Hyperthermic Intraperitoneal Chemotherapy (HIPEC) as Part of an Integrative Treatment Plan for Colorectal Peritoneal Carcinomatosis
|
|
- Carol Clark
- 7 years ago
- Views:
Transcription
1 Hyperthermic Intraperitoneal Chemotherapy (HIPEC) as Part of an Integrative Treatment Plan for Colorectal Peritoneal Carcinomatosis T. Christopher Windham, M.D., F.A.C.S. Medical Director, Florida Hospital Memorial Medical Center Cancer Care Institute, Daytona Beach, Florida Associate Clinical Professor of Surgery Florida State University College of Medicine
2 Background Traditional 5-FU regimens for PC colorectal patients associated with 5.2-7mth survival Modern treatment regimens with Oxaliplatin, bevazizumab, irinotecan etc. are reporting median survival rages of 15-23mths Jayne,et al., Br J Surg, 2002 Minsky, et al., J Clin Oncol, 1988 Chua, et al., Ann Surg Oncol 2011
3 Background Synchronous PC at initial Sx found in 7-15% of colorectal cases PC develops in 4-19% during follow-up Pts with synchronous PC, 58% had no systemic disease Those who develop subsequent PC, 3-4% have isolated disease to the peritoneum Jayne,et al., Br J Surg, 2002 Koppe, et al., Ann Surg, 2006 Minsky, et al., J Clin Oncol, 1988
4 Background Suggests a third route of spread, rather than hematogenous or lymphatic Spread from tumor dissemination from invasion of the bowel wall through the serosal surface Webber, et al., Clin Colorectal Can, 2012.
5 Carcinomatosis
6 Scope of Problem Major problem in cancer management Hard to detect by imaging Difficult to manage Marked deterioration in quality of life Short survival
7 Natural History of Carcinomatosis Crampy abdominal pain Anorexia/ weight loss Bowel obstruction Ascites Infection
8 Scope of Problem Combined- Gastric, Pancreatic, Small bowel, 20,000 Gall Bladder Colorectal Cancer 23,000 Ovarian Cancer 22,000 Appendiceal Cancer 1,200 Mesothelioma 500 Of these approximately 25,000 are candidates for cytoreduction/ HIPEC. In 2009 only 5% received this treatment
9 Current Treatment Options Systemic Chemotherapy Radiation - Poor penetration to peritoneum Surgical Treatment Surgery with or without systemic chemotherapy has shown to be inadequate for the treatment of patients with PC.
10 Rationale for Cytoreduction and HIPEC Cytoreduction reduces tumor to minimal disease increasing the effect of chemotherapy Hyperthermia has direct tumoricidal effects Hyperthermia can act synergistically with chemotherapy
11 Definitions Carcinomatosis Cancer cells that have spread within the abdominal cavity Considered Stage IV disease Initially these cells grow into nodules of tumor on the of the lining of the abdomen (peritoneum) or on the surface of abdominal organs There may be associate ascites (fluid or mucous) within the abdominal cavity
12 Definitions Cytoreduction The surgical removal of disease identified in the abdominal cavity- Completeness of Cytoreduction (CCR) CCR0- No residual macroscopic disease CCR1- Residual tumor implants max diam <5mm CCR2- Residual tumor implants max diam >5mm
13 Definitions Hyperthermic Intraperitoneal Chemotherapy HIPEC The treatment of peritoneal surface malignancies with the instillation of a heated chemotherapy agent directly in the peritoneal cavity This can be done through catheters left in the abdomen following surgery (dwell) technique (EPIC)
14 Rationale for Cytoreduction and HIPEC We can achieve more than 20 fold higher doses of chemotherapy within the peritoneal cavity Higher doses with limited systemic side effects as seen with IV chemotherapy Direct contact of both heat and chemotherapeutic agents with malignant cells
15 Rationale for Cytoreduction and HIPEC Hyperthermia Directly toxic to malignant cells Disrupts microtubule system and induces apoptosis Potentiates the cytotoxic effects of chemotherapy Improves tissue absorption of chemotherapy Has a selective lethal effect on cancer cells (41 0 C-43 0 C)
16 Rationale for Cytoreduction and HIPEC Peritoneal Cavity Subperitoneal Layer Peritoneal Nodule Capillaries Peritoneum Adapted from: Zoctmulder J. Surg Onc., 2002
17 Cytoreduction/HIPEC Procedure Heat Chemotherapy
18 EPIC Technique
19 Rationale for Cytoreduction and HIPEC Performed at the time of surgery -Eliminating pain and discomfort for patient -Improves distribution of heat and chemotherapy -At the time of lowest tumor burden
20 Candidates Disease confined to the peritoneal cavity Excellent performance status Disease from gastrointestinal, ovarian, primary peritoneal or mesothelioma origins
21 Cytoreduction/HIPEC Procedure Pre-operative Evaluation/preparation- History/physical examination Laboratory/Imaging Studies Review at Cancer Multidisciplinary Conference Surgery- Emphasis on pain control Cytoreduction/HIPEC Post-operative- ICU-2-3 days In hospital days
22 Cytoreduction/HIPEC Procedure Recovery- At least 4-8 weeks Gastrointestinal discomfort Poor appetite Need for IV nutrition support
23 Cytoreduction/HIPEC Procedure Surgery may be extensive and require multiple organs be resected Splenectomy, Omentectomy, Bowel resection, and Hysterectomy/Oophorectomy are often required Some patients may require an ostomy
24 Cytoreduction/HIPEC Procedure Meticulous removal of implants from the peritoneal surface Then catheters are placed in the abdominal cavity with temperature probes
