Considerations in Medication Assisted Treatment of Opiate Dependence. AOAAM OMED Education Program Sunday, October 7, Stephen A. Wyatt, D.O.

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Considerations in Medication Assisted Treatment of Opiate Dependence. AOAAM OMED Education Program Sunday, October 7, Stephen A. Wyatt, D.O."

Transcription

1 Considerations in Medication Assisted Treatment of Opiate Dependence AOAAM OMED Education Program Sunday, October 7, 2012 Stephen A. Wyatt, D.O. Addiction Psychiatrist Middlesex Hospital Middletown, Connecticut

2 Objectives Review the development, science and prescribing policies of the currently available medications for the treatment of opiate dependence. Understand the factors important in the decision of which treatment would be indicated. Understand the factors associated with the initiation of a treatment for opiate dependence.

3 Current Treatments Medically assisted withdrawal and abstinence. Methadone maintenance Naltrexone: oral and injectable Buprenorphine/naloxone

4 Fatal Poisonings in France - Decreases with Availability of Opiate Treatment Source:Carrieri PM, 2006, Clin Infect Dis, 43: S , data from Emmanueli, et al.

5 Historical Review The 1914 Harrison was a commerce act restricting the sales of narcotics, it excluded physician treating patients In 1919 when the Harrison Act was upheld by the Supreme Court it excluded the treatment of opiate dependence: not considered a disease. No longer was it legal for physicians to prescribe opiates maintaining opiate dependence or for the treatment of the disease. Medically assisted withdrawal of opiates and abstinence was the only legal treatment. The historical records identify the relapsing nature of this disease. Hunt and Odoroff 1962, Duvall et al. 1963

6 Historical Review As the death rate of heroin injection patients continued to rise in the late 50 s and early 60 s, with a concurrent rise in associated crime, there was growing support for the establishment of opiate maintenance programs. There was an increase in Federal funding for research into treating these patients. In 1962 Vincent Dole, MD received a grant to study the feasibility of opiate maintenance treatment. In1964 Marie Nyswander, MD, psychiatrist with experience in treating addicted patients joined the research team. Methadone was eventually selected as the most efficacious opiate for maintenance treatment.

7 Historical Review The Comprehensive Drug Abuse Prevention and Control Act of 1970 was a Nixon initiative in the evolution of the war on drugs. However, included was a Dept. of Health, Education, and Welfare authorization to improve drug prevention and treatment. This included, under the direction of Jerome Jaffe, MD a federal effort to widen the availability of opiate maintenance programs.

8 Historical Review The next approved medication for Opiate dependence was naltrexone approved in As an opiate antagonist it blocks the opiate receptor significantly changing the patient response to the administration of an opiate. The lack of compliance and less reduction in craving are thought to be the prominent problems associated with poor efficacy of the oral product. A sustained release form was determined to have an adequate safety profile and to be effective by the FDA in 2010.

9 Historical Review With the establishment of DATA 2000 another treatment option was made available. This act of congress established that any class III, IV, V controlled substance with FDA approval for opiate dependence treatment could be prescribed by a qualified physician. This opened the door to buprenorphine. Resulting in availability of office based opiate treatment with an agonist medication. This further broadened the available of maintenance treatment.

10 Medication Assisted Treatment of Opiate Dependence METHADONE

11 Neurobiology: Methadone blocks the euphoric and sedating effects of other opiates; reduces the craving for other opiates relieves symptoms associated with withdrawal from opiates; does not cause euphoria or intoxication itself (with stable dosing), thus allowing a person to work and participate near normal in society; Has a long half life and is excreted slowly allowing for once a day dosing. CDC 2002

12 Methadone Treatment Methadone maintenance treatment, a program in which addicted individuals receive daily doses of methadone. Multi-component treatment program Abstinence of other drugs of abuse including alcohol Resocialization Sober supports Vocational training Coordination of healthcare HIV Hepititis C Pregnancy

13 Methadone Treatment Identified benefits include: reduced or stopped use of injection drugs; Reduced risk of acquiring or transmitting diseases such as HIV, hepatitis B or C, bacterial infections, endocarditis, soft tissue infections, thrombophlebitis, tuberculosis, and STDs; possible reduction in sexual risk taking reduced risk of overdose reduced mortality death rate of opiatedependent individuals in MMT is 30 percent that of those not in MMT; Improved Social Status reduced criminal activity; improved family stability improved employment potential; improved pregnancy outcomes. CDC 2002

14 Methadone Treatment Drawbacks Physical dependence, possibly strengthening neurobiologicaladaptation to opiate dependence. Initial daily administration at a licensed methadone treatment center Early mild to moderate opiate like effects; e.g. sedation, reduction in cognitive awareness Long term maintenance effects on hormonal adaptations; reduction in testosterone, menstruation, calcium metabolism Drug/Drug interactions Neonatal abstinence syndrome

15 Methadone Formulation Methadone for Pain or Addiction Methadone for outpatient pain treatment is in tablet form. 410,000 patients in third quarter of 2006 Methadone used in managing opioid dependence is usually liquid or wafer 260,000 patients in March, 2006 SAMHSA, N-SSATS 2007 Report

16 Percent of methadone Mentions Methadone Formulations reported RADARS System (Rocky Mountain Poison and Drug Center) Drug Diversion Opioid Treatment Program

17 Medication Assisted Treatment of Opiate Dependence NALTREXONE

18 Neurobiology: Naltrexone Naltrexone, a opiate antagonist. Attaches to the opiate receptor without activation. PET studies that a single 50 mg dose of naltrexone in a naive subject results in a 90% blockade of mu receptors at 24 hours. At 48 hours it s about 72%, and even at 96 hours some blockade is still present. No physical dependence Possible reduction in opiate craving through a combination of; blockade of the opiate receptor effecting endorphin activation and dopamine activation of the nucleus accumbens or pleasure center in the brain. Total opiate blockade reducing initial consideration of opiate use.

