Intraocular Lenses - Global Strategic Business Report

Transcription

1 Brochure More information from Intraocular Lenses - Global Strategic Business Report Description: This report analyzes the worldwide markets for Intraocular Lenses in US$ Million and Thousand Units by the following Segments: Standard Intraocular Lenses, and Premium Intraocular Lenses. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for the period 2013 through Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 32 companies including many key and niche players such as: - Abbott Medical Optics, Inc. - Alcon, Inc. - Bausch & Lomb, Inc. - Carl Zeiss Meditec AG - Hoya Corporation Contents: I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS Study Reliability and Reporting Limitations Disclaimers Data Interpretation & Reporting Level Quantitative Techniques & Analytics Product Definitions and Scope of Study Intraocular Lenses Standard Intraocular Lenses Premium Intraocular Lenses Toric Intraocular Lenses Other Premium Intraocular Lenses Premium Monofocal Lenses Multifocal IOLs Accommodative IOLs II. EXECUTIVE SUMMARY 1. INDUSTRY OVERVIEW Increasing Incidence of Vision Disorders: A Business Case for Ocular Products Table 1: Per-Capita Healthcare Expenditure in Select Regions (2013) (includes corresponding Table 2: Global Vision Correction Market (2013): Percentage Share Breakdown by Category (includes corresponding IOLs - Advancing Vision Care Growth Drivers and Restraints - In a Nutshell Driving Factors Restraining Factors Developed Countries Dominate, While Emerging Markets Drive Growth US - Leading the Way in the Global IOLs Market Premium Products Drive Revenue Growth Impact of Recession in Retrospect Product-Level Market Dynamics 2. COMPETITION A Peek into the Global IOL Competitive Landscape Table 3: World Intraocular Lenses Market (2014E): Percentage Breakdown of Value Sales by Company (includes corresponding Alcon - The Global Leader in Cataract Surgery Devices Abbott Medical Optics - Product Development and Global Expansion to Drive Sales STAAR Surgical - Eyeing Increased Role in IOL Market

2 Visian ICL Dominates Global Phakic IOLs Market Table 4: Leading Players in the Global Anterior Phakic IOL Market (2013): Percentage Breakdown of Unit Sales for STAAR Surgical, Ophtec and Novartis (includes corresponding 3. MARKET DYNAMICS The Epic Transition from Non-foldable to Foldable Continues Growing Demand for Phacoemulsification Drives Adoption of Foldable Lenses Dramatic Growth in Aging Population to Fuel Growth Table 5: Global Population Statistics for the 65+ Age Group (2013) (includes corresponding Table 6: Elderly Population (65+ Years) as a % of Total Population (2000 & 2025) (includes corresponding Table 7: Percentage of Population Aged 65 and Above in EU Countries, the US and Japan ( ) (includes corresponding Table 8: Aging Population by Age Group in More Developed Countries: (includes corresponding Table 9: Aging Population by Age Group in Less Developed Countries: (includes corresponding Table 10: Aging Population by Age Group in Least Developed Countries: (includes corresponding Table 11: Life Expectancy at Age 60 and 80 Years ( ), ( ) & ( ) (includes corresponding Cataract Incidence Rises in Tandem with Old Age Table 12: Recent Past, of Cataract Procedures Worldwide Analyzed in terms of Number of Procedures in Millions for Years 2010 through 2018 (includes corresponding Table 13: World Cataract Surgeries (2013): Percentage Breakdown of Procedures by Country (includes corresponding Table 14: Cataract Surgery Market Worldwide by Product Segment (2013) - Percentage Share Breakdown of Revenues for Intraocular Lenses (IOLs), Viscoelastics, Equipment, Instruments and Others (includes corresponding Table 15: Distribution of Ophthalmic Devices by Treatment Modality (in %) (includes corresponding Expanding Population and Urbanization Fuel Demand Table 16: World Population in Millions by Geographic Region ( ) (includes corresponding Table 17: Top 20 Populated Countries Worldwide (2013) (includes corresponding Select Mega-Urban Regions Worldwide (2035) Table 18: Percentage of Urban Population in Select Countries (2010 & 2050P) (includes corresponding Economic Development: A Key Driver of Market Growth Table 19: Economic Growth (In %) Worldwide by Region: E (includes corresponding Table 20: World Real GDP (2014 & 2015E): GDP Growth Rates in % by Select Region/ Country (includes corresponding Table 21: GDP Per Capita (in US$) and GDP (in US$ Billion) in Developed Countries Vs BRIC Vs CIVETS (2013) (includes corresponding Rising Prevalence of Diabetes Fuels Growth Table 22: Worldwide Prevalence of Diabetes Mellitus by Region: 2013 & 2035 (includes corresponding Table 23: Incidence of Diabetes in Select Countries (2013 & 2035) (includes corresponding Target Customer Groups & their Requirement Patterns Technological Innovations: A Boon to the IOL Industry Lasers: The High-Tech Solution Viscosurgery: A Safer Alternative Low Energy Methods for Cataract Removal Femtosecond Laser - Heralds Next Generation of Refractive Surgery Product Innovations in Accommodative IOLs Pep-Up the Market PC-IOLs: Raising the Standard Accommodative IOLs or Multifocal IOLs - The Tussle Carries On Post-Operative Refractive Errors: A Concern for Premium IOLs Adjustable IOLs - Addressing Refractive Concerns of IOLs Debate Continues on Whether UV Protection is Essential in IOLs The Blue Light Saga US Lags Behind Europe in IOL Approvals US & Europe Divided on Choice of Phakic IOL Options