25 Cytoreduction/HIPEC Procedure
26
27 Cytoreduction/HIPEC Procedure
28 Does it Work?
29 Median Survival (mths) 105 pts CRC Carcinomatosis Standard Systemic Chemo +/-palliative Sx 12.6 P=0.032 Cytoreduct/HIPEC Systemic Chemo % mortality 19% Bone marrow toxicity 15% Fistula rate Survival affected by extent of debulking Verwaal, J Clin Onc., 2003
30 Results/Outcomes Verwaal, J Clin Onc., 2003
31 Results/Outcomes Verwaal, J Clin Onc., 2003
32 Complete Cytoreductive Surgery Plus Intraperitoneal Chemohyperthermia With Oxaliplatin for Peritoneal Carcinomatosis of Colorectal Origin By: Elias, D., et. al -Comparison of complete resection/hipec (n=48) with retrospectively analyzed matched patients treated with best systemic therapy alone -Those not treated with cytoreduction /HIPEC- due to travel and unable to accommodate schedule
33 Median Survival 23.9mths vs 62.7 mths 5yr OS 13% vs 51% Elias, D., J. Clin Oncol., 2009
34 Results/Outcomes Weber, et al., Clin Colorectal Canc
35 Problems/Future Directions Lack of standardization -Drugs Mitomycin Oxaliplatin Carboplatin -Temperature C EPIC normothermic -Time Intraoperative-HIPEC Early Post-operative- EPIC
36 Problems/Future Directions Lack of standardization -Technique Open Coliseum Closed -Duration 30-90min
37 Conclusions Cytoreductive surgery with HIPEC offers the chance for long-term survival in selected patients with CRC with PC This approach is complementary to systemic chemotherapy not a replacement Careful patient selection and complete cytoreduction are important to maximize benefits
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Now and the Future
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Now and the Future Mazin Al-kasspooles, MD Associate Professor of Surgery Division of Surgical Oncology Director, Regional Therapy
More informationLuis D. Carcorze Soto, MD PGY-3
Luis D. Carcorze Soto, MD PGY-3 Peritoneal Surface Malignancies Peritoneum Patient Selection Operative Technique HIPEC EPIC Primary: Primary Peritoneal Carcinoma Malignant Peritoneal Mesothelioma Metastatic:
More informationIntraoperative Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Volodymyr Labinskyy MD
Intraoperative Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Volodymyr Labinskyy MD KCHC 8/29/13 52 y.o. F presented with severe pain in the right back and right flank, sharp, 8 out of 10, for 7 days.
More informationManagement of Peritoneal Metastases (PM) from colorectal cancers: New Perspectives. Dominique ELIAS
Management of Peritoneal Metastases (PM) from colorectal cancers: New Perspectives Dominique ELIAS Declaration of interest BOARDS Congress and teaching 0 Merck 0 Ipsen Novartis Sanofi Trials The peritoneum
More informationPeritoneal Surface Malignancies. Ira Allen Jacobs, MD, FACS Surgical Oncology San Diego, CA
Peritoneal Surface Malignancies Ira Allen Jacobs, MD, FACS Surgical Oncology San Diego, CA Cancer dissemination routes Hematogenous metastases Lymphatic metastases Implants on peritoneal surfaces Surgically
More informationCytoreduction and hyperthermic intraperitoneal chemotherapy for the treatment of pseudomyxoma
Medical Policy Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pseudomyxoma Peritonei and Peritoneal Carcinomatosis of Gastrointestinal Origin, and Peritoneal Mesothelioma
More informationCorporate Medical Policy
Corporate Medical Policy Hyperthermic Intraperitoneal Chemotherapy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hyperthermic_intraperitoneal_chemotherapy 5/19/2005 3/2016 3/2017
More informationPeritoneal Carcinomatosis: Pathophysiology, Prevention, and Treatment
Peritoneal Carcinomatosis: Pathophysiology, Prevention, and Treatment Wim Ceelen, MD, PhD, FACS GI Surgery, UZ Gent KAGB 27/4/2013 Overview What is peritoneal carcinomatosis? Rationale for IP drug delivery
More informationINTRAPERITONEAL HYPERTHERMIC CHEMOTHERAPY (IPHC) FOR PERITONEAL CARCINOMATOSIS AND MALIGNANT ASCITES. INFORMATION FOR PATIENTS AND FAMILY MEMBERS
INTRAPERITONEAL HYPERTHERMIC CHEMOTHERAPY (IPHC) FOR PERITONEAL CARCINOMATOSIS AND MALIGNANT ASCITES. INFORMATION FOR PATIENTS AND FAMILY MEMBERS Description of Treatment A major difficulty in treating
