International Clinical Research Center

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1 INTERNATIONAL CLINICAL RESEARCH CENTER CREATING THE FUTURE OF MEDICINE International Clinical Research Center New concept of medical research, clinical care, and education

2 International Clinical Research Center PLATFORM FOR MULTIDISCIPLINARY INTERNATIONAL COOPERATION integrating clinical research, clinical care, medical education and technology transfer

3 PARTICIPATION OF MAYO CLINIC Essential contribution to ICRC concept development Comprehensive Research Project Management and direct participation of leading Mayo specialists in R&D programs Substantial contribution to joint research project financing and realization Special educationalprograms mentoring of Czech/European Young Investigators

4 International Clinical Research Center ICRC is an innovative science and research centerand a top-quality public healthcare center focusing on prevention, early detectionand therapyprimarily of cardiovascular and neurological diseases. 250 core employees 260 million USD investment Fully operational in 2012 Multidisciplinary platform

5 ICRC PLATFORM Clinical Research and Healthcare Research projects initiated by FNUSA- ICRC and/or academic partners Pharmaceutical, biotechnological companies and producers of medical technology IDEAS Innovation Cycle TECHNOLOGY Results and publications Patents, commercialization Production of advanced technology in CR Start-up companies Basic Research Preclinical Research

6 Organization of Research at FNUSA-ICRC FNUSA-ICRC CARDIO-program NEURO-program Shared research platforms: AC, CBCE, ICCT, BME, CMI, CPU

7 CARDIOVASCULAR PROGRAM CARDIO 1:Cardiovascular and transplant surgery, heart failure treatment and transplant programs -development of novel diagnostic and therapeutic strategies(brooks S. Edwards, MD,PhD, Petr Nemec, MD, PhD) CARDIO 2:Interventional cardiology and acute coronary syndromes -development of novel strategies for early detection and advanced treatment (David R. Holmes, MD,PhD, Ota Hlinomaz, MD, PhD) CARDIO 3:Cardiac electrophysiology and pacing -development of advanced diagnostic and therapeutic strategies (Samuel J. Asirvatham, MD, PhD, Miroslav Novak, MD, PhD) CARDIO 4:Cardiovascular and metabolic disorders -identification of novel risk factors and development of novel therapeutic methods(virend K. Somers, MD, PhD, Tomas Kara, MD, PhD) CARDIO 5:Non-invasive cardiovascular imaging -development of novel methods and technologies (Andreas Melzer, MD, PhD, Marek Orban, MD) CARDIO 6: Development of novel methods and interventions to reduce risk factors and cardiovascular diseases in the general population (Francisco Lopez-Jimenez, MD, MSc., Ondrej Sochor, MD) CARDIO 7:Tissue engineering in cardiovascular research(christopher G. A. McGregor, MD, PhD, Pavel Piler, MD)

8 NEUROLOGICAL PROGRAM NEURO 1:Cerebrovascular disease -Development of Novel Strategies for Early Detection and Advanced Treatment of Cerebrovascular Diseases(Andrei V. Alexandrov, MD, PhD, Robert Mikulik, MD, PhD) NEURO 2:Neuroepidemiology (with pilot projects of dementia) (Yonas Geda, MD, MSc, Jakub Hort, MD, PhD) NEURO 3:Development of Advanced Neuroimaging (Bredley J. Erickson,MD, PhD, Daniel Horinek, MD, PhD) NEURO 4:Multiple Sclerosis(Moses Rodriguez, MD)

9 MULTIDISCIPLINARY PLATFORM AC: Animal Center (Michal Vlasin, PhD) CBCE:Center of Biomolecular and Cellular Engineering (Petr Dvorak, PhD) ICCT: Integrated Center of Cellular Therapy and Regenerative Medicine(Dan S. Kaufman, MD, PhD, Martin Klabusay, MD, PhD) BME: Center of Biomedical Engineering (Holmes David R. III., MD, PhD, Pavel Leinveber,MSc) CMI: Center of Molecular Imaging (Milan Kaminek, PhD) CPU: Clinical Pharmacology Unit (Jiri Skopek, MD, PhD)

10 Potential models of collaboration 1. Contract research - activities performed on behalf of an undertaking - FNUSA-ICRC receives payment for services -contracting partyis owner of all research outcomes(ipetc.) 2. Collaborative research - joint collaboration of two or more independent entities - entities could be undertakings or other R&D institutions - partners share the risks and outcomes of research 3. Renting out of infrastructure -any business entity utilizesany equipment (including operating staff) for performance of their own projects

11 WHAT ICRC OFFERS TO PARTNERS Services in all phases of drugs and medical devices development Unique combination of research and clinical practice Collaboration with key world opinion leaders Modern technology equipment Strong conflict of interest policy Experiencedand motivated research teams Openess to joint research projects focused on medicine

12 Animal Center: technology

13 Hi-Tech Operating Theatre: Technology

14 INTERNATIONAL CLINICAL RESEARCH CENTER CREATING THE FUTURE OF MEDICINE Thank you for your attention! St. Anne s University Hospital Brno International Clinical Research Center Pekařská Brno, Czech Republic Tel:

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