Programme Specification MSc in Molecular Genetics

Transcription

1 Programme Specification MSc in Molecular Genetics Entry-level Honours degree in Bioscience subject or a science degree with a relevant bioscience component. Overall minimum level 2:2. International applicants with a wide variety of degree types and structures are dealt with on an individual basis. Aims and objectives The MSc Course aims: To respond to an international need for scientists that can apply a molecular approach to fundamental research in the biomedical arena. To prepare graduates for employment as scientists either by direct entry or by further study such as PhD. To teach research skills to ensure that students are equipped to develop a career in science To give students a direct experience of research during a Six month project placement in a University research laboratory or with an equivalent placement at collaborating industrial partner such as a research facility at a major drug company. To provide a positive learning environment where students can actively participate in their academic development. Students should be able to: Show core knowledge of prokaryote and eukaryote genetics, and molecular biology of the cell Demonstrate an in depth knowledge of examples of molecular mechanisms in many areas of cell biology. Use research skills including the ability to design experiments, show knowledge of molecular techniques, analyse data, and review literature critically Show good laboratory skills including the application of molecular techniques and statistical methods Use transferable skills in oral presentations, report writing, and the use of information technology Demonstrate experience of research through a six -month project placement in a research laboratory. Programme quality indicators: QAA subject review [www/qaa.org/.] Recent external examiners reports for this course have been highly complimentary Student feedback forms Some of the most relevant quality indicators are the academic details of recruits and their forward placement after the course: MSc Molecular genetics attracts a truly international range of applicants (These students have first degrees typically in medicine, microbiology, biochemistry and vetinerinary science). Apart from one student in who had a Chevening Award, these students are all self funding as we have no course scholarships or fee waivers. They are all high achievers, Internet literate and will go to whatever country or institution they believe will be best for their further education. 1

2 total of 10 students, 7 international (outside EU) students recruited, one of whom Leicester retained as 3 year self funding Phd student (this student is Iranian and is in clinical sciences) total of 16 students, 10 international (outside EU) students recruited two of whom Leicester have retained as 3 year self funding Phd students (these students are from Mexico and Taiwan and are in Genetics and Biochemistry respectively) total of 32 students, 21 international (outside EU) recruited [countries of origin include India (10), PR China (6), Saudi Arabia (1), Bangladesh (1), Thailand (1) UAE (1) and Nigeria (1)). The student from Saudi Arabia will undertake a Saudi Government funded 4year placement (continuing with a PhD in Immunology) after successful completion of this MSc year and I hope others from this cohort will also eventually become self funding PhD students at Leicester. Out of a total of 26 MSc students that have graduated over the last two years ( ) 7 are continuing with PhD study within the Faculty of Medicine and Biological Sciences of which 3 of are self funding (mentioned above) and one is on a Joint Astra-Zeneca/University of Leicester studentship. A Further 12 Students from these 2 years have also obtained PhD studentships in Penn State University, USA, Switzerland, Cambridge, Glasgow (4 year Wellcome Program), Birmingham and the Institute of Animal Health or Research Assistantships/Technical positions at Oxford, Cardiff and London Hospitals. Five are still looking for permanent employment and two have long-term illnesses. 2

3 Subject and Professional Skills Intended Outcomes Teaching Methods How demonstrated Knowledge Core knowledge of genomics, molecular/cellular biology and molecular techniques. Advanced research topics Concepts Molecular mechanism of genetic control. Molecular and cellular biology Techniques Practical demonstration of experimental method. Competent use of standard and specialized equipment, Knowledge of safety procedures and safety assessment Critical analysis Critical appraisal of results. Critical review of literature Presentation Presentation of scientific results, Participation in scientific discussion Appraisal of evidence Experimental method, Project design Lectures, Specified reading, Laboratory classes, Tutorials, Lectures, Laboratory classes, Tutorials Laboratory classes, Laboratory project supervision, Practical demonstrations, Lectures Taught Laboratory and research project supervision, Tutorials Tutorials, Taught Laboratory classes, Group projects supervision, Taught Laboratory and research and project supervision, project phase laboratory meeting participation Lectures, Taught phase project supervision, Research Project supervision, Assessed Laboratory reports, Tutorial performance, Assessed 3000 word research review. Formal examination. Assessed Laboratory reports, Tutorial performance, Formal examination. Assessed Laboratory reports, Research Project progress and report, Course examinations Written examination, Assessed Laboratory reports, Research Project progress and report Laboratory presentations, Group presentations in tutorials, Project presentations Written examinations, Assessed taught phase Laboratory reports, Dissertation content /scientific value assessment 3