More informationChirurgia Avanzata Del Carcinoma Ovarico Nuove Strategie A Confronto Ovarian Cancer Advanced Surgery New Strategies in Comparison
Peritoneal dissection and intraperitoneal chemotherapy under hyperthermic conditions. If you select the right patients long-term survival can be achieved. Chirurgia Avanzata Del Carcinoma Ovarico Nuove
More informationH. Richard Alexander, Jr., M.D. Department of Surgery and The Greenebaum Cancer Center University of Maryland School of Medicine Baltimore, Md
Major Advances in Cancer Prevention, Diagnosis and Treatment~ Why Mesothelioma Leads the Way H. Richard Alexander, Jr., M.D. Department of Surgery and The Greenebaum Cancer Center University of Maryland
More informationA succesfull case of HIPEC in a peritoneal mesothelioma patient
A succesfull case of HIPEC in a peritoneal mesothelioma patient Firmino, NLJ¹²; Miranda, E¹³; Oliveira, DA ²; Lima, MBA ¹²; Diniz, AF ¹²; Gomes, GES ¹²; Azevedo, LW ¹²; Soares,MC¹²; Gomes, ASA³. ¹Pernambuco
More informationComments: Policy Accepted during 2013 Annual Review with no changes.
Health Plan Coverage Policy ARBenefits Approval: 01/01/2012 Effective Date: 01/01/2012 Revision Date: 09/18/2013 Title: Cytoreduction Surgery with Hyperthermic Intraperitoneal Chemotherapy Comments: Policy
More informationINTRAOPERATIVE HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (HIPEC)
MEDICAL POLICY INTRAOPERATIVE HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (HIPEC) Policy Number: CS141.A Effective Date: September 1, 2015 Table of Contents COVERAGE RATIONALE DEFINITIONS... APPLICABLE CODES..
More informationPRODYNOV. Targeted Photodynamic Therapy of Ovarian Peritoneal Carcinomatosis ONCO-THAI. Image Assisted Laser Therapy for Oncology
PRODYNOV Targeted Photodynamic Therapy of Ovarian Peritoneal Carcinomatosis ONCO-THAI Image Assisted Laser Therapy for Oncology Inserm ONCO-THAI «Image Assisted Laser Therapy for Oncology» Inserm ONCO-THAI
More informationRachel E. Kirby, Jing Zhao, Terence Chua, Winston Liauw and David L. Morris *
Send Orders for Reprints to reprints@benthamscience.net The Open Surgical Oncology Journal, 2014, 5, 1-5 1 Open Access Avoidance of Early Post-Operative Intraperitoneal Chemotherapy (EPIC) Following Peritonectomy
More informationPost-operative intrapleural chemotherapy for mesothelioma
Post-operative intrapleural chemotherapy for mesothelioma Robert Kratzke, MD John Skoglund Chair for Lung Cancer Research Section of Heme-Onc-Transplant University of Minnesota Medical School Efficacy
More informationClinical Commissioning Policy: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Mesothelioma
Clinical Commissioning Policy: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Mesothelioma Reference: NHS England B03/P/a 1 Information Reader Box (IRB) to be inserted
More informationPOLICY PRODUCT VARIATIONS DESCRIPTION/BACKGROUND RATIONALE DEFINITIONS BENEFIT VARIATIONS DISCLAIMER CODING INFORMATION REFERENCES POLICY HISTORY
Original Issue Date (Created): July 1, 2002 Most Recent Review Date (Revised): July 22, 2014 Effective Date: October 1, 2014 POLICY PRODUCT VARIATIONS DESCRIPTION/BACKGROUND RATIONALE DEFINITIONS BENEFIT
More informationPopulation Pharmacokinetics and Pharmacodynamics of Cisplatinum During Intraperitoneal Chemohyperthermia Using a Closed Abdominal Procedure
Population Pharmacokinetics and Pharmacodynamics of Cisplatinum During Intraperitoneal Chemohyperthermia Using a Closed Abdominal Procedure Eddy Cotte, Brigitte Tranchand, Annie-Claude Beaujard, François-Noël
More informationCytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis in the elderly
Huang et al. World Journal of Surgical Oncology (2015) 13:262 DOI 10.1186/s12957-015-0682-7 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Cytoreductive surgery and perioperative intraperitoneal chemotherapy
More informationCytoreduction and Intraperitoneal Chemotherapy for the Management of Non-Gynecological Peritoneal Surface
J. Exp. Clin. Cancer Res., 22, 4, 2003 - Supplement Cytoreduction and Intraperitoneal Chemotherapy for the Management of Non-Gynecological Peritoneal Surface Malignancy Yan T.D., Esquivel J., Carmignani
More informationClinical Commissioning Policy: Cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Mesothelioma
