1 UROLOGY ROBOTIC SURGERY Arch. Esp. Urol., 60, 4 ( ), 2007 VATTIKUTI INSTITUTE PROSTATECTOMY (VIP) AND CURRENT RESULTS. Mahendra Bhandari and Mani Menon. Vattikuti Urology Institute. Henry Ford Health System. Detroit. USA. Summary.- OBJECTIVES: To describe a technique of Robot Assisted Radical Prostatectomy (RAP) for localized carcinoma of the prostate, the Vattikuti Institute Prostatectomy (VIP) and an innovative incremental nerve preservation technique, the Veil of Aphrodite. We also report complications, oncolgical and functional outcomes in a cohort of the patient operated during METHODS: patients with localiced carcinoma of prostate underwent VIP at our centre between Our current technique involves: early division of the bladder neck, preservation of the lateral pelvic fascia and control of the dorsal vein complex after apical dissection of the prostate. Oncological, functional and follow-up information was obtained through ROBO- SURG data base, which is managed by an independent group not involved in the patient care. VIP, as it has evolved in our hands over a period of 5 years, has given excellent outcomes in terms of cancer control, continence and erectile function. Our modifications of the surgical technique had a singular focus on consistent improvement of the so called Trifecta, taking radical retropubic prostatectomy (RRP) published data as a reference standard. We present our current technique of VIP with preservation of the lateral prostatic fascia ( Veil of Aphrodite ). RESULTS: In this report we include 2077 patients with follow-up ranging from 4 weeks to 260 weeks (median 68 weeks). We have a low incidence (1.5%) of perioperative complications. 97.6% of our patients had a hospital stay of less than 48 hours. There were 5.8% unscheduled postoperative visits. With the PSA cut-off limit of 0.4ng/ml, the overall biochemical recurrence rate was 3.9%. Median duration of incontinence was 4 weeks; 0.8% patients had total incontinence at 12 months. The intercourse rate was 93% in men with no pre-operative erectile dysfunction undergoing veil nervesparing surgery, although only 51% returned to baseline function. Correspondence Mahendra Bhandari M.D. Vattikuti Urology Institute Henry Ford Health System 2799 West Grand Blvd. Detroit, MI, 48202, USA. CONCLUSION: Vattikuti Institute Prostatectomy offers excellent patient recovery with significant reduction in first 30 days morbidity and provides excellent oncological and functional outcomes. The preservation of the Veil of Aphrodite helps in postoperative return of erectile function in patients with normal preoperative erectile function. Keywords: Robotic. Radical prostatectomy. Prostate cancer. Laparoscopy.
2 398 M. Bhandari and M. Menon. INTRODUCTION METHODS Radical prostatectomy for localized carcinoma of the prostate reduces disease-specific and overall mortalities as well as the risk of metastases and local progression (1). Over past several decades RRP has consolidated as a refined surgical procedure, with excellent outcomes (2-4). Recent trends favor minimally invasive surgical techniques for removing the prostate (5,6). Our technique, the Vattikuti Institute Prostatectomy (VIP), was implemented to the routine surgical care of patients with localized prostate cancer in 2001 (7,8) and has been widely adopted by others (9-11). In 2003 we introduced a major modification of the preservation of lateral pelvic fascia - the Veil of Aphrodite which has improved postoperative erectile function significantly (12,13). From we have performed 2652 RRPs. In this report, we describe our current technique; early oncological and functional results in 2077 patients. DEVELOPMENT OF V.I.P The post PSA era has significantly contributed to the early diagnosis of prostate cancer as well as increased its cure rates. Erectile dysfunction is the most distressing adverse outcome that the patients sustain following open radical prostatectomy (14). Our technique harnesses the precision inherent in robotic surgery for better nerve preservation and resultant improved potency, without compromising cancer control. Over a period of 5 years, we made the following modifications in our technique and found certain maneuvers helpful in achieving our objectives including division of the bladder neck initially (first done in 2001), application of a running suture for urethrovesical anastomosis (2001), and incising the prostatic fascia anterolaterally to release the nerves (2003). These techniques have resulted in a decrease in operative times, incidence of anastomotic leaks and of erectile dysfunction, respectively. In 2004 (after more than 1000 cases) we changed our technique of traction on the bladder neck and abandoned initial bulk ligation of the dorsal vein complex, in favor of precise suturing after urethral transection. Starting in 2002, we eliminated the use of monopolar cauterization after the division of the seminal vesicle. In 2004 we stopped opening endopelvic fascia, and started preserving