3 Reimbursement Programs - The Key Determinant for Advanced IOLs IOL Reimbursement - A Comparison between the US and European Systems 4. PRODUCT LANDSCAPE Multifocal IOLs Multifocal Lenses - Bridging Gap between Conventional and Accommodative IOLs List of Select Approved and Under-Development Multifocal IOLs Overview of Select Multifocal IOLs ReZoom (Abbott Medical Optics) ReSTOR (Alcon) Tecnis (Abbott Medical Optics) Tecnis Vs. ReSTOR A Comparison of Major Multifocal IOLs - ReSTOR, ReZoom and Tecnis Multifocal AcrySof IQ ReSTOR IOL - Types Lentis MPlus (Oculentis) AT LISA (Carl Ziess Meditec) FineVision (PhysIOL) Accommodative Intraocular lenses Mechanisms in Accommodative IOL Creation Accommodative Lenses and Their Need List of Select Approved and Under-Development Accommodative IOLs Overview of Select Accommodative IOLs Crystalens (Bausch & Lomb) Crystalens - A Brief History Synchrony (AMO/Visiogen) The Need for a Suitable Injector Femtosecond Laser-Based Capsulorhexis - Further Increasing Efficient of Synchrony Tetraflex (Lenstec) Tetraflex - Awaiting FDA Nod in the US FluidVision Lens (PowerVision) Assessing the Strengths of FluidVision. DynaCurve (NuLens Ltd.) Concerns Drive Changes in Initial Product Design for DynaCurve Near Vision - The Key Target for DynaCurve Tek-Clear IOL (Tekia) 1CU Lens (HumanOptics AG) A Comparison of Major Accommodative IOLs - Crystalens, Synchrony and Tetraflex Monofocal Lenses Monofocal IOLs - Fighting for Attention Monofocal Lenses - Advantages and Disadvantages Advantages Disadvantages Europe Takes the Front Seat in Monofocal IOLs Overview of Select Monofocal Lens EC-3 Lenses (Aaren Scientific) Clinical Data isymm Lens (Hoya Optics) isymm IOL isert IOL Softec HD (Lenstec) Toric IOLs Toric Intraocular Lenses - Gaining Impetus Wide Range of Power and Improved Surgical Procedures Drive Volumes of Toric Lenses List of Select Approved and Under-Development Toric IOLs Overview of Select Toric Lenses STAAR Toric IOL (STAARSurgical) Acri.Comfort and Acri.LISA Toric Lenses (Acri.Tec AG/Carl Zeiss Meditec) MicroSil Toric IOL (HumanOptics) AcrySof Toric IOL (Alcon Laboratories Inc.) LENTIS Unico (Oculentis) Rayner T-flex Toric (Rayner) Phakic IOLs List of Select Approved and Under-Development Phakic IOLs

