DoReMi Low Dose Research towards Multidisciplinary Integration 1st Periodic Meeting Programme 4-6 July Programme

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1 DoReMi Low Dose Research towards Multidisciplinary Integration 1st Periodic Meeting Programme 4-6 July 2011 The Royal Academies for Sciences and Arts of Belgium Programme Monday, July 4, Meeting room Espace Baudouin 09:00 10:00 Registration: in the area just outside the meeting room Poster set-up Coffee 10:00 10:10 Welcome Prof. Hans Vanmarcke, SCK CEN, Belgium 10:10 10:20 Introduction DoReMi and MELODI Prof. Sisko Salomaa, STUK, Finland 10:20 10:50 DoReMi Transitional Research Agenda and MELODI Strategic Research Agenda 10:50-11:00 EC expectations Dr. André Jouve, EC, Belgium 11:00-11:30 ModInIr: Work plan and capabilities of the new beneficiaries UKER, GUF, UROS Prof. Udo Gaipl, UKER, Germany 11:30 12:00 FIGARO: Work plan and capabilities of the new beneficiaries UMB, NRPA, NIPH Prof. Deborah Oughton, UMB, Norway, Ann-Karin Olsen, NIPH, Norway and Dr. Tamara Zhunussova, NRPA, Norway 12:00 13:00 Lunch break and poster viewing (Patio) 13:00 13:20 DDRE-BrainCancer: Work plan and capabilities of the new beneficiaries ENEA, IES Dr. Anna Saran, ENEA, Italy 13:20 13:40 PRISM: Work plan and capabilities of the new beneficiary DIT Dr. Fiona Lyng, DIT, Ireland

2 13:40 14:00 LoGiC: Work plan and capabilities of the new beneficiary Erasmus MC Dr. Dik van Gent, Erasmus MC, The Netherlands 14:00 15:00 Presentations by other Euratom project representatives: Dr. Peter Jacob, HMGU, Germany: EpiRadBio (12 min) Dr. Filip Vanhavere, SCK CEN, Belgium: ORAMED (12 min) Prof. Andrzej Wojcik, SU, Sweden: MULTIBIODOSE (12 min) Dr. Bernd Grosche, BfS, Germany: STORE (12 min) Dr. Richard Haylock, HPA, UK: SOLO (12 min) 15:00 15:30 Coffee break and poster viewing (Patio) 15:30 16:40 Presentations by other Euratom project representatives (continues): Dr. Ausrele Kesminiene, IARC, France: EPI-CT + ARCH (20 min) Dr. Thomas Hinton, IRSN, France: STAR (12 min) Prof. Sisko Salomaa, STUK, Finland: NOTE (12 min) Prof. Andrea Ottolenghi, UNIPV, Italy: ALLEGRO (12 min) Ms. Ritva Bly, STUK, Finland: DDM2 (12 min) 16:40 17:10 Fukushima lecture Dr. Mitsuru Nenoi, NIRS 17:10 18:00 Discussion: Enlarged DoReMi consortium and other Euratom projects - new possibilities for cooperation Chair: Prof. Sisko Salomaa, STUK, Finland Rapporteur: Dr. Eeva Salminen, STUK, Finland 18:00 20:00 Reception hosted by SCK CEN Dr. Frank Hardeman, SCK CEN, Belgium Poster viewing (Patio) Tuesday, July 5, Meeting room Espace Baudouin 09:00 10:30 WP5 session: Work performed, future activities, discussion 09:00 09:05 Introduction to WP5 Dr. Simon Bouffler, HPA, UK 09:05 09:15 Task 5.1: Phase shifts in responses and processes at high/low doses and dose rates

3 09:15 09:25 Task 5.2: Assessing the relative contribution of targeted (DNA), non-targeted and systemic processes to radiation carcinogenesis Prof. Sisko, Salomaa, STUK, Finland 09:25 09:35 Task 5.3: The dynamics of preneoplastic change and clonal development Dr. Christophe Badie, HPA, UK 09:35 09:45 Task 5.4: Mathematical models to link experimental findings and epidemiological data Dr. Peter Jacob, HMGU, Germany 09:45 09:55 Task 5.5: Assessing the risk from internal exposures Dr. Dominique Laurier, IRSN, France 09:55 10:30 Discussion: chaired by Dr. Simon Bouffler, HPA, UK - Brief statement on the new work added - Future priorities - Other 10:30 11:00 Coffee break and poster viewing (Patio) 11:00 12:30 WP6 session: Work performed, future activities, discussion 11:00 11:05 Opening: Summary of WP6 activities 11:05 11:15 Report on genetic susceptibility studies on thyroid carcinogenesis 11:15 11:25 Introducing the new partners: DIT Dr. Fiona Lyng, DIT, Ireland 11:25 11:35 Introducing the new partners: ENEA Dr. Anna Saran, ENEA, Italy 11:35 11:40 Report on the workshop and further discussion Biomarkers and individual sensitivity + Review of Cohorts (WP4) Dr. Elisabeth Cardis, CREAL, Spain 11:45 11:55 Some thoughts about modeling individual susceptibility in radiation risk of humans Dr. Peter Jacob, HMGU, Germany. 11:55 12:05 Suggestion to contribute to the Systems Biology Workshop, Stockholm October 12:05 12:15 Report on the workshop Epigenetics and individual susceptibility 12:15 12:30 Discussion: Chaired by 12:30 13:30 Lunch break and poster viewing (Patio)

