CV, Alfred C. Schouten, February 23, 2012 page 1 of 9

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1 CV, Alfred C. Schouten, February 23, 2012 page 1 of 9 Alfred C. Schouten Assistant professor Delft University of Technology Faculty of 3mE Dept. of Biomechanical Engineering Mekelweg CD Delft, the Netherlands Phone: Fax: a.c.schouten@tudelft.nl University of Twente Faculty of Engineering Technology Dept. of Biomechanical Engineering P.O. Box AE, Enschede, the Netherlands Phone: Fax: a.c.schouten@utwente.nl Positions since PhD now (0.8 fte, permanent) Assistant professor at the Delft University of Technology, Faculty of Mechanical Engineering, Department of Biomechanical Engineering now (0.2 fte, permanent) Assistant professor (0.2 fte) at the University of Twente, Faculty of Engineering Technology, Department of Biomechanical Engineering (1.0 fte, fixed-term) Postdoc, Delft University of Technology, Faculty of Mechanical Engineering, Department of Biomechanical Engineering. Education PhD. student at the Delft University of Technology, Mechanical Engineering, Man- Machine Systems ( ). MSc. student at the Delft University of Technology, Mechanical Engineering, Man- Machine Systems ( ). BSc. student at the HTS Dordrecht, Mechanical Engineering ( ). HAVO (high school) at Krimpenerwaard college Krimpen a/d IJssel ( ).

2 CV, Alfred C. Schouten, February 23, 2012 page 2 of 9 Research summary: My research focuses on methods and devices to assess and understand neuromuscular control in both healthy subjects and patients with neurological dysfunction. Key is the use of force-controlled robotic manipulators, neuromuscular modelling, and closed-loop system identification techniques to untangle the human motor control system. My research focus at the Delft University of Technology is motor control of upper limbs; and lower limbs and balance control at the University of Twente. Since my PhD I have developed system identification techniques that enable to quantify the contributions of different feedback pathways. My research resulted in a unique method that can distinguish and quantify the position, velocity and force feedback gains simultaneously. The key concept is the use of force-controlled robotic manipulators which allow for natural movement. The prototype wrist manipulator developed during my PhD project has been commercialized together with MOOG and we are currently developing a MR compatible wrist manipulator. At the UT I developed a novel robotic manipulator to investigate the individual contribution of both ankle joints to balance. Together with medical specialist from academic medical centers (e.g. LUMC, AMC, ErasmusMC) we apply the methodology to get insight in neurological dysfunction and working to use these manipulators as diagnostic tools. Recent years I started to apply the methodology of perturbations and closed-loop system identification to understand the cortical contribution to human motor control. Very recently we demonstrated that the cortico-muscular coherence, a measure for the functional connectivity between the brain and muscles, increases with external perturbations. Funding & grants Grants over the last 5 years: 2011 STW H-Haptics Haptic fidelity, co-pi, 687k, 1 PhD at TUD 2009 STW NeuroSIPE Beyond pain, co-pi, 645k, 1 PhD at TUD 2009 STW NeuroSIPE Movement Diagnostic System, co-pi, 750k, 1 PD at TUD 2009 STW NeuroSIPE BalRoom, co-pi, 750k, 1 PhD at UT 2009 STW NeuroSIPE Torticollis, co-pi, 722k, 1 PhD at TU 2009 internal grant UT Cortico-muscular coupling, co-pi, 200k, 1 PhD at UT 2008 STW perspectief* NeuroSIPE program, co-author (5.5 M ) *STW perspectief involved a two-stage program grant. First, the program was approved and STW allocated the budget; and second, projects were submitted, ranked by independent peer reviewers and selected for the NeuroSIPE program. NeuroSIPE consists of 8 projects; each joining university medical centers and universities of technology. In 4 NeuroSIPE projects, I am project leader for the technical part and PhD/PD supervisor.