the anterior fibromuscular stroma of the prostate in select patients with low volume disease. PATIENT SELECTION While respecting patient preferences for surgery, we generally recommend that men with low PSA and focal Gleason 6 cancer of the prostate undergo active monitoring with follow-up biopsies. We offer surgery for men with non-focal Gleason 6 cancer (35.6% of our patients), Gleason 7 (54.7%) and Gleason 8-10 cancer (9.7 %). Patients with >25% Gleason 7 disease get conventional nerve sparing (2,3) on the ipsilateral side: all others get the veil nerve sparing (12). TECHNIQUE OF VIP (15) Patient positioning and port placement The patient is padded at pressure points and placed in dorsal lithotomy position. Pneumoperitoneum is created using a Veress needle and ports are placed under vision. We use a six port approach. (Figure 1) The table is then moved to steep (30 degree) Trendelenburg position. Robotic Instruments The operation can be done with either the 8 mm or 5 mm robotic instruments. We currently prefer the latter. We use a combination of the monopolar hook, the cold round tip scissors, a Maryland or triangular (Precise) bipolar grasper and needle holders. In patients in whom nerve-sparing is not contemplated, the scissors can be eliminated and the procedure can be done with 3 instruments, thus reducing the cost. FIGURE 1. Port Placement.
3 VATTIKUTI INSTITUTE PROSTATECTOMY (VIP) AND CURRENT RESULTS. 399 FIGURE 2. Transperitoneal access to the extraperitoneal space. The extraperitoneal space is entered through an inverted, U-shaped incision on the parietal peritoneum, superior to the dome of the bladder and lateral to the medial umbilical ligaments. The vertical limb of the peritoneal incision is made lateral to the medial umbilical ligament, and medial to the internal inguinal ring. The incisions are joined anteriorly, dividing the bilateral medial umbilical ligaments (yellow- arrow heads) and urachus, and then the bladder is dissected off the anterior abdominal wall to enter into the space of Retzius Development of the extraperitoneal space The peritoneal cavity is inspected using the 30-degree upward-looking lens. A transverse peritoneal incision is made extending from the left to the right medial umbilical ligament; this incision is extended in an inverted U to the level of the vasa on either side. The space anterior to the peritoneum and space of Retzius is thus entered. The rest of the surgery is performed in this space anterior to the peritoneal reflection of the bladder and prostate (Figure 2). Lymph node dissection The tissue overlying the external iliac vein is incised and lymph nodal package is pushed medially. The dissection is started at the lymph node of Cloquet in the femoral canal and continued proximally toward the bifurcation of iliac vessels. The obturator nerve lies on the floor of this dissection and is carefully preserved (Figure 3). In patients with Gleason 8-10 disease, the nodal package between the obturator nerve and the hypogastric vein is also removed. Bladder Neck Transection We next approach the bladder neck directly, without opening endopelvic fascia or ligating the dorsal vein complex, a modification over our previously FIGURE 3. Pelvic lymphadenectomy. The packet is cleared from the anterior and medial surface of the external iliac vein (blue- arrow head). Obturator nerve (yellow- arrow head) is identified and serves as the posterior margin of dissection. The packet of fibro-fatty and nodal tissue (red- arrow head) is dissected toward the bifurcation of the external iliac vein. described technique (8). This portion of the procedure is best done with a 30-degree lens looking down. The right assistant grasps the anterior bladder wall in the mid line with an atraumatic grasper, lifts it directly towards the anterior abdominal wall and the left assistant deflates the Foley balloon while keeping the catheter in the bladder. This simple maneuver aids in the identification of the bladder neck as the bladder pulls away from the prostate excepting at the midline anterior to the catheter (Figure 4). A 1 cm incision is made in the anterior bladder neck at 12 O clock, cutting down the detrusor to expose the catheter in the mid-line (Figure 5). A detrusor apron may be seen on the anterior surface of the prostate (17). The incision in the bladder neck is made immediately superior to the detrusor apron. After the anterior bladder neck is incised, the Foley catheter is delivered and the left-side assistant grasps the tip of the Foley catheter with firm anterior traction. This exposes the posterior bladder neck, which is then incised (Figure 6). The posterior bladder neck is gradually dissected away from the prostate. The anterior layer of Denonvillier s fascia is now exposed. (Figure 7) and is incised precisely, exposing the vasa and the seminal vesicles. The left-side assistant provides upward traction to the posterior base of the prostate to facilitate dissection of the vasa and seminal vesicles.
