Hoe het brein bij patiënten met depressie ervoor zorgt dat emotionele geheugen vertekeningen ontstaan

Size: px
Start display at page:

Download "Hoe het brein bij patiënten met depressie ervoor zorgt dat emotionele geheugen vertekeningen ontstaan"

Transcription

1 Indira Tendolkar Hoe het brein bij patiënten met depressie ervoor zorgt dat emotionele geheugen vertekeningen ontstaan Department of Psychiatry

2 Overview of the talk Basic principle of emotional memory enhancement The interaction between mood and emotional memory Depressive trait effects in emotional memory

3 Overview of the talk Basic principle of emotional memory enhancement The interaction between mood and emotional memory Depressive trait effects in emotional memory

4 Enhanced memory for emotional events Is a well-recognized phenomenon Has an obvious adaptive value in evolutionary terms It is vital to remember both dangerous and favorable situations

5 Basic principle of emotional memory enhancement Emotional memory enhancement occurs in different memory systems MEMORY Declarative Non-declarative episodic semantic skills priming conditioning others

6 Neural basis of emotional memory enhancement An impression may be so exciting emotionally as almost to leave a scar upon the cerebral tissues. William James (1890)

7 Functional neuroimaging Methods

8 Memory Formation and Retrieval: General Experimental Design Camera Milk Chain Power Milk Study 87 Distraction? Test Trials: (later) remembered (later) forgotten Contrasts: remembered > forgotten

9 Modulation Hypothesis: First functional imaging evidence Stronger correlation between amygdala and entorhinal activity for succesful encoding of emotional pictures Dolcos F et al., Neuron (5):

10 Neural basis of emotional memory enhancement Amygdala modulates regions critical for memory

11 Overview of the talk Basic principle of emotional memory enhancement The interaction between mood and emotional memory Depressive trait effects in emotional memory

12 Mood can bias emotional memory enhancement Facilitation predictions from Bower's Associative Network Model(1981)

13 Deficits in semantic labeling of emotions in depression Currently depressed individuals show a higher neural activation than recovered and healthy individuals during semantic labeling of emotion in contrast to perceptual matching of emotion. This effect was evident in the right amygdala (A), left inferior frontal gyrus (B), and anterior cingulate cortex (C) Psychol Med :1-9

14 Emotional memory enhancement in depression is mood congruent Negative Self referent Thinking Hopelessness Depressed Mood Memory Bias Dysfunctional Attitude Fatigue (model adapted from Williams and colleagues)

15 Study Design: How mood interacts with memory + angst + straat ~ 5 s liefde ~ 5 s 0.5 s 4 Negative, 4 Neutral, 4 Positive words per run (20 runs in total) 0.5 s vriendschap vijand angst straat Free Recall Study (~60 s) Distraction (~40 s) Test (~30 s) Video 1 (15m) Video 2 (6m) Video 3 (4m) Video 4 (7 min) NeuroImage :

16 Study Design Participants: 21 Dutch speaking healthy volunteers (7 males, mean age 22.8 ± 3.7 years) MRI Protocol: Avanto (1.5T) 2340, ms TR, 35 ms TE, 32 slices 3.3 x 3.3 x 3.5 mm voxels Paradigm: - Video clips used to induce mood NeuroImage : Sophie s Choice Happy Feet

17 Behavioral results * * * * * NeuroImage :

18 Imaging results results Successful memory formation was related to an activity increase in left frontal and MTL regions Greater activity for sad compared to happy mood was found in the amygdala Processing of affective words was marked by increased activity compared to neutral words NeuroImage :

19 Imaging results results: Three way interaction Mood-incongruent effect: Subsequent memory effects were larger for negative words during happy compared to sad mood in left MPFC Mood-congruent effect: During sad mood, subsequent memory effects for negative words were significantly greater in left OFC compared to activity for negative words following happy mood induction NeuroImage :

20 Summary of the results Behavioral results confirmed the presence of a mood-congruent memory bias Amygdala and hippocampus were engaged in overall mood and memory formation respectively Increased activity to negative words in the inferior-frontal gyrus for the mood-incongruent condition and in the orbito-frontal cortex for the congruent condition. NeuroImage :

21 Discussion These results suggest that different pre-frontal regions mediate dichotomous interactions between mood and memory: left inferior frontal gyrus may serve semantic control processes in overcoming incongruency between mood state and item valence for successful encoded words orbito-frontal cortex is involved in enhancing congruency between mood and stimulus valence during successful memory formation NeuroImage :

22 How do our findings relate to neural circuit theories of depression Phillips et al., Biological Psychiatry 2003

23 Overview of the talk Basic principle of emotional memory enhancement The interaction between mood and emotional memory Depressive trait effects in emotional memory

24 Depressive traits in emotional memory enhancement In acute depression (Hamilton et al., 2008): Increased memory sensitivity for negative stimuli Over-activation of amygdala-hippocampus amygdala-caudate-putamen system In remission (with mood induction) (Ramel et al., 2007): Bilateral amygdala response predicted increased recall of negative self-referent words

25 Depressive traits in emotional memory Subject characteristics Remitted Patients Controls N=14 Demographic variables Mean SD Mean SD N=14 Group effect Age Sex (male/female) 0/14 0/ Handedness (left/right) 0/14 0/ Educational level (1-5) Clinical variables HDRS 17-item score STAI State Mean Trait Mean Total Mean Life events PANAS Positive Negative Age of onset (years) Mean p Number of episodes J Affect Disord (1-3):214-23

26 Study Design: Depressive traits in emotional memory J Affect Disord (1-3):214-23

27 Behavioral bias in remission? Remitted Patients N=14 Healthy Control N=14 Group effect Recall Rates Mean SD Mean SD p-values 50 Total Recall Negative words Neutral words Positive words Controls Remitted Total Recall Negative words Neutral words Positive words Controls Remitted J Affect Disord (1-3):214-23

