BJC HealthCare CORPORATE COMPLIANCE POLICY. APPLIES TO: BJC HealthCare and all BJC Members and Affiliates

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1 Page 1 of 11 BJC HealthCare CORPORATE COMPLIANCE POLICY APPLIES TO: BJC HealthCare and all BJC Members and Affiliates TITLE: BJC HealthCare Financial Conflict of Interest in Research Policy NUMBER: 9.1 PURPOSE: This policy outlines the principles and procedures used by BJC HealthCare and its members or affiliates ( BJC ) to identify, disclose, and manage financial conflicts of interest (FCOI) Interest in such a way as to further BJC s commitment to conduct business in compliance with all applicable Public Health Services (PHS) regulations, in accordance with the highest standards of ethics and integrity. I. Policy Statement BJC HealthCare ( BJC ) is committed to overseeing the conduct of research in a manner that ensures the integrity of the research process and maintains the public trust and that of sponsors in the integrity and credibility of its faculty, its staff, and its research programs. This commitment requires BJC to ensure that there is no reasonable perception that research results are biased by the external commitments and financial interests of persons who are responsible for the design, conduct, reporting, or direct administration of BJC member organization research. This policy identifies and addresses the real or apparent financial conflicts of interest presented by the intersection of research activities and personal financial interests, and defines the requirements of all research personnel to ensure that those activities are conducted objectively and without consideration of personal financial gain. II. Definitions: BJC: Collectively BJC HealthCare, BJC Member Organizations, BJC Service Organizations, and their Affiliates, as defined in the Amended and Restated System Affiliation Agreement dated March 11, 2009, and any other entities which become Institutions or Affiliates as defined in and pursuant to said Agreement, as may be amended, from time to time. Conflict Management: Measures taken to address the risk of bias or the appearance of bias, protect research subjects, and maintain public trust in the institution s research and its personnel when research personnel may have a real or apparent financial conflict of interest

2 Page 2 of 11 Design, Conduct, or Reporting of Research: Oversight, decision-making, or participation in research that includes creating the structure, roles, and/or protocol of a research project; participating in the execution of the research roles and protocol; participant in the publishing, presentation, or discussion of the research results. Direct Administration of Research: Oversight or decision-making impacting research that includes, selection of vendors, determining the allocation of funds, sponsor negotiations for the research project, protocol review and approval, or managing resulting intellectual property and licensing opportunities. Disclose/Disclosure: To provide relevant information about research personnel s financial interests related to a research project to parties inside and outside the institution to assure full awareness of potential conflicts and institutional efforts to address them. External Commitment: An obligation or activity (e.g. management, employment, advisory, or consulting role) that is not related to primary commitments or obligations to the BJC or its member organization. External Entity: An entity other than the BJC member organization participating in the PHS funded research. Family member: A Covered Individual s spouse (including same-gender domestic partner), ancestors, brothers and sisters (whole or half-blood), children (natural, adopted and those of same-gender domestic partner), grandchildren, great grandchildren, and spouses of brothers, sisters, children, grandchildren, and great grandchildren. Financial Conflict of Interest Real, Apparent (FCOI): A Real Financial Conflict of Interest arises when a financial interest, or other opportunity for personal financial gain, is likely to compromise or influence the objective design, conduct, reporting, or direct administration of research. An Apparent Conflict of Interest arises when there is a reasonable apprehension, which reasonably well-informed persons are likely to have, that an individual s opportunity for personal financial gain could compromise or influence the design, conduct, reporting, or direct administration of research. Financial Interest: A monetary interest or relationship excluding stock owned through mutual funds or reimbursement for reasonable travel expenses, including, but not limited to, compensation for management, advisory, or consulting roles; gifts, services, loans; payments or in-kind gifts for services; licensing, patent, royalty, and other intellectual property agreements; equity interests (e.g., stocks, stock options, bonds, property interests, dividends, convertible securities); and legal partnership interests. Management Plan: See Conflict Management above. BJC Member or Affiliate Organization ( BJC Member or Affiliate ): An individual BJC Member Organization, BJC Service Organization, or BJC affiliate, as defined in the

