Advanced Course Environmental Biotechnology 9 19 June 2015

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1 Advanced Course Environmental Biotechnology 9 19 June 2015 Aim Environmental Biotechnology is a rapidly developing, increasingly important branch of science that has implications for both the prevention and clean-up of pollution in domestic and industrial waste streams. This international training course will introduce mixed microbial culture theory and reactor technology in relation to the design and scale-up of advanced treatment processes from the laboratory to the full scale implementation. Course description The course has been held already 18 times since 1993 and is based on the expertise of the microbiologists and process engineers within the Environmental Biotechnology Group at Delft University of Technology. Internationally known experts from other universities and industry will present the guest lectures. The course integrates fundamental aspects of microbiology and biochemical engineering with consideration of practical applications towards process design and scale-up. The advantages and pitfalls of applying biotechnological methods to environmental problems will be emphasized. Microbiological topics include thermodynamics, kinetics and ecophysiology of pure and mixed cultures, (geo)biochemical element cycles and biofilm formation. Biochemical engineering subjects will include mathematical modelling, biomass retention by various separation techniques, mass transport in biofilms and three phase reactors, scale up/scale down, integration of processes and process control, and process design from flask to full scale and back. For a better understanding of the lectures and to enhance active participation by those attending, this intensive training course consists of lectures, exercises, computer simulations (existing, widely used simulation programs) and an excursion to the Dokhaven Sewage Treatment Plant (including Anammox and Sharon process). A three-day case study will offer the participants the opportunity to practice on the integration of the different topics and to design a process for the treatment of a C, S and N containing industrial waste stream. The results and conclusions will be discussed in a plenary session. The official course language is English. A pocket calculator is required. Who should attend? This Advanced Course is aimed at professionals (MSc, PhD or equivalent experience) in microbiology, biochemistry or biochemical engineering with a basic working knowledge of the two other disciplines. Also, molecular biologists with a microbial background may apply. The course is primarily aimed at those already employed in industry who wish to up-date their theoretical knowledge and practical insight in this field. In addition, this Advanced Course is an option in the two-year postgraduate programs of.

2 Duration and Location This Advanced Course will be given on Tuesday, 9 June Friday, 19 June 2015 The course will be held at the Department of Biotechnology Julianalaan BC Delft The Netherlands P E W Accommodation Hotel accommodation can be arranged at your request addressed to the BSDL secretary Lunches, the buffet on Tuesday, June 9th and the course dinner on Thursday, June 19th will be provided. For the other meals a variety of restaurants may be found in the centre of the city. PROGRAM, 9 19 June 2015 Tuesday, June 9th Theme: Fundamentals of environmental biotechnology: basic microbiology, stoichiometry and kinetics Welcome: outline of the course Metabolic diversity and environmental microbiology Gerard Muyzer Stoichiometry of microbial growth Kinetic description of microbial growth in axenic and mixed cultures Parallel sessions: Exercises with the stoichiometry of microbial systems Exercises with kinetics of microbial systems Social event and buffet Wednesday, June 10th Theme: Fundamentals of environmental biotechnology: thermodynamics, dynamics and competition Basic thermodynamics of biological systems Bioenergetics of microbial growth Mixed substrate utilization and microbial competition Thomas Egli Exercises with thermodynamics, competition and growth of mixed cultures

3 Thursday, June 11th Theme: Fundamentals of environmental biotechnology: (bio)process engineering principles Basic principles of transport processes in bioreactors / Gas-liquid interphase transport Biofilms and flocs: - diffusive transport - modelling of the structures Exercises on the integration of microbial conversions (zero and first order kinetics) and transport Visit to the research projects of BSDL Friday, June 12th Theme: Scale up Scale-up of environmental processes using regime analysis Aerobic granular sludge: scaling-up a new technology Scale-up case study: aerobic granular sludge Ecological theory in engineering design: progress, problems and prospects Tom Curtis Monday, June 15th Theme: Modelling microbial population dynamics: an engineering approach WORKSHOP BioWin Modelling and simulation of activated sludge systems Bas Meijer Process engineering principles of microalgae cultivation Marcel Janssen Social drink Tuesday, June 16th Theme: Microbiology for environmental biotechnology Microbial S-conversions Gerard Muyzer Microbial P-conversions Microbial N-conversions Maaike Hoekstra Microbiology of methanogenic processes Robbert Kleerebezem Excursion to the Dokhaven Sewage Treatment Plant, Rotterdam (including Anammox and Sharon process)