28 MRI Acquisition 1.5T Siemens AVANTO MR scanner (Siemens, Erlangen, Germany) Functional T2*-weighted BOLD EPI images (33 axial slices, 3.4mm, slice-gap= 0.34mm, FOV= 212mm, TR= 2190ms, TE= 35ms, FA=90, final voxel dimension= 3.3x3.3x3.4 and a bandwidth of 1628Hz/Px) Anatomical T1-weighted MP-RAGE sequence (176 slices, voxel size: 1.0 x 1.0 x 1.0mm, TR= 2250ms; TE= 2.95ms, FA= 15 ). MRI Analysis Standardized analysis with SPM5 (Wellcome Department of Imaging Neuroscience, London, UK) Whole brain exploratory analysis Region of interest analysis within amygdala and hippocampus J Affect Disord (1-3):214-23

29 MRI results: three-way interaction Patients show increased neural activity when successfully encoding positive words This effect is evident in - right anterior cingulate - left posterior cingulate - right inferior frontal gyrus - right amygdala J Affect Disord (1-3):214-23

30 Neural correlates of memory bias act as vulnerabilitymarker of depression Prefrontal top-down processes play are involved in mood-related emotional learning Amygdala/hippocampal processes are involved in trait related maintenance of emotional memory bias William James (1890)

31 Cognitive memory bias as intermediate phenotype (Franke et al. Hum Genet (1):13-50.)

32 Brain Imaging Genetics study Ongoing cohort study Data collection started 2009 Healthy subjects (currently N >1000) Excl. criteria: a history of somatic disease potentially affecting the brain, current or past psychiatric or neurological disorder medication (except hormonal contraceptives) or illicit drug use during the past 6 months history of substance abuse, current or past alcohol dependence, pregnancy, lactation, menopause MRI contraindications

33 Additional evidence for an intermediate phenotype Structural MRI (1.5 T Siemens scanner, T1-weighted 3D MPRAGE sequence) in 272 healthy participants (62% female, yrs old) Automatic segmentation of amygdala and hippocampus was performed using the FIRST module of FSL. Negative memory bias was assessed by the self-referent encoding/evaluation test Analysis of general linear models adjusted for age, sex, total brain volume and negative mood was conducted. Psychol Med :1-9 Negative memory bias was associated with larger amygdala (p=0.042) and smaller hippocampal volume (p=0.029)

34 Additional evidence for an intermediate phenotype Spearman correlations, within sample with negative memory bias (N=72). Ratio volumes adjusted for age, sex, total brain volume, scanning protocol and PANAS negative scale The ratio of amygdala to hippocampal volume was most strongly related to negativity bias (p=0.021) There was neither an association between regional brain volumes and positive memory bias nor with negative and total recall Psychol Med :1-9

35 Additional finding: 5 HTTLPR, memory bias and brain

36 Possible underlying mechanism Negative memory bias Depression

37 Science is always a collaborative endeavour Center of Cognitive Neuroimaging, Nijmegen Jennifer Arnold Guillén Fernández Lotte Gerritsen Guido van Wingen Department of Psychiatry Nijmegen Iris van Oostroom Philip van Eijndhoven Anne Speckens Barbara Franke Alessandro Ariez Vasquez Behavioral Science Institute, Department of Clinical Psychology, Nijmegen Daniel Fitzgerald Mike Rinck Eni Becker

Supplementary Information

Supplementary Information Supplementary Information ADHD diagnostic algorithm To determine psychiatric diagnoses, all participants (children and parents alike) were assessed with a combination of ADHD rating scales and a semi-structured

More information

Brain Networks in Schizophrenia and Bipolar Disorder: Targets for Novel Therapies. Cameron S. Carter, MD.

Brain Networks in Schizophrenia and Bipolar Disorder: Targets for Novel Therapies. Cameron S. Carter, MD. Brain Networks in Schizophrenia and Bipolar Disorder: Targets for Novel Therapies Cameron S. Carter, MD cameron.carter@ucdmc.ucdavis.edu Schizophrenia and Bipolar Disorder Each affects 1% of the population

More information

Structural Brain Changes in remitted Major Depression

Structural Brain Changes in remitted Major Depression Structural Brain Changes in remitted Major Depression Andreas Berger unter der Anleitung von Assoc.Prof. Priv.Doz. Dr. Lukas Pezawas Universitätsklinik für Psychiatrie und Psychotherapie Medizinische Universität

More information

MRI Volumetric Studies in Alcoholism and Psychopathy: A Focus to the Medial Temporal Lobe Structures

MRI Volumetric Studies in Alcoholism and Psychopathy: A Focus to the Medial Temporal Lobe Structures MRI Volumetric Studies in Alcoholism and Psychopathy: A Focus to the Medial Temporal Lobe Structures Hannu J. Aronen Helsinki Brain Research Center University of Helsinki Motivation for MRI Volumetry of

More information

How emotion enhances the feeling of remembering

How emotion enhances the feeling of remembering How emotion enhances the feeling of remembering Tali Sharot, Mauricio R Delgado & Elizabeth A Phelps Studies examining memories of arousing real-life events show that emotion heightens the feeling of remembering,

More information

The Neurobiology of Suicidal Behavior

The Neurobiology of Suicidal Behavior The Neurobiology of Suicidal J. John Mann, MD Chief, Department of Neuroscience New York State Psychiatric Institute Professor of Psychiatry and Radiology College of Physicians and Surgeons of Columbia

More information

Activation neuroimaging studies - GABA receptor function - alcohol cues in alcoholism

Activation neuroimaging studies - GABA receptor function - alcohol cues in alcoholism Activation neuroimaging studies - GABA receptor function A - alcohol cues in alcoholism Professor David Nutt Psychopharmacology Unit, University of Bristol. MRC Clinical Sciences Centre, London. Study

More information

Supporting Online Material for

Supporting Online Material for www.sciencemag.org/cgi/content/full/320/5882/1510/dc1 Supporting Online Material for Transfer of Learning After Updating Training Mediated by the Striatum Erika Dahlin,* Anna Stigsdotter Neely, Anne Larsson,

More information

Ch 12. Executive Functions and Frontal Lobes Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed.,

Ch 12. Executive Functions and Frontal Lobes Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed., Ch 12. Executive Functions and Frontal Lobes Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed., M. S. Gazzaniga,, R. B. Ivry,, and G. R. Mangun,, Norton, 2002. Summarized by K. Kim, E. S. Lee,

More information

Working vs Long-Term Memory. Neural correlates of a working memory process that influences long-term memory formation. WM-LTM Interaction

Working vs Long-Term Memory. Neural correlates of a working memory process that influences long-term memory formation. WM-LTM Interaction Center for Neuroscience UNIVERSITY OF CALIFORNIA AT DAVIS Neural correlates of a working memory process that influences long-term memory formation Phonological Loop Working vs Long-Term Memory Central

More information

Does the brain change with psychotherapy?

