CRME PROFILE. Achievements ( ) C R M E Estd. 1st May

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1 CRME PROFILE Achievements ( ) C R M E Estd. 1st May A N N I V E R S A R Y SILVER JUBILEE CELEBRATIONS Centre for Research in Medical Entomology (Indian Council of Medical Research) Madurai , Tamil Nadu, INDIA

2 SILVER LVER JUBILE LEBRATIO JUBILEE SILVE BRATIONS JUB CELEBRA CRME PROFILE Achievements ( ) C R M E Estd. 1st May A N N I V E R S A R Y SILVER JUBILEE CELEBRATIONS Centre for Research in Medical Entomology (Indian Council of Medical Research) Madurai , Tamil Nadu, INDIA

3 Background Mission Vision Mandate Significant Achievements Research facilities Laboratory Diagnosis Field investigations Trainings Museum Symposium / Workshops Collaboration (both National/International) University Affiliations Major Research Programmes Disease control Research Projects Library Publications Funding Agencies CRME- New Building Printed at Sree Vinayaga Screens (Offset Printers) 12A, Subramania Pillai Street, S.S. Colony, Madurai Ph. : ,

4 Background The Centre for Research in Medical Entomology (CRME) was established on 1st May, 1985 as one of the permanent institutes of Indian Council of Medical Research (Ministry of Health and Family Welfare, Government of India). The Centre has three field stations at Virdhachalam, Tirukoilur and Chennai. There are four divisions at its headquarters Madurai, viz., (1) Ecology & Research Modeling (2) Epidemiology & disease vector control (3) Molecular Biology, and (4) Mosquito colony, Extension and Training These divisions, along with the field stations, are engaged in research on various aspects of Japanese encephalitis (JE), dengue, filariasis, malaria, Chikungunya etc. The Centre is equipped with adequate infrastructure to undertake research related to molecular entomology, molecular taxonomy, vector ecology, vector biology, vector control, disease epidemiology and serology. The Scientific Advisory Committee comprising eminent scientists from all over the country governs the scientific activities of the Centre. CRME Profile 01

5 Mission The CRME aims at becoming the world's best institute in medicoentomological / arthropodological sciences particularly in the field of vector-borne diseases. Vision The vision of CRME is to provide excellent knowledge on vectors and vector-borne diseases to achieve better health through application of modern tools. Mandate Surveillance and development of early-warning systems for epidemic outbreaks of vector-borne diseases. Stratification of vector-borne diseases. Survey of haematophagous arthropods. Major Research Fields Surveillance & Control Molecular research in vectors and pathogens Vaccine Research Tissue Culture Faunistic Survey (Western Ghats) Disease Burden Bioterrorism preparedness Extension activites Development of control strategies. Technology transfer to the user agencies. 02 CRME Profile CRME Profile 03

6 Significant Achievements Extensive surveys were carried out on the mosquito biodiversity in the Western Ghats, Eastern Ghats, Mangrove forests, Assam, Andaman & Nicobar ils., areas. Five new mosquito species were described and several hitherto undescribed larval and adult stages of mosquito species reported. A simple identification key with illustrations was developed to identify the JE vectors. Demonstrated that the annual, single-dose of DEC and albendazole combination therapy during MDA was operationally feasible at the community level. Our experiment also suggests that the vector control, when used as an adjunct to MDA, curtailed transmission and prevented the resurgence of LF transmission. The development of resistance in a wild population of the filariasis vector Cx. quinquefasciatus to Bacillus sphaericus (the microbial insecticide) was detected and reported for the first time in India. Demonstrated that the children <5years had higher antigenaemia clearance when compared to the minimal change in youth after a single-dose combination therapy (MDA with DEC+albandazole). Incrimination of Ochlerotatus niveus (Aedes niveus) as a vector of sub-periodic bancroftian filariasis in Andaman & Nicobar Islands was made. Established that the combination therapy of DEC +albendazole for filariasis resulted in enhanced efficacy against geohelminths and the magnitude of infestation remained at a significantly low level for about a year after intervention. Detection of JE virus antigen in desiccated vector mosquitoes was established. JE surveillance network established Tamil Nadu to monitor JE virus activity using desiccated vectors. The isolation methodology of JE virus from mosquito larva and human by using Toxorhynchites splendens mosquito immuno-fluorescence assay (Toxo-IFA system) was standardized in place of suckling mice. Studies on vectors of JE breeding in rice-fields showed that larval populations of vectors were significantly enhanced by the use of synthetic nitrogenous fertilizers. Application of urea was found to increase the oviposition of JE vectors. These findings may help in explaining increased incidence of disease in recent decades. Extensive studies were carried out on use of neem products and application of water management system for the control of JE vectors in rice ecosystem. Our experiment suggested that the annual single dose mass drug administration (MDA) of diethylcarbamazine (DEC) and albendazole combination therapy has an edge over DEC alone in the process of lymphatic filariasis (LF) elimination. Reported that location, accessibility and sensitivity of adult filarial worm to DEC could be responsible for greater susceptibility in children. Brought out the therapeutic effect of DEC alone on geohelminths in a community-based study for the first time in India. Detection, isolation and serotyping of dengue virus from Aedes vectors by using Toxo-IFA system has been standardized. Dengue virus antigen detected in desiccated specimen of Aedes aegypti. Dengue epidemic outbreak in Chennai city was predicted well in advance in the year Aedes albopictus was identified as the only vector of dengue in Kerala, and DEN-2 isolated for the first time in this State. An Indian Patent was won on the invention of Mechanical Mosquito Sampler, in CRME Profile CRME Profile 05

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