3 CV, Alfred C. Schouten, February 23, 2012 page 3 of 9 Mentoring Postdocs Winfred Mugge (TUD), , Movement Diagnostic System Phd Students Bram Onneweer (TUD), , Haptic fidelity Yusang Wu (TUD), , Beyond pain Denise Engelhart (UT), , Balroom Patrick Forbes (TUD), , Torticollis Floor Campfens (UT), , Cortico-muscular coupling Ard Westerveld (UT), , Arm rehabilitation Winfred Mugge (TUD), , Reflexes in CRPS Jasper Schuurmans (TUD), , CRPS explained with a biological realistic neural network (during the project Jasper founded VirtuaLock, a company in theft prevention software, and eventually did not finish his PhD) MSc Delft University of Technology 1. Vreede, D. Ongoing 2. Potgieter, S. Ongoing 3. Perenboom, T. Ongoing 4. Sharifi, M. Ongoing 5. Geers, A. Ongoing 6. Ullrich, I. Ongoing 7. Frankemolle, A. Ongoing 8. Ansari, E. Ongoing 9. Vlaar, M.P Targeted brain activation using isometric motor tasks during functional magnetic resonance imaging. 10. Bode, C.H.D Design of an MR-safe haptic wrist manipulator for movement disorder diagnostics. 11. Kornaropoulos, E Current source density application to study corticomuscular communication. 12. Ethemam, F Galvanic vestibular stimulation elicits consistent neck motions in seated subjects. 13. Rozenbrand, D.M Intrinsic and reflexive contributions to endpoint stiffness during motor learning of unstable force fields. 14. van de Ruit, M Studying cortical involvement in the long latency stretch reflex response using subthreshold TMS. 15. Dagioglou M Design of an electromagnetic actuator to perturb the rabbit eye 16. Balderas S., D.C Time-varying identification of human properties using the wavelet analysis 17. Lagoda C Design of an electric series elastic actuated joint (eseaj) for robotic gait rehabilitation training 18. Koning T.A Synaptic plasticity in the stretch reflex; a modeling study

4 CV, Alfred C. Schouten, February 23, 2012 page 4 of Ruiz Torres, R Corticomuscular communication: modeling of neural pathways with electrophysiological recordings and system identification techniques 20. Bast G.J Stretch reflexes in patients with complex regional pain syndrome 21. Cooman P Reflexive contribution to postural control of the human arm: a modeling approach 22. Stienen A.H.A Integrating a biological realistic neural network into a musculoskeletal model to analyse postural control reflex modulation 23. Zwaan B.C.P Quantifying proprioceptive reflexes at the wrist 24. Abbink D.A The effect of position and force tasks on human arm University of Twente 25. Pasma J, , Asymmetry in sensory reweighting of proprioceptive information during balance control in healthy subjects 26. Kolk S, , Influence of stimulus frequency content on sensory reweighting in balance control 27. van Vuuren W, , Modeling and control of a hydraulic series elastic actuator. 28. Campfens S.F., , Proprioceptive feedback of the left and right ankle in balance control 29. Westenveld A., , Measurement of calf muscle length change during perturbed stance Teaching Supervision of MSc and BSc students during their thesis research project (2000- now). Organization and lectures on the NeuroSipe Summer School (2010 and 2011). Lecturer Human Movement Control B: neuromuscular control (TUD, code BM1250, 3 EC), 2010-now Lecturer System Identification and Parameters Estimation (TUD, code WB2301, 7 EC), 2007-now Lecturer Human Movement Control (TUD, code WB2407, 4 EC), Teaching assistant System Identification and Parameters Estimation (TUD, code WB2301, 7 EC), Teaching assistant Human Movement Control (TUD, code WB2407, 4 EC), Guest Lectures for several courses at University of Twente (o.a. Identification of Human Movement Control, Biomechatronics, Human Movement Control), now