19 Naltrexone: Treatment Naltrexone has great potential as a therapeutic drug in assisting patients opiate treatment, Oral However the oral administration failed because primarily due to poor compliance. Extended Release (XR) Injectable has antagonist effects that last many weeks. the XR-NTX formulation currently available results in blood levels of 1-2 nanograms per milliliter (ng/ml) can provide adequate blockade for four to five weeks. compliance, remains a problem but is less problematic

20 Naltrexone Oral vs. Injection

21 Naltrexone Treatment Drawbacks Patients needs to have completed the withdrawal process prior to being started on naltrexone, Otherwise precipitated withdrawal will occur. following the injection formulation it is likely to be more intense on day 2 than day 1 May elevate liver transaminases Patients cannot be on opiate pain medication. If injected may have injection site inflammation (particularly obese patients)

22 Naltrexone Adverse effects If reinitiating opiates patient may be at increased risk due to loss of tolerance and possible upregulation. Some evidence of up-regulation of receptors in patients on naltrexone, possible increased risk of overdose deaths. At this point there is only evidence of this in rats. One study in humans was negative but this remains a concern. Vitally important to tell patients who have stopped taking naltrexone that if they do go back to using heroin, starting with anything more than a very small dose might result in death.

23 Medication Assisted Treatment of Opiate Dependence BUPRENORPHINE

24 Neurobiology: Buprenorphine Partial opiate agonist High affinity Slow dissociation Displaces other opiates including heroin Improved safety profile due to reduction in potential respiratory depression

25 Buprenorphine Treatment Approved for office based treatment Allows for normalization of treatment in the primary care or behavioral health care practices. Allows for wider availability of agonist treatment Reduces potential for overdose Once a day administration Minimal drug interaction Relative blocking of other opiates Significant reduction in craving Improved reentry into normal socialization

26 Buprenorphine Treatment Drawbacks Physical dependence, possible strengthening of the opiate dependence. Diversion for sustained opiate dependence and non-dependent abuse May reduces the drive to put in place relapse prevention behaviors due to the pharmacologic reduction in the drive to use other opiates. There is evidence of both hormonal adaptation and neonatal abstinence syndrome though less than that seen in the Methadone treated patient.

27 Medication Assisted Treatment of Opiate Dependence TREATMENT SELECTION

28 Treatment Selection Logistical considerations Access to a methadone treatment center has been a major limitation to this form of treatment Buprenorphine has limited availability due to limited access to a waivered physician, though private office availability has improved treatment access in rural areas in particular. Physician access to assistance with drug counseling Need for detoxification of opiates prior to the administration of naltrexone.

29 Treatment Selection There is significant overlap in the indications of one form of therapy over another. Patients may have a strong bias to one form of treatment over another. Honoring this may improve compliance and effectiveness. Physician knowledge and level of comfort will also be a consideration.

30 Treatment Selection Patients co-occurring medical or psychiatric problems should be considered. Poly substance abuse may need the daily oversight of MMT Mental health problems - availability of buprenorphine in medical/behavioral health specialty clinics Pregnancy - The opportunity for the patient to be treated in an established methadone maintenance pregnancy program should be a strongly considered. However, buprenorphine is gaining greater evidence of reducing both days of NAS and morphine dose following delivery.

31 Treatment Selection Methadone Access to care sometimes easier than others and sometimes not Patient in need of greater supervision Greater concerns of diversion. Limited social supports available Polysubstance abuse or dependence Possibly those with higher daily dose of opiate use prior to treatment however this is now in dispute. Concurrent chronic pain

32 Treatment Selection Naltrexone Patient currently abstinent with history of frequent relapse, opiate craving Recently incarcerated Recently detoxified from opiate maintenance treatment Not anticipating surgical treatment or pain requiring opiate treatment. Physician not waivered to use schedule III drug for office based treatment. Patient with evidence of being moderately compliant with treatment. The injectable form can be coupled to strong contingencies improving compliance and outcomes.

33 Treatment Selection Buprenorphine Access to waivered physician Access to relapse prevention treatment Possible lower level of opiate use though this is in dispute. Opportunity for coordination with other services both medical and psychiatric. The evidence of a reduction in drug-drug interaction with buprenorphine over methadone should be considered in the HIV pos. population. Moderate level of social supports available. Concurrent chronic pain

34 Treatment Selection Cost Comparison of medications vs. no medication of costs for medications, inpatient, outpatient, and pharmacy costs, 29% lower for patients who received a medication for opioid dependence versus patients treated without medication. Injectable sustained release naltrexone had fewer opioid-related and non opioid-related hospitalizations than patients receiving oral medications. Total healthcare costs were not significantly different between oral or injectable naltrexone and buprenorphine, and were 49% lower than those for methadone. This in part was a reflection on the increase co-morbidity seen in the Methadone population. Baser, AJ of Managed Care, 2011

35 Medically Assisted Opiate Treatment Abstinence remains an option particularly in the young low level dependent patient. However: There is strong evidence of improved outcomes with medication assisted treatment Patients should be made aware of their options Treatment providers should be aware of these medications to better educate patients and make appropriate treatment recommendations.

36 Conclusion There are yet clear answers to what is the best opiate treatment for a specific patient. In the end it is between the doctor and patient to determine the best fit.

Considerations in Medication Assisted Treatment of Opiate Dependence. Stephen A. Wyatt, D.O. Dept. of Psychiatry Middlesex Hospital Middletown, CT

Considerations in Medication Assisted Treatment of Opiate Dependence. Stephen A. Wyatt, D.O. Dept. of Psychiatry Middlesex Hospital Middletown, CT Considerations in Medication Assisted Treatment of Opiate Dependence Stephen A. Wyatt, D.O. Dept. of Psychiatry Middlesex Hospital Middletown, CT Disclosures Speaker Panels- None Grant recipient - SAMHSA

More information

Methadone. Buprenorphine 10/9/2015

Methadone. Buprenorphine 10/9/2015 Medication Assisted Treatment for Opioid Addiction Tanya Hiser, MS, LPC Premier Care of Wisconsin, LLC October 21, 2015 How Did We Get Here? Civil War veterans and women 19th Century physicians cautious

More information

Treatment of Opioid Dependence with Buprenorphine/Naloxone (Suboxone )

Treatment of Opioid Dependence with Buprenorphine/Naloxone (Suboxone ) Treatment of Opioid Dependence with Buprenorphine/Naloxone (Suboxone ) Elinore F. McCance-Katz, M.D., Ph.D. Professor and Chair, Addiction Psychiatry Virginia Commonwealth University Neurobiology of Opiate

More information

EPIDEMIOLOGY OF OPIATE USE

EPIDEMIOLOGY OF OPIATE USE Opiate Dependence EPIDEMIOLOGY OF OPIATE USE Difficult to estimate true extent of opiate dependence Based on National Survey of Health and Mental Well Being: 1.2% sample used opiates in last 12 months