4 400 M. Bhandari and M. Menon. FIGURE 4. Bladder neck identification. FIGURE 5. Division of anterior bladder neck. The right assistant grasps the anterior bladder wall in the mid line with an atraumatic grasper, lifts it directly towards the ceiling and the left assistant deflates the Foley balloon while keeping the catheter in the bladder. The bladder pulls away from the prostate excepting at the midline anterior to the catheter. (Black- arrow heads) A one cm incision is made in the anterior bladder neck at 12 O clock, cutting down the detrussor to the expose the catheter in the midline (Yellow-arrow head). If correct plane is entered there is minimal bleeding from the incision (Blue-arrow head). First the vasa are skeletonized and transected, then held upward by the left assistant providing further traction for dissection of the seminal vesicles. The artery to the seminal vesicle is controlled by clipping or fine bipolar coagulation. Both the vasa and seminal vesicles are then grasped and the posterior prostate is retracted upwards, allowing exposure of posterior layer of the Denonvilliers fascia. An incision is made in this fascia and a plane is developed between the posterior layer of the Denonvillier s fascia and perirectal fat. This hypo-vascular plane can be created easily using blunt dissection. The dissection is carried down to the apex of the prostate. This plane of dissection is extended laterally to expose the lateral pedicles of the prostate. The base of the seminal vesicle is retracted superomedially by the assistant on the opposite side and the prostatic pedicle is delineated and divided. This pedicle lies anterior to the pelvic plexus and neurovascular bundle and includes only prostatic blood supply. The pedicles are controlled by either clipping or individually coagulating the vessels by bipolar cauterization. Nerve sparing techniques: the Veil of Aphrodite Although the classical description of the neurovascular bundles is that of two bundles of tissue that are located near the posterolateral surface of the prostate (2) there is accumulating evidence that there is variability in this complex. In some patients, rather than distinct neurovascular bundles, the cavernosal nerves form lattices or curtains that extend from the postero-lateral to the antero-lateral surface of the prostate (17-20). In order to preserve these nerves, several surgeons (4,22) and we (12) have modified FIGURE 6. Dissection of the posterior bladder neck. After the anterior bladder neck is incised, the left-side assistant grasps the tip of the Foley catheter with firm anterior traction. (Blue-arrow head). This pulls up the posterior bladder neck (Yellow-arrow head)., which is then incised.
5 VATTIKUTI INSTITUTE PROSTATECTOMY (VIP) AND CURRENT RESULTS. 401 nerve-sparing techniques by dissecting the prostatic fascia off the prostate postero-laterally and incising it anteriorly. We termed this approach, the veil of Aphrodite nerve-sparing technique (Aphrodite is the Greek goddess of love who causes strong men to fight over her); latterly, others have called it high anterior release, curtain dissection, or incremental nerve sparing. In the Veil procedure we accomplish this through an antegrade approach. A plane between the prostatic capsule and the prostatic fascia is developed cranially, at the base of the seminal vesicles (Figure 8). With appropriate counter-traction provided by the assistants the surgeon is able to enter a plane between the prostatic fascia and the prostate. This plane is deep to the venous sinuses of Santorini s plexus. Careful sharp and blunt dissection of the neurovascular bundle and contiguous prostatic fascia is performed using the articulated cold scissors until the entire prostatic fascia up to the pubourethral ligament is mobilized in continuity. This plane is mostly avascular, except anteriorly where the fascia is fused with the pubo-prostatic ligament, and covers the dorsal venous plexus. When performed properly, curtains of periprostatic tissue hang from the pubourethral ligament, the veil of Aphrodite (Figure 9). If this plane is difficult to enter (patients with post-biopsy fibrosis), we perform part of the dissection retrograde, and enter the plane on the anterolateral surface of the prostatic capsule at the 10- or 2- o clock position. Exposure of prostatic apex and control of dorsal venous complex The prostatic apex is best visualized using the 0 degree lens; this is particularly useful in patients with an overhanging pubic symphysis. Once the lateral prostatic fascia is dissected off the prostatic apex, the right assistant retracts the prostate firmly to the patient s head. The puboprostatic ligament is incised with the cold scissors where it inserts into the apical