The German Programme for Guidelines in Oncology
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1 The German Programme for Guidelines in Oncology Ina Kopp Markus Follmann International Symposium on Evidence-based Cochrane Reviews in Haemato-Oncology 10th Anniversary of the Cochrane Haematological Malignancies Group July 2011 GERMAN GUIDELINE PROGRAMME IN ONCOLOGY (GGPO) BACKGROUND AND RATIONALE - need for quality improvement in cancer care - need for better knowledge management - need for a common basis to improve networking of quality initiatives - German National Cancer Plan launched 2008, setting the goal to develop and implement high quality clinical practice guidelines (CPGs) in oncology
2 GERMAN GUIDELINE PROGRAMME IN ONCOLOGY (GGPO) CPG-development in Germany: strong engagement of Scientific Medical Societies and Professional Organisations, lack of funding GERMAN GUIDELINE PROGRAMME IN ONCOLOGY (GGPO) PARTNERS Association of the Scientific Medical Societies (AWMF) German Cancer Society (DKG) German Cancer Aid (DKH)
3 GERMAN GUIDELINE PROGRAM IN ONCOLOGY (GGPO) OBJECTIVES to support CPG development by scientific medical societies to provide independent funding for CPG development to improve methodological quality of CPGs to improve implementation and evaluation by - patient guidelines - short / long / pocket versions of CPGs - performance measures / quality indicators to consolidate the network of quality initiatives GGPO CONTEXT: QUALITY IMPROVEMENT IN ONCOLOGY Clinical Practice Guidelines (CPG) provide evidence- and consensus-based recommendations Guideline-based Quality Indicators Cancer Registries assess and report processes and outcomes are linked with Quality Assurance within the framework of the German Social Code Book ( 137a SGB V) Certified Cancer Centers support implementation transfer of guidelines into practice
4 GGPO: ORGANISATION STEERING COMMITTEE WORKING GROUP METHODOLOGY programme planning prioritisation project proposal CPG development GGPO Office coordination support GUIDELINE DEVELOPMENT GROUPS Titel GGPO: METHODOLOGY BASIS: GERMAN INSTRUMENT FOR METHODOLOGICAL GUIDELINE APPRAISAL Key elements: - stake holder and patient involvement - editorial independence - systematic search, selection and appraisal of the evidence - formal consensus process (nominal group technique, delphi, structured consensus conference) - facilitation of implementation and evaluation (patient guidelines, performance measures)
5 STAKEHOLDER AND PATIENT INVOLVEMENT REPRESENTATIVITY: PROFESSIONAL GROUPS AND PATIENTS - scientific medical societies - professional organisations (e.g. nurses, physiotherapists) - methodologists (strongly recommended) - patient self help organisations / consumer organisations HEURISTICS - match with target population, scope and purpose of the guideline - consider method to identify views, expectations and preferences (surveys/ literature search especially, if no direct involvement) EDITORIAL INDEPENDENCE SOURCE OF FUNDING - independent funding by GGPO - no influence on guideline content COMPETING INTERESTS OF GUIDELINE DEVELOPMENT GROUP MEMBERS - form sheet according to ICMJE - disclosure of financial and academical interests (table) - measures taken to minimise the influence of competing interests
6 SYSTEMATIC SEARCH AND APPRAISAL OF THE EVIDENCE documentation of strategy used to search for evidence clinical questions, databases, time period covered, search terms, inclusion criteria stepwise process, beginning with guidelines and systematic reviews e.g. GIN, AHRQ, NICE, Cochrane Library, PubMed, CINAHL, Hand search identification of risks of bias checklists to assess quality of guidelines, systematic reviews, studies documentation of results evidence tables, GRADE profiles, strength of evidence explanatory background text: strengths and limitations of the body of evidence, health benefits, side effects and risks Identifying key questions, setting priorities for evidence synthesis CLINICAL ALGORITHM Pat. with known CAD Management in case of contra-indications? Expert Consensus (GCP) Excercise ECG before imaging? Adaptation of existing Guidelines/Systematic Reviews Risk stratification? Systematic search de-novo National Disease Management Guideline for Chronic Coronary Artery Disease (2006)
7 GRADING RECOMMENDATIONS: CONSENSUS PROCESS Quality of evidence 1 high 2 - moderate 3 - low 4 - very low Strength of recommendation do / don t do we recommend probably do/don t do we suggest uncertain can be considered we do not know considered judgment a group decision GermanDM-CPG programme method report ( European Council, Recommendation (2001) 13, GRADE 2004 ( CRITERIA FOR CONSIDERED JUDGMENT - relative importance of the outcomes - quality of evidence for each outcome - overall quality of evidence - balance of benefit and harm (burden) - magnitude of the effects - precision of the estimates of the effects - applicability of the evidence to the target population - ethical, legal, economical considerations The GRADE Working Group,
8 CRITERIA FOR CONSIDERED JUDGMENT The strength of a recommendation reflects the degree of confidence that the desirable effects of adherence to a recommendation outweigh the undesirable effects strong recommendations are candidates for performance indicators why do we need formal methods for consensus? Safety in numbers several people are less likely to arrive at a wrong decision than a single individual. Authority a selected group of individuals is more likely to lend some authority of the decision produced. Rationality decisions are improved by reasoned arguments in which assumptions are challenged and members forced to justify their views. Controlled process by providing a structured process formal methods can eliminate negative aspects of group decision-making. Scientific credibility formal consensus methods meet the requirements of scientific methods. Murphy, Black et al. HTA 1998 (2)
9 TOOLS TO FACILITATE IMPLEMENTATION Long Version (Book, Journal Supplement, Internet) Short Version (Internet) Report on Methodology Evidence-Report (Systematic Review) Patient Guideline /Lay Version Pocket Versions (Algorithms) Apps and Electronic Reminders Titel GUIDELINE BASED QUALITY INDICATORS Guideline Recommendation Goal Quality Indicator (Reference Range) 2005 We strongly recommend that in all patients diagnosed with invasive breast cancer the hormone-receptor status is determined. LoE 1a, GoR A Immunehistochemical analysis of hormone-receptor status (Process Quality) Numerator: patients with documented hormone receptor-status Denominator: all patients with diagnosed invasive breast cancer (>95%) 95,82% Schulz, Albert et al.: S3-Guideline Early Detection of Breast Cancer Results: National Quality Report, BQS 2005
10 Titel QUALITY INDICATORS AND QUALITY IMPROVEMENT Breast Cancer: Hormone Receptor Status Assessment: year 2003, 40 Hospitals, county Hessen (10% of Patients in Germany) Presentation: U.-S. Albert, 5th Annual G-I-N Conference, Helsinki 2008 Titel GGPO: PROJECTS TUMOR SPECIFIC CPGs (12): Breast Cancer, Colorectal Cancer, Prostate Cancer, Cervical Cancer, Gastric Cancer, Ovarian Cancer, Oral Cavity Cancer, Pancreatic Cancer; Hepatocellular Carcinoma, Skin (prevention, early detection), Melanoma (diagnosis, therapy) Hodgkin s Lymphoma CROSS-SECTIONAL, ASPECT-SPECIFIC CPGs (2) Psychooncology (diagnosis, counseling, therapy) Palliative Care in Oncology
11 Titel CONCLUSION THE GERMAN GUIDELINE PROGRAMME IN ONCOLOGY (GGPO): solid framework for the development of high quality guidelines key instrument for quality improvement in oncology powerful start- 14 projects launched in 3 years monitoring of CPG effects and GGPO effects are essential Thank you!...
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