More information

Neurobiology and Treatment of Opioid Dependence. Nebraska MAT Training September 29, 2011

Neurobiology and Treatment of Opioid Dependence. Nebraska MAT Training September 29, 2011 Neurobiology and Treatment of Opioid Dependence Nebraska MAT Training September 29, 2011 Top 5 primary illegal drugs for persons age 18 29 entering treatment, % 30 25 20 15 10 Heroin or Prescription Opioids

More information

Treatment of opioid use disorders

Treatment of opioid use disorders Treatment of opioid use disorders Gerardo Gonzalez, MD Associate Professor of Psychiatry Director, Division of Addiction Psychiatry Disclosures I have no financial conflicts to disclose I will review evidence

More information

Substitution Therapy for Opioid Dependence The Role of Suboxone. Mandy Manak, MD, ABAM, CCSAM Methadone 101-Hospitalist Workshop, October 3, 2015

Substitution Therapy for Opioid Dependence The Role of Suboxone. Mandy Manak, MD, ABAM, CCSAM Methadone 101-Hospitalist Workshop, October 3, 2015 Substitution Therapy for Opioid Dependence The Role of Suboxone Mandy Manak, MD, ABAM, CCSAM Methadone 101-Hospitalist Workshop, October 3, 2015 Objectives Recognize the options available in treating opioid

More information

DEVELOPING MANUFACTURING SUPPLYING. Naltrexone Implants. Manufactured by NalPharm Ltd WWW.NALPHARM.COM

DEVELOPING MANUFACTURING SUPPLYING. Naltrexone Implants. Manufactured by NalPharm Ltd WWW.NALPHARM.COM DEVELOPING MANUFACTURING SUPPLYING Naltrexone Implants Background to Nalpharm NalPharm is a specialist pharmaceutical company supplying proprietary branded medications and generic drugs in the area of

More information

Medication Assisted Therapy and Pregnancy: An Introduction

Medication Assisted Therapy and Pregnancy: An Introduction Medication Assisted Therapy and Pregnancy: An Introduction Deborah A. Orr, Ph.D. The Center For Drug Free Living Adapted from the NIDA Blending Initiative Curriculum Presentation Objectives Define opioids

More information

MEDICATION ASSISTED TREATMENT (MAT)

MEDICATION ASSISTED TREATMENT (MAT) MEDICATION ASSISTED TREATMENT (MAT) STATISTICS: ALCOHOL AND OPIOID USE Last year 33 Iowans died from opioid overdose deaths; an additional 19 individuals died of a heroin overdose. The number of drug overdose

More information

Beyond SBIRT: Integrating Addiction Medicine into Primary Care

Beyond SBIRT: Integrating Addiction Medicine into Primary Care Beyond SBIRT: Integrating Addiction Medicine into Primary Care Community Clinic Association of Los Angeles County 14 th Annual Health Care Symposium March 6, 2015 Keith Heinzerling MD, Karen Lamp MD; Allison

More information

Frequently asked questions

Frequently asked questions Naltrexone Pellet Treatment for Opiate, Heroin, and Alcohol Addiction Frequently asked questions What is Naltrexone? Naltrexone is a prescription drug that completely blocks the effects of all opioid drugs

More information

One example: Chapman and Huygens, 1988, British Journal of Addiction

One example: Chapman and Huygens, 1988, British Journal of Addiction This is a fact in the treatment of alcohol and drug abuse: Patients who do well in treatment do well in any treatment and patients who do badly in treatment do badly in any treatment. One example: Chapman

More information

MEDICATION ASSISTED TREATMENT FOR OPIOID ADDICTION

MEDICATION ASSISTED TREATMENT FOR OPIOID ADDICTION MEDICATION ASSISTED TREATMENT FOR OPIOID ADDICTION Sidarth Wakhlu,M.D. Addiction Team Leader North Texas VA Health Care System Addiction Psychiatry Fellowship Director Associate Professor Of Psychiatry

More information

Naltrexone Pellet Treatment for Opiate, Heroin, and Alcohol Addiction. Frequently Asked Questions

Naltrexone Pellet Treatment for Opiate, Heroin, and Alcohol Addiction. Frequently Asked Questions Naltrexone Pellet Treatment for Opiate, Heroin, and Alcohol Addiction Frequently Asked Questions What is Naltrexone? Naltrexone is a prescription drug that effectively blocks the effects of heroin, alcohol,

More information

Using Drugs to Treat Drug Addiction How it works and why it makes sense

Using Drugs to Treat Drug Addiction How it works and why it makes sense Using Drugs to Treat Drug Addiction How it works and why it makes sense Jeff Baxter, MD University of Massachusetts Medical School May 17, 2011 Objectives Biological basis of addiction Is addiction a chronic

More information

Integrating Medication- Assisted Treatment (MAT) for Opioid Use Disorders into Behavioral and Physical Healthcare Settings

Integrating Medication- Assisted Treatment (MAT) for Opioid Use Disorders into Behavioral and Physical Healthcare Settings Integrating Medication- Assisted Treatment (MAT) for Opioid Use Disorders into Behavioral and Physical Healthcare Settings All-Ohio Conference 3/27/2015 Christina M. Delos Reyes, MD Medical Consultant,

More information

Ohio Legislative Service Commission

Ohio Legislative Service Commission Ohio Legislative Service Commission Bill Analysis Brian D. Malachowsky H.B. 378 130th General Assembly () Reps. Smith and Sprague BILL SUMMARY Prohibits a physician from prescribing or personally furnishing

More information

Frequently Asked Questions (FAQ s): Medication-Assisted Treatment for Opiate Addiction

Frequently Asked Questions (FAQ s): Medication-Assisted Treatment for Opiate Addiction Frequently Asked Questions (FAQ s): Medication-Assisted Treatment for Opiate Addiction March 3, 2008 By: David Rinaldo, Ph.D., Managing Partner, The Avisa Group In this FAQ What medications are currently

More information

Care Management Council submission date: August 2013. Contact Information

Care Management Council submission date: August 2013. Contact Information Clinical Practice Approval Form Clinical Practice Title: Acute use of Buprenorphine for the Treatment of Opioid Dependence and Detoxification Type of Review: New Clinical Practice Revisions of Existing

More information

Like cocaine, heroin is a drug that is illegal in some areas of the world. Heroin is highly addictive.