Clinical Commissioning Policy: Cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Mesothelioma Reference: NHS England A08/P/c 2 NHS England INFORMATION READER BOX Directorate
More informationNational Medical Policy
National Medical Policy Subject: Policy Number: Intraperitoneal Hyperthermic Chemotherapy for Abdominopelvic Cancers NMP346 Effective Date*: June 2007 Updated: November 2014 This National Medical Policy
More informationLaparoscopic Hyperthermic Intraperitoneal Chemotherapy: Indications, Aims, and Results: A Systematic Review of the Literature
Ann Surg Oncol DOI 10.1245/s10434-012-2360-0 ORIGINAL ARTICLE REVIEW ARTICLE Laparoscopic Hyperthermic Intra Chemotherapy: Indications, Aims, and Results: A Systematic Review of the Literature Enrico Facchiano,
More informationColumbia University Mesothelioma Applied Research Foundation - 2009 - www.curemeso.org. Mesothelioma Center www.mesocenter.org
Columbia University Mesothelioma Center www.mesocenter.org Multimodal clinical trials, treatment (surgery, radiation, chemotherapy) Peritoneal mesothelioma program Immunotherapy translational, experimental
More informationIN MANY PATIENTS WITH ABDOMINAL OR PELVIC MALIGNANCIES, surgical treatment
Sugarbaker, Cancerología 3 (2008): 119-124 1 Washington Cancer Institute, Washington, DC, USA Overview of Peritoneal Carcinomatosis Paul H. Sugarbaker 1 Abstract IN MANY PATIENTS WITH ABDOMINAL OR PELVIC
More informationPeritoneal Carcinosis
Peritoneal Carcinosis What is it and how to cure it Peritoneum Peritoneum is a thin and transparent membrane that covers the internal part of the abdominal and pelvic cavity and all the viscera contained
More informationTreating Mesothelioma - A Quick Guide
Treating Mesothelioma - A Quick Guide Contents This is a brief summary of the information on Treating mesothelioma from CancerHelp UK. You will find more detailed information on the website. In this information
More information2nd International Symposium on Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)
2nd International Symposium on Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) Wednesday Oct 7th, 2015 Congress Center (Hörsaal 1 3) Marien Hospital Herne Accreditation by the Medical Chamber
More informationIntegrating Chemotherapy and Liver Surgery for the Management of Colorectal Metastases
I Congresso de Oncologia D Or July 5-6, 2013 Integrating Chemotherapy and Liver Surgery for the Management of Colorectal Metastases Michael A. Choti, MD, MBA, FACS Department of Surgery Johns Hopkins University
More informationQuick Facts about Appendix Cancer
Quick Facts about Appendix Cancer What is the appendix? The appendix is a pouch-like tube attached to the first part of the large intestine (cecum). The appendix is about 10 centimetres long and has no
More informationOverview of Gynaecologic Cancer
Overview of Gynaecologic Cancer Stuart Salfinger Gynaecologic Oncologist St John of God Hospital King Edward Memorial Hospital Cervical Cancer Cervical Cancer Risk HPV Smoking?OCP Cervical Cancer Symptoms
More informationCOMMISSIONING. for ULTRA-RADICAL SURGERY ADVANCED OVARIAN CANCER
COMMISSIONING for ULTRA-RADICAL SURGERY in ADVANCED OVARIAN CANCER WHY THIS MUST HAPPEN PERSPECTIVE COMMISSIONING FOR WHO, FOR WHAT? Biological Basis Surgical Basis International and national standards
More informationFrequently Asked Questions About Ovarian Cancer
Media Contact: Gerri Gomez Howard Cell: 303-748-3933 gerri@gomezhowardgroup.com Frequently Asked Questions About Ovarian Cancer What is ovarian cancer? Ovarian cancer is a cancer that forms in tissues
More informationPrincipal Investigator: Valerie W. Rusch, MD, FACS, Chief, Thoracic Surgery Memorial Sloan-Kettering Cancer Center
Protocol 1101-1088 Phase I study of intra-pleural administration of GL-ONC1 in patients with malignant pleural effusion: primary, metastases and mesothelioma Principal Investigator: Valerie W. Rusch, MD,
More informationAvastin: Glossary of key terms
Avastin: Glossary of key terms Adenocarcinoma Adenoma Adjuvant therapy Angiogenesis Anti-angiogenics Antibody Antigen Avastin (bevacizumab) Benign A form of carcinoma that originates in glandular tissue.