4 Wednesday, June 17th Theme: Case study of a C-, S- and N-containing industrial waste stream: process and reactor design by integration of microbiology and chemical engineering Annamox technology Case study, Part I: analysis of problem / Robbert Kleerebezem Case study, Part IIa: generation of process options / Robbert Kleerebezem Case study, Part IIb: reporting process options and choices / Robbert Kleerebezem Thursday, June 18th Theme: Continuation of the case study Recent developments in anaerobic wastewater treatment Jules van Lier Case study, Part III: design and calculations on the chosen process options / Robbert Kleerebezem PHA Production Leonie Marang Continuation of the case study, Part III Course dinner Friday, June 19th Theme: Continuation of the case study Continuation of the case study, Part III / Robbert Kleerebezem Case study, Part IV: scale-up / Robbert Kleerebezem Reporting of results / Robbert Kleerebezem Resource Recovery Willy Verstraete Evaluation of the course Farewell drink Fees and Registration Please fill in the application form on our website or complete and return the form below if you are interested to attend the course or would like to receive information on other courses. Applications will be handled in order of the date of receipt. The course fee is: in case of payment received before April 27th, 2015 or in case of payment received after this date. In the event of cancellation before April 27th, 2015, a full refund will be granted, after this date, a 25% fee charge will be made. To facilitate enrolment of employees from non-profit organisations and universities, a limited number of fellowships is available with a reduced fee of for employees of non-profit organisations and for PhD-students. To apply, please include a copy of your enrolment as a PhD-student from your university. The fee includes course materials, lunches, the buffet on Tuesday, June 9th and the course dinner on Thursday, June 18th. The fee does not cover other meals and lodging.

5 When the number of participants is too low to have a fruitful course, the Institute BSDL will cancel the event no later than six weeks before the start of the course. The course fee will be reimbursed within three weeks after cancellation. In case a speaker will not be able to present his/her lecture, due to unforeseen circumstances, BSDL will arrange an equivalent replacement. Hotel accommodation can be arranged at your request. Preparatory texts will be sent after receipt of the course fee. The complete course book will be supplied at the start of the course. ============================================================== Advanced Course Environmental Biotechnology o I wish to attend the course of 9 19 June 2015 o I would like to receive information of the other courses of the Institute BSDL o Please, send me announcements of the future Advanced Course Environmental Biotechnology Family name, title, Mr/Ms First name. Organisation/Company. Address... Phone. address. Educational background Diet wishes.. Date / Signature.. ==============================================================

6 Board of the course Prof. M.C.M. van Loosdrecht Environmental Biotechnology Prof. J.J. Heijnen Cell Systems Engineering Dr. R. Kleerebezem Wastewater Treatment Faculty staff Ir. M. Hoekstra L. Marang, MSc Dr. C. Picioreanu Guest lecturers Prof. T. Curtis Newcastle University Newcastle, United Kingdom Prof.em. T. Egli EAWAG Dübendorf, Switzerland Dr. M.G.J. Janssen Bioprocess Engineering Wageningen University Wageningen, the Netherlands Prof. J.B. van Lier Department of Water Management Faculty of Civil Engineering and Geosciences Dr. S.C.F. Meijer ASM Design Utrecht, the Netherlands Prof. G. Muyzer University of Amsterdam Faculty of Science Amsterdam, the Netherlands Dr. J.-P. Steyer INRA LBE Laboratoire de Biotechnologie de l'environnement Narbonne, France Prof.em. W. Verstraete Ghent University Laboratory of Microbial Ecology and Technology (LabMET) Ghent, Belgium Course coordinators Ms. Jenny Boks-Zondervan Dr. Eline Huisjes Department of Biotechnology

7 The institute Biotechnology Sciences Delft Leiden (BSDL-EDU) constitutes a joint initiative in biotechnological post-graduate education of and Leiden University and is coordinated from the department of Biotechnology of. BSDL-EDU was founded in 1987 and has since then very successfully organised various types of postdoctoral education: the Advanced Course Quality Management in Pharma and Biotech, the PDEng programmes and the Advanced Courses in biotechnology. The Advanced Course Quality Management in Pharma and Biotech was developed by BSDL-EDU and is currently organised by PAO Farmacie. The PDEng programmes are special two-year postgraduate programmes that are aimed at those who wish to tailor their own specialisation to the needs of multidisciplinary biotechnological research and design, and lead to the degree of Professional Doctorate in Engineering. Originally developed by BSDL-EDU, these programmes are now hosted by the 3TU School for Technological Design / Stan Ackermans Institute. Currently BSDL-EDU offers various Advanced Courses covering the multidisciplinary spectrum of biotechnology: MICROBIAL PHYSIOLOGY AND FERMENTATION TECHNOLOGY BIOCATALYSIS AND PROTEIN ENGINEERING BIOPROCESS DESIGN DOWNSTREAM PROCESSING GENOMICS IN INDUSTRIAL FERMENTATION METABOLOMICS FOR MICROBIAL SYSTEMS BIOLOGY Further information Ms. Jenny Boks-Zondervan Dr. Eline Huisjes P E W Address Institute Biotechnology Studies Delft Leiden Department of Biotechnology, Julianalaan 67, 2628 BC

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