4 13:30 15:00 WP7 session: Work performed, future activities, discussion 13:30 13:40 Introduction to WP7 Dr. Jean-René Jourdain, IRSN, France 13:40 13:50 Task 7.1 Structuring the research effort on non-cancer effects according to the HLEG roadmap: organisation of consultation/exploratory meetings and funding integrative RTD projects Dr. Jean-René Jourdain, IRSN, France 13:50 14:00 Task 7.2 Preparation of a pilot study to conduct molecular epidemiology studies in vascular radiation damage Dr. Elisabeth Cardis, CREAL, Spain 14:00 14:10 Task 7.3 Feasibility study towards a systems biology approach of radiation response of the endothelium 14:10 14:20 Task 7.4 Pilot epidemiological study of lens opacities among a cohort of interventional radiologists and cardiologists Dr. Sophie Jacob, IRSN, France 14:20 14:30 Task 7.5 Pilot study of external irradiation versus internal contamination effects on neurogenesis Dr. Rafi Benotmane, SCK CEN, Belgium 14:30 15:00 Discussion: chaired by Dr. Jean-René Jourdain, IRSN, France - with the participation of every WP7 Task Leaders 15:00 15:30 Coffee break and poster viewing (Patio) Parallel activities: 15:30 18:00 Joint MB-EAB meeting in Salle Bordet (separate agenda available) Student/post-doc session in Espace Baudouin (separate agenda available) 18:30 20:30 Dinner for MB/EAB meeting participants Possible evening activities for Student/post-doc session participants Wednesday, July 6, Meeting room Espace Baudouin 09:00 10:30 WP3 session: Work performed, future activities, discussion 09:00 09:15 Summary of WP3 objectives and activities of the first 18 months Dr. Vere Smyth, Prof. Andrea Ottolenghi and Prof. Klaus Trott, UNIPV, Italy 09:15 10:05 Reports by the organizers of the two week courses (8 min each):

5 - Radiation-induced effects with particular emphasis on genetics, development and space-related health issues Prof. Sarah Baatout, SCK CEN, Belgium - Molecular radiation carcinogenesis - Radiation epidemiology and radioecology Prof. Klaus Trott, UNIPV, Italy - Cellular effects of low doses and low dose-rates with focus on DNA damage and stress response Prof. Andrzej Wojcik, SU, Sweden - Interdisciplinary radiation research focussing on radiation protection Dr. Ulrike, Kulka, BfS, Germany - Modelling radiation effects from initial physical events Prof. Andrea Ottolenghi, UNIPV, Italy 10:05 10:30 Discussion: The way forward, including: - The next call - Debate on possible Bologna-agreement like courses - DoReMi/Melodi Training and Education meeting in Rome Dr. Vere Smyth, Prof. Andrea Ottolenghi and Prof. Klaus Trott, UNIPV, Italy 10:30 11:00 Coffee break and poster viewing (Patio) 11:00 12:30 WP4 session: Work performed, future activities, discussion 11:00-11:05 Introduction to WP4 Dr. Radhia M Kacher, CEA, France 11:05-11:20 Task 4.1 Survey of existing facilities for low dose in vitro irradiation Dr. Isabelle Testard, CEA, France 11:20-11:30 Task 4.2 Pilot structure of low dose-exposure with low dose rate 11:30-11:45 Databases of European Pilot Project Dr. Bernd Grosche 11:45-11:55 Task 4.4 Cytogenetic platform in DoReMi Pilot study in medical cohort Chromosomal instability and viral infection in Hodgkin lymphoma patients Dr. Radhia M Kacher, CEA, France 11:55-12:25 Task 4.4 Genomic and proteomic platform in DoReMi Dr. Rafi Benotmane, SCK CEN, Belgium and Dr. Christophe Badie, HPA, UK 12:25-12:30 Conclusion and presentation of the program of WP4 in MELODI meeting Dr. Radhia M Kacher, CEA, France

6 12:30 12:40 Group photo 12:40 13:30 Lunch break and poster viewing (Patio) 13:30 15:00 WP2 session: Work performed, future activities, discussion 13:30 13:40 Introduction to WP2 13:40 13:50 Task 2.1 (RTD) Establishing and updating Joint Programme of Integration (JPI) 13:50 14:00 Task 2.2 (RTD) Establishing and updating the Transition Research Agenda and Joint Programme of Research 14:00 14:10 Task 2.3 (Dissemination) Establishing and updating the Joint Programme of Spreading Excellence (JPSE) 14:10 14:25 Website presentation Dr. Serge Candéias, CEA, France 14:25 14:30 Task 2.4 (Dissemination) Support from Experts 14:30 15:00 Discussion: chaired by Dr. Dietrich Averbeck, IRSN - Future activities of WP2 - The way forward for TRA and SRA - Input of different WP2 partners to structuring MELODI - Ideas for sustainability - Future national and international multidisciplinary activities and support - Other 15:00 15:30 Coffee break and poster viewing (Patio) 15:30 16:10 WP1 session: Work performed, future activities, reporting issues, discussion Prof. Sisko Salomaa, STUK, Finland 16:10 16:30 EAB conclusions Prof. William Morgan, PNNL, USA 16:30 18:00 General Assembly meeting Chaired by Dr. Sarah Baatout, SCK CEN, Belgium (separate agenda available) End of the meeting

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