More informationColocutaneous Fistula. Disclosures
Colocutaneous Fistula Madhulika G. Varma MD Associate Professor Chief, Colorectal Surgery University of California, San Francisco Honoraria Applied Medical Covidien Disclosures 1 Colocutaneous Fistula
More informationYue Zhu, Nader Hanna, Cherif Boutros, H. Richard Alexander Jr. Background
Review Article Assessment of clinical benefit and quality of life in patients undergoing cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for management of peritoneal metastases Yue
More informationStomach (Gastric) Cancer. Prof. M K Mahajan ACDT & RC Bathinda
Stomach (Gastric) Cancer Prof. M K Mahajan ACDT & RC Bathinda Gastric Cancer Role of Radiation Layers of the Stomach Mucosa Submucosa Muscularis Serosa Stomach and Regional Lymph Nodes Stomach and Regional
More informationPATIENT INFORMATION ABOUT ADJUVANT THERAPY AFTER THE WHIPPLE OPERATION FOR ADENOCARCINOMA ( CANCER ) OF THE PANCREAS AND RELATED SITES.
PATIENT INFORMATION ABOUT ADJUVANT THERAPY AFTER THE WHIPPLE OPERATION FOR ADENOCARCINOMA ( CANCER ) OF THE PANCREAS AND RELATED SITES. Radiation Oncology Sidney Kimmel Cancer Center at Johns Hopkins Last
More informationTargeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma
The Use of Kinase Inhibitors: Translational Lab Results Targeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma Sheelu Varghese, Ph.D. H. Richard Alexander, M.D.
More informationEvidence-Based Medicine in the Treatment of Peritoneal Carcinomatosis: Past, Present, and Future
2009;100:335 344 Evidence-Based Medicine in the Treatment of Peritoneal Carcinomatosis: Past, Present, and Future AVIRAM NISSAN, MD, 1,2 * ALEXANDER STOJADINOVIC, MD, 3,4 ALFREDO GAROFALO, MD, 5{ JESUS
More informationChing-Yao Yang, Yu-Wen Tien
Ching-Yao Yang, Yu-Wen Tien Division of General Surgery, Department of Surgery, National Taiwan University Hospital Oct-30-2010 Pancreatic NET have poorer prognosis when presence of liver metastases at
More informationMALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT
MALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT Written by: Karyn Varley MS, SCT(ASCP) The donating laboratory would like to remain anonymous. PATIENT HISTORY 28 year old female Lived
More informationNew strategies in anticancer therapy
癌 症 診 療 指 引 簡 介 及 臨 床 應 用 New strategies in anticancer therapy 中 山 醫 學 大 學 附 設 醫 院 腫 瘤 內 科 蔡 明 宏 醫 師 2014/3/29 Anti-Cancer Therapy Surgical Treatment Radiotherapy Chemotherapy Target Therapy Supportive
More informationClinical Policy Bulletin: Hyperthermia in Cancer Therapy
Hyperthermia in Cancer Therapy Page 1 of 28 Aetna Better Health 2000 Market Street, Suite 850 Philadelphia, PA 19103 AETNA BETTER HEALTH Clinical Policy Bulletin: Hyperthermia in Cancer Therapy Number:
More informationHospital: IRB #: Principal Phone Fax Email Investigator: Dr. A. Co-investigators: Dr. C Dr. D Dr. E Dr. F
Title: Protocol for the Implementation of Treatment of Patients with Peritoneal Surface Malignancy with Hyperthermic Intraoperative Intraperitoneal Chemotherapy and Normothermic Early Postoperative Intraperitoneal
More informationFact sheet 10. Borderline ovarian tumours. The difficult cases. What is borderline ovarian cancer (BOC)?
For this reason, some doctors prefer the term borderline ovarian tumour rather than borderline ovarian cancer. Fact sheet 10 Borderline ovarian tumours We, Ovacome, are a support network for people affected
More informationA PATIENT S GUIDE TO ABLATION THERAPY
A PATIENT S GUIDE TO ABLATION THERAPY THE DIVISION OF VASCULAR/INTERVENTIONAL RADIOLOGY THE ROBERT WOOD JOHNSON UNIVERSITY HOSPITAL Treatment options for patients with cancer continue to expand, providing
More informationPeritoneal Mesothelioma: The Columbia Experience
48 Peritoneal Mesothelioma: The Columbia Experience Jennifer A. Wagmiller, Mary-Louise Keohan, John A. Chabot, Karen Fountain, Mary Hesdorffer, and Robert N. Taub Malignant peritoneal mesothelioma is a
More informationMesoPDT. Photodynamic Therapy for malignant pleural mesothelioma ONCO-THAI. Image Assisted Laser Therapy for Oncology
MesoPDT Photodynamic Therapy for malignant pleural mesothelioma ONCO-THAI Image Assisted Laser Therapy for Oncology Unité Inserm ONCO-THAI «Image Assisted Laser Therapy for Oncology» Inserm ONCO-THAI "Image
More informationO. Glehen 1,2, E. Cotte 1,2, J. C. Lifante 1,2, C. Arvieux 2,3, N. Moles 1, C. Brigand 2,4, A. C. Beaujard 1,2, Y. François 1,2, F. N.