4 A Comparison of Approved and Under-Development Phakic IOLs Verisyse/Artisan, Veriflex/Artiflex, Visian ICL and Cachet IOL Potential Issues with Alcon s Cachet IOL Veriflex - A Versatile Innovation Will the New Phakic IOLs be the Game Changer? Aspheric IOLs Aspheric Lenses Revolutionizing Vision List of Select Marketed Aspheric IOLs Overview of Select Aspheric Lenses akromalens SeeLens AC (Hanita) nanoflex IOL (STAAR Surgical) Micro-Incision IOLs Available Products that Support MICS Acri.Smart Lens (Acri Tec GmbH, Germany) SlimFlex (PhysIOL, Belgium) Idea Lens (Xcelens S.A, Switzerland) ThinOptX (ThinOptX, US) ELENZA s Electronic IOL - a New Revolution in the Making Evolution of Lens Material Various Materials Used in IOLs & their Characteristics Rigid PMMA acrylic Foldable Acrylics Silicone Elastomers Major Differentiating Characteristics Refractive Index Glass Transition Temperature Water Content Postoperative Calcification Glisterings 5. PRODUCT OVERVIEW Evolution of Intraocular Lenses Structure of IOL Types of IOLs Classification Based on Material Used PMMA Silicones Flexible Acrylic Hydrogels Polymer with Thermo Mechanical Properties Classification Based on In-Situ Location Anterior Chamber IOLs Iris-Clip Lens Posterior Chamber IOLs Classification Based on Focus Monofocal IOLs Standard Monofocal IOLs Premium Lenses Premium Monofocal Lenses Multifocal IOLs Types of Multifocal Lenses Accommodative IOLs Toric IOLs Phakic IOLs Types of Phakic IOLs A Comparison of Four Key IOL Types - Standard Monofocal IOLs, Toric IOLs (Premium), Multifocal IOLs and Accommodative IOLs The Formation of Cataract Astigmatism Presbyopia Cataract Extraction Procedures Intracapsular Cataract Extraction Extracapsular Cataract Extraction (ECCE)

5 Phacoemulsification Post Cataract Extraction: The Alternatives Intraocular Lenses: A Much Better Solution A Retrospection 6. EFFECTS OF INTRAOCULAR LENSES IMPLANTATIONS Changes in the Size of Capsulorhexis Following IOL Implantation Effect of Anterior Chamber Baikoff Phakic IOLs on the Cornea Posterior Chamber IOL Fixed Sclerally for Children with Monocular Aphakia Aging of the Ciliary Sulcus on the Placement of Posterior Chamber IOLs Cystic Epithelial Downgrowth: A Complication of Intraocular Surgery Occurrence of Endophthalmitis After Secondary IOL Implantations Effect of Implantation of Silicone IOLs through Different Types of Incisions Width of the Anterior Capsule Opening After IOL Implantations Evaluation of the Cellular Reaction on the Surface of PMMA IOLs Incidence of Glaucoma in Children after Cataract Extraction & IOL Implantation Effect of Incision Length During IOL Implantation On Corneal Astigmatism Occurrence of Capsular Capture During Silicone IOL Implants Evaluation of the Anis Circular Lens Effect of Foldable Intraocular Lens Insertion On Incision Width Corneal Complications After Cataract & IOL Surgery Side Effects of Oval IOLs Implantation Effects of Phacoemulsification & Small-incision IOL Implantation on Incision Width Capsular Fibrotic Changes Suitable Lens After Cataract Surgery: Multifocal or Monofocal? Aspheric IOL Improves Visual Performance 7. REGULATIONS GOVERNING THE PRODUCTION AND APPROVAL OF IOLS IOL Compressibility Test IOL Vault Testing Haptic Fatigue Testing Dardenne Testing Process of IOL Approval 8. PRODUCT INTRODUCTIONS/INNOVATIONS ZEISS Launches CT LUCIA Bausch + Lomb Extends TRULIGN Toric Intraocular Lens Range Abbott Launches TECNIS Toric In Japan Rayner Rolls Out T-FLEX Aspheric Toric IOL in China Rayner Launches C-flex Advance Aspheric Bausch + Lomb Rolls Out INCISE Microincision Intraocular Lens Slade & Baker Introduces Toric Crystalens IOL Bausch & Lomb Rolls Out Incise IOL in Europe Aaren Scientific Unveils HPI Preloaded Intraocular Lens Injection System Lenstec Launches Softec HD Oval IOL in the US Bausch & Lomb Rolls Out TORIC Version of envista IOL in Europe Carl Zeiss Launches AT LISA tri 839MP 9. RECENT INDUSTRY ACTIVITY ZEISS Acquires Aaren Scientific Rayner Intraocular Takes Over Rayner Surgical Ophtec Collaborates With i-optics Abbott Joins Hands with Carl Zeiss Acu Focus IC-8 Receives CE Mark Abbott to Establish Intraocular Lens Production Facility Abbott Receives CE Marking in Europe Alcon Receives FDA Approval Rayner Bags Korean Approval for Sulcoflex Aspheric System Valeant Pharmaceuticals Acquires Bausch + Lomb Abbott s Tecnis Toric Intraocular Lens Receives FDA Approval Hoya Recalls Intraocular Lenses Rayner Receives Sales Approval OPHTEC Signs Partnership Agreement with Labtician Ophthalmics

