Int. J. Environ. Res. Public Health 2016, 13, 479; doi: /ijerph

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1 Int. J. Environ. Res. ublic Health 016, 13, 479; doi: /ijerph S1 of S8 Supplementary aterials: Hospitalisation Resulting from edicine-related roblems in Adult atients with Cardiovascular iseases and iabetes in the United Kingdom and Saudi Arabia Abdullah Al Hamid, Zoe Aslanpour, Hisham Aljadhey and aisoon Ghaleb atient Table S1. Characteristics of Rs (n = 103) encountered in the UK study. Type Severity R N edicine Involved 1 oderate Chest pain, nausea and vomiting, sweating, Hyperkalaemia, continuous cough 1 ACEI (lisinopril 10 mg) ow Chest pain (due to unregulated dose, troponin level was too high) 1 3 oderate High blood sugar level 1 vomix 30 (short acting insulin) 4 oderate High blood sugar level, vomiting 1 Humulin 3 (Intermediate and long acting insulin) 5 oderate Cough Olanzapine 5 mg Ramipril 1.5 mg 6 oderate Uncontrolled blood pressure, Headache, palpitation 1 Telmisartan 80 mg oxazosin 8 mg 7 oderate Continuous high blood pressure, rising troponin level due to medication cardiotoxicity Amlodipine 10 mg Clopidogrel 75 mg (?) 8 ow 1 antus insulin 6U 9 ow High B 1 antus insulin 6U SC vorapid SC 10 oderate olyurea and polydipsia, ketoacidosis 1 etformin 1 g vorapid 4 8 u/day and u at lunch or dinner antus 8 u at evening 11 ow drowsiness, fall and head injury, confusion, dehydration and tachycardia 1 methadone 50 m dihydrocodeine 30 mg 1 oderate 1 Gliclazide 80 mg 13 p ow Near syncope, hypertension 1 oxazosin 8 mg Amlodipine 10 mg Atorvastatin 80 mg Ramipril 10 mg 14 oderate Hypertension, headache, dizziness 1 Temisartan 40 mg 15 oderate Angina, chest pain at rest, heavy ache down the left arm, tightness of jaw, nausea and vomiting 1 Nitrglycerine Isosorbide mononitrate 16 oderate Chest pain troponin negative 1 Isosorbide mononitrate

2 Int. J. Environ. Res. ublic Health 016, 13, 479; doi: /ijerph S of S8 atient Table S1. Cont. Type Severity R N edicine Involved 17 oderate ild chest discomfort and exertion, Troponin level high 1 18 ow Chest pain, troponin level low 1 Nitroglycerine 19 oderate elena 1 0 Severe R bleeding and abdominal pain 1 ethotrexate 1.5 mg 1 Severe elena 1 Clopidogrel 75 mg oderate eranged liver function test 1 Atorvastatin 40 mg 3 oderate Hypotension 1 Ramipril.5 mg Spironolactone 5 mg 4 Severe Bleeding Confusion (potential) Antibiotic resistance (potential) Hypotension 4 Warfarin 3 mg/4 mg Ferrous fumarate igoxin 6.5 mg Quinine sulfate 300 mg Amlodipine 5 mg Spironolactone 5 mg 5 ow elena 1 6 ow Anaemia, chronic kidney disease, fluid overload which resulted in pulmonary oedema Ferrous fumarate Furosemide 7 ow Hypercalcemia 1 Calcium 8 oderate SOB, palpitation, abnormal TINR Bisoprolol 5 mg Warfarin 1 mg 9 ow Cough 1 30 Severe Haemoptysis 1 Warfarin 31 oderate alpitations 1 Amlodipine 5 mg 3 oderate Ankle swelling 1 Amlodipine 10 mg 33 ow Oedema 1 Furosemide 0 mg 34 oderate SOB 1 igoxin 35 oderate Hypoglycaemia 1 Insulin 36 oderate 37 oderate High blood pressure iarrhoea High B Glycosuria 3 Candesartan 4 mg Insulin Amoxicillin etformin 850 mg Gliclazide 160 mg ioglitasone 45 mg

