Disease overview. Acne is a skin disorder, due to many intrinsic factors. Acne improves mainly upon reaching adulthood

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1 Innovative treatment for acneic skin

2 Disease overview Acne is a skin disorder, due to many intrinsic factors Acne improves mainly upon reaching adulthood Acne affects 80% of adolescents & 20% of adults 20% of Acne consultations are with Dermatologists Main consequences of acne are: Abnormal desquamation (comedogenesis) Excessive sebum production Proliferation and inflammation (caused by Propioni bacterium) Follicular reactivity Heredity

3 Disease overview: causes Acne is the result from a combination of 3 successive factors Hypo-seborrhea Bacterial proliferation/ inflammation Hyper- keratinization, that means thickening of the epidermis and obstruction of the pores Hereditary factors Secondary causes are Stress, overwork, anxiety Medications

4 Disease overview: classification Acne is the disease of filo sebaceous follicles unit On the face(forehead, nose & chin) Chest area Back & shoulders The Secondary condition causes is are classified Mild, with open and closed Hereditary comedones, factors some pustules and papules Moderate, with comedones with more frequent papules Severe, with comedones, papules, Medications nodular abscesses

5 Disease overview: type of lesions Retentional lesions (i.e. Accumulation of sebum and obstruction of the pores) Inflammatory lesion Scarring Blackheads (open comedones) Whiteheads (closed comedones) Pustules (white spots) Papules (red spots) Nodules (Large cysts)

6 Disease overview: Cook system classification Need not to be perfect; 3 small comedones and /or papules are permitted, if they are scattered Very few pustules, up to 3 dozen papules and /or comedones; no big or prominent lesions; lesions are hardly visible from 2,5 m away Between grades 2 and 6. Red lesions and inflammation are present to a significant degree. Worthy of treatment Numerous comedones, but no inflammation or inflammatory lesions, numerous pustules, lesions, easily recognized at 2,5m, some pustules may be quite large (1-2 cm) Conglobated, sinus or cystic type acne or highly inflammatory acne covering most of the yellow pustules extend to neck and chin

7 Current Treatment Key objectives in the treatment of Acne Resolution of inflammation The choice of treatment depends on type and severity of Acne Regulation of sebum production Topical treatments for mild and moderate Acne Elimination of non inflammatory lesions Systemic treatments for severe Acne or resistance to topical treatments

8 Current treatment Acne Treatment: retinoid topical or systemic treatment + special formulated hygiene + special formulated skincare Market need: to have a special formulated line of hygienic products, that covers skin hygiene and skincare for all different types of Acne and all different types of skin

9 Current treatment Management: topical treatment Topical retinoid: Keratolytic agents Anti-inflammatory and Keratolytic agent Local antibiotics: Anti-inflammatory Tretinoin and Isotretinoin Adapalene Benzoyl peroxide Erythromycin 4% Clindamycin 1% Treatment generally associated with an active hydrating cream in order to minimize induced dryness and to improve compliance Due to this multi component disease, an appropriate combination anti acne therapy is chosen

10 Current treatment Management: oral treatment Hormone therapy (women only) Cyproterone acetate: anti androgenic action Zinc (gluconate) Anti inflammatory action Antibiotic therapy Cyclines Macrolides Isotretinoin Severe nodulocystic Acne Acne resistant to treatments used in traditional therapies (oral antibiotics > 3 months + topical)

11 Current disease Management: dermocosmetic Skin hygiene Products is soap free Gently cleansing of the face which: is gentle to the skin Skincare Products has a non greasy texture has a physiological ph Skincare products which: is enriched with active keratolytic, sebo-regulating, anti inflammatory, antibacterial agents and have a mattifying effect

12 Acne Kit: Product description Aknekit represents a complete daily management of signs and symptoms of light to moderate Acne The Aknekit is an original and exclusive concept based on a unique combination of ingredients Combination of 3 products Day treatment, available in 30ml tube Cleanser, available in 100ml bottle Night treatment, available in 30ml tube

13 Step 1 : Cleanser Non-aggressive cleansing Prevents dehydration of the skin Soothes Purifies with an exfoliating effect Leaves a feeling of freshness To be used in the skincare routine morning and night Based on Salycilic acid, Glycolic acid and Urea Peroxide, it has an exfoliating action; its ingredients penetrate deep within the pores to reduce the formation of sebum and attack the formation of skin imperfections.