Does the brain change with psychotherapy? Does the brain change with psychotherapy? Why do we care about identifying the brain mediators of symptom change Agenda: 2 Longitudinal Neuroimaging Studies of Symptom Change following Psychotherapy Every

More information

An fmri study on reading Hangul and Chinese Characters by Korean Native Speakers

An fmri study on reading Hangul and Chinese Characters by Korean Native Speakers 언 어 치 료 연 구, 제14 권 제4호 Journal of Speech & Hearing Disorders 2005, Vol.14, No.4, 29 ~ 36 An fmri study on reading Hangul and Chinese Characters by Korean Native Speakers Hyo-Woon Yoon(Brain Science Research

More information

Neuro-imaging to understand refractory breathlessness. Copenhagen May 2015

Neuro-imaging to understand refractory breathlessness. Copenhagen May 2015 Neuro-imaging to understand refractory breathlessness Copenhagen May 2015 1 Different perceptions Two people with the same patho-physiology Different perceptions Different restrictions Different lives

More information

Cognitive Control, Executive Control, and Frontal Lobe Functions

Cognitive Control, Executive Control, and Frontal Lobe Functions Cognitive Control, Executive Control, and Frontal Lobe Functions Anatomy of Cognitive Control Cognitive Control Goal-Oriented Behavior Involves prefrontal cortex (PFC) Highly advanced and evolved in humans

More information

MPI Literature Review - Marijuana s effects on the adolescent brain

MPI Literature Review - Marijuana s effects on the adolescent brain General Summary: - Marijuana use appears to have a significant effect on adolescents brain structure and development. In particular, heavy marijuana use is associated with attention, memory, and planning

More information

SLC6A15 rs1545853 and depression: implications from brain

SLC6A15 rs1545853 and depression: implications from brain SLCA1 rs1 and depression: implications from brain imaging data Ming Li, M.Sc.; Tian Ge, M.Sc.; Jianfeng Feng, Ph.D.; Bing Su, Ph.D. From the State Key Laboratory of Genetic Resources and Evolution, Kunming

More information

Neuromodulation: An Old Idea Reinvented

Neuromodulation: An Old Idea Reinvented Neuromodulation: An Old Idea Reinvented Dr. Jonathan Becker, DO, MS Assistant Professor of Clinical Psychiatry Vanderbilt University Electricity as a treatment modality Scientists have experimented with

More information

Neurobiology of Depression in Relation to ECT. PJ Cowen Department of Psychiatry, University of Oxford

Neurobiology of Depression in Relation to ECT. PJ Cowen Department of Psychiatry, University of Oxford Neurobiology of Depression in Relation to ECT PJ Cowen Department of Psychiatry, University of Oxford Causes of Depression Genetic Childhood experience Life Events (particularly losses) Life Difficulties

More information

BRAIN, DEPRESSION AND PSYCHOANALYSIS

BRAIN, DEPRESSION AND PSYCHOANALYSIS GERHARD ROTH BRAIN, DEPRESSION AND PSYCHOANALYSIS BRAIN RESEARCH INSTITUTE UNIVERSITY OF BREMEN GENERAL VIEW OF NEUROBIOLOGY ON MENTAL DISORDERS Mental affective disorders such as anxiety disorders, depression,

More information

Let s Get to Know the Parietal Lobes!

Let s Get to Know the Parietal Lobes! Let s Get to Know the Parietal Lobes! A brief primer on parietal lobe function (as it relates to memory). By Rebecca Emily Martin 1 Brodmann Areas associated with parietal lobes BA 3, 1, 2, 5 - somatosensory

More information

Part 1: Don t get testy!

Part 1: Don t get testy! Number of Students Part 1: Don t get testy! Introduction: Ms. Smith, the high school English Language Arts teacher, made a graph of the exam scores from a recent test she gave her 27 students as she always

More information

Psychiatric Disorders

Psychiatric Disorders Psychiatric Disorders Learning about the brain from diagnosis to treatment Tedi Asher Harvard Medical School Talk overview Part I: Defining psychiatric disorders Part II: Biological underpinnings of depression

More information

Structural brain imaging is a window on postnatal brain development in children. Terry Jernigan

Structural brain imaging is a window on postnatal brain development in children. Terry Jernigan Structural brain imaging is a window on postnatal brain development in children Terry Jernigan Old (but still widely held) View of Human Brain Structure All neurons are present at birth. Myelination of

More information

Memory Systems I Where Stored

Memory Systems I Where Stored Memory Systems I Where Stored Reading: BCP Chapter 24 www.123rf.com Memory Systems Learning is the acquisition of new knowledge or skills. Memory is the retention of learned information. Many different

More information

Remembering the specific visual details of presented objects: Neuroimaging evidence for effects of emotion

Remembering the specific visual details of presented objects: Neuroimaging evidence for effects of emotion Neuropsychologia 45 (2007) 2951 2962 Remembering the specific visual details of presented objects: Neuroimaging evidence for effects of emotion Elizabeth A. Kensinger a,c,, Daniel L. Schacter b,c a Department

More information

Investigation of the Brain Regions Involved in Improvisation

Investigation of the Brain Regions Involved in Improvisation Investigation of the Brain Regions Involved in Improvisation Richard Falco 1, Frederick Bianchi 1, and Karl G. Helmer 2,3, 1 Department of Humanities and Arts, Worcester Polytechnic Institute 2 Athinoula

More information

Brain Functioning & ADHD. Charles P. Roth, Ph.D.