3 Int. J. Environ. Res. ublic Health 016, 13, 479; doi: /ijerph S3 of S8 atient Table S1. Cont. Type Severity R N edicine Involved 38 oderate Glycosuria 1 Gliclazide 160 mg etformine 1 g Humulin mix 5 39 oderate 1 etformin 500 mg 40 oderate 1 Insulatard 41 oderate 1 Glimipiride 4 oderate Renal failure 1 Spironolactone 43 oderate OR bleeding due to aspirin 1 Aspirin 44 oderate GOR 1 Aspirin 45 oderate Chest pain, SOB Aspirin GTN 46 oderate Sinus bradycardia 1 Bisoprolol 47 p oderate SOB, palpitation, abnormal TINR 1 Aspirin 48 ow worsening heart failure 1 Ramipril 1.5 mg 49 oderate Angina 1 Asassantin retard 50 oderate Impaired kidney function 1 Ramipril 51 oderate Hypoglycaemia 1 Gliclazide 80 mg 5 oderate Gastroenteritis 1 rednisolone 5 mg 53 oderate Stroke 1 54 Severe SOB, chest pain, sweating 1 isopyramide 300 mg 55 oderate aortic stenosis contraindication/ risk of hypotension 1 Isosorbide mononitrate 56 oderate 57 oderate 58 oderate palpitation atrial fibrillation NSTEI HF SOB in asthmatic patient ow systolic B 59 ow iarrhoea 1 1 osartan potassium 100 mg Atorvastatin 0 mg Ramipril 1.5 mg ropranolol 0 mg Indapamide.5 mg Nifedipine 40 mg oxonidine 30 mg Tiotropium 18 mcg Aminophylline 450 mg Salbutamol

4 Int. J. Environ. Res. ublic Health 016, 13, 479; doi: /ijerph S4 of S8 atient Table S1. Cont. Type Severity R N edicine Involved 60 oderate Syncope 1 Glyceryl trinitrate 61 Severe 6, oderate 63 low SOB on exertion associated with chest pain ACS Bradycardia A (iver function tests) Eye sight loss 64 low Chest pain 1 1 atient stopped taking his medication Ticagrelor 90 mg Bisoprolol 1.5 mg Ezetimibe 10 mg Ramipril.5 mg Sotalol 40 mg Bisoprolol 1.5 mg Atorvastatin 80 mg Ramipril 1.5 mg 65 low Kidney function (low creatinine) 1 Ramipril 1.5 mg 66 low Chest pain 1 isinopril 10 mg 67 low Chest pain 1 Ramipril 7.5 mg 68 low Chest pain 1 Ramipril.5 mg 69 low Bleeding ulcer 1 Ferrous fumarate 305 mg 70,, oderate Increased INR iarrhoea Nausea, dizziness and weakness 3 Warfarin Antibiotic Warfarin and bisoprolol 1.5 mg 71 low Right leg swelling 1 Hydrocortisone 7 oderate ulmonary embolism 1 Warfarin 8.5 mg 73 oderate ulmonary embolism 1 Warfarin 8.5 mg 74 ow Hallucination 1 adopar 6.5 mg 75 low Tightness of chest and tachycardia 1 Glyceryl trinitrate 76 low Tachycardia 1 Salbutamol TT 77 low izziness and low blood pressure 1 Bisoprolol 10 mg 78 low Sinus rhythm 1 igoxin 79 low Tachycardia 1 Sotalol 80 mg 80 low Tachycardia 1 Sotalol 80 mg 81 low Hypoglycaemia 1 examethasone 8 low Hypotension 1 Atenolol 50 mg 83 low alpitation 1 ercandipine 10 mg

5 Int. J. Environ. Res. ublic Health 016, 13, 479; doi: /ijerph S5 of S8 atient Table S1. Cont. Type Severity R N edicine Involved 84 low alpitation 1 oxazosin 4 mg Amlodipine 5 mg 85 low alpitation 1 ropafenone 150 mg 86 low alpitation 1 igoxin 15 mcg Bisoprolol 7.5 mg Table S. Characteristics of Rs encountered in the SA study. atient Type Severity R N edicine 1 High blood pressure isinopril 10 mg ercanidipine 0 mg Insulin mix etformine 500 mg 3 S Acute coronary syndrome 1 Simvastatin 0 mg 4 S 1 Humulin issing medicine 9 HTN vomix 30 Amlodipine 10 mg Bisoprolol 1.5 mg Ramipril 10 mg 10 1 etformin 500 mg 11 1 Insulin mix 1 1 etformin 1 g Insulin rapid 13 1 Insulin rapid 14 S Gastric bleeding 1 Aspirin 81 mg 15 1 Humalog mix 50:40 units etformin g 16 1 Insulin mix 17 1 Insulin mix etformin 500 mg 18 Anaemia 1 Iron 19 Cough 1 isinopril 10 mg