prostatic notch (Figure 10). It is important not to skeletonize the urethra as maintaining the fibrovascular support of the urethra intact hastens the return of continence. The cavernosal nerves are close to the urethra and are vulnerable to thermal or traction injury. The urethra is then dissected into the prostatic notch and transected sharply 5mm distal to the notch. The freed specimen is then placed in an Endopouch TM (Ethicon Endo-Surgery Inc.). FIGURE 7. Incision of the Denonvillier s fascia. After the division of full thickness of detrussor at posterior bladder neck the left-side assistant provides upward traction to the posterior base of the prostate (Blue-arrow head).the right assistant retracts the bladder posterior (Yellow-arrow head). This exposes the anterior layer of Denonvillier s fascia covering both vasa deferentia and seminal vesicles (Red-arrow head). This fascia in incised to create a window from where the vasa deferentia and seminal vesicles can be pulled anteriorly and dissected. FIGURE 8. Dissection of the plane for Veil of Aphrodite. After the prostatic pedicle are controlled. A plane between the prostatic capsule (Black-arrow head) and the periprostatic fascia layer (Yellow-arrow head) is developed at the cranial extent of the prostate. Dissection in this plane is continued anteriorly and caudally separating the peri-prostatic fascia from the prostate on its anterolateral aspect.
6 402 M. Bhandari and M. Menon. The dorsal venous complex is controlled with an overrunning suture of 2-0 braided polyglactin on 17 mm tapercut needle. (Figure 11). Depending on the amount of oozing from the dorsal vein complex, control is done before or after urethral transection Urethrovesical Anastomosis A running suture is used for the urethrovesical anastomosis. We use a minor modification of the technique described by Van Velthoven (22). One dyed and one undyed seven-inch 3-0 monofilament polyglecaprone-25 sutures on 17 mm tapercut needles are tied back to back. The suture is now double-armed with a pledget of the knots in the middle. We start with dyed arm, on the posterior bladder wall at 4 o clock position outside-in, continuing into the urethra at the corresponding site, inside-out. The dyed arm is run for two bites in the urethra and three in the bladder neck; the bladder is then cinched down to the urethra, with the right assistant following the suture. After the posterior urethral wall is approximated to the bladder neck in its entirety, the direction of the stitch is then changed to get passage of the needle from outside-in bladder to inside out. The suture is run clockwise up to 11 o clock position, and handed to the left assistant to hold with gentle, approximating traction. The undyed arm is then run counter clockwise from 4 o clock to 11 o clock. During the placement of anastomotic sutures the left assistant moves the tip of urethral Foley in an out of the urethral stump to prevent suturing of the back wall of urethra. Both arms of the suture are tied to each other to complete the anastomosis. A new 20 French Foley catheter is introduced and its balloon is inflated to 20 cc. The bladder is filled with 250 cc saline to test the integrity of the anastomosis. Retrieval of specimen and completion of surgery A Jackson-Pratt drain is placed through left 5 mm port. The specimen is removed after enlarging the umbilical port incision as required. The incision is closed with interrupted sutures of 0 braided polyester. The skin is closed with self-absorbing subcuticular sutures. Postoperative care In order to minimize the urine spillage in to the operating field, intravenous fluids are restricted to a minimum during the surgery. All patients receive a 1000 ml bolus of intravenous fluid in recovery room. Once on the floor they start on clear liquid diet and advance to regular diet after a bowel movement. All patients are encouraged to ambulate within four hours of arrival on floor. The Jackson-Pratt drain is removed on day one and patients are discharged within 24 hours with an indwelling Foley catheter. The catheter is removed on day 7 or after under cystographic control. FIGURE 9. Veil of Aphrodite. Preserved veil of Aphrodite after the prostate is extirpated. After removal of the prostate from the prostatic fossa, peri-prostatic fascia (White-arrow heads) hangs from the bladder (Yellow-arrow head) to the urethra on either side. FIGURE 10. Apical dissection. The puboprostatic ligaments and the dorsal venous complex (blue-arrow head) are divided to expose urethra. The urethra is then dissected into the prostatic notch (Redarrow head). The urethra is transected sharply 3-5mm distal to the notch. The anterior wall is cut with the Foley catheter across the urethra (Yellow-arrow head).