Brain Functioning & ADHD. Charles P. Roth, Ph.D. Brain Functioning & ADHD Charles P. Roth, Ph.D. www.drcproth.com Primary Source of Information Thomas E. Brown, Ph.D. Attention Deficit Disorder: The Unfocused Mind in Children and Adults. Yale University

More information

Interactions between Working Memory and Long-term Memory

Interactions between Working Memory and Long-term Memory Interactions between WM and LTM Interactions between Working Memory and Long-term Memory Memory Disorders Research Society Chicago, Paul J. Reber, Northwestern Univ. Intro, fmri Charan Ranganath, UC Davis

More information

Discuss the Function of Emotions Differentiate Attitudes, Mood, and Emotion Examine the evidence for and against basic emotions

Discuss the Function of Emotions Differentiate Attitudes, Mood, and Emotion Examine the evidence for and against basic emotions EMOTION CHAPTER 11.4 1 LEARNING GOALS Discuss the Function of Emotions Differentiate Attitudes, Mood, and Emotion Examine the evidence for and against basic emotions Discuss the cross-cultural research

More information

The Limbic System. Broca s Limbic Lobe MacLean s Limbic System Papez circuit Today s Limbic System Today s Emotional Brain Amygdala.

The Limbic System. Broca s Limbic Lobe MacLean s Limbic System Papez circuit Today s Limbic System Today s Emotional Brain Amygdala. The Limbic System Broca s Limbic Lobe MacLean s Limbic System Papez circuit Today s Limbic System Today s Emotional Brain Amygdala. A/Prof. Pascal CARRIVE SOMS UNSW Australia Today the word limbic is associated

More information

Autism and the Social Brain A Visual Tour. Charles Cartwright, M.D. Director YAI Autism Center

Autism and the Social Brain A Visual Tour. Charles Cartwright, M.D. Director YAI Autism Center Autism and the Social Brain A Visual Tour Charles Cartwright, M.D. Director YAI Autism Center Social cognition refers to the fundamental abilities to perceive, categorize, remember, analyze, reason with,

More information

Negative symptoms of schizophrenia de Lange, Jozarni

Negative symptoms of schizophrenia de Lange, Jozarni Negative symptoms of schizophrenia de Lange, Jozarni IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version

More information

Face to face. Molecular and functional neural mechanisms of social interaction. Lauri Nummenmaa! Aalto University and Turku PET Centre

Face to face. Molecular and functional neural mechanisms of social interaction. Lauri Nummenmaa! Aalto University and Turku PET Centre Face to face Molecular and functional neural mechanisms of social interaction Lauri Nummenmaa! Aalto University and Turku PET Centre Where is she is looking at? What is she thinking about me? How do I

More information

Toward Understanding Girls with Autism: A Scientist & Father s Perspective

Toward Understanding Girls with Autism: A Scientist & Father s Perspective Toward Understanding Girls with Autism: A Scientist & Father s Perspective Kevin Pelphrey Carbonell Family Professor and Director Autism and Neurodevelopmental Disorders Institute October 12, 2016 S L

More information

PATTERN PERFORMANCE OF SCHIZOPHRENIC PATIENTS ON LURIA-NEBRASKA NEURO-PSYCHOLOGICAL BATTERY

PATTERN PERFORMANCE OF SCHIZOPHRENIC PATIENTS ON LURIA-NEBRASKA NEURO-PSYCHOLOGICAL BATTERY Indian Journal of Psychiatry, 2002,44(1),47-52 PATTERN PERFORMANCE OF SCHIZOPHRENIC PATIENTS ON LURIA-NEBRASKA NEURO-PSYCHOLOGICAL BATTERY B.P. MISHRA, V.GUPTA, R. MAHAJAN & R.L. NARANG ABSTRACT Luria-Nebraska

More information

Decision making performance in Obsessive-Compulsive Disorder

Decision making performance in Obsessive-Compulsive Disorder 5 Decision making performance in Obsessive-Compulsive Disorder Abstract Several neuro-imaging studies in OCD have found the orbitofrontal cortex to be functionally abnormal. As these brain regions are

More information

Learning with Your Brain. Teaching With the Brain in Mind

Learning with Your Brain. Teaching With the Brain in Mind Learning with Your Brain Should what (and how) we teach be associated with what we know about the brain and the nervous system? Jonathan Karp, Ph.D. Dept of Biology 5/20/2004 Teaching With the Brain in

More information

Outline. No financial or non financial interests to disclose. Emotional Communication. Emotions 9/26/2014. Expressive. Receptive

Outline. No financial or non financial interests to disclose. Emotional Communication. Emotions 9/26/2014. Expressive. Receptive No financial or non financial interests to disclose Outline What is? How is assessed in research? after brain injury Using Neuroimaging in evaluating Emotional Processing Intervention for improving Future

More information

MRI DATA PROCESSING. Compiled by: Nicolas F. Lori and Carlos Ferreira. Introduction

MRI DATA PROCESSING. Compiled by: Nicolas F. Lori and Carlos Ferreira. Introduction MRI DATA PROCESSING Compiled by: Nicolas F. Lori and Carlos Ferreira Introduction Magnetic Resonance Imaging (MRI) is a clinical exam that is safe to the patient. Nevertheless, it s very important to attend

More information

The Negative Effects of Acute Stress on Short-term Memory. Derek Moran. Broome Community College

The Negative Effects of Acute Stress on Short-term Memory. Derek Moran. Broome Community College STRESS AND MEMORY 1 The Negative Effects of Acute Stress on Short-term Memory Derek Moran Broome Community College STRESS AND MEMORY 2 Abstract This study will analyze whether acute stress has a negative