3 Page 3 of 11 Amended and Restated System Affiliation Agreement dated March 11, 2009, and any other entities which become Institutions or Affiliates as defined in and pursuant to said Agreement, as may be amended, from time to time. Policy: This Financial Conflict of Interest Policy. Research: Research, for the purposes of this policy, includes all sponsored projects, including research and extension. Research Administration Department ( RAD ): The Research Administration Department is the group of individuals at each BJC Member or Affiliate who are charged with the management and administration of Research related activities. Investigator: Any individual responsible for the design, conduct, or reporting of research, including key personnel, as well as those responsible for the direct administration of research. Investigator(s) also includes sub-recipients of funding who perform the aforementioned tasks. An Investigator need not be BJC employees, as long as they serve in any of the roles described above for research in which a BJC member organization is the funding recipient. Research Related: An external commitment or financial interest that is likely to bias the outcome of research. Same Gender Domestic Partner: As defined in BJC HealthCare Human Resources Benefits policy #4-12, but applicable to both employees and non-employees who are considered key personnel as defined above. Senior/Key Research personnel: The Project Director or Principal Investigator of an NIH-funded project and any other person identified as senior/key personnel by the BJC Member or Affiliate in the grant application, progress report, or any other report submitted to the NIH by the BJC Member or Affiliate. Significant Equity Interest: For a publicly held business, an equity interest that when aggregated for you and your family (as defined in the procedures for each campus) exceeds the Public Health Service (PHS) threshold, currently: (i) $5,000 in value as determined through reference to public prices or other reasonable measures of fair market value, or (ii) representing five percent ownership in such business. For a privately held business, any equity interest in such business, regardless of the amount. Significant Financial Income: Payments or anything of monetary value (including the value of an equity interest) from a single entity that when aggregated for you and your family for the past 12 months or expected over the next 12 months, exceeds the PHS threshold, currently $5,000.

4 Page 4 of 11 Significant Financial Interest: A financial interest (see definition of Financial interest above) that includes a significant equity interest or significant financial income. Sponsor: An external entity that funds or supports research. Sponsors include federal, state, and local governments and private entities, both non-profit and for-profit. Sponsored Research: Research funded by a sponsor through a grant, contract, or agreement. III. Policy The conduct of research in compliance with applicable regulations and free from any reasonable perception that the research results are biased by the financial self-interest of research personnel ensures the integrity of the research process, protects the public s investment, and engenders and maintains the public trust in the integrity of the BJC Member or Affiliate s research and education mission. 1. External Relationships and Research BJC recognizes the value of engagement in external organizations and activities. Such activities and relationships enable the transfer of knowledge and skills that enhance teaching, research, service, and inspire solutions to benefit the world. Entrepreneurial endeavors and productive relationships with businesses can stimulate inquiry and provide opportunities to further academic research. However, the financial interests that accompany such relationships may lead to real or apparent financial conflicts of interest. 2. Legal Compliance This policy promotes compliance with all applicable federal and state laws and regulations regarding financial conflicts of interest, including the National Institutes of Health, the National Science Foundation, and the Food and Drug Administration. 3. Full and Accurate Reporting Real and potential financial conflicts of interest may arise from any number and type of external commitments and financial interests, and particular expertise is required to determine whether they could affect, or could be perceived to affect, research activities and results. BJC research personnel are required to report fully and accurately all external commitments and all research-related financial interests in accordance with the procedures for each campus, in order to provide sufficient information for the identification of real and potential financial conflicts of interest. Research personnel must include the external commitments and financial interests of his/her spouse or same-sex partner and dependent child(ren) in accordance with the procedures for each campus. 4. Timely Reporting