Acta chir belg, 2006, 106, 285-290 Peritoneal Carcinomatosis in Digestive Cancers : Cytoreductive Surgery Combined with Intraperitoneal Chemohyperthermia. The Experience in Centre Hospitalier et Universitaire
More informationIntraperitoneal Chemotherapy
Intraperitoneal Chemotherapy What is Intraperitoneal (IP) Chemotherapy? Intraperitoneal (IP) chemotherapy is a way to put some of your chemotherapy into your abdomen (also called the peritoneal cavity)
More informationOncologist. The. Clinical Pharmacology. Update on Chemotherapeutic Agents Utilized for Perioperative Intraperitoneal Chemotherapy
The Oncologist Clinical Pharmacology Update on Chemotherapeutic Agents Utilized for Perioperative Intraperitoneal Chemotherapy PAUL H. SUGARBAKER, a JORGE TORRES MORA, b PABLO CARMIGNANI, a O. ANTHONY
More informationPseudomyxoma Peritonei Where are we in 2014?
Pseudomyxoma Peritonei Where are we in 2014? Santiago González-Moreno, MD, PhD Head, Department of GI Surgical Oncology Peritoneal Surface Oncology Program Medical Director * * * * * * * * * * * * French
More informationHow To Treat A Uterine Sarcoma
EVERYONE S GUIDE FOR CANCER THERAPY Malin Dollinger, MD, Ernest H. Rosenbaum, MD, Margaret Tempero, MD, and Sean Mulvihill, MD 4 th Edition 2001 Uterus: Uterine Sarcomas Jeffrey L. Stern, MD Uterine sarcomas
More informationMR Imaging of Peritoneal Malignancy Russell N. Low, MD
MR Imaging of Peritoneal Malignancy Russell N. Low, MD From: Sharp and Children's MRI Center and Sharp HealthCare, 7901 Frost Street, San Diego, California, 92123. Phone: (858) 939-3600. Email: rlow@ucsd.edu
More informationAdiuwantowe i neoadiuwantowe leczenie chorych na zaawansowanego raka żołądka
Adiuwantowe i neoadiuwantowe leczenie chorych na zaawansowanego raka żołądka Neoadiuvant and adiuvant therapy for advanced gastric cancer Franco Roviello, IT Neoadjuvant and adjuvant therapy for advanced
More informationCarcinoma of the vagina is a relatively uncommon disease, affecting only about 2,000 women in
EVERYONE S GUIDE FOR CANCER THERAPY Malin Dollinger, MD, Ernest H. Rosenbaum, MD, Margaret Tempero, MD, and Sean Mulvihill, MD 4 th Edition, 2001 Vagina Jeffrey L. Stern, MD Carcinoma of the vagina is
More informationJ Clin Oncol 27:6237-6242. 2009 by American Society of Clinical Oncology INTRODUCTION
VOLUME 27 NUMBER 36 DECEMBER 20 2009 JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L R E P O R T Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma:
More informationU.S. Food and Drug Administration
U.S. Food and Drug Administration Notice: Archived Document The content in this document is provided on the FDA s website for reference purposes only. It was current when produced, but is no longer maintained
More informationRe irradiation Using HDR Interstitial Brachytherapy for Locally Recurrent. Disclosure
Re irradiation Using HDR Interstitial Brachytherapy for Locally Recurrent Cervical lcancer Yasuo Yoshioka, MD Department of Radiation Oncology Osaka University Graduate School of Medicine Osaka, Japan
More informationGastrointestinal Oncology Peritoneal Mesothelioma
Gastrointestinal Oncology Two Decades of Progress in the Management of a Rare Disease Paul H Sugarbaker, MD, FACS, FRCS Medical Director, Center for Gastrointestinal Malignancies, MedStar Washington Hospital
More informationMesothelioma. Malignant Pleural Mesothelioma
Mesothelioma William G. Richards, PhD Brigham and Women s Hospital Malignant Pleural Mesothelioma 2,000-3,000 cases per year (USA) Increasing incidence Asbestos (50-80%, decreasing) 30-40 year latency
More informationCorso Integrato di Clinica Medica ONCOLOGIA MEDICA AA 2010-2011 LUNG CANCER. VIII. THERAPY. V. SMALL CELL LUNG CANCER Prof.