14 Step 2 : Day treatment Hydrates the skin with no oily effect Clinically proven Non photosensitizing, can be used also during summer period No side effect Leaves a feeling of freshness Perfume free The presence of Hyaluronic acid gives an hydrating action and favors a filmforming action. The Hydrogen peroxide is well know in bibliography as an anti-bacterial agent

15 Step 3 : Night treatment Synergic action of Ratania extract, Glycolic acid & Kojic acid Regulates sebum production Perfume free Dermatologically tested Exfoliating action thanks to Glycolic and Kojic acid Limits bacterial proliferation and inflammation Ratania extract has been frequently used in oral products as anti-bacterial agent: it is useful in oily skin and in presence of blackheads

16 Competitors : USA Product Composition Company Clinicals Price Proactiv Cleanser with Benzoyl peroxide+ revitalizing toner with Glycolic acid+ repairing treatment with Benzoyl peroxide Guthy Renker Yes $ 29,95 Complete acne therapy system Cleanser with Salicylic acid+ lotion with Benzoyl peroxide+ oil free SPF15 lotion with botanical complex Neutrogena Yes $ 24,99 Clean & clear advantage acne control Cleanser with Benzoyl peroxide+ moisturizer+ clearing spot treatment J&J Yes Not available Acne introductory kit Clarifying cleanser with salicylic acid+ exfoliating gel with Hydrogen peroxide+ skin lotion with algae extract+ & Arnica+ acne spot treatment with Sulfur+ clarifying mask Murad Yes $ 29,95 Acne complex kit Clarifying cleanser with salicylic acid+ exfoliating gel with Hydrogen peroxide+ skin lotion with algae extract+ & Arnica+ acne spot treatment with Sulfur Murad Yes $ 60,00 Acne repair kit Drying lotion with Salicylic acid+ drying cream with Sulfur, Titanium dioxide and Beeswax+ buffering lotion with Niacinamide Mario Badescu No $ 46,00 Outer peace acne relief kit Foaming cleanser+ acne spot relief+ acne relief lotion + acne relief pads Aveda Yes $ 129,50

17 Competitors : Italy Product Composition Company Clinicals Price 3 step system antiblemish solutions clear skin system Kit acne speciale brufoli Kit pelle con acne Kit Neos acne Anti-blemish solutions cleansing foam 50ml + anti-blemish solutions clarifying lotion 100ml + antiblemish solutions cleaning moisturizer 30ml Cleansing gel 200ml + intensive treatment 30ml+ purifying cream 50ml Cream with Salicylic acid & Azelaic acid+ vial with Salicylic acid, Azelaic acid & Glycolic acid Regular cream with Salicylic acid & Azelaic acid+ balancing cream with Azelaic acid & Mandelic acid+ calm cream with Vit B3 & teat tree oil+ modulating cream with Chamomile & Glycerrethic acid Clinique Not available 39,60 Tabiano Not available 26,00 Cosmeceutica mirata Not available 59,40 Neoglis Not available Not available

18 Clinicals : Study in Italy Multicenter, randomized, controlled 3 centers in Italy Rome, Istituto san Gallicano, Prof. Berardesca Milan, Prof. Veraldi Catania, Clinica dermatologica, Prof. Micali Evaluation of the efficacy of Akne kit versus Proactiv 120 patients affected by mild to moderate acne Duration of the study : 8 weeks + evaluation at 15 days, 4 and 8 weeks Evaluation based on : GAGS (Global Acne Grading System) Cosmetic acceptability by the patients Efficacy and safety by the doctors and the patients Presentation/Publications : Acne e rosacea day, Milan, September 2013 Dermo-venerologia days, Catania, February 2014 AAD Denver, USA, March 2014

19 Packaging presentation

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