5 Page 5 of 11 Reports of external commitments and financial interests must be made at regular intervals, as required by BJC policy and federal regulation, to allow the BJC Member or Affiliate to identify and manage real and apparent financial conflicts of interest in a timely manner. Additional reporting events are prescribed by federal regulation, agencyand award-specific terms, and human subject protocol submission requirements. All research personnel must report (1) annually, (2) when external commitments and financial interests materially change, (3) when submitting a proposal or IRB protocol, (4) when required by the specific terms of an award, (5) when newly assigned to a research personnel role, and (6) when otherwise required. 5. Oversight A central review committee at each BJC Member or Affiliate develops conflict review procedures that ensure expert, confidential, and consistent review of reports across BJC HealthCare. Reviewers identify situations in which external commitments and financial interests may potentially compromise, or appear to compromise, the professional judgment of research personnel in conducting or reporting research, including the collection, analysis, and interpretation of data, the hiring of staff, procurement of materials, sharing of results, choice of protocol, involvement of human participants, and the use of statistical methods. 6. Training Requirements The RAD of each BJC Member or Affiliate is responsible for dissemination of this policy along with applicable federal regulations available at: All research personnel are required to complete conflict of interest training when they first seek funding from the PHS, the National Science Foundation, the American Heart Association, or any other agency which requires disclosure, as well as no less than every four years thereafter. In addition, just in time training will be conducted by the RAD in the following situations: i. BJC revises this conflict of interest policy in such a way that the requirements of the investigators is modified, ii. An investigator is new to the BJC Member or Affiliate or to the study for which the BJC Member or Affiliate received PHS funding, or iii. An investigator is not in compliance with this policy or management plan. 7. Who Must File a Conflict of Interest Disclosure Form Research Personnel: All BJC Member or Affiliate Senior/Key Research personnel, are required to report their external commitments and financial interests annually and on an event-required basis for themselves and their spouse/same-gender domestic partners and children (hereinafter called family ). For current, active awards or IRB protocols:

6 Page 6 of 11 Research personnel who are required to report per this policy, but were not previously required to report, must report at the time of award renewal or protocol continuation. 8. What must be reported a. Irrespective of dollar amount, a reporter s external commitments or financial interests with an external entity that could constitute a conflict of commitment, such as employment, service or consulting; or intellectual property or licensing. b. Irrespective of dollar amount, a reporter s family s financial interest or commitments with an external entity, whose activities could be related to the reporter s duties at a BJC Member or Affiliate. c. Significant financial interest, as defined in this policy, for a reporter or family with any external entity whose activities could be related to the reporter s duties at a BJC Member or Affiliate. d. Any financial interests or external commitments not explicitly stated in the reporting form. For each such external relationship or financial interest, reporters must provide all of the information required in the reporting form. 9. When Must Filing Occur a. Annual Reports i. Required Reporting: All research personnel must update their reports of external commitments and financial interests at the time of application for funding and at least annually ( annual report ). The BJC Member or Affiliate is responsible for identifying individuals responsible for the direct administration of research and any newly appointed individuals who participate in research, and ensuring that they file annual reports ii. Handling of Annual Reports: The RAD at each BJC Member or Affiliate will coordinate the solicitation and collection of the annual reports and review reports for the purpose of identifying real and apparent conflicts of interest related to research. iii. Timely Reporting Requirement: All research personnel must complete and submit their annual reports by the required deadlines. b. Event-based Reports i. Newly Assigned Responsibilities: Individuals who become newly responsible for the design, conduct, reporting, or direct administration of research are required to complete annual reports within one month of their assumption of such responsibilities.

7 Page 7 of 11 ii. Material Change in Circumstances: All research personnel must amend their annual reports within 30 days of any material changes to their responses. Material changes include but are not limited to the initiation or elimination of are reportable external commitment or financial interest for the reporter and family, a change in, or the initiation of, a sponsor, or any change that might affect a current management plan. iii. Handling of Event-based Reports: The RAD at each BJC Member or Affiliate will coordinate the collection of Event-Based reports and review reports for the purpose of identifying real and apparent conflicts of interest related to research. 10. Report Review and Conflict Management The BJC Member or Affiliate s RAD is responsible for reviewing reports, collecting additional required information, identifying financial conflicts of interest, and determining required management plans. The BJC Corporate Compliance and Legal Departments will assist by consulting on process revisions and providing updates on relevant laws and regulations. Each RAD will review all report files to make the preliminary determination as to whether the report file shall be processed as follows: a. Exemption from review: No real or apparent financial conflict of interest exists and hence the report does not require further consideration. b. Expedited Review Required: External commitments and financial interests pose real or apparent financial conflicts of interest that can be easily addressed by standard management plan measures (e.g. disclosure of the interest to journal publishers). c. Escalated Review Required: External commitments and financial interests exist that pose real or apparent financial conflicts of interest that require full review and development of an appropriate management plan. All management plans resulting from an escalated review must be reviewed by the President of the BJC Member or Affiliate and the BJC Compliance Officer. 11. Management Plan Development and Monitoring Management measures may, as appropriate, include, but are not limited to, the following: Disclosure of the external commitment or financial interest to human participants, fellow researchers, students involved in the research activity, journal publishers, and/or others Research personnel s abstention from certain project segments or decisions Modification of the external commitment or financial interest

8 Page 8 of 11 Modification of the research plan (including the assignment of responsibilities) Monitoring of the potentially affected research activity by an independent individual or subcommittee Divestiture or severance of an external commitment or financial interest The management plan will state who is responsible for overseeing the implementation of the plan, and for reporting on compliance at stated intervals to the BJC Member or Affiliate s RAD. If the management plan prescribes monitoring of the activity, it will describe specifically how the monitoring shall be performed, who shall perform it, what records are to be kept, and what reports are made to the BJC Member or Affiliate s RAD. a. Management Plan Notification: The BJC Member or Affiliate s RAD communicates the decision and management plan to the research personnel, the Primary Investigator of the relevant sponsored project (if different from the research personnel at issue), and those responsible for implementation of the management plan. In addition, sponsors will be notified of the existence of a managed conflict if the regulations of that agency or award so require. b. Appeals Process: Within two weeks of notification of the management plan, research personnel must acknowledge in writing agreement to comply with any required management plan, or submit a written request for reconsideration to the BJC Member or Affiliate s RAD, which has the authority to review and affirm the previous decision or amend the management plan. The BJC Member or Affiliate s RAD will notify the research personnel of the result of the appeal and issue a binding decision. 12. Sanctions for Noncompliance a. Submitting the annual report by the filing deadline is a requirement of all research personnel. During the submission timeframe, research personnel will be reminded of the reporting deadline. Those who fail to submit the report will be referred to the BJC Member or Affiliate s RAD leadership. At the discretion of the BJC Member or Affiliate s RAD, the failure of an individual to comply with reporting requirements may result in one or more of the following sanctions, until the report is submitted: The individual will be deemed ineligible to maintain principal investigator status on sponsored projects Any annual salary increase will be withdrawn until the individual comes into compliance The individual s research activities and associated salary will be suspended until the individual comes into compliance. Any suspension of research activities and associated salary will be undertaken in accordance with BJC policies and codes, including the existing BJC Human Resources policies related to Disciplinary Action.

9 Page 9 of 11 For studies that receive NIH funding, the NIH will be promptly notified of noncompliance with this policy. b. In any case which the Department of Health and Human Services determines that a NIH-funded research project of clinical research whose purpose is to evaluate the safety or effectiveness of a drug, medical device, or treatment has been designed, conducted, or reported by Research Personnel with an Financial Conflict of Interest that was not managed or reported by the BJC Member or Entity, the Research personnel must: i. Disclose the FCOI in each public presentation of the results of the research, and ii. Request an addendum to previously published presentations. 13. NIH Reporting Requirements a. Who must submit the NIH report: The BJC Member or Entity RAD is responsible for sending initial, annual (i.e. ongoing) and revised Financial Conflict of Interest reports by way of the on-line FCOI reporting system. b. When and how often must the report be submitted: The report must be submitted? i. Prior to the expenditure of funds ii. Within 60 days of identification for research personnel who are newly participating in the project iii. At least annually (at the same time as when the BJC Member or Entity is required to submit the annual progress report, multi-year progress report, if applicable, or at time of extension) to provide the status of the FCOI and any changes to the management plan, if applicable, until the completion fo the project iv. Following a retrospective review to update a previously submitted report, if appropriate. c. Notification of bias: The NIH must be notified promptly if bias is found with the design, conduct, or reporting of NIH-funded research. A Mitigation Report must also be submitted in accordance with the regulation. 14. Subrecipient Requirements Each BJC member or entity who is awarded NIH funding ( awardee institution ) is responsible for ensuring subrecipient compliance with the conflict of interest policy and procedures for NIH funded research. The awardee must incorporate as part of a written agreement with a subrecipient terms that establish whether the financial Conflict of Interest Policy of the awardee, or that of the subrecipient will apply to subrecipient Investigators and include time periods to meet disclosure and/or financial conflict of interest reporting requirements.

10 Page 10 of 11 Subrecipient Institutions who rely on their Financial Conflict of Interest policy must report identified financial conflicts of interests to the awardee Institution in sufficient time to allow the awardee Institution to report the Financial Conflict of Interest to the NIH to meet its reporting obligations. Subrecipient institutions that must comply with the awardee Institution s policy must submit all Investigator disclosures of Significant Financial Interests to the awardee in sufficient time to allow the awardee to review, manage and report identified FCOIs to the NIH. The RAD at each awardee Institutions is responsible for monitoring the subrecipient s compliance with the Financial Conflict of Interest regulation, management plans, and for reporting all identified financial conflicts of interest to the NIH. 15. Audit The BJC Corporate Compliance Department may conduct investigations of potential noncompliance with reporting requirements, management plans, or other policy-related issues, when necessary. Instances of non-compliance that require reporting to federal agencies, sponsors, and/or other regulatory bodies will be determined by the BJC Corporate Compliance Department in collaboration with the BJC Legal Services department. The BJC Internal Audit department may conduct audits and process/compliance reviews to identify needed improvements to the financial conflicts of interest process. 16. Record Retention The Member of Affiliate s RAD will maintain the records regarding the financial conflicts of interest process, in accordance with BJC policies and sponsors requirements. Records will be maintained for at least three years from the date the final expenditures report is submitted to the NIH. 17. Public Accessibility a. Policy publication: This policy will be posted on each BJC member and entity s public website that participates in NIH funded research. b. Financial Conflict of Interest Disclosure: Financial conflicts of interest identified through the process described herein will be made available on each BJC member and entity s public website that participates in NIH funded research. This information will be published on the website prior to the expenditure of funds. The publically available information shall include all of the following elements: Investigator s name;

11 Page 11 of 11 Investigator s title and role with respect to the research project; Name of the entity in which the Significant Financial Interest is held; Nature of the Significant Financial Interest; and Approximately dollar value of the Significant Financial Interest (dollar ranges are permissible: $0-$4,999; $5,000-$9,999; $10,000-$19,999; amounts between $20,000-$100,000 by increments of $20,000; amounts above $100,000 by increments of $50,000) or a statement that the interest is one whose value cannot be readily determined through reference to public prices or other reasonable measures of fair market value. Information posted on the public websites will be updated and reviewed at least annually. The website will also be updated within 60 days of a newly identified financial conflict of interest. All information posted must remain available for three years from the date the information was most recently updated. IV. Corporate Compliance and Legal Services Department Review, Approval and Assistance Any exception, change, or deviation from this Policy must be reviewed and approved by the BJC Corporate Compliance Department and/or the BJC Legal Services Department. These Departments will be available to answer any questions and to provide assistance and advice concerning this Policy. Questions regarding specific terms, situations, or problems may be forwarded to the Corporate Compliance Department or Legal Services Department. RECOMMENDED BY: EFFECTIVE DATE: Corporate Compliance Department Legal Services Department August 24, 2012 (Original) AUTHORIZED BY: Michael A. DeHaven Senior Vice President, General Counsel, and Corporate Compliance Officer

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