCMR. Acquisition and analysis of pilotdata. Project name: Using MR-scanning to image macromolecules in the brain.
6 BSc/MSc-project: Using MR-scanning to image macro-molecules in the brain. Example: Pyruvate signal enhanced by New approximately method established: a factor 10000! Substance Carbon13-hyperpolarization is heated, injected and metabolization (magnetic nuclear is imaged labelling) scanner. Project: Measurement of the magnetization of hyperpolarized Carbon13 used for MRI. Build simple coil, interface it and program measurement.
7 Serotonin (5-Hydroxytryptamin) a key player in regulating emotions 5HT plays an important role as a neurotransmitter in the modulation of anger, aggression, mood, sleep, sexuality, appetite, body temperature
8 Altered brain activity in individuals at risk for depression: Serotonin re-uptake inhibitor normalizes latent dysfunction SSRI or Placebo (4weeks) 1st fmri session 2nd fmri session Healthy subjects with increased familial risk Julian Macoveanu, PhD. MSc drcmr.dk); Tel Prof. Hartwig Siebner, MD drcmr.dk); Bettina Hornbøll, MSc drcmr.dk) Prof. Lars Kessing (MD, DMSc, Department of Psychiatry, Rigshospitalet)
9 How do acute changes in the serotonergic system modify the functional cross-talk within functional brain networks? Reduced serotonergic tone - Acute Tryptophan Depletion - Blockade of 5-HT2A (Ketanserin) Increased serotonergic tone - Selective Serotonin Re-uptake Inhibitor (SSRI) Angry Julian Macoveanu, PhD, MSc, drcmr.dk; Tel Prof. Hartwig Siebner, MD drcmr.dk); Bettina Hornbøll, MSc drcmr.dk) Prof. Gitte Moos Knudsen, MD, PhD (CIMBI, NRU, Rigshospitalet)
10 Morphometric changes in brain structure triggered by experimentally induced changes in serotonergic function Voxel-based morphometry (VBM) Reduced serotonergic tone - Acute Tryptophan Depletion - Blockade of 5-HT2A (Ketanserin) Increased serotonergic tone - Selective Serotonin Re-uptake Inhibitor (SSRI) Prof. Hartwig Siebner, MD (DRCMR, Hvidovre Hospital), drcmr.dk; Prof. Olaf Paulsen, MD, PhD (DRCMR,, Hvidovre Hospital; NRU, Rigshospitalet) Prof. Gitte Moos Knudsen, MD, PhD (CIMBI, NRU, Rigshospitalet)
11 Additional information The five projects are described in detail at Learn more at the poster session, and. contact the supervisors to learn more. See also and
Projects at the Danish Research Centre for Magnetic Resonance
Projects at the Danish Research Centre for Magnetic Resonance Five projects involving Magnetic Resonance Imaging (MRI) Hvidovre Hospital Magnetic Resonance Imaging, MRI Magnetic Resonance Imaging Nuclei
Projects at the Danish Research Centre for Magnetic Resonance
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