Corso Integrato di Clinica Medica ONCOLOGIA MEDICA AA 2010-2011 LUNG CANCER. VIII. THERAPY. V. SMALL CELL LUNG CANCER Prof. Alberto Riccardi SMALL CELL LUNG CARCINOMA Summary of treatment approach * limited
More informationSurgical Staging of Endometrial Cancer
Surgical Staging of Endometrial Cancer I. Endometrial Cancer Surgical Staging Overview Uterine cancer types: carcinomas type I and type II, sarcomas, carcinosarcomas Hysterectomy with BSO Surgical Staging
More informationAdvances in Treatment of Malignant Pleural Mesothelioma: A Reason for Hope
Advances in Treatment of Malignant Pleural Mesothelioma: A Reason for Hope Daniel H. Sterman, M.D. Associate Professor of Medicine and Surgery Co-Director, PENN Mesothelioma and Pleural Program University
More informationNational Coverage Determination (NCD) for Tumor Antigen by Immunoassay - CA 125 (190.28)
National Coverage Determination (NCD) for Tumor Antigen by Immunoassay - CA 125 (190.28) Tracking Information Publication Number Manual Section Number 100-3 190.28 Manual Section Title Tumor Antigen by
More informationMesothelioma: Questions and Answers
CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Mesothelioma: Questions
More informationCigna Medical Coverage Policy
Cigna Medical Coverage Policy Subject Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Table of Contents Coverage Policy... 1 General Background... 1 Coding/Billing Information... 8 References... 8 Effective
More informationChoosing a Clinical Trial for Advanced Mesothelioma
Choosing a Clinical Trial for Advanced Mesothelioma RN Taub (Onc) J Chabot (Surg) A Borczuk (Path) J Sonnet (Surg) M Kluger (Surg) R Fawwaz (Nuc. Med) E Hare (Onc) Columbia University Mesothelioma Center
More informationGallbladder Diseases and Problems
Gallbladder Diseases and Problems Introduction Your gallbladder is a pear-shaped organ under your liver. It stores bile, a fluid made by your liver to digest fat. There are many diseases and problems that
More informationUrinary Diversion: Ileovesicostomy/Ileal Loop/Colon Loop
Urinary Diversion: Ileovesicostomy/Ileal Loop/Colon Loop Why do I need this surgery? A urinary diversion is a surgical procedure that is performed to allow urine to safely pass from the kidneys into a
More informationContents. Updated July 2011
- Updated July 2011 Guideline Authors: Todd S. Crocenzi, M.D.; Mark Whiteford, M.D.; Matthew Solhjem, M.D.; Carlo Bifulco, M.D.; Melissa Li, M.D.; Christopher Cai, M.D.; and James Durham, M.D. Contents
More informationPANCREATIC AND PERIAMPULLARY TUMORS: PANCREATICODUODENECTOMY. Dr. Shailesh V. Shrikhande
PANCREATIC AND PERIAMPULLARY TUMORS: PANCREATICODUODENECTOMY Dr. Shailesh V. Shrikhande Associate Professor & Consultant Surgeon GI and HPB Surgical Oncology Tata Memorial Hospital, Mumbai INDIA HELICAL
More information1400 Telegraph Bloomfield Hills, MI 48302 248-334-6877-Phone number/248-334-6877-fax Number CANCER TREATMENT
1400 Telegraph Bloomfield Hills, MI 48302 248-334-6877-Phone number/248-334-6877-fax Number CANCER TREATMENT Learning that your pet has a diagnosis of cancer can be overwhelming. We realize that your pet
More informationHow To Treat Lung Cancer At Cleveland Clinic
Treatment Guide Lung Cancer Management The Chest Cancer Center at Cleveland Clinic, which includes specialists from the Respiratory Institute, Taussig Cancer Institute and Miller Family Heart & Vascular
More informationHow To Understand How Cancer Works
Mesothelioma Understanding your diagnosis Mesothelioma Understanding your diagnosis When you first hear that you have cancer, you may feel alone and afraid. You may be overwhelmed by the large amount of
More informationChemotherapy in Ovarian Cancer. Dr R Jones Consultant Medical Oncologist South Wales Gynaecological Oncology Group
Chemotherapy in Ovarian Cancer Dr R Jones Consultant Medical Oncologist South Wales Gynaecological Oncology Group Adjuvant chemotherapy for early stage EOC Fewer than 30% women present with FIGO stage
More informationLaparoscopic Surgery of the Colon and Rectum (Large Intestine) A Simple Guide to Help Answer Your Questions
Laparoscopic Surgery of the Colon and Rectum (Large Intestine) A Simple Guide to Help Answer Your Questions What are the Colon and Rectum? The colon and rectum together make up the large intestine. After
More informationDie multimodale Behandlung der Peritonealkarzinose
Die multimodale Behandlung der Peritonealkarzinose Pompiliu Piso Chirurgische Klinik der Universität Regensburg 80 Mio Inhabitans 70.000 new cases CRC/year. Henriettenstiftung Hannover Medizinische Hochschule
More informationJames Rhio O Conner Memorial Scholarship Essay
Farris 1 James Rhio O Conner Memorial Scholarship Essay Cancer is a growing medical phenomenon that is continuing to increase and take the lives of many people. There are several beliefs and opinions as