Like cocaine, heroin is a drug that is illegal in some areas of the world. Heroin is highly addictive. Heroin Introduction Heroin is a powerful drug that affects the brain. People who use it can form a strong addiction. Addiction is when a drug user can t stop taking a drug, even when he or she wants to.

More information

Medication is not a part of treatment.

Medication is not a part of treatment. Medication is not a part of treatment. Medication can be an effective part of treatment. Medication is used in the treatment of many diseases, including addiction. Medical decisions must be made by trained

More information

Ever wish you could... Quit using heroin? Protect yourself from HIV infection? Get healthier?

Ever wish you could... Quit using heroin? Protect yourself from HIV infection? Get healthier? Ever wish you could... Quit using heroin? Protect yourself from HIV infection? Get healthier? Good News: Medical treatments called opioid (oh-pee-oyd) maintenance can help you! Injecting heroin puts you

More information

Update on Buprenorphine: Induction and Ongoing Care

Update on Buprenorphine: Induction and Ongoing Care Update on Buprenorphine: Induction and Ongoing Care Elizabeth F. Howell, M.D., DFAPA, FASAM Department of Psychiatry, University of Utah School of Medicine North Carolina Addiction Medicine Conference

More information

Medication treatments for opioid use disorders

Medication treatments for opioid use disorders Medication treatments for opioid use disorders Summary for counties JUDITH MARTIN, Medical Director of Substance Use Services, San Francisco Department of Public Health Brief history of Methadone and Buprenorphine

More information

Joel Millard, DSW, LCSW Dave Felt, LCSW

Joel Millard, DSW, LCSW Dave Felt, LCSW Joel Millard, DSW, LCSW Dave Felt, LCSW 1. Provide an overview of the effectiveness of medication assisted treatment, to include a discussion of the different types of medications and how they are used

More information

ARCHIVED BULLETIN. Product No. 2004-L0424-013 SEPTEMBER 2004 U. S. D E P A R T M E N T O F J U S T I C E

ARCHIVED BULLETIN. Product No. 2004-L0424-013 SEPTEMBER 2004 U. S. D E P A R T M E N T O F J U S T I C E BULLETIN INTELLIGENCE Product No. 2004-L0424-013 SEPTEMBER 2004 U. S. D E P A R T M E N T O F J U S T I C E NDIC Within the past 2 years buprenorphine a Schedule III drug has been made available for use

More information

Opiate Addiction and the Prescription Drug Crisis. Paul Updike, MD Medical Director of Chemical Dependency Services, Catholic Health System

Opiate Addiction and the Prescription Drug Crisis. Paul Updike, MD Medical Director of Chemical Dependency Services, Catholic Health System Opiate Addiction and the Prescription Drug Crisis Paul Updike, MD Medical Director of Chemical Dependency Services, Catholic Health System Objectives Define what addiction is Describe what opiates are

More information

The Use of Non-Opioid Pharmacotherapies. for the Treatment of Alcohol Dependence

The Use of Non-Opioid Pharmacotherapies. for the Treatment of Alcohol Dependence M00K02 Alcohol and Drug Abuse Administration Department of Health and Mental Hygiene The Use of Non-Opioid Pharmacotherapies for the Treatment of Alcohol Dependence Introduction The 2011 Joint Chairmen

More information

MEDICATION ASSISTED TREATMENT FOR OPIOID ADDICTION

MEDICATION ASSISTED TREATMENT FOR OPIOID ADDICTION MEDICATION ASSISTED TREATMENT FOR OPIOID ADDICTION Mark Fisher Program Administrator State Opioid Treatment Adminstrator Kentucky Division of Behavioral Health OBJECTIVES Learn about types of opioids and

More information

Hulpverleningsmodellen bij opiaatverslaving. Frieda Matthys 6 juni 2013

Hulpverleningsmodellen bij opiaatverslaving. Frieda Matthys 6 juni 2013 Hulpverleningsmodellen bij opiaatverslaving Frieda Matthys 6 juni 2013 Prevalence The average prevalence of problem opioid use among adults (15 64) is estimated at 0.41%, the equivalent of 1.4 million

More information

Heroin. How is Heroin Abused? What Other Adverse Effects Does Heroin Have on Health? How Does Heroin Affect the Brain?

Heroin. How is Heroin Abused? What Other Adverse Effects Does Heroin Have on Health? How Does Heroin Affect the Brain? Heroin Heroin is a synthetic opiate drug that is highly addictive. It is made from morphine, a naturally occurring substance extracted from the seed pod of the Asian opium poppy plant. Heroin usually appears

More information

Office-based Treatment of Opioid Dependence with Buprenorphine

Office-based Treatment of Opioid Dependence with Buprenorphine Office-based Treatment of Opioid Dependence with Buprenorphine David A. Fiellin, M.D Professor of Medicine, Investigative Medicine and Public Health Yale University School of Medicine Dr. Fiellin s Disclosures

More information

Applicant Webinar for BJA s Drug Court Discretionary Grant Solicitation

Applicant Webinar for BJA s Drug Court Discretionary Grant Solicitation Applicant Webinar for BJA s Drug Court Discretionary Grant Solicitation Cynthia Caporizzo, Senior Criminal Justice Advisor, Office of National Drug Control Policy (ONDCP) - Review of the administration

More information

Medication Assisted Treatment of Substance Use Disorders. Michael Ballue, CADC II, BSBA Geoff Kane, MD, MPH

Medication Assisted Treatment of Substance Use Disorders. Michael Ballue, CADC II, BSBA Geoff Kane, MD, MPH Medication Assisted Treatment of Substance Use Disorders Michael Ballue, CADC II, BSBA Geoff Kane, MD, MPH 1 Addiction: The Bare Essentials 2 Addiction The Person: Loss of Control The Observer: Persistent

More information

Treatment Approaches for Drug Addiction

Treatment Approaches for Drug Addiction Treatment Approaches for Drug Addiction NOTE: This is a fact sheet covering research findings on effective treatment approaches for drug abuse and addiction. If you are seeking treatment, please call 1-800-662-HELP(4357)

More information

Medications for Alcohol and Drug Dependence Treatment

Medications for Alcohol and Drug Dependence Treatment Medications for Alcohol and Drug Dependence Treatment Robert P. Schwartz, M.D. Medical Director Rschwartz@friendsresearch.org Friends Research Institute Medications for Alcohol Dependence Treatment Disulfiram