5 CV, Alfred C. Schouten, February 23, 2012 page 5 of 9 Publications Peer reviewed Articles 1. Schouten AC, Campfens SF (2012) Directional coherence disentangles causality within the sensorimotor loop, but can not open the loop. Letter to the editor. J Physiol. In press. 2. Schilder JCM, Schouten AC, Perez RS, Huygen FJ, Dahan A, Noldus LP, van Hilten JJ, Marinus J (2012) Motor control in Complex Regional Pain Syndrome: a kinematic analysis. Pain. In press. 3. Groenewegen JS, de Groot JH, Schouten AC, Maier AB, Arendzen JH, Meskers CGM (2012) Spinal reflex properties in the long term after stroke. J Electomyogr Kines 22: Mugge W, Schouten AC, Bast GJ, Schuurmans J, van Hilten JJ, van der Helm FC (2012). Stretch reflex responses in Complex Regional Pain Syndrome-related dystonia are not characterized by hyperreflexia. Clin Neurophysiol 123: Westerveld AJ, Schouten AC, Veltink PH van der Kooij H (2012) Selectivity and Resolution of Surface Electrical Stimulation for Grasp and Release. IEEE Trans Neural Syst Rehabil Eng 20: Mugge W, Munts AG, Schouten AC, van der Helm FCT (2012) Modeling movement disorders - CRPS-related dystonia explained by abnormal proprioceptive reflexes. J Biomech 45: Schouten AC, Boonstra TA, Nieuwenhuis F, Campfens SF, van der Kooij H. (2011) A Bilateral Ankle Manipulator to Investigate Human Balance Control. IEEE Trans Neural Syst Rehabil Eng 19: Forbes PA, Happee R, van der Helm FC, Schouten AC (2011) EMG feedback tasks reduce reflexive stiffness during force and position perturbations. Exp Brain Res 213: Munts AG, Mugge W, Meurs TS, Schouten AC, Marinus J, Moseley GL, van der Helm FC, van Hilten JJ (2011) Fixed dystonia in complex regional pain syndrome: a descriptive and computational modeling approach. BMC Neurol 11: Schuurmans J, van der Helm FC, Schouten AC (2011) Relating reflex gain modulation in posture control to underlying neural network properties using a neuromusculoskeletal model. J Comput Neurosci 30: van der Meer JN, Schouten AC, Bour LJ, de Vlugt E, van Rootselaar AF, van der Helm FC, Tijssen MA (2010) The intermuscular 3-7 Hz drive is not affected by distal proprioceptive input in myoclonus-dystonia. Exp Brain Res 202: Meskers CG, Schouten AC, Rich MM, de Groot JH, Schuurmans J, Arendzen JH (2010) Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis. Exp Brain Res 201: Mugge W, Abbink DA, Schouten AC, Dewald JP, van der Helm FC (2010) A rigorous model of reflex function indicates that position and force feedback are flexibly tuned to position and force tasks. Exp Brain Res 200: Stienen AHA, Hekman EEG, Schouten AC, van der Helm FCT, van der Kooij H (2009) Suitability of hydraulic disk brakes for passive actuation of upper-extremity rehabilitation exoskeletons. Appl Bionics Biomech 6:

6 CV, Alfred C. Schouten, February 23, 2012 page 6 of Happee R, de Vlugt E, Schouten AC (2009) Posture Maintenance of the Human Upper Extremity; Identification of Intrinsic and Reflex Based Contributions. SAE Int J of Pass Cars - Mech Sys 1: Meskers CG, Schouten AC, de Groot JH, de Vlugt E, van Hilten BJ, van der Helm FC, Arendzen HJ (2009) Muscle weakness and lack of reflex gain adaptation predominate during post-stroke posture control of the wrist. J Neuroeng Rehabil 6: Mugge W, Schuurmans J, Schouten AC, van der Helm FC (2009) Sensory weighting of force and position feedback in human motor control tasks. J Neurosci 29: Schuurmans J, de Vlugt E, Schouten AC, Meskers CG, de Groot JH, van der Helm FC (2009) The monosynaptic Ia afferent pathway can largely explain the stretch duration effect of the long latency M2 response. Exp Brain Res 193: Schouten AC, Mugge W, van der Helm FC (2008) NMClab, a model to assess the contributions of muscle visco-elasticity and afferent feedback to joint dynamics. J Biomech 41: Schouten AC, Vlugt ED, van der Helm FC (2008) Design of perturbation signals for the estimation of proprioceptive reflexes. IEEE Trans Biomed Eng 55: Schouten AC, de Vlugt E, van Hilten JJ, van der Helm FC (2008) Quantifying proprioceptive reflexes during position control of the human arm. IEEE Trans Biomed Eng 55: Stienen AH, Schouten AC, Schuurmans J, van der Helm FC (2007) Analysis of reflex modulation with a biologically realistic neural network. J Comput Neurosci 23: de Vlugt E, Schouten AC, van der Helm FCT (2006) Quantification of intrinsic and reflexive properties during multijoint arm posture. J Neurosci Methods 155: Schouten AC, De Vlugt E, Van Hilten JJ, Van der Helm FCT (2006) Design of a torque-controlled manipulator to analyse the admittance of the wrist joint. J Neurosci Methods 154: Schouten AC, Van de Beek WJT, Van Hilten JJ, Van der Helm FCT (2003) Proprioceptive reflexes in patients with Reflex Sympathetic Dystrophy. Exp Brain Res 151: De Vlugt E, Schouten AC, Van der Helm FCT, Teerhuis PC, Brouwn GG (2003) A force controlled planar haptic manipulator for posture control analysis of the human arm. J Neurosci Methods 129: De Vlugt E, Schouten AC, Van der Helm FCT (2003) Closed-loop multivariable system identification for the characterization of the dynamic arm compliance using continious force disturbances: a model study. J Neurosci Meth 122: Van der Helm FCT, Schouten AC, De Vlugt E, Brouwn GG (2002) Identification of intrinsic and reflexive components of human arm dynamics during postural control. J Neurosci Meth 119: De Vlugt E, Schouten AC, Van der Helm FCT (2002) Adaptation of reflexive feedback during arm posture to different environments. Biol Cybern 87: De Vlugt E, Van der Helm FCT, Schouten AC, Brouwn GG (2001) Analyses of the reflexive feedback control loop during posture maintenance. Biol Cybern 84:

7 CV, Alfred C. Schouten, February 23, 2012 page 7 of Schouten AC, De Vlugt E, Van der Helm FCT, Brouwn GG (2001) Optimal posture control of a musculoskeletal arm model. Biol Cybern 84: Peer reviewed conference proceedings (available on WoS) 1. Meskers CGM, Maier AB, Schouten AC, Arendzen JH, de Groot JH (2012). Neural compensation in sarcopenia. Age & Aging 41: i53 2. Mulder M, Verspecht T, Abbink DA, van Paassen MM, Balderas DC, Schouten A, de Vlugt E, Mulder M (2011) Identification of Time Variant Neuromuscular Admittance using Wavelets IEEE SMC Stienen AHA, McPherson JG, Schouten AC, Dewald JPA (2011) The ACT-4D: A Novel Rehabilitation Robot for the Quantification of Upper Limb Motor Impairments Following Brain Injury. 12th IEEE International Conference on Rehabilitation Robotics (ICORR 2011) 4. Otten A, van Vuuren W, Stienen A, van Asseldonk E, Schouten A,van der Kooij H (2011) Position and Torque Tracking: Series Elastic Actuation versus Model- Based-Controlled Hydraulic Actuation. 12th IEEE International Conference on Rehabilitation Robotics (ICORR 2011) 5. Campfens SF, Schouten AC, van der Kooij H, van Putten MJAM (2011) Corticomuscular system tunes to external perturbations during a motor task as revealed by corticomuscular coherence. Clin Neurophysiol 122: S92 6. Lagoda C, Schouten AC, Stienen AHA, Hekman EEG, van der Kooij H (2010) Design of an electric Series Elastic Actuated Joint for robotic gait rehabilitation training. 3rd IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, pages: de Vlugt E, Schouten AC, van der Helm FCT (2007) The Delft Laboratory for Neuromuscular control: Haptic robots for the identification of neuro-muscular control 10th IEEE International Conference on Rehabilitation Robotics (ICORR 2007), Vols 1-2, pages: Meskers CGM, Schouten AC, de Groot JH, Arendzen JH, van der Helm FCT (2004) Proprioceptive reflexes in spasticity after stroke. 15th Congress of the International Society of Electrophysiology & Kinesiology (ISEK 2004), pages: de Vlugt E, Schouten AC, van der Helm FCT Identification of intrinsic and reflexive muscle parameters of the human arm in 3D joint space. Conference proceedings of IEEE International conference on Systems, Man & Cybernetics, Vols 1-7, pages: Schouten AC, de Vlugt E, van der Helm FCT (2004) Quantification of spinal reflexes in neurological disorders. Conference proceedings of IEEE International conference on Systems, Man & Cybernetics, Vols 1-7, pages: Van der Helm FCT, Brouwn GG, Vlugt E, Schouten AC (2000). Identification of intrinsic and reflexive components of human arm dynamics during postural control Proceedings of the 3rd conference of the international shoulder group (ISG), pages: Other proceedings (first author at international conferences only) 1. Schouten AC, Boonstra TA, Vlutters M, van der Kooij H (2011) Bipedal support surface rotations to investigate ankle stiffness during stance. International Society of Biomechanics XXIIIrd congress, Brussels, Belgium, July 3-7.