More information

1. In your text the authors discuss a patient named Donna. The point of the dialogue was to illustrate:

1. In your text the authors discuss a patient named Donna. The point of the dialogue was to illustrate: Section: Chapter 13: Multiple Choice 1. In your text the authors discuss a patient named Donna. The point of the dialogue was to illustrate: p.489 brain recovery after a closed-head injury. the many facets

More information

Functional Magnetic Resonance Imaging (fmri)

Functional Magnetic Resonance Imaging (fmri) Functional Magnetic Resonance Imaging (fmri) Beth Meyerand, PhD Department of Medical Physics University of Wisconsin-Medical School Madison, Wisconsin Outline: Introduction to fmri physics ( BOLD ) Overview

More information

Adolescent Brain Development and Effects of Alcohol Use

Adolescent Brain Development and Effects of Alcohol Use Adolescent Brain Development and Effects of Alcohol Use Monica Luciana, Ph.D. Professor and Chair Department of Psychology and Center for Neurobehavioral Development University of Minnesota (lucia003@umn.edu)

More information

Ch 8. Learning and Memory

Ch 8. Learning and Memory Ch 8. Learning and Memory Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed., M. S. Gazzaniga,, R. B. Ivry,, and G. R. Mangun,, Norton, 2002. Summarized by H.-S. Seok, K. Kim, and B.-T. Zhang Biointelligence

More information

Poor recognition vs. recall: Indicator of performance invalidity or legitimate clinical presentation?

Poor recognition vs. recall: Indicator of performance invalidity or legitimate clinical presentation? Poor recognition vs. recall: Indicator of performance invalidity or legitimate clinical presentation? Simon Walker Associate Professor Lynette Tippett Dr Jamie MacNiven (ADHB). Background Neuropsychology

More information

The Effect of Positive Mood Induction on Eye Fixation in a Visual Search Task

The Effect of Positive Mood Induction on Eye Fixation in a Visual Search Task The Effect of Positive Mood Induction on Eye Fixation in a Visual Search Task Lauren Fox, Hannah Mariani, Eric McAnally, and Jacob Huffman The effects of positive mood induction on eye fixation were examined.

More information

Powered by TCPDF (www.tcpdf.org)

Powered by TCPDF (www.tcpdf.org) Powered by TCPDF (www.tcpdf.org) Title What is the difference between metaphor and simile? : fmri study Author 柴田, みどり (Shibata, Midori) Publisher Centre for Advanced Research on Logic and Sensibility

More information

Functional MRI: techniques and applications. Susan Bookheimer, Ph.D. UCLA Center for Cognitive Neurosciences

Functional MRI: techniques and applications. Susan Bookheimer, Ph.D. UCLA Center for Cognitive Neurosciences Functional MRI: techniques and applications Susan Bookheimer, Ph.D. UCLA Center for Cognitive Neurosciences none Disclosures Outline Basis of fmri signal; how it works, what it measures fmri experimental

More information

Interpretative Bias: Indicators of Cognitive Vulnerability to Depression

Interpretative Bias: Indicators of Cognitive Vulnerability to Depression Reprinted from the German Journal of Psychiatry http://www.gjpsy.uni-goettingen.de ISSN 1433-1055 Interpretative Bias: Indicators of Cognitive Vulnerability to Depression Rashmi Gupta and Bhoomika R. Kar

More information

Diseases of the Nervous System. Neal G. Simon, Ph.D. Professor, Dept of Biological Sciences Lehigh University

Diseases of the Nervous System. Neal G. Simon, Ph.D. Professor, Dept of Biological Sciences Lehigh University Diseases of the Nervous System Neal G. Simon, Ph.D. Professor, Dept of Biological Sciences Lehigh University Outline A. Stress-related Disorders 1. Emotional Circuitry: Key Components 2. The Hypothalamic

More information

PREFRONTAL AND MEDIAL TEMPORAL LOBE INTERACTIONS IN LONG-TERM MEMORY

PREFRONTAL AND MEDIAL TEMPORAL LOBE INTERACTIONS IN LONG-TERM MEMORY PREFRONTAL AND MEDIAL TEMPORAL LOBE INTERACTIONS IN LONG-TERM MEMORY Jon S. Simons* and Hugo J. Spiers Cognitive neuroscience has made considerable progress in understanding the involvement of the medial

More information

Chapter Fourteen. Emotion, Reward, Aggression, and Stress

Chapter Fourteen. Emotion, Reward, Aggression, and Stress Chapter Fourteen Emotion, Reward, Aggression, and Stress EMOTIONS! Emotions generally include a Physical component, and a Subjective component or quality, and a Valence Emotions a product of Evolution?

More information

About Memory, Interpretation Guidelines, and Clues to Diagnosis

About Memory, Interpretation Guidelines, and Clues to Diagnosis About Memory, Interpretation Guidelines, and Clues to Diagnosis Revised November 2007 19782 MacArthur Blvd. #310 Irvine, CA 92612 Customer Service: (888) 565-5535 www.mccare.com Memory is a recording in

More information

Modeling perceptual abnormalities. Kate Lomakina TNU seminar: schizophrenia 17 August 2012

Modeling perceptual abnormalities. Kate Lomakina TNU seminar: schizophrenia 17 August 2012 Modeling perceptual abnormalities Kate Lomakina TNU seminar: schizophrenia 17 August 2012 Outline Mismatch negativity Perception of visual illusions Affective processing Visual object recognition Brain

More information

Brain and Memory. By: Pamela L. Washbourne

Brain and Memory. By: Pamela L. Washbourne Brain and Memory By: Pamela L. Washbourne Neurocognitive Networks Recent advances in basic and cognitive neurosciences now allow a more detailed analysis of networks Memory and Learning can be dissociated

More information

Maguire on Navigation and the Human Brain

Maguire on Navigation and the Human Brain Maguire on Navigation and the Human Brain Program Support Notes by: Sylvia Wood B.Ed Executive Producer: Simon Garner B.Ed, Dip Management You may download and print one copy of these support notes from