6 Int. J. Environ. Res. ublic Health 016, 13, 479; doi: /ijerph S6 of S8 Table S. Cont. atient Type Severity R N edicine 0 S Sweating, nausea and vomiting increasing 1 evothyroxine 50 micrograms in intensity 1 HTN 1 Bisoprolol 1.5 mg 1 Glibenclamide 5 mg 3 HTN 1 Bisoprolol 5 mg 4 1 Insulin rapid 5 Cough 1 isinopril 10 mg 6 HTN 1 Bisoprolol 7.5 mg Furosemide 80 mg 7 Epigastric pain 1 8 Anaemia no iron intake Iron Glibenclamide 5 mg 9 1 vomix 30:14 units 30 Cough 1 31 Tachycardia 1 Thyroid hormone 3 Tachycardia 1 evothyroxin 100 mcg harm harm S S Hyperlipidaemia anaemia Epigastric pain Infection hyperglycaemia Gastroenteritis Simvastatin 0 mg issing medicine Insulatard Clopidogrel 75 mg Augmentin 500 mg etformin 500 mg Insulin mixtard 37 harm 1 issing medicine 38 harm 1 issing medicine 39 harm 1 Insulatard mix etformin 50 mg 40 Uncontrolled blood pressure Insulin mix Ramipril 1.5 mg 41 1 issing medicine 4 harm 1 issing medicine

7 Int. J. Environ. Res. ublic Health 016, 13, 479; doi: /ijerph S7 of S8 Table S. Cont. atient Type Severity R N edicine 43 harm 1 Insulin NH Insulin regular 44 harm 1 issing medicine 45 1 issing medicine harm harm harm harm Elevated triglycerides Abdominal pain issing medicine issing medicine 48 harm 1 Glibenclamide 5 mg 49 harm 1 Insulin regular 50 harm 1 Insulin mix 51 1 issing medicine 5 harm 1 issing medicine 53 harm HTN 1 Bisoprolol 3.75 mg 54 harm issing medicines harm Elevated triglycerides 55 harm 1 Insulin mix 56 1 issing medicine 57 harm roductive cough/infection 1 Azithromycin 500 mg 58 harm Hypertension 1 etoprolol 1.5 mg 59 harm Anaemia 1 Iron Folic acid 5 mg 60 1 issing medicine 61 harm S Theophylline toxicity 6 Uncontrolled HTN 1 Gliclazide 160 mg Theophylline 150 mg Amlodipine 10 mg Furosemide 0 mg Isosorbide dinitrate 0 mg etoprolol 5 mg erindopril 5 mg 63 igitalis toxicity 1 igoxin 15 mcg 64 harm 1 Insulin mix

8 Int. J. Environ. Res. ublic Health 016, 13, 479; doi: /ijerph S8 of S8 Table S. Cont. atient Type Severity R N edicine 65 harm harm alpitations Insulin rapid etoprolol 5 mg 66 harm 1 Insulin mix 67 1 issing medicine 68 1 Insulin 69 1 Insulin mix 70 harm High cholesterol 1 Simvastatin 10 mg 71 harm Vomiting 1 Aspirin 34 mg 7 no harm Cough 1 Simvastatin 10 mg 73 Bradycardia 74 HTN 1 Insulin Tamsulosin 0.4 mg Nifedipine 30 mg Valsartan 160 mg 75 Hypoglycaemia 1 issing medicine 76 1 issing medicine 77 HTN 1 issing medicine 78 harm Orthopnoea 1 Aspirin 81 mg NA 79 1 Insulin rapid 80 S Gastric bleeding 1 81 HTN 1 isinopril 10 mg 8 Abdominal pain 1 Clopidogrel 75 mg 016 by the authors; licensee I, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (