Advanced International Breast Cancer Course

Transcription

1 Section of Oncology 10 th Meet the Professor Advanced International Breast Cancer Course Padua, November 6 th -7 th -8 th, 2014 Directors Pier Franco Conte, Gabriel N. Hortobagyi

2 Presentation Breast cancer mortality is declining in most countries; a detailed knowledge of the mechanisms of cancer progression, phenotypic and genotypic characterization of the disease, screening programs, advanced imaging, local therapies and molecularly targeted drugs have all been fundamental to achieve this success. Nowadays, breast cancer represents the front runner in the path to comparative effectiveness, where new therapeutic interventions are implemented on the basis of average benefit, to personalized cancer medicine, where the right treatment is provided to the right patient at the right moment. An updated, multifaceted approach to our patients is now becoming more and more demanding and with these goals in mind, the Programme of this international Conference includes lectures on molecular characterization, updated management of early and advanced disease, strategies to overcome resistance to available therapies, innovative therapies, and multimodal treatments for advanced disease. Clinical case discussions and debates are planned to allow a continuous and fruitful exchange of experiences and opinions between speakers and participants. This 10 th Breast Cancer Conference includes a highly qualified international faculty, but will maintain its characteristics of a friendly forum where international opinion leaders and attendees will exchange experiences and share the most exiting advances. In order to reward scientific excellence and to foster international cooperation, the International Scientific Committee of the 10 th AIBCC will award the 4 th International Prize for Breast Cancer Research to a scientist who has published a breakthrough paper in the previous year and the Monica Boscolo Research Grant to an Italian scientist for a research project to be conducted in cooperation with a foreign institution. We welcome medical oncologists, pathologists, breast surgeons, radiation oncologists and basic scientists to listen to breast cancer leaders and to exchange experiences in a friendly atmosphere. Addressed to The Meeting is addressed to physicians specialized in: oncology, radiodiagnostics, radiotherapy, clinical pathology, general surgery, gynaecology and obstetrics, biologists and nurses.

3 Programme Thursday, November 6 th 8.00 Registration 8.45 Introduction to the Conference Pier Franco Conte, Gabriel N. Hortobagyi SESSION I - PATHOLOGY Chairmen: Alberto Amadori, Massimo Rugge 9.00 Standardization of breast cancer diagnosis: pathology Anna Sapino 9.30 Standardization of breast cancer diagnosis: genomics Giampaolo Bianchini SESSION II - LOCOREGIONAL THERAPIES Chairmen: Nicola Balestrieri, Graziano Meneghini Evolving loco-regional management Post-mastectomy radiotherapy: a new standard? Philip Poortmans Management of the axilla: an update after recent trials Carlos A. Garcia-Etienne Hypofractionated breast irradiation Philip Poortmans Discussion Coffee break SESSION III - IMAGING Chairmen: Gabriel N. Hortobagyi, Luigi Pescarini Role of MRI in breast cancer diagnosis Clinical cases will be presented to discuss the following items: Is MRI the standard screening procedure in young women? Enrica Baldan Is MRI the gold standard to assess the response to neoadjuvant therapy? Ilaria Polico Is MRI appropriate to plan the type of surgery? Alessandro Coran the audience will be asked to vote. After the vote, two senior speakers will debate items in favor or contra. The audience will be asked to vote again after the debate. Pro: Pietro Panizza Contra: Petra Steyerova Conclusive remarks of the Chairmen

4 13.15 Lunch SESSION IV - STAGING AND ADJUVANT Chairman: Philip Poortmans Appropriate staging work-up in early breast cancer Jassem Jacek Is there a role for adjuvant bisphosphonates? Robert Coleman Discussion SESSION V - GUIDELINES Chairman: Philip Poortmans Role of guidelines in the era of personalized cancer medicine Do guidelines impact on patients outcome? Petra Boelens Genomics platforms as decision making tools Miguel Martin Adjourn Ceremony for the presentation of the University of Padua Award for Advances Breast Cancer 2014 and the Monica Boscolo Research Grant Lecture of the Awardee Cocktail The Ceremony and the cocktail will take place in Palazzo Bo, Via VIII Febbraio 2, Padua. Friday, November 7 th SESSION VI - EARLY BREAST CANCER 9.00 Adjuvant Clinical Case Discussion I Chairmen: Pier Franco Conte, Miguel Martin Presenters of the cases: Zora Baretta, Cristina Falci the presenter will introduce a clinical case and will ask questions to the audience. The discussants will comment the vote and will review the state of art Discussants: Fertility preservation Lucia Del Mastro Adjuvant therapy for low risk HER2+ patients Valentina Guarneri

5 Endocrine adjuvant therapy in premenopause Stephen Johnston Extended adjuvant endocrine therapy Jonas Bergh Discussion Coffee break Neoadjuvant Clinical Case Discussion II Chairmen: Fernando Bozza, Pier Franco Conte Presenters of the cases: Silvia Michieletto, Tania Saibene the presenter will introduce a clinical case and will ask questions to the audience. The discussants will comment the vote and will review the state of art. Discussants: Locoregional management Philip Poortmans HR+/HER2 negative Stephen Johnston Triple negative breast cancer Maria Vittoria Dieci Adjuvant therapy in suboptimal responders after neoadjuvant therapy Pier Franco Conte Discussion Lunch SESSION VII - ADVANCED BREAST CANCER Chairmen: Valentina Guarneri, Sibylle Loibl Clinical case discussion III the presenter will introduce a clinical case and will ask questions to the audience. The discussants will comment the vote and will review the state of art. Sequence and duration of anti-her2 therapy Presenter: Cristina Falci Discussant: Pier Franco Conte Therapeutic options for HR+ disease Presenter: Carlo Alberto Giorgi Discussant: Gabriel N. Hortobagyi Triple negative advanced breast cancer Presenter: Giovanni Faggioni Discussant: Sabine Charlotte Linn Discussion Coffee break

6 Chairmen: Gabriel N. Hortobagyi, Donato Nitti Clinical case discussion IV the presenter will introduce a clinical case and will ask questions to the audience. The discussants will comment the vote and will review the state of art. BRCA test as tool for therapy selection Presenter: Zora Baretta Discussant: Miguel Martin Surgery of the primary in de novo stage IV disease Presenter: Antonella Brunello Discussant: Miranda Ernst Discussion Adjourn Saturday, November 8 th SESSION VIII - HIGHLIGHTS OF THE YEAR Chairmen: Jonas Bergh, Stefania Gori 9.00 Advances in biology Aleix Prat 9.30 HR+/HER2- disease Stephen Johnston HER2+ disease Fabio Puglisi Triple negative disease Cornelia Liedtke Coffee break SESSION IX - COMING SOON Chairman: Gabriel N. Hortobagyi New promising drugs Jonas Bergh Trials likely to impact on clinical practice in the near future: EBC Sibylle Loibl Trials likely to impact on clinical practice in the near future: ABC Paolo Pronzato Adjourn and final evaluation questionnaire

7 Directors Pier Franco Conte Department of Surgery, Oncology and Gastroenterology Gabriel N. Hortobagyi Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center Houston (USA) Scientific Committee Jonas Bergh Department of Oncology-Pathology Karolinska Institute and University Hospital Stockholm (SW) Valentina Guarneri Department of Surgery, Oncology and Gastroenterology Jacek Jassem Department of Oncology and Radiotherapy Medical University of Gdansk (PL) Stephen Johnston NIHR Biomedical Research Centre for Cancer Royal Marsden NHS Foundation Trust & Institute of Cancer Research London (UK) Sibylle Loibl German Breast Group Department of Medicine and Reasearch University of Frankfurt (D) Miguel Martin Medical Oncology Service Hospital Universitario Gregorio Maranon Madrid (S) Donato Nitti Department of Surgery, Oncology and Gastroenterology Philip Poortmans President-elect of ESTRO Department of Radiation Oncology Radboud University Medical Centre Nijmegen (NL)

8 Speakers Alberto Amadori Division of Oncological Molecular Diagnostic and Immunology Department of Surgery, Oncology and Gastroenterology Enrica Baldan Breast Unit Nicola Balestrieri Breast Center Cà Foncello Regional Hospital ULSS 9 Treviso (I) Zora Baretta Jonas Bergh Department of Oncology-Pathology Karolinska Institute and University Hospital Stockholm (SW) Giampaolo Bianchini Department of Medical Oncology IRCCS San Raffaele Hospital Milan (I) Petra Boelens Department of Surgery Leiden University Medical Center Leiden (NL) Fernando Bozza Division of Breast Surgery Padua (I) Antonella Brunello Division of Medical Oncology 1 Padua (I) Robert E. Coleman Academic Unit of Clinical Oncology Weston Park Hospital - University of Sheffield Sheffield (UK) Pier Franco Conte Department of Surgery, Oncology and Gastroenterology Alessandro Coran Breast Imaging Unit Padua (I) Lucia Del Mastro Medical Oncology A- Innovative therapies development IRCCS A.O.U. San Martino - IST Genoa (I) Maria Vittoria Dieci Department of Surgery, Oncology and Gastroenterology Miranda Ernst Division of Oncology Surgery Alexander Monro Clinic Bilthoven (NL) Giovanni Faggioni Padua (I) Cristina Falci Carlos A. Garcia-Etienne Division of Breast Surgery Humanitas Research Hospital Rozzano (I) Carlo Alberto Giorgi Padua (I) Stefania Gori Department of Medical Oncology Sacro Cuore - Don Calabria Hospital Negrar, VR (I)

9 Valentina Guarneri Department of Surgery, Oncology and Gastroenterology Gabriel N. Hortobagyi Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center Houston (USA) Jacek Jassem Department of Oncology and Radiotherapy Medical University of Gdansk (PL) Stephen Johnston NIHR Biomedical Research Centre for Cancer Royal Marsden NHS Foundation Trust & Institute of Cancer Research London (UK) Cornelia Liedtke Campus Lübeck Department of Gynecology and Obstetrics University Hospital of Schleswig-Holstein Lubeck (D) Sabine Charlotte Linn Dept. of Medical Oncology The Netherlands Cancer Institute Antoni van Leeuwenhoek Amsterdam (NL) Sibylle Loibl German Breast Group Department of Medicine and Reasearch University of Frankfurt (D) Graziano Meneghini Breast Center ULSS 5 Ovest Vicentino Montecchio Maggiore (VI) Miguel Martin Medical Oncology Service Hospital Universitario Gregorio Maranon Madrid (S) Silvia Michieletto Division of Breast Surgery Padua (I) Donato Nitti Department of Surgery, Oncology and Gastroenterology Pietro Panizza Department of Diagnostic Radiology IRCCS National Cancer Institute Milan (I) Luigi Pescarini Department of Radiology Diagnostic Breast Unit Ilaria Polico Breast Imaging Unit Padua (I) Philip Poortmans President- elect of ESTRO Department of Radiation Oncology Radboud University Medical Centre Nijmegen (NL) Aleix Prat Institute of Oncology (VHIO) Vall d Hebron Barcellona (E) Paolo Pronzato Medical Oncology IRCCS A.O.U. San Martino - IST Genoa (I) Fabio Puglisi Department of Oncology University Hospital of Udine (I) Massimo Rugge General Pathology & Cytopathology Unit Department of Medicine-DIMED Tania Saibene Division of Breast Surgery Padua (I) Anna Sapino Department of Biomedical Science and Human Oncology University of Torino (I) Petra Steyerova Clinic of Radiology General University Hospital Center for Breast Disease of V. Polak Prague (CZ)

10 Awards Monica Boscolo Research Grant The Scientific Committee will select the winner of the Monica Boscolo Research Grant. This Research Award is restricted to young Italian researchers (< 40 years) who will carry out a research project at a foreign institution. UNIVERSITY OF PADUA AWARD FOR ADVANCES IN BREAST CANCER 2014 The Scientific Committee will select young researchers (< 40 years from any country) who have published in an international peer-reviewed journal, as the principal author, a manuscript reporting important clinical or biological advances in breast cancer. Prof. Conte and Prof. Hortobagyi will select the final winner which will be invited to present his/her study during the annual Conference Under 35 Free admission is available for 5 persons Under 35. Registration forms will be accepted on a first-come, first-served basis until spaces are filled. The Organization Secretariat will confirm the registration by . Un azione sostenibile a favore della formazione Iscrizione gratuita per i medici UNDER 35 fino a esaurimento posti

11 CME Based on the in force Italian regulations, Accademia Nazionale di Medicina (provider n. 31) will assign to the activity CME ( ): 8 CME points. The Meeting is addressed to physicians specialized in: oncology, radiodiagnostics, radiotherapy, clinical pathology, general surgery, gynaecology and obstetrics, biologists and nurses. It will not be possible to give credits to physicians specialized in different fields. The credit certification is subject to: attendance at the entire Meeting the completion of the meeting evaluation form the completion of the final questionnaire (at least 75% of correct answers) We would like to remind to participants that only 1/3 of CME credits acquired during the years 2014/2016 can come frome a sponsorship. Official Language The official language of the Meeting is English. No simultaneous translation will be provided.

12 Registration The registration fee is 250,00 tax free. It includes the conference bag, the conference book and all coffee breaks and lunches. It does not include Hotel accomodation, dinners and travel expenses. Under the article 54 T.U.I.R and within the limits set out therein, the costs of participation in this activity are deductible in determining self-employment income. To register, please send: registration form duly filled out (even when sponsored by a Pharmaceutical Company privacy statement and consent to the use of personal data (as in the back of the form) payment to Accademia Nazionale di Medicina Palazzina CUP II Piano, Via Massarenti 9, Bologna (fax e.mail: info.bologna@accmed.org, within october 27 th, Registration quote can be paid by: non-transferable cheque addressed to Accademia Nazionale di Medicina; bank transfer addressed to: ACCADEMIA NAZIONALE DI MEDICINA, Banca Intesa Spa - Filiale 2475 Ge-Marose - IBAN code: IT 27 J SWIFT code: BCITITMM (indicate: Registration of Dr.... at Course 14_RE_1064 ); Credit Card Details Mastercard. Visa, Eurocard (NO AMEX). Online registration is possible on the website By submitting the form and the payment, your registration is completed with the exception of specific decisions of the Meeting Secretariat. Incomplete registration will NOT be admitted. The registration will be confirmed by , please put your address on the registration form. Cancellation if the participants minimum number is not reached, Accademia Nazionale di Medicina will advise by a written communication and proceed with the total refund of the fee. In order to cancel please give advise with a written communication to Accademia Nazionale di Medicina within 10 days from the beginning. A 70% of the registration fee will be returned. Any cancellation after that deadline will not be reimbursed.

13 Meeting Venue Centro Congressi Padova A. Luciani Via Forcellini 170/A Padova Tel / How to reach the meeting venue: By Car: The Highway exits are Padova Est, 5 Km from the Meeting Venue Padova Zona Industriale, 6 Km from the Meeting Venue By Train: Padova is in the Center of Veneto, it is easy to reach with the trains Milano- Venezia and Bologna-Venezia. The Meeting Venue is 4 Km from the train station By Plane Venezia Airport - Marco-Polo: 43 km (about 40 minutes by car) Treviso Airport- Canova: 63 km (about 50 minutes by car)

14 With the patronage of Institutions Comune di Padova Scientific Societies

15 With the unconditional contribution of gold SPONSOR SILVER SPONSOR BRONZE SPONSOR CONTRIBUTORS EISAI GENOMIC HEALTH MYRIAD GENETICS PHARMA MAR PIERRE FABRE PHARMA SANOFI AVENTIS

16 Sponsored by ACCADEMIA NAZIONALE DI MEDICINA General Manager: Stefania Ledda Organizing Partner Forum Service Via Martin Piaggio 17/ Genova Information: Ph Fax Hotel booking Ph Fax