More information

The Neuroscience of Stereotyping and Prejudice. David M. Amodio New York University

The Neuroscience of Stereotyping and Prejudice. David M. Amodio New York University The Neuroscience of Stereotyping and Prejudice David M. Amodio New York University Overarching question: Talk Overview How are stereotypes and prejudices regulated? Can interventions be designed to limit

More information

Depression After Stroke. William M. Petrie, MD Professor of Clinical Psychiatry Vanderbilt University Medical Center

Depression After Stroke. William M. Petrie, MD Professor of Clinical Psychiatry Vanderbilt University Medical Center Depression After Stroke William M. Petrie, MD Professor of Clinical Psychiatry Vanderbilt University Medical Center Depression After Stroke 33% (29-79%) Hackett et al. 2004 Major Depression 19% Minor Depression

More information

Module 1 Introduction to Borderline Personality Disorder

Module 1 Introduction to Borderline Personality Disorder Module 1 Introduction to Borderline Personality Disorder Borderline personality disorder (BPD), sometimes called emotionally unstable personality disorder, is one of many diagnosable personality disorders.

More information

fmri references Lea, P., McColl, R., Maxham, K.Y. & Thompson, L.T. (2000). Aging and event Page 1

fmri references Lea, P., McColl, R., Maxham, K.Y. & Thompson, L.T. (2000). Aging and event Page 1 Arthurs, O.J. & Boniface, S. (2002). How well do we understand the neural origins of the fmri BOLD signal? Trends in Neuroscience 25(1): 27-31. The successful use of functional magnetic resonance imaging

More information

Processing of emotional expression in subliminal and low-visibility images

Processing of emotional expression in subliminal and low-visibility images Processing of emotional expression in subliminal and low-visibility images Submitted by Hannah Lucy Filmer to the University of Exeter as a thesis for the degree of Doctor of Philosophy in Psychology May

More information

Attentional bias for valenced stimuli as a function of personality in the dot-probe task

Attentional bias for valenced stimuli as a function of personality in the dot-probe task Journal of Research in Personality 38 (2004) 15 23 JOURNAL OF RESEARCH IN PERSONALITY www.elsevier.com/locate/jrp Attentional bias for valenced stimuli as a function of personality in the dot-probe task

More information

Differential Functional Connectivity of Prefrontal and Medial Temporal Cortices During Episodic Memory Retrieval

Differential Functional Connectivity of Prefrontal and Medial Temporal Cortices During Episodic Memory Retrieval Human Brain Mapping 5:323 327(1997) Differential Functional Connectivity of Prefrontal and Medial Temporal Cortices During Episodic Memory Retrieval A.R. McIntosh, 1 * L. Nyberg, 2 F.L. Bookstein, 3 and

More information

Thinking, Memory and Parkinson s Disease

Thinking, Memory and Parkinson s Disease Thinking, Memory and Parkinson s Disease Benzi M. Kluger M.D., M.S. Director, Movement Disorders Center Associate Professor of Neurology & Psychiatry University of Colorado OUTLINE I. Defining Terminology

More information

Clinical Depression. Lewis Wolpert

Clinical Depression. Lewis Wolpert Clinical Depression It was the worst experience of my life. More terrible even than watching my wife die of cancer. I am ashamed to admit that my depression felt worse than her death but it is true. Lewis

More information

Lecture 7: Occipital and Temporal Lobe Visual Perception and Memory

Lecture 7: Occipital and Temporal Lobe Visual Perception and Memory C81BIO: Introduction to Cognitive Neuroscience and Biological Psychology Lecture 7: Occipital and Temporal Lobe Visual Perception and Memory Tobias Bast, School of Psychology, University of Nottingham

More information

Prevalence/Types of Child Abuse. The Effects of Child Abuse on Brain Development

Prevalence/Types of Child Abuse. The Effects of Child Abuse on Brain Development The Effects of Child Abuse on Brain Development R. Christopher Qualls, Ph.D. Professor; Emory & Henry College Consulting Psychologist; Mt. Rogers CSB Overview Prevalence & Types of Child Abuse Neurological

More information

ADDICTION, STIGMA, TREATMENT, RECOVERY

ADDICTION, STIGMA, TREATMENT, RECOVERY ADDICTION, STIGMA, TREATMENT, RECOVERY John F. Kelly, Ph.D. Elizabeth R. Spallin Associate Professor of Psychiatry in Addiction Medicine, Harvard Medical School Director, MGH Recovery Research Institute

More information

1H-MRS MESIAL TEMPORAL LOBE ABNORMALITIES AND NEUROPSYCHOLOGICAL FUNCTION IN EPILEPSY PATIENTS

1H-MRS MESIAL TEMPORAL LOBE ABNORMALITIES AND NEUROPSYCHOLOGICAL FUNCTION IN EPILEPSY PATIENTS 1H-MRS MESIAL TEMPORAL LOBE ABNORMALITIES AND NEUROPSYCHOLOGICAL FUNCTION IN EPILEPSY PATIENTS Robert C. Doss, PsyD John R. Gates, MD David B. Kispert, MD Britt Carlson-Emerton, BA This paper has been

More information

displacement- items currently in STM are pushed out to make room for incoming new items

displacement- items currently in STM are pushed out to make room for incoming new items Forgetting To understand how the memory system works, it is important to look at some of the reasons why we lose information - in other words, how we forget. We will look at some psychological explanations

More information

Neuropsychological Mechanisms of Antidepressant Drug Action. Catherine Harmer Dept. Psychiatry, University of Oxford

Neuropsychological Mechanisms of Antidepressant Drug Action. Catherine Harmer Dept. Psychiatry, University of Oxford Neuropsychological Mechanisms of Antidepressant Drug Action Catherine Harmer Dept. Psychiatry, University of Oxford How do antidepressant treatments work? Pharmacological focus: We think that antidepressants

More information

Aging and Mental Agility Alzheimer's and Dementia. Manjunath N. K., Ph.D., Professor and Head Anvesasa Research Laboratories S-VYASA, Bengaluru

Aging and Mental Agility Alzheimer's and Dementia. Manjunath N. K., Ph.D., Professor and Head Anvesasa Research Laboratories S-VYASA, Bengaluru Aging and Mental Agility Alzheimer's and Dementia Manjunath N. K., Ph.D., Professor and Head Anvesasa Research Laboratories S-VYASA, Bengaluru The best gift we are bestowed with The ability to Remember

More information

Deep processing activates the medial temporal lobe in young but not in old adults

Deep processing activates the medial temporal lobe in young but not in old adults Neurobiology of Aging 24 (2003) 1005 1011 Deep processing activates the medial temporal lobe in young but not in old adults Sander M. Daselaar a,, Dick J. Veltman b, Serge A.R.B. Rombouts c, Jeroen G.W.