4 Transferable Skills Intended Outcomes Teaching Methods How demonstrated Managing, reflecting on, and developing one s own learning Study skills, Information management, Developing specialization and interests, Project management Research skills Literature review, Experimental design, Laboratory skills, Data analysis, Statistics Working relationships Project management, Organization skills, Time management, Working in pairs /groups Data presentation Bioinformatics and IT, Analytical and graphical methods, Statistics Communication skills Report writing, Scientific communication, Tutorials and interviews, Library and IT skills, Study skills support, Project supervision, Tutorials, problem solving, Lectures, Project supervision Taught phase and research Project supervision, Tutorials, Group practical classes, Group problem solving Taught phase and research Project supervision, Bioinformatics and IT skills, tutorials, Tutorials, Laboratory classes, Taught phase and research Project supervision and assessment Presentation skills Interviews, Feedback, Tutorial performance, IT, Assessed taught phase Laboratory reports, Assessed dissertation Tutorial performance, Project report, Assessed dissertation Tutorial performance, Assessed laboratory reports, Research Project assessment IT Coursework, taught phase Practical reports, Tutorial performance, Assessed Taught phase Laboratory reports, research Project dissertation. Oral presentations 4

5 MSc in Molecular Genetics Module Specification GE 7001 Introduction to Techniques in Molecular Genetics Credits 10 Semester 1 Contact: Dr Raymond Dalgleish Genetics, Dr Colin Ferris, Biology Assessment Arrangements: Assessed practical reports and analysis of work undertaken Lectures 4 Tutorials 2 Private study 10 Lab. Classes 60 Total hours 76 : Synopsis: This module provides a basic introduction to PCR technology and to the analysis of genetic diversity using both lecturer-directed and student-directed learning. A series of informal lectures and tutorials are used in each of the areas outlined below. The module focuses on mechanistic and experimental approaches in genetics leading towards more advanced topics covered later in the taught phase of the course. Aims: To introduce two fundamental techniques in genetics. Learning objectives: An understanding of core genetics: knowledge and molecular methodologies. Assessment: Two assessed laboratory reports (each 50 %) with an accompanying analysis of work undertaken. Aims: Subject knowledge and basic concepts in genetics Learning outcomes: By the end of the Human genomic PCR part of this module, students should: Be able to describe the theoretical basis of the Polymerase Chain Reaction (PCR) and its optimisation Have experience of isolating samples of their own DNA Have experience of PCR amplification of DNA samples Be familiar with the basic concepts of population genetics including Hardy Weinberg equilibrium Be able to design PCR primers using computer-based methods 5

6 By the end of the Plant systematics section of this module students should be able to: Extract DNA from plant material using Qiagen kits. PCR amplify DNA using primers supplied and clean the products using PCR clean-up kits. Perform PCR cycle sequencing reactions and product clean-up. Analyse sequences using Sequence Navigator. Align sequences using DNA* Megalign, and perform phylogenetic analyses using PAUP. compare sequences against the DNA databases on the web using a BLAST search. interpret phylogenetic trees and understand the statistical methods of bootstrapping. Methods: Directed laboratory work Lectures, self directed reading, Tutorials. Assessment: The ability to convey scientific information via written report 6

7 GE 7002 Applications of Molecular Techniques to Research Credits 20 Semester 1 Contact: Prof. Julian Ketley, Dr Fred Tata, Dr Mike Hennessy (All dept. genetics) Assessment Arrangements: Assessed practical reports and analysis of work undertaken Lectures 10 Lab Classes 150 Private study 25 Total hours 175 Synopsis: This module introduces a variety of up to date, cutting edge techniques in genetic analysis genome structure and function. Aims: To become familiar with these techniques, the associated terminology and concepts and to develop an ability to work in hitherto novel laboratory and conceptual environments. Learning objectives: Subject knowledge and application of advanced concepts of Molecular Genetics. Methods: Lectures, Specified Reading, Tutorials, practical classes. Assessment: Three assessed laboratory reports (two at 40% one at 20%) with an accompanying analysis of work undertaken. Aims: To introduce advanced concepts in molecular genetics Learning outcomes: By the end of this module, students should be able to demonstrate expertise in the following areas: Molecular Genetic Approaches to Characterising Bacterial Virulence Mechanisms: a) Experience in experimental organization and time management leading to improved ability in experimental design and the solution of technical problems. b) Further experience in a variety of molecular genetic methods including DNA preparation, ligation, transformation, restriction analysis, PCR, and DNA sequencing. c) The ability to write a paper suitable for submission to a scientific journal. Enhancer trapping in Drosophila Trypanosome genome sequencing: a) The ability to undertake useful medically related research by trapping and characterising highly variable trypanosome subtelomeric DNA with yeast artificial chromosomes. b) Understand how this research helps to provide a fuller picture of a complete genome sequence and to be able to explain why this is desirable and necessary. Methods: Lectures, Specified Reading, Tutorials, practical classes Assessment: The ability to write succinct short practical reports and analyses of complex experimental results 7

8 GE7003 Practical Problems and Data Analysis based on course work and supporting tutorials Credits 15 Semester 1 Contact: Dr JM Hennessy Assessment Arrangements: Formal examination Tutorials 18 Rev. lectures 6 Lab classes 28 Private study 54 Total hours 108 Molecular Cell Biology Synopsis: This module requires the student to collate knowledge and techniques from all components of the taught laboratory phase, and 6 specific tutorial sessions. The emphasis is on learning how techniques are used in the context of molecular research. Data analysis and practical abilities are also assessed. This knowledge is then assessed in a formal examination. Aims: To consolidate and reinforce the students knowledge base. Learning objectives: Students should be able to: Demonstrate knowledge in an the confidence to use complex techniques for real research Methods: Tutorials, laboratory projects, informal lectures Assessment: Examination Aims: Subject knowledge, concepts and practical application to advanced research. Learning outcomes: Demonstrate that they have both, a basic ability in the production and maintenance and understanding of the action of chemicals and solutions used for molecular biology. Describe the range of techniques developed over recent years to identify, locate and describe the presence and action of genes and proteins in biological material. The range of Techniques include cloning technologies, PCR, sequencing, library construction, southern, northern, western, yeast two hybrid, footprinting and gel retardation. Undertake a range of plasmid mapping challenges. Methods: Lectures, Specified Reading, IT, practical classes Assessment: Ability to convey information through formal examination 8

9 GE7004 Topics in Molecular Genetics based on Lecture Programme Credits 15 Semester 1 Contact: Dr JM Hennessy Lectures 24 Tutorials 18 Private study 80 Total hours 112 Literature review Synopsis: This comprises the production of a 300 word referenced essay based on a specific topic relevant to research being carried out by a member of department and part of the lecturing team Aims: To develop an awareness of the required level of depth and understanding needed for this process. And to practice this technique prior to using the skills to research the subject matter needed during the laboratory project and subsequent dissertation Learning objectives: The ability to undertake independent scientific review of a given topic Methods: private study with academic help if necessary, 6 specific tutorials, lecture courses Assessment: A 3000 word fully referenced literature review. Aims: Knowledge and concepts, Techniques, Critical analysis, Presentation of data, Appraisal of evidence related to a specific research area. Learning outcomes: Students should be able to: Understand how to use all available resources text, human, library and internet to undertake the literature review and be able to assess the level and depth of understanding required. Be able to properly refer to texts reviews and current research and understand when each are appropriate. Methods: Lectures, tutorials, private study Assessment: Individual assessment by a member of academic staff with research interest in the specified topic. 9

10 GE 7005 Practical Research Project Credits 20 Semester 2 Contact: Dr JM Hennessy Assessment Arrangements: Continuous assessment Laboratory work 280 (28 weeks x 10) Total hours 280 Synopsis: This module comprises a seven-month research project placement within a molecular research laboratory at the University of Leicester or at similar research facilities with a collaborating industrial partner. A range of suitable projects are requested and then presented to the students. All students have a free choice in which project is take and are encouraged to investigate a few before their final choice is made. This gives the student I invaluable experience in choosing their own project, place of work research area colleagues and supervisor. Aims: To give students the opportunity to complete a major research project within the university or with a collaborating industrial partner. Learning objectives: The ability to participate in current laboratory research, developing a specialization and experience in how to pursue scientific interests Methods: Project supervision, project appraisals, interim seminars and reports. MSc students are also normally incorporated into laboratory routines such as laboratory seminars, journal clubs and reports on their work. Assessment: The project supervisor provides an assessment of the students laboratory skills, performance, and aptitude for laboratory research Aims: Knowledge and concepts, Techniques, Critical analysis, Presentation of data, Appraisal of evidence, Study skills, Research skills, Working relationships, Data presentation, Communication skills Learning outcomes: Students should be able to: show experience of a placement in a university research laboratory or in industry; carry out novel and fundamental background in to a project; design and implement their own experiments; interpret data and analyse their own results. Methods: Project supervision, project review Assessment: supervisors report 10

11 PT7006 Dissertation Presentation Credits 40 Semester 2 Contact: Dr JM Hennessy Assessment Arrangements: continuous assessment Research project 280 Private study 40(10 x 4) Total hours 320 Synopsis: The module is the presentation of an advanced research project report. Aims: That the student learns how to produce a dissertation Learning objectives: To be able to prepare to standard PhD thesis format, a concise, informative, well structured and argued report of the research undertaken. The report must make proper use of tables, figures and indicate full and proper use of references. Methods: Academic supervision, colleague and peer support, previous years dissertation for comparisons Assessment: Assessment by Supervisor, second marker and moderation by external examiner Aims: Knowledge and concepts, Appraisal of evidence, Managing, reflecting on, and developing one s own learning Learning outcomes: Subject Knowledge, Critical review of literature, Presentation of scientific results, Participation in scientific discussion, Experimental method, Project management, Information management, Literature review, Experimental design, Laboratory skills, Data analysis, Statistics, Organization, Time management, Bioinformatics, Images and Image analysis, Analytical and graphical methods, Report writing, Scientific communication Methods: Academic supervision, colleague and peer support, previous years dissertation for comparisons Assessment: Dissertation production (suggested words). 11

12 PT7007 Dissertation Content Credits 40 Semester 2 Contact: Dr JM Hennessy Assessment Arrangements: Continuous assessment Research project 280 Private study 40 (10 x 4) Scientific capability and understanding Synopsis: The module is the presentation of an advanced research project report. Aims: That the student learns how to produce scientific data form well arranged, fully controlled experiments, and can present that data so that it can be robust when critically analysed. Learning objectives: To be able to demonstrate the intellectual analysis required to place the self directed laboratory research topic within the current field of international knowledge and to demonstrate developing specialization and interests. Methods: Knowledge from taught phase assignments, supervisor instruction, second marker involvement /support throughout the appraisal process, peer and colleague support. Assessment: Supervisor, second marker and moderation by external examiner dissertation production (suggested words). Aims: Knowledge and concepts, Appraisal of evidence, Managing, reflecting on, and developing one s own learning. Learning outcomes: To be able to prepare to standard PhD thesis format (The masters dissertation is restricted to 10,000 words) the results of experiments undertaken. The report must make proper use of all aspects of the scientific method such that the student is able to defend their research. Methods: Knowledge from taught phase assignments, supervisor instruction, second marker involvement/support throughout the appraisal process, peer and colleague support Assessment: Supervisor, second marker and moderation by external examiner dissertation production. 12

13 GE7008 Research Seminar Credits 20 Semester 2 Contact: Dr JM Hennessy Assessment Arrangements: Continuous assessment Research project 140 (28 x5) Private study 40 (10 x 4) Total hours 180 Synopsis: The module is the presentation of advanced research in seminar form. Aims: To teach the students how to present scientific research to an audience. Learning objectives: That the student learns how to produce and present scientific in an audio visual form to an audience. Methods: 20 minute seminar followed by 5 minutes of questions Assessment: A panel of academic staff. Aims: Knowledge and concepts, Appraisal of evidence, Managing, reflecting on, and developing one s own ability to present research in a seminar form. Learning outcomes: To demonstrate the ability to combine verbal introduction, explanation and conclusions with the full range of standard techniques (ohp, slide, board) are expected. It should be noted however that data projection using programs such as powerpoint have now become virtually universal for the students. The data and verbal explanation must indicate well arranged, fully controlled experiments, and the student must also be able to respond verbally to critical analysis and questioning. Methods: 20 minute seminar Assessment: A panel of academic staff 13