6 Bausch + Lomb to Distribute Hydrophilic Acrylic Intraocular Lenses of PhysIOL Rayner Bags Approval to Market IOL System Packs in Ukraine Lumetrics Acquires Assets of WaveFront Sciences Bausch & Lomb Gains FDA Clearance for envista IOL FDA Approves Hoya s isymm and isert IOLs 10. FOCUS ON SELECT PLAYERS Abbott Medical Optics, Inc. (US) Alcon, Inc. (US) Bausch & Lomb, Inc. (US) Carl Zeiss Meditec AG (Germany) Aaren Scientific, Inc. (US) Hoya Corporation (Japan) OPHTEC BV (Netherlands) Rayner Intraocular Lenses Limited (UK) STAAR Surgical Company (US) The HumanOptics AG (Germany) 11. GLOBAL MARKET PERSPECTIVE Table 24: World Recent Past, Current & Future Analysis for Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Table 25: World Historic Review for Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Table 26: World 15-Year Perspective for Intraocular Lenses by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2006, 2014 & 2020 (includes corresponding Table 27: World Recent Past, Current & Future Analysis for Standard Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Table 28: World Historic Review for Standard Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Table 29: World 15-Year Perspective for Standard Intraocular Lenses by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2006, 2014 & 2020 (includes corresponding Table 30: World Recent Past, Current & Future Analysis for Premium Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Table 31: World Historic Review for Premium Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Table 32: World 15-Year Perspective for Premium Intraocular Lenses by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2006, 2014 & 2020 (includes corresponding III. MARKET 1. THE UNITED STATES Imperative Need for Cataract Surgery Table 33: Number of Ophthalmic Procedures Performed in the US by Ocular Disease Condition (2010, 2014 & 2016) (in Millions) (includes corresponding Table 34: Prevalence of Cataract in the United States for the Years 2007, 2010 & 2013 (In Millions of Individuals) (includes corresponding Table 35: Percentage of Occurrence of Cataract in the US by Age Group (2013E) (includes corresponding Economy Upheavals & Impact on Ophthalmology Procedures