More information

Understanding Schizophrenia: An Integrative Perspective

Understanding Schizophrenia: An Integrative Perspective Understanding Schizophrenia: An Integrative Perspective Kristin Mickel Immaculata University Introduction Much attention has been devoted to understanding the positive and negative symptoms of schizophrenia

More information

D-KEFS Verbal Fluency Test. The Verbal Fluency Test measures letter and category

D-KEFS Verbal Fluency Test. The Verbal Fluency Test measures letter and category e-methods Neuropsychological testing. D-KEFS Verbal Fluency Test. The Verbal Fluency Test measures letter and category fluency. In this study, we used the letter fluency task, which requires subjects to

More information

Article. Borderline Personality Disorder, Impulsivity, and the Orbitofrontal Cortex

Article. Borderline Personality Disorder, Impulsivity, and the Orbitofrontal Cortex Article Borderline Personality Disorder, Impulsivity, and the Orbitofrontal Cortex Heather A. Berlin, D.Phil., M.P.H. Edmund T. Rolls, D.Phil., D.Sc. Susan D. Iversen, Ph.D., Sc.D. Objective: Orbitofrontal

More information

Assignment #3 you do not need to hand this assignment in. It is for study purposes only. Only the multiple choice answers are listed at the bottom.

Assignment #3 you do not need to hand this assignment in. It is for study purposes only. Only the multiple choice answers are listed at the bottom. Assignment #3 you do not need to hand this assignment in. It is for study purposes only. Only the multiple choice answers are listed at the bottom. 1. The premotor cortex is responsible for: A) planning

More information

The Neural Dynamics of Fear Memory R.M. Visser

The Neural Dynamics of Fear Memory R.M. Visser The Neural Dynamics of Fear Memory R.M. Visser The neural dynamics of fear memory Summary While much of what we learn will be forgotten over time, emotional memory appears to be particularly resilient

More information

Virginia Warner, Dr. P.H. 1 Priya Wickramaratne, Ph.D. 1,2 Christian Grillion, Ph.D. 3 Myrna M. Weissman, Ph.D. 1,2

Virginia Warner, Dr. P.H. 1 Priya Wickramaratne, Ph.D. 1,2 Christian Grillion, Ph.D. 3 Myrna M. Weissman, Ph.D. 1,2 Virginia Warner, Dr. P.H. 1 Priya Wickramaratne, Ph.D. 1,2 Christian Grillion, Ph.D. 3 Myrna M. Weissman, Ph.D. 1,2 1 NYS Psychiatric Institute, Division of Epidemiology 2 Columbia University, Department

More information

Christof Karmonik, PhD Mario Dulay, PhD Amit Verma, MD Robert G. Grossman, MD

Christof Karmonik, PhD Mario Dulay, PhD Amit Verma, MD Robert G. Grossman, MD Christof Karmonik, PhD Mario Dulay, PhD Amit Verma, MD Robert G. Grossman, MD Specific set of brain regions engaged when subject are engaged on internally focused tasks Autobiographical memory retrieval

More information

Functional magnetic resonance imaging in multiple sclerosis patients with fatigue before and after neurorehabilitation therapy

Functional magnetic resonance imaging in multiple sclerosis patients with fatigue before and after neurorehabilitation therapy Functional magnetic resonance imaging in multiple sclerosis patients with fatigue before and after neurorehabilitation therapy Poster No.: C-2496 Congress: ECR 2010 Type: Topic: Authors: Keywords: DOI:

More information

Okami Study Guide: Chapter 11 1

Okami Study Guide: Chapter 11 1 Okami Study Guide: Chapter 11 1 Chapter Test 1. These psychological states are typically less intense than emotions, but may pervade a person s life for days, weeks, months, or possibly even years at a

More information

The Medial Temporal Lobe Distinguishes Old from New Independently of Consciousness

The Medial Temporal Lobe Distinguishes Old from New Independently of Consciousness The Journal of Neuroscience, May 24, 2006 26(21):5835 5839 5835 Brief Communications The Medial Temporal Lobe Distinguishes Old from New Independently of Consciousness Sander M. Daselaar, 1,2 Mathias S.

More information

COURSE SYLLABUS. Department of Behavioral Sciences and Human Services

COURSE SYLLABUS. Department of Behavioral Sciences and Human Services COURSE SYLLABUS 1. Department, Course Number, and Title Department of Behavioral Sciences and Human Services PSY 11 General Psychology 2. Group and Area Group IV Behavioral Sciences 3. Transferability

More information

AGENDA. Brain Development A Few Facts. The Impact of Trauma, Neglect, and FASD on the Developing Brain

AGENDA. Brain Development A Few Facts. The Impact of Trauma, Neglect, and FASD on the Developing Brain The Impact of Trauma, Neglect, and FASD on the Developing Brain Karen Serrett, Ph.D. Collaborative Mental Health Care Program November 25 th, 2010 AGENDA Early brain development The relational brain Toxic

More information

Neural correlates of viewing photographs of one s own body and another woman s body in anorexia and bulimia nervosa: an fmri study

Neural correlates of viewing photographs of one s own body and another woman s body in anorexia and bulimia nervosa: an fmri study Research Paper Neural correlates of viewing photographs of one s own body and another woman s body in anorexia and bulimia nervosa: an fmri study Silja Vocks, PhD; Martin Busch, PhD; Dietrich Grönemeyer,

More information

Recognizing and Treating Depression in Children and Adolescents.