More information

TENNESSEE BOARD OF MEDICAL EXAMINERS POLICY STATEMENT OFFICE-BASED TREATMENT OF OPIOID ADDICTION

TENNESSEE BOARD OF MEDICAL EXAMINERS POLICY STATEMENT OFFICE-BASED TREATMENT OF OPIOID ADDICTION TENNESSEE BOARD OF MEDICAL EXAMINERS POLICY STATEMENT OFFICE-BASED TREATMENT OF OPIOID ADDICTION The Tennessee Board of Medical Examiners has reviewed the Model Policy Guidelines for Opioid Addiction Treatment

More information

EPIDEMIC 4.6 % OF INDIVIDUALS 18 25 USED PAIN RELIEVERS FOR NON-MEDICAL REASONS. 1.5 MILLION YOUNG ADULTS USED PAIN RELIEVERS IN THE PAST MONTH.

EPIDEMIC 4.6 % OF INDIVIDUALS 18 25 USED PAIN RELIEVERS FOR NON-MEDICAL REASONS. 1.5 MILLION YOUNG ADULTS USED PAIN RELIEVERS IN THE PAST MONTH. Drug Court EPIDEMIC In the 10 years (1997 2007) the per capita retail purchases of Methadone, Hydrocodone and Oxycodone in the United States increased 13-fold, 4-fold and 9-fold, respectively. 4.6 % OF

More information

Heroin. How Is Heroin Abused? How Does Heroin Affect the Brain? What Other Adverse Effects Does Heroin Have on Health?

Heroin. How Is Heroin Abused? How Does Heroin Affect the Brain? What Other Adverse Effects Does Heroin Have on Health? Heroin Heroin is an opiate drug that is synthesized from morphine, a naturally occurring substance extracted from the seed pod of the Asian opium poppy plant. Heroin usually appears as a white or brown

More information

Treatment Approaches for Drug Addiction

Treatment Approaches for Drug Addiction Treatment Approaches for Drug Addiction [NOTE: This is a fact sheet covering research findings on effective treatment approaches for drug abuse and addiction. If you are seeking treatment, please call

More information

Death in the Suburbs: How Prescription Painkillers and Heroin Have Changed Treatment and Recovery

Death in the Suburbs: How Prescription Painkillers and Heroin Have Changed Treatment and Recovery Death in the Suburbs: How Prescription Painkillers and Heroin Have Changed Treatment and Recovery Marvin D. Seppala, MD Chief Medical Officer Hazelden Betty Ford Foundation This product is supported by

More information

Dependence and Addiction. Marek C. Chawarski, Ph.D. Yale University David Metzger, Ph.D. University of Pennsylvania

Dependence and Addiction. Marek C. Chawarski, Ph.D. Yale University David Metzger, Ph.D. University of Pennsylvania Dependence and Addiction Marek C. Chawarski, Ph.D. Yale University David Metzger, Ph.D. University of Pennsylvania Overview Heroin and other opiates The disease of heroin addiction or dependence Effective

More information

Information for Pharmacists

Information for Pharmacists Page 43 by 42 CFR part 2. A general authorization for the release of medical or other information is NOT sufficient for this purpose. Information for Pharmacists SUBOXONE (buprenorphine HCl/naloxone HCl

More information

IN THE GENERAL ASSEMBLY STATE OF. Ensuring Access to Medication Assisted Treatment Act

IN THE GENERAL ASSEMBLY STATE OF. Ensuring Access to Medication Assisted Treatment Act IN THE GENERAL ASSEMBLY STATE OF Ensuring Access to Medication Assisted Treatment Act 1 Be it enacted by the People of the State of Assembly:, represented in the General 1 1 1 1 Section 1. Title. This

More information

Opioid Treatment Services, Office-Based Opioid Treatment

Opioid Treatment Services, Office-Based Opioid Treatment Optum 1 By United Behavioral Health U.S. Behavioral Health Plan, California Doing Business as OptumHealth Behavioral Solutions of California ( OHBS-CA ) 2015 Level of Care Guidelines Opioid Treatment Services,

More information

Suboxone Programs: Treating Opioid Dependence in CHCs Andrew Putney, MD Medical Director SSTAR ATS and CHC, Fall River, Massachusetts

Suboxone Programs: Treating Opioid Dependence in CHCs Andrew Putney, MD Medical Director SSTAR ATS and CHC, Fall River, Massachusetts Suboxone Programs: Treating Opioid Dependence in CHCs Andrew Putney, MD Medical Director SSTAR ATS and CHC, Fall River, Massachusetts Educational Objectives: Review epidemiology of opioid addiction in

More information

Prior Authorization Guideline

Prior Authorization Guideline Prior Authorization Guideline Guideline: CSD - Suboxone Therapeutic Class: Central Nervous System Agents Therapeutic Sub-Class: Analgesics and Antipyretics (Opiate Partial Agonists) Client: County of San

More information

Opiate Abuse and Mental Illness

Opiate Abuse and Mental Illness visited on Page 1 of 5 LEARN MORE (HTTP://WWW.NAMI.ORG/LEARN-MORE) FIND SUPPORT (HTTP://WWW.NAMI.ORG/FIND-SUPPORT) GET INVOLVED (HTTP://WWW.NAMI.ORG/GET-INVOLVED) DONATE (HTTPS://NAMI360.NAMI.ORG/EWEB/DYNAMICPAGE.ASPX?