7 Table 36: Number of Refractive Surgeries in the US ( ) (In 000) (includes corresponding Table 37: Refractive Surgery Procedures in the US (2013): Percentage Share Breakdown of Procedure Volume by Age-Group (includes corresponding The State of the US Premium IOL Market Product Benefits Drive Sales of Premium IOLs Premium IOLs See Lethargic Growth in Adoption Rates Future Bodes Well for Presbyopia- Correcting IOLs Femtolasers Open New Ground for Cataract Surgery Has the Delayed Approval for Crystalens been a Boon for US Patients? Demand for Phakic IOLs - Yet to Pick Up Has the Initial Passion for Phakic IOLs Waned? Cataract Surgery Reimbursement in the US Table 38: Reimbursement in Cataract Procedures in the US (2012): Percentage Breakdown of Payment for Procedures for Medicare, Medicare Plus and Non-Medicare Insurers (includes corresponding Revised ASC Payment Rates for Ophthalmic Services Table 39: Table ASC Payment Rates for Ophthalmic Procedures in 2014 (US$) (includes corresponding Competitive Landscape Table 40: Leading Players in the US IOL Market (2013): Percentage Share Breakdown of Revenues for Alcon, AMO, Bausch & Lomb and Others (includes corresponding Table 41: Leading Players in the US Standard Monofocal Lens Market (2013): Percentage Breakdown of Value Sales for Alcon, Bausch & Lomb and Others (includes corresponding Table 42: Leading Players in the US Premium Monofocal Lens Market (2013): Percentage Breakdown of Value Sales for Alcon, Abbott and Bausch & Lomb (includes corresponding Table 43: Leading Brands in the US Refractive IOL Market (2013): Percentage Breakdown of Value Sales for ReSTOR, Crystalens, ReZoom, Tecnis Multifocal and Others (includes corresponding Product Introductions/Innovations Strategic Corporate Developments Select Players Value Analysis Table 44: US Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Standard Intraocular Lenses and Premium Intraocular Lenses (Toric and Others) Markets Independently Analyzed with Annual Table 45: US Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses and Premium Intraocular Lenses (Toric and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Table 46: US 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses (Toric and Others) Markets for Years 2006, 2014 & 2020 (includes corresponding Volume Analysis Table 47: US Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Standard Intraocular Lenses and Premium Intraocular Lenses (Toric and Others) Markets Independently Analyzed with Annual Sales Figures in 000 Units for Years 2013 through 2020 (includes corresponding Table 48: US Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses and Premium Intraocular Lenses (Toric and Others) Markets Independently Analyzed with Annual Sales Figures in 000 Units for Years 2006 through 2012 (includes corresponding Table 49: US 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Volume Sales for Standard Intraocular Lenses and Premium Intraocular Lenses (Toric and Others) Markets for Years 2006, 2014 & 2020 (includes corresponding 2. CANADA Strategic Corporate Development Table 50: Canadian Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 51: Canadian Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses

8 Table 52: Canadian 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 3. JAPAN Competition Table 53: Leading Players in the Japanese IOL Market (2013): Percentage Breakdown of Value Sales for Alcon Japan, Hoya, AMO Japan and Others (includes corresponding Strategic Corporate Developments Hoya Corporation - Select Player Value Analysis Table 54: Japanese Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 55: Japanese Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 56: Japanese 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding Volume Analysis Table 57: Japanese Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Sales Figures in 000 Units for Years 2013 through 2020 (includes corresponding Table 58: Japanese Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses and Premium Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in 000 Units for Years 2006 through 2012 (includes corresponding Table 59: Japanese 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Volume Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 4. EUROPE A Focus on the European Premium IOL Market Major PC-IOLs in Europe AcrySofReSTOR Leads European Multifocal IOL Market List of Multifocal IOLs Approved/In-Use in Europe New Products Throng the European Diffractive Multifocal IOL Market Refractive Multifocal IOLs in Europe Market Sees Increase in Options of Toric IOLs Phakic IOL - A Popular Lens Type in Europe Strategic Corporate Developments Value Analysis Table 60: European Recent Past, Current & Future Analysis for Intraocular Lenses by Geographic Region - France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets Independently Analyzed with Annual Table 61: European Historic Review for Intraocular Lenses by Geographic Region - France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Table 62: European 15-Year Perspective for Intraocular Lenses by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets for Years 2006, 2014 & 2020 (includes corresponding Table 63: European Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 64: European Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses

9 Table 65: European 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding Volume Analysis Table 66: European Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Sales Figures in 000 Units for Years 2013 through 2020 (includes corresponding Table 67: European Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses and Premium Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in 000 Units for Years 2006 through 2012 (includes corresponding Table 68: European 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Volume Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 4a. FRANCE Table 69: French Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 70: French Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 71: French 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 4b. GERMANY Strategic Corporate Developments Select Players Table 72: German Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 73: German Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 74: German 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 4c. ITALY Table 75: Italian Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 76: Italian Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 77: Italian 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 4d. THE UNITED KINGDOM Overview of Cataract Reimbursement System in the UK Restrictions Continue despite Government s Ruling against such Rationing Rationing Forces Patients to Resort to Self Pay Product Introduction/Innovation Rayner Intraocular Lenses Limited - A Major Player Table 78: UK Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Standard Intraocular Lenses and Premium Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2013 through 2020 (includes corresponding Table 79: UK Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses and

