Gibbs Pharmacy 1427-b Baddour Parkway Lebanon, TN Phone Fax
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1 Gibbs Pharmacy 1427-b Baddour Parkway Lebanon, TN Phone Fax Scar/Wound Treatment Compound Ingredients All Scar Types Pracasil -Plus compounding base Pracasil -Plus is a silicone compounding base made with oil derived from the seeds of the Amazonian Pracaxi tree. It can be used alone or with active ingredients to smooth, soothe, and soften skin. Pracaxi oil is an anti-inflammatory, antioxidant, antibacterial, and antifungal. Pracasil-Plus is ideal for all kinds of scars, including new scars, old scars, surgical scars, keloids, stretch marks, acne scars, etc. Figure 1: Subject s scar (A) before application of PracaSil-Plus (left) and at week eight of application of PracaSil-Plus. Figure 2: Subject s scar (B) before application of PracaSil-Plus (left) and at week eight of application of PracaSil- Plus. Figure 3: Patient old ankle scar beforepracasil-plus (left) and after Pracasil-Plus Figure 4:Patient new ankle scar before PracaSil-Plus (left) and after Pracasil-Plus
2 Figure 5: Infant facial burnbefore PracaSil- Plus(left) and 8 days after PracaSil-Plus Figure 6: Infant diaper rashbefore PracaSil- Plus(left) and 3 days after PracaSil-Plus Keloids and Hypertrophic Scars Betamethasone Tamoxifen Gabapentin Lidocaine Prilocaine Anti-inflammatory (corticosteroid) and downregulator of collagen synthesis Non-steroidal anti-estrogen that may lead to improved wound healing in keloids by decreasing the expression of of TGF-β 1, which consequently inhibits both fibroblast proliferation and collagen production Induces differentiation and proliferation in epidermal keratinocytes, induces apoptosis Blocks firing of overactive neurons involved in pain transmission and sensation for local analgesia Local anesthetic (quick acting) Local anesthetic (longer acting) Decreases collagen production, increases activity of collagenase in dermis, and inhibits fibroblast hyperactivity Antioxidant Figure 7: Patient facial scars before PracaSil-Plus compound with,, and (left) and after PracaSil-Plus compound Post-Surgical Scars/New Scars Collagenase/Hyaluronidase Reduces collagen and connective tissue matrix production
3 Scar Prevention Dimethylsulfone Ascorbic acid Antioxidant Anti-inflammatory Vitamin essential for collagen formation and tissue repair and antioxidant properties Induces differentiation and proliferation in epidermal keratinocytes, induces apoptosis Painful Scars Gabapentin Lidocaine Prilocaine Blocks firing of overactive neurons involved in pain transmission and sensation for local analgesia Local anesthetic (quick acting) Local anesthetic (longer acting) Stretch Marks/Pregnancy/Acne Scars Tretinoin Increased skin cell turnover rates and collagen production to decrease acne and smooth appearance of rough skin Skin Ulcers/Wounds Mupirocin Nifedipine Antibacterial Decreases collagen production, increases activity of collagenase in dermis, and inhibits fibroblast hyperactivity Improved blood flow to ulcers/wounds, decreased healing time Figure 8: Patient right elbowbefore PracaSil-Plus compound with mupirocin (left) and 11 days after PracaSil-Plus compound Figure 9: Patient left elbowbefore PracaSil-Plus compound with mupirocin (left) and 11 days after PracaSil-Plus compound
4 Figure 10:Ulcerated Leg Wound before PracaSil-Plus compound with mupirocin and simultaneous treatment with Lipoderm compound with pentoxifylline and nifedipine (left) and after treatment Key articles Pracasil -Plus Tamoxifen PCCA (2013b) PCCA Pracasil -Plus Studies & Report. Files/98638_PracasilStudies_ALL.pdf Rawlins J, Lam W, Lam L, Karrom RO, Naylor IL, Sharpe DT. inhibits mature burn scar fibroblasts in culture. Burns. 2006;32(1): Yamada H, Tajima S, Nishikawa T, et al., a selective inhibitor of collagen synthesis in human skin fibroblasts. J Biochem. 1994;116(4): Murakami T, Yoshioka M, Yumoto R, et al. Topical delivery of keloid therapeutic drug. Journal of Pharmacy and Pharmacology.1998;50(1):49-54 Gragnani A, Warde M, Furtado F, Ferreira L. Topical tamoxifen therapy in hypertrophic scar or keloids in burn. Archives of Dermatological Research.2010;302(1):1-4. Collagenase and Hyaluronidase Turkovski I, et al. "Comparative evaluation of the depth of collagen and hyaluronic acid hydrolysis in vitro by collagenase and hyaluronidase preparations." Bulletin of experimental biology and medicine. 2008; 146(1): Laugher JP, Shuster S, Rosdy M, Csoka AB, Stern R, Maibach HI. Topical hyaluronidase decreases hyaluronic acid and CD44 inhuman skin and in reconstituted human epidermis: evidencethat hyaluronidase can permeate the stratum corneum. B J Dermatol.2000; 142: Corticosteroids (betamethasone, hydrocortisone etc.) Nuutinen P, Riekki R, Parikka M, et al. Modulation of collagen synthesis and mrna by continuous and intermittent use of topical hydrocortisone in human skin. B J Dermatol.2003; 148:
5 Gabapentin Nifedipine Mupirocin Nomura, Masaaki, et al. "Inhibition of epidermal growth factor induced cell transformation and Akt activation by caffeine." Molecular carcinogenesis. 2005;44(1): Brown S. Prescribing flexibility through prescription compounding.techniques in Regional Anesthesia and Pain Management (2008) 12: Boardman L, Cooper AS, Blais LR, Raker CR. Topical gabapentin in the treatment of localized and generalized vulvodynia. Obstet Gynecol. 2008;112: Syed, Farhatullah, et al. "Ex vivo evaluation of antifibrotic compounds in skin scarring: EGCG and silencing of PAI-1 independently inhibit growth and induce keloid shrinkage." Laboratory Investigation.2013; 93(8): PCCA (2013b) PCCA Case Study: Case Study: Athletic Injury Treatment. PCCA PracaSil -Plus.
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