More information

Section Editor Andrew J Saxon, MD

Section Editor Andrew J Saxon, MD Official reprint from UpToDate www.uptodate.com 2015 UpToDate Pharmacotherapy for opioid use disorder Author Eric Strain, MD Section Editor Andrew J Saxon, MD Deputy Editor Richard Hermann, MD All topics

More information

Use of Vivitrol for Alcohol and Opioid Addiction

Use of Vivitrol for Alcohol and Opioid Addiction Use of Vivitrol for Alcohol and Opioid Addiction Ken Bachrach, Ph.D. Clinical Director, Tarzana Treatment Centers, Inc. kbachrach@tarzanatc.org What is Vivitrol? An injectable from of naltrexone, which

More information

Opioid Addiction and Methadone: Myths and Misconceptions. Nicole Nakatsu WRHA Practice Development Pharmacist

Opioid Addiction and Methadone: Myths and Misconceptions. Nicole Nakatsu WRHA Practice Development Pharmacist Opioid Addiction and Methadone: Myths and Misconceptions Nicole Nakatsu WRHA Practice Development Pharmacist Learning Objectives By the end of this presentation you should be able to: Understand how opioids

More information

BUPRENORPHINE TREATMENT

BUPRENORPHINE TREATMENT BUPRENORPHINE TREATMENT Curriculum Infusion Package (CIP) Based on the Work of Dr. Thomas Freese of the Pacific Southwest ATTC Drug Addiction Treatment Act of 2000 (DATA 2000) Developed by Mountain West

More information

Using Buprenorphine in an Opioid Treatment Program

Using Buprenorphine in an Opioid Treatment Program Using Buprenorphine in an Opioid Treatment Program Thomas E. Freese, PhD Director of Training, UCLA Integrated Substance Abuse Programs Director, Pacific Southwest Addiction Technology Transfer Center

More information

Joanna L. Starrels. 2 ND YEAR RESEARCH ELECTIVE RESIDENT S JOURNAL Volume VIII, 2003-2004. A. Study Purpose and Rationale

Joanna L. Starrels. 2 ND YEAR RESEARCH ELECTIVE RESIDENT S JOURNAL Volume VIII, 2003-2004. A. Study Purpose and Rationale Outpatient Treatment of Opiate Dependence with Sublingual Buprenorphine/Naloxone versus Methadone Maintenance: a Randomized Trial of Alternative Treatments in Real Life Settings Joanna L. Starrels A. Study

More information

Medication-Assisted Addiction Treatment

Medication-Assisted Addiction Treatment Medication-Assisted Addiction Treatment Molly Carney, Ph.D., M.B.A. Executive Director Evergreen Treatment Services Seattle, WA What is MAT? MAT is the use of medications, in combination with counseling

More information

Treatment for Addiction in the Community Reduces Drug Use, Crime and Recidivism

Treatment for Addiction in the Community Reduces Drug Use, Crime and Recidivism Treatment for Addiction in the Community Reduces Drug Use, Crime and Recidivism Richard A. Rawson, Ph.D, Professor Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine University

More information

Update and Review of Medication Assisted Treatments

Update and Review of Medication Assisted Treatments Update and Review of Medication Assisted Treatments for Opiate and Alcohol Use Disorders Richard N. Whitney, MD Medical Director Addiction Services Shepherd Hill Newark, Ohio Medication Assisted Treatment

More information

Heroin. How Is Heroin Abused? How Does Heroin Affect the Brain? What Other Adverse Effects Does Heroin Have on Health?

Heroin. How Is Heroin Abused? How Does Heroin Affect the Brain? What Other Adverse Effects Does Heroin Have on Health? Heroin Heroin is an opiate drug that is synthesized from morphine, a naturally occurring substance extracted from the seed pod of the Asian opium poppy plant. Heroin usually appears as a white or brown

More information

DrugFacts: Treatment Approaches for Drug Addiction

DrugFacts: Treatment Approaches for Drug Addiction DrugFacts: Treatment Approaches for Drug Addiction NOTE: This is a fact sheet covering research findings on effective treatment approaches for drug abuse and addiction. If you are seeking treatment, please

More information

The Federation of State Medical Boards 2013 Model Guidelines for Opioid Addiction Treatment in the Medical Office

The Federation of State Medical Boards 2013 Model Guidelines for Opioid Addiction Treatment in the Medical Office The Federation of State Medical Boards 2013 Model Guidelines for Opioid Addiction Treatment in the Medical Office Adopted April 2013 for Consideration by State Medical Boards 2002 FSMB Model Guidelines

More information

Treatment of Opioid Dependence: A Randomized Controlled Trial. Karen L. Sees, DO, Kevin L. Delucchi, PhD, Carmen Masson, PhD, Amy

Treatment of Opioid Dependence: A Randomized Controlled Trial. Karen L. Sees, DO, Kevin L. Delucchi, PhD, Carmen Masson, PhD, Amy Category: Heroin Title: Methadone Maintenance vs 180-Day psychosocially Enriched Detoxification for Treatment of Opioid Dependence: A Randomized Controlled Trial Authors: Karen L. Sees, DO, Kevin L. Delucchi,

More information

Quick Guide. For Physicians. Based on TIP 40 Clinical Guidelines for the Use of Buprenorphine in the Treatment. of Opioid Addiction TIP

Quick Guide. For Physicians. Based on TIP 40 Clinical Guidelines for the Use of Buprenorphine in the Treatment. of Opioid Addiction TIP Buprenorphine Clinical Guide Quick Guide For Physicians Based on TIP 40 Clinical Guidelines for the Use of Buprenorphine in the Treatment Clinical Guidelines for the Use of Buprenorphine in the Treatment

More information

Buprenorphine/Naloxone Maintenance Treatment for Opioid Dependence

Buprenorphine/Naloxone Maintenance Treatment for Opioid Dependence Buprenorphine/Naloxone Maintenance Treatment for Opioid Dependence Information for Family Members Family members of patients who have been prescribed buprenorphine/naloxone for treatment of opioid addiction

More information

Use of Buprenorphine in the Treatment of Opioid Addiction

Use of Buprenorphine in the Treatment of Opioid Addiction Use of Buprenorphine in the Treatment of Opioid Addiction Multiple Choice Identify the choice that best completes the statement or answers the question. 1. Executive Summary Which of the following is an

More information

Prescriber Behavior, Pain Treatment and Addiction Treatment

Prescriber Behavior, Pain Treatment and Addiction Treatment Prescriber Behavior, Pain Treatment and Addiction Treatment Mary Fleming, M.S. Director, Office of Policy, Planning, and Innovation Substance Abuse and Mental Health Services Administration NGA Policy

More information

A G U I D E F O R U S E R S N a l t r e x o n e U

A G U I D E F O R U S E R S N a l t r e x o n e U A GUIDE FOR USERS UNaltrexone abstinence not using a particular drug; being drug-free. opioid antagonist a drug which blocks the effects of opioid drugs. dependence the drug has become central to a person

More information

TREATMENT MODALITIES. May, 2013

TREATMENT MODALITIES. May, 2013 TREATMENT MODALITIES May, 2013 Treatment Modalities New York State Office of Alcoholism and Substance Abuse Services (NYS OASAS) regulates the addiction treatment modalities offered in New York State.