10 Premium Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2006 through 2012 (includes corresponding Table 80: UK 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 4e. SPAIN Table 81: Spanish Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 82: Spanish Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 83: Spanish 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 4f. RUSSIA Table 84: Russian Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 85: Russian Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 86: Russian 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 4g. REST OF EUROPE Torics Gain Popularity in Ireland Strategic Corporate Developments Select Player Table 87: Rest of Europe Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment Table 88: Rest of Europe Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 89: Rest of Europe 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 5. ASIA-PACIFIC An Overview of the Asia-Pacific Cataract Market IOL Market in Asia-Pacific: Benefiting from High-Growth Indian and Chinese Markets Lethargic Adoption Typifies Premium IOLs Market in Asia-Pacific Table 90: Asia-Pacific Recent Past, Current & Future Analysis for Intraocular Lenses by Geographic Region China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2013 through 2020 (includes corresponding Table 91: Asia-Pacific Historic Review for Intraocular Lenses by Geographic Region - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2006 through 2012 (includes corresponding Table 92: Asia-Pacific 15-Year Perspective for Intraocular Lenses by Geographic Region - Percentage Breakdown of Dollar Sales for China, India and Rest of Asia-Pacific Markets for Years 2006, 2014 & 2020 (includes corresponding Table 93: Asia-Pacific Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment Table 94: Asia-Pacific Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular

11 Lenses Table 95: Asia-Pacific 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 5a. CHINA Strategic Corporate Development Table 96: Chinese Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 97: Chinese Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 98: Chinese 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 5b. INDIA An Overview of the Eye Care Market in India IOL Market in India: An Insight Adoption of Premium IOLs Limited Table 99: Indian Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 100: Indian Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 101: Indian 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 5c. REST OF ASIA-PACIFIC Strategic Corporate Developments Table 102: Rest of Asia-Pacific Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment Table 103: Rest of Asia-Pacific Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses and Premium Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Table 104: Rest of Asia-Pacific 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 6. LATIN AMERICA Table 105: Latin American Recent Past, Current & Future Analysis for Intraocular Lenses by Geographic Region Brazil and Rest of Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2013 through 2020 (includes corresponding Table 106: Latin American Historic Review for Intraocular Lenses by Geographic Region - Brazil and Rest of Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2006 through 2012 (includes corresponding Table 107: Latin American 15-Year Perspective for Intraocular Lenses by Geographic Region - Percentage Breakdown of Dollar Sales for Brazil and Rest of Latin America Markets for Years 2006, 2014 & 2020 (includes corresponding

12 Table 108: Latin American Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment Table 109: Latin American Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 110: Latin American 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 6a. BRAZIL Table 111: Brazilian Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment - Table 112: Brazilian Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 113: Brazilian 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 6b. REST OF LATIN AMERICA Table 114: Rest of Latin America Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment Table 115: Rest of Latin America Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses and Premium Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Table 116: Rest of Latin America 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding 7. REST OF WORLD Table 117: Rest of World Recent Past, Current & Future Analysis for Intraocular Lenses by Product Segment Table 118: Rest of World Historic Review for Intraocular Lenses by Product Segment - Standard Intraocular Lenses Table 119: Rest of World 15-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Dollar Sales for Standard Intraocular Lenses and Premium Intraocular Lenses Markets for Years 2006, 2014 & 2020 (includes corresponding IV. COMPETITIVE LANDSCAPE Total Companies Profiled: 32 (including Divisions/Subsidiaries - 42) The United States (19) Canada (1) Japan (5) Europe (11) - France (1) - Germany (4) - The United Kingdom (1) - Rest of Europe (5) Asia-Pacific (Excluding Japan) (3) Middle East (3) Ordering: Order Online - Order by Fax - using the form below

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15 Page 1 of 2 Payment Information Please indicate the payment method you would like to use by selecting the appropriate box. Pay by credit card: You will receive an with a link to a secure webpage to enter your credit card details. Pay by check: Please post the check, accompanied by this form, to: Research and Markets, Guinness Center, Taylors Lane, Dublin 8, Ireland. Pay by wire transfer: Please transfer funds to: Account number Sort code Swift code IBAN number Bank Address ULSBIE2D IE78ULSB Ulster Bank, Main Street, Blackrock, Co. Dublin, Ireland. If you have a Marketing Code please enter it below: Marketing Code: Please note that by ordering from Research and Markets you are agreeing to our Terms and Conditions at Please fax this form to: (646) or (646) From USA or From Rest of World