Recognizing and Treating Depression in Children and Adolescents. Recognizing and Treating Depression in Children and Adolescents. KAREN KANDO, MD Division of Child and Adolescent Psychiatry Center for Neuroscience and Behavioral Medicine Phoenix Children s Hospital

More information

ADOLESCENT BRAIN DEVELOPMENT: IMPLICATIONS FOR DRUG USE PREVENTION. Jessie Breyer, B.A. & Ken C. Winters, Ph.D. Center for Substance Abuse Research

ADOLESCENT BRAIN DEVELOPMENT: IMPLICATIONS FOR DRUG USE PREVENTION. Jessie Breyer, B.A. & Ken C. Winters, Ph.D. Center for Substance Abuse Research ADOLESCENT BRAIN DEVELOPMENT: IMPLICATIONS FOR DRUG USE PREVENTION Jessie Breyer, B.A. & Ken C. Winters, Ph.D. Center for Substance Abuse Research Department of Psychiatry, University of Minnesota & Mentor

More information

FTD occurs primarily between the ages of 35 and 75. The disease affects both sexes equally. About 40% of patients have a clear-cut family history.

FTD occurs primarily between the ages of 35 and 75. The disease affects both sexes equally. About 40% of patients have a clear-cut family history. FRONTOTEMPORAL DEMENTIA (FTD) The term "Frontotemporal Dementia" or FTD refers to a group of diseases that are commonly misdiagnosed as Alzheimer's Disease (AD). We use the term FTD as a general term to

More information

1/23/2012 HEALTH AND HEALTH DISORDERS. Mortality Rates and Causes of Death. THE JOURNEY OF ADULTHOOD Barbara R. Bjorklund

1/23/2012 HEALTH AND HEALTH DISORDERS. Mortality Rates and Causes of Death. THE JOURNEY OF ADULTHOOD Barbara R. Bjorklund THE JOURNEY OF ADULTHOOD Barbara R. Bjorklund Chapter 3 HEALTH AND HEALTH DISORDERS Mortality Rates and Causes of Death Morbidity rates, illness, and disability Specific diseases Mental disorders Individual

More information

The Mindful Brain. Objectives 4/23/2012

The Mindful Brain. Objectives 4/23/2012 The Mindful Brain Bev Klug, M.A., LMFT Director of Mindfulness-Based Programs Department of Psychiatry University of Iowa Hospitals and Clinics The aim is to develop an inner balance of mind that allows

More information

Chapter 2 Storing and Keeping Memories

Chapter 2 Storing and Keeping Memories Chapter 2 Storing and Keeping Memories Forming Memories How memories are formed in the brain is an extremely complex process that is only partly understood. Memories are fundamental for learning and being

More information

Four Main Approaches COGNITIVE NEUROPSYCHOLOGY. Cognitive Neuropsychology. Experimental cognitive psychology. Cognitive neuropsychology

Four Main Approaches COGNITIVE NEUROPSYCHOLOGY. Cognitive Neuropsychology. Experimental cognitive psychology. Cognitive neuropsychology Four Main Approaches Experimental cognitive psychology Cognitive neuropsychology Computational cognitive science Cognitive neuroscience COGNITIVE NEUROPSYCHOLOGY Cognitive Neuropsychology Concerned with

More information

Parkinson s disease and Memory. Christie Chung 8/2/06

Parkinson s disease and Memory. Christie Chung 8/2/06 Parkinson s disease and Memory Christie Chung 8/2/06 PD and Memory PD without dementia impairs declarative memory processes Recall Recognition (Recollection and Familiarity) Prospective memory Metamemory

More information

Dose-Response Effects of Low-Level Light Therapy on Brain and Muscle Prof. Dr. Francisco Gonzalez-Lima The University of Texas at Austin

Dose-Response Effects of Low-Level Light Therapy on Brain and Muscle Prof. Dr. Francisco Gonzalez-Lima The University of Texas at Austin Dose-Response Effects of Low-Level Light Therapy on Brain and Muscle Prof. Dr. Francisco Gonzalez-Lima The University of Texas at Austin The 13 th Annual International Conference on Dose-Response, April

More information

Ons brein als plastisch orgaan in een

Ons brein als plastisch orgaan in een Ups and Downs Forum, 12.10.13 Ons brein als plastisch orgaan in een Chronische depressie: voelen en denken gegijzeld. maatschappelijke context Een actueel neurobiologisch inzicht. Prof. Dr. Kurt Audenaert

More information

Spatial Dispersion of Lesions as a Surrogate Biomarker for Disability in Multiple Sclerosis

Spatial Dispersion of Lesions as a Surrogate Biomarker for Disability in Multiple Sclerosis Spatial Dispersion of Lesions as a Surrogate Biomarker for Disability in Multiple Sclerosis Fahime Sheikhzadeh MS/MRI Research Group University of British Columbia Vancouver, BC, Canada, V6T 1Z4 fahime@msmri.medicine.ubc.ca

More information

Arcuate Fasciculus. From Geschwind, Science, 1970

Arcuate Fasciculus. From Geschwind, Science, 1970 Arcuate Fasciculus From Geschwind, Science, 1970 Outline 1. Background 2. Afferent & Efferents 3. Neurophysiology 4. Neurochemical systems 5. Behavioral correlates 6. Physiological correlates 6. Clinical

More information

LIMBIC SYSTEM. The hypothalamus & limbic system are intimately concerned with emotional expression and with genesis of emotion.

LIMBIC SYSTEM. The hypothalamus & limbic system are intimately concerned with emotional expression and with genesis of emotion. LIMBIC SYSTEM OBJECTIVES What is limbic system Structures included in limbic system Functions of limbic system Connections of limbic system The Brain and Memory LIMBIC SYSTEM The term limbic system is

More information