More informationL Lang-Lazdunski, A Bille, S Marshall, R Lal, D Landau, J Spicer
Pleurectomy/decortication, hyperthermic pleural lavage with povidone-iodine and systemic chemotherapy in malignant pleural mesothelioma. A 10-year experience. L Lang-Lazdunski, A Bille, S Marshall, R Lal,
More informationPancreatic Cancer: FDA Approved Treatments and Clinical Trials
Pancreatic Cancer: FDA Approved Treatments and Clinical Trials Vincent J Picozzi MD MMM Virginia Mason Medical Center Seattle WA 1 Pancreatic cancer is the hardest cancer of all to treat 2 Pancreatic cancer:
More informationEffects of sex hormones on survival of peritoneal mesothelioma
Huang et al. World Journal of Surgical Oncology (2015) 13:210 DOI 10.1186/s12957-015-0624-4 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Effects of sex hormones on survival of peritoneal mesothelioma
More informationTreatment and Surveillance of Non- Muscle Invasive Bladder Cancer
Treatment and Surveillance of Non- Muscle Invasive Bladder Cancer David Josephson, MD FACS Fellowship Director, Urologic Oncology and Robotic Surgery Program Staging Most important in risk assessment and
More informationAdvances in Surgical Oncology
3-4 December 2015 Advances in Surgical Oncology 3 rd International Conference of the Medical University of Lublin 10 th anniversary of first Intraoperative Radiotherapy in Lublin 1 Scientific Chairman
More informationCorporate Medical Policy
Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_epithelial_ovarian_cancer 2/2001 11/2015 11/2016 11/2015 Description
More informationCANCERS OF THE PERITONEUM PERITONEAL MESOTHELIOMA PREFERRED MODEL OF CARE AND CRITERIA FOR REFERENCE CENTRES
CANCERS OF THE PERITONEUM PERITONEAL MESOTHELIOMA PREFERRED MODEL OF CARE AND CRITERIA FOR REFERENCE CENTRES Coordinator: Alex Kartheuser (Colorectal Surgery, Cliniques universitaires St-Luc, UCL) Authors
More informationINTRODUCTION. Abstract Background. 3 Centre hospitalier Lyon Sud Hospices Civils de Lyon, Pierre-Bé
Childbearing after hyperthermic intraperitoneal chemotherapy: results from an international survey Pablo Ortega-Deballon 1 2 *, Olivier Glehen 3, Edward Levine 4, Pompiliu Piso, Paul H. Sugarbaker 6, Andrea
More informationMalignant Mesothelioma State of the Art
Malignant Mesothelioma State of the Art Paul Baas The Netherlands Cancer Institute August 12, 2011, Carlsbad, CA Summary Diagnosis; epithelial type subdivided Pleiomorphic vs other Staging: IASLC-IMIG
More informationIntravesical Therapy for Bladder Cancer
Intravesical Therapy for Bladder Cancer Norm D. Smith, M.D. Chief of Urologic Oncology Department of Urology Northwestern University Feinberg School of Medicine The Problem Bladder cancer Superficial disease
More informationSmoking and misuse of certain pain medicines can affect the risk of developing renal cell cancer.
Renal cell cancer Renal cell cancer is a disease in which malignant (cancer) cells form in tubules of the kidney. Renal cell cancer (also called kidney cancer or renal adenocarcinoma) is a disease in which
More informationCANCER TREATMENT: Chemotherapy
CANCER TREATMENT: Chemotherapy Chemotherapy, often called chemo, is the use of drugs to treat a disease. The term chemotherapy is now most often used to describe a type of cancer treatment. Dr. Khuri:
More informationJ of Evidence Based Med & Hlthcare, pissn- 2349-2562, eissn- 2349-2570/ Vol. 2/Issue 33/Aug. 17, 2015 Page 5063
PERITONEAL MALIGNANT MESOTHELIOMA: A RARE S. R. Dhamotharan 1, S. Shanthi Nirmala 2, F. Celine Foustina Mary 3, M. Arul Raj Kumar 4, R. Vinothprabhu 5 HOW TO CITE THIS ARTICLE: S. R. Dhamotharan, S. Shanthi
More information4 th Edition Paul H. Sugarbaker, MD, FACS, FRCS
December 5, 2005 Technical Handbook for the Integration of Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy into the Surgical Management of Gastrointestinal and Gynecologic Malignancy
More informationGUIDELINES FOR THE MANAGEMENT OF LUNG CANCER
GUIDELINES FOR THE MANAGEMENT OF LUNG CANCER BY Ali Shamseddine, MD (Coordinator); as04@aub.edu.lb Fady Geara, MD Bassem Shabb, MD Ghassan Jamaleddine, MD CLINICAL PRACTICE GUIDELINES FOR THE TREATMENT
More informationHow To Treat A Cancer With A Radical
Management of mesothelioma Jan.vanmeerbeeck@ugent.be Amsterdam, March 6, 2010 1 management Palliation Symptomatic care Pain Breathlessness Radiotherapy Chemotherapy Surgery Radical (intention to cure)
More informationColorectal Cancer Treatment
Scan for mobile link. Colorectal Cancer Treatment Colorectal cancer overview Colorectal cancer, also called large bowel cancer, is the term used to describe malignant tumors found in the colon and rectum.
More information