8 CV, Alfred C. Schouten, February 23, 2012 page 8 of 9 2. Schouten AC, Schuurmans J, Mugge W, van der Helm FCT (2011) Where are my parameters? A visualization tool to investigate how parameters affect dynamic behaviour during postural control. ISB Technical Group on Computer Simulation Symposium, Leuven, Belgium, June 30 - July Schouten AC, Mugge W, de Vlugt E, Van der Helm FCT (2010) Time variant system identification of human limb dynamics using wavelets. 40th annual meeting of the Society for Neuroscience, San Diego, USA, November Schouten AC, Boonstra TA, Campfens SF, van der Kooij (2010) H Bipedal support surface rotations to investigate human balance control. XVIII congress of the ISEK, Aalborg, Denmark, June Schouten AC, Campfens SF, Boonstra TA,van der Kooij H (2009) Unloading responses in the ankle during balance: the afferent contribution to balance. 39th annual meeting of the Society for Neuroscience, Chicago, USA, October Schouten AC, Mugge W, van der Helm FCT (2008) How afferent feedback adapts to instantaneous changes of the mechanical load during continuous posture tasks. 38th annual meeting of the Society for Neuroscience, Washington DC, USA, November Schouten AC, Mugge W, de Vlugt E, van der Helm FCT (2008) Humans optimally adapt afferent feedback to stabilize unstable loads. Advances in Computational Motor Control, Washinton DC, USA, November Schouten AC, Mugge W, van der Helm FCT (2007) NMClab, a model to assess the contributions of muscle visco-elasticity and afferent feedback to joint dynamics, 37th annual meeting of the Society for Neuroscience, San Diego, USA, November Schouten AC, De Vlugt E, Van der Helm FCT (2006) Spinal reflexes optimally adapt to unstable environments, 6th Conference of the international shoulder group, Chicago, USA, October Schouten AC, de Graaf WW, Munts AG, van Hilten JJ, Veeger HEJ, van der Helm FCT (2006) Quantifying proprioceptive reflexes aroun dthe wrist in patients with complex regional pain syndrome, XVI congress of the ISEK, Torino, Italy, June 29- July 1. p Schouten AC, De Vlugt E, Van der Helm FCT (2006) Spinal reflexes optimally adapt to unstable environments, XVI congress of the ISEK, Torino, Italy, June 29- July 1. p Schouten AC, Munts AG, Veeger HEJ, Van der Helm FCT, Van Hilten JJ (2005) Quantifying bradykinesia in neurological patients, Measuring Behavior 2005, 5th International Conference on Methods and Techniques in Behavioral Research, Wageningen, The Netherlands, August 30 - September Schouten AC, De Vlugt E, Van der Helm FCT (2004) Quantification of spinal reflexes in neurological disorders, IEEE International Conference on Systems, Man & Cybernetics, The Hague, The Netherlands, October p Schouten AC, De Vlugt E, Van der Helm FCT (2004) Quantification of proprioceptive reflexes, 5th Conference of the international shoulder group, Lisbon, Portugal, August p Schouten AC, De Vlugt E, Van Hilten JJ, Van der Helm FCT (2004) Quantifying proprioceptive reflexes around the wrist during postural control 14th European society of biomechanics conference, 's Hertogenbosch, The Netherlands, July 4-7.

9 CV, Alfred C. Schouten, February 23, 2012 page 9 of Schouten AC, De Vlugt E, Van der Helm FCT (2004) Design of perturbation signals to estimate the reflexive impedance from surface EMG VIII-th Quantitative EMG conference, Nijmegen, The Netherlands, June p Schouten AC, De Vlugt E, Van der Helm FCT (2003) Quantifying proprioceptive reflexes during posture tasks International society of biomechanics XIXth congress, Dunedin, New Zealand, July p Schouten AC, De Vlugt E, Van der Helm FCT (2003) Quantifying proprioceptive reflexes during posture tasks European workshop on movement science (EWOMS), Münster, Germany, May p Book chapters 1. Schouten AC (2004) Proprioceptive reflexes and neurological disorders. PhD thesis, Delft University of Technology, Delft, The Netherlands. ISBN