More information

CLINICAL POLICY Department: Medical Management Document Name: Vivitrol Reference Number: NH.PHAR.96 Effective Date: 03/12

CLINICAL POLICY Department: Medical Management Document Name: Vivitrol Reference Number: NH.PHAR.96 Effective Date: 03/12 Page: 1 of 7 IMPORTANT REMINDER This Clinical Policy has been developed by appropriately experienced and licensed health care professionals based on a thorough review and consideration of generally accepted

More information

Opiate Addiction in Ohio: An Update on Scope of Problem Ashland Ohio

Opiate Addiction in Ohio: An Update on Scope of Problem Ashland Ohio Governor s Cabinet Opiate Action Team Promoting Wellness and Recovery John R. Kasich, Governor Tracy J. Plouck, Director Opiate Addiction in Ohio: An Update on Scope of Problem Ashland Ohio November 14,

More information

New York State Office of Alcoholism & Substance Abuse Services Addiction Services for Prevention, Treatment, Recovery

New York State Office of Alcoholism & Substance Abuse Services Addiction Services for Prevention, Treatment, Recovery New York State Office of Alcoholism & Substance Abuse Services Addiction Services for Prevention, Treatment, Recovery USING THE 48 HOUR OBSERVATION BED USING THE 48 HOUR OBSERVATION BED Detoxification

More information

Buprenorphine: what is it & why use it?

Buprenorphine: what is it & why use it? Buprenorphine: what is it & why use it? Dr Nicholas Lintzeris, MBBS, PhD, FAChAM Locum Consultant, Oaks Resource Centre, SLAM National Addiction Centre, Institute of Psychiatry Overview of presentation

More information

Non medical use of prescription medicines existing WHO advice

Non medical use of prescription medicines existing WHO advice Non medical use of prescription medicines existing WHO advice Nicolas Clark Management of Substance Abuse Team WHO, Geneva Vienna, June 2010 clarkn@who.int Medical and Pharmaceutical role Recommendations

More information

Presentation to Senate Health and Human Services Committee: Prescription Drug Abuse in Texas

Presentation to Senate Health and Human Services Committee: Prescription Drug Abuse in Texas Presentation to Senate Health and Human Services Committee: Prescription Drug Abuse in Texas David Lakey, MD Commissioner, Department of State Health Services Lauren Lacefield Lewis Assistant Commissioner,

More information

Impact of Systematic Review on Health Services: The US Experience

Impact of Systematic Review on Health Services: The US Experience Impact of Systematic Review on Health Services: The US Experience Walter Ling MD Integrated Substance Abuse Programs (ISAP) UCLA The effectiveness of interventions for addictions: The Drug and Alcohol

More information

MEDICAL ASSISTANCE BULLETIN

MEDICAL ASSISTANCE BULLETIN ISSUE DATE September 4, 2015 SUBJECT EFFECTIVE DATE September 9, 2015 MEDICAL ASSISTANCE BULLETIN NUMBER *See below BY Prior Authorization of Opiate Dependence Treatments, Oral Buprenorphine Agents - Pharmacy

More information

Assessment and Management of Opioid, Benzodiazepine, and Sedative-Hypnotic Withdrawal

Assessment and Management of Opioid, Benzodiazepine, and Sedative-Hypnotic Withdrawal Assessment and Management of Opioid, Benzodiazepine, and Sedative-Hypnotic Withdrawal Roger Cicala, M. D. Assistant Medical Director Tennessee Physician s Wellness Program Step 1 Don t 1 It is legal in

More information

Federal Response to Opioid Abuse Epidemic

Federal Response to Opioid Abuse Epidemic Healthcare Committee Federal Response to Opioid Abuse Epidemic On May 1, 20215 the Energy and Commerce Subcommittee on Oversight and Investigations held a hearing entitled What is the Federal Government

More information

Opioid Dependence Treatment with Buprenorphine/Naloxone: An Overview for Pharmacists and Physicians

Opioid Dependence Treatment with Buprenorphine/Naloxone: An Overview for Pharmacists and Physicians Opioid Dependence Treatment with Buprenorphine/Naloxone: An Overview for Pharmacists and Physicians Phyllis A. Grauer, PharmD, CGP, CPE Clinical Pharmacist Legislation Passed Enabling Office Based Treatment

More information

FRN Research Report January 2012: Treatment Outcomes for Opiate Addiction at La Paloma

FRN Research Report January 2012: Treatment Outcomes for Opiate Addiction at La Paloma FRN Research Report January 2012: Treatment Outcomes for Opiate Addiction at La Paloma Background A growing opiate abuse epidemic has highlighted the need for effective treatment options. This study documents

More information

Opioid Agonist Therapy: The Duration Dilemma Edwin A. Salsitz, MD, FASAM Mount Sinai Beth Israel, New York, NY March 10, 2015

Opioid Agonist Therapy: The Duration Dilemma Edwin A. Salsitz, MD, FASAM Mount Sinai Beth Israel, New York, NY March 10, 2015 Q: I have read 40 mg of methadone stops withdrawal, so why don t we start at 30mg and maybe later in the day add 10mg? A: Federal Regulations stipulate that 30mg is the maximum first dose in an Opioid

More information

Heroin Overdose Trends and Treatment Options. Neil A. Capretto, D.O., F.A.S.A.M. Medical Director

Heroin Overdose Trends and Treatment Options. Neil A. Capretto, D.O., F.A.S.A.M. Medical Director Heroin Overdose Trends and Treatment Options Neil A. Capretto, D.O., F.A.S.A.M. Medical Director Type date here www.gatewayrehab.org Drug Overdose Deaths Increasing in Allegheny County Roberta Lojak holds

More information

What Is Opioid Use Disorder?

What Is Opioid Use Disorder? What Is Opioid Use Disorder? Implications for Its Treatment and Management Ron Jackson, M.S.W., L.I.C.S.W. Affiliate Professor School of Social Work University of Washington Opioid Use Disorder: DSM-5

More information

Tufts Health Care Institute Program on Opioid Risk Management Pharmacotherapy for Prescription Opioid Addiction: Implications for Pain Management

Tufts Health Care Institute Program on Opioid Risk Management Pharmacotherapy for Prescription Opioid Addiction: Implications for Pain Management Tufts Health Care Institute Program on Opioid Risk Management Pharmacotherapy for Prescription Opioid Addiction: Implications for Pain Management June 10 and 11, 2011 Executive Summary Introduction Opioid

More information

Allyse Adams PC, LICDC Oriana House, Inc.

Allyse Adams PC, LICDC Oriana House, Inc. Allyse Adams PC, LICDC Oriana House, Inc. 98 Heroin Overdose Deaths from 1/1/2015-7/26/2015 Last year enough narcotic pain medicines were prescribed to supply 67 pills to every man, woman and child In

More information

Developing Medications to Treat Addiction: Implications for Policy and Practice. Nora D. Volkow, M.D. Director National Institute on Drug Abuse

Developing Medications to Treat Addiction: Implications for Policy and Practice. Nora D. Volkow, M.D. Director National Institute on Drug Abuse Developing Medications to Treat Addiction: Implications for Policy and Practice Nora D. Volkow, M.D. Director National Institute on Drug Abuse Medications Currently Available For Nicotine Addiction Nicotine

More information

The Results of a Pilot of Vivitrol: A Medication Assisted Treatment for Alcohol and Opioid Addiction

The Results of a Pilot of Vivitrol: A Medication Assisted Treatment for Alcohol and Opioid Addiction The Results of a Pilot of Vivitrol: A Medication Assisted Treatment for Alcohol and Opioid Addiction James H. Barger, MD SAPC Medical Director and Science Officer Desiree A. Crevecoeur-MacPhail, Ph.D.

More information

Medication Assisted Treatment

Medication Assisted Treatment Medication Assisted Treatment Tanya Hiser, MS, LPC State Opioid Treatment Authority Bureau Of Prevention, Treatment, & Recovery State of Wisconsin Elizabeth Collier, MSW, CSAC, ICS, LCSW TANF Best Practice

More information

Narcotic Replacement Therapy Policy San Mateo County Alcohol and Other Drug Services. Lea Goldstein, Ph.D. Brian Greenberg, Ph.D.

Narcotic Replacement Therapy Policy San Mateo County Alcohol and Other Drug Services. Lea Goldstein, Ph.D. Brian Greenberg, Ph.D. Narcotic Replacement Therapy Policy San Mateo County Alcohol and Other Drug Services Lea Goldstein, Ph.D. Brian Greenberg, Ph.D. The Narcotic Replacement Therapy (NRT) Policy Narcotic replacement programs

More information

Low dose naltrexone secondary progressive ms

Low dose naltrexone secondary progressive ms Low dose naltrexone secondary progressive ms Findings to date of these studies effects of naltrexone patients were randomized dosr receive either could overcome low dose naltrexone secondary progressive

More information

Program Assistance Letter

Program Assistance Letter Program Assistance Letter DOCUMENT NUMBER: 2004-01 DATE: December 5, 2003 DOCUMENT TITLE: Use of Buprenorphine in Health Center Substance Abuse Treatment Programs TO: All Bureau of Primary Health Care

More information

John R. Kasich, Governor Orman Hall, Director

John R. Kasich, Governor Orman Hall, Director John R. Kasich, Governor Orman Hall, Director 2 3 Epidemics of unintentional drug overdoses in Ohio, 1979-2011 1,2,3 1800 1600 1400 1200 1000 800 Prescription drugs are causing a larger overdose epidemic

More information

Minimum Insurance Benefits for Patients with Opioid Use Disorder The Opioid Use Disorder Epidemic: The Evidence for Opioid Treatment:

Minimum Insurance Benefits for Patients with Opioid Use Disorder The Opioid Use Disorder Epidemic: The Evidence for Opioid Treatment: Minimum Insurance Benefits for Patients with Opioid Use Disorder By David Kan, MD and Tauheed Zaman, MD Adopted by the California Society of Addiction Medicine Committee on Opioids and the California Society

More information

Medications to address the opioid crisis - methadone, buprenorphine, naltrexone, and naloxone

Medications to address the opioid crisis - methadone, buprenorphine, naltrexone, and naloxone Medications to address the opioid crisis - methadone, buprenorphine, naltrexone, and naloxone Alexander Y. Walley, MD, MSc Director, Addiction Medicine Fellowship and Addiction Medicine Consult Service

More information

Medication-Assisted Treatment for Opiate Addiction and the Public Financing of that Treatment

Medication-Assisted Treatment for Opiate Addiction and the Public Financing of that Treatment Medication-Assisted Treatment for Opiate Addiction and the Public Financing of that Treatment Introduction March 3, 2008 By: Suzanne Gelber, MSW, Ph.D., Managing Partner, The Avisa Group Defining Characteristics

More information

Increasing Issues of Polypharmacy and Off-Label Drug Use in Psychiatric Care

Increasing Issues of Polypharmacy and Off-Label Drug Use in Psychiatric Care Increasing Issues of Polypharmacy and Off-Label Drug Use in Psychiatric Care Stefan P. Kruszewski, MD Board Certified in Adult, Geriatric, Adolescent and Addiction Psychiatry, and Addiction Medicine Speaker

More information

Opioid Prescribing for Chronic Pain: Guidelines for Marin County Clinicians

Opioid Prescribing for Chronic Pain: Guidelines for Marin County Clinicians Opioid Prescribing for Chronic Pain: Guidelines for Marin County Clinicians Although prescription pain medications are intended to improve the lives of people with pain, their increased use and misuse

More information

Substance Abuse lifestyle Concern for mother - fetus - and - neonate

Substance Abuse lifestyle Concern for mother - fetus - and - neonate OBJECTIVES Learn about types of opioids and associated withdrawal symptoms Learn what medications are available to treat opioid addiction Understand the pros and cons associated with each medication Understand

More information

We re glad you are here! Agenda for the Day Breaks Lunch Q&A and note cards Phones

We re glad you are here! Agenda for the Day Breaks Lunch Q&A and note cards Phones We re glad you are here! Agenda for the Day Breaks Lunch Q&A and note cards Phones Learn about the history of opioid addiction and discuss what is happening today in Kentucky Learn about the disease of

More information

Medication-Assisted Treatment for Opioid Addiction

Medication-Assisted Treatment for Opioid Addiction Medication-Assisted Treatment for Opioid Addiction This document contains a general discussion of medications approved by the U.S. Food and Drug Administration (FDA) for use in the treatment of opioid

More information