7 VATTIKUTI INSTITUTE PROSTATECTOMY (VIP) AND CURRENT RESULTS. 403 Data collection and analysis Preoperative demographic and operative data were collected prospectively in a customized database ROBOSURG. Pathological specimens were examined by one of several individual pathologists, with randomly selected specimens being reviewed by a referee pathologist. Patients were surveyed with a mailed-in questionnaire that included IPSS and SHIM scoring sheets, and questions about pad usage and duration of incontinence. Non-respondents were followed-up persistently by the database manager through a series of periodic communications including phone call reminders. The data were analyzed with an SPSSTM (SPSS Corporation, Chicago, IL) statistical software package. increasing house staff participation and surgical complexity (greater utilization of veil nerve sparing). The positive margin rate at the apex was 12% for the first 100 cases (23). When initial bulk ligation of the dorsal vein complex was replaced with suture ligation of RESULTS Preoperative and operative parameters From March 2001 to September 2006, we have operated on 2652 patients, 2582 at our own institution. Pre operative and operative parameters are detailed in Figure 12. In keeping with our philosophy, patients in this series had higher Gleason grade disease (64.4% > than Gleason 6) than those in many contemporary radical prostatectomy studies. The average operative time decreased from 195 minutes (min) in the first 100 patients to 131 min in the last 100 patients, robotic console time decreased from 165 min to 92 min respectively. This decrease in times was noted despite progressively FIGURE 11. Suturing of Dorsal Venous Complex. The dorsal venous complex (blue-arrow head) is controlled by overrunning suture of 2-0 vicryl on RB1 needle. The urethro-sphincter complex (yellow-arrow head) is identified and excluded in the suture. FIGURE 12. Patient Characteristics.
8 404 M. Bhandari and M. Menon. FIGURE 13. K-M Curve: Overall Biochemical Recurrence-Free Survival (BRFS). FIGURE 14. K-M Curve: Biochemical Recurrence-Free Survival (BRFS) by Preoperative PSA. the individual vessels after removal of the prostate, the apical margin rate decreased to 1.5% in patients with T2 disease. Biochemical recurrence Eighty one patients of the 2077 patients with a median follow up of 68 weeks and mean follow up of 82 weeks (range 4-260weeks) had a biochemical recurrence. The BCR rate was 3.9% with the median time to recurrence of 32 weeks (mean 54 weeks, range 0-263weeks) (24). The biochemical recurrence free survival (BRFS) probabilities at 1, 3 and 5 years are 97%, 93% and 92% respectively. Time to BCR and BRFS probabilities are represented in the Kaplan- Meir curves for overall BRFS (Figure 13), by preoperative PSA (Figure14), Organ confined status (Figure15) and Pathological Gleason score (Figure16). On multivariable analysis, preoperative PSA, pathologic Gleason score, percent tumor volume and non-organ confined status were significant factors affecting time to biochemical recurrence. Return of continence 95.2% of patients were continent at the end of 12 months. We considered patients to be conti- FIGURE 15. K-M Curve: Biochemical Recurrence-Free Survival (BRFS) by Organ confined status. FIGURE 16. K-M Curve: Biochemical Recurrence-Free Survival (BRFS) by Pathology Gleason.
9 VATTIKUTI INSTITUTE PROSTATECTOMY (VIP) AND CURRENT RESULTS. 405 nent if they were not using any pads or if they used a safety liner for security reasons. About 26 % patients were totally dry at the time of catheter removal. 55 % of our patients were dry at 4 weeks postoperatively. Only 1.1% of patients required the use of 2-3 pads per day at the end of 12 months. Of these, 4 had collagen injections and 3 opted to have artificial urinary sphincters. The mean pre-operative IPSS and Quality of Life scores (7.7 and 1.66) were significantly more than the post operative values.(6.5 and 1.5, P <0.002 and <0.02). Incontinent patients had a higher rate of anastomotic stricture (6.6% vs 0.71 %) or post-operative radiation therapy (9.09% vs 2.41%). Return of potency 42% of patients underwent standard nerve sparing on both sides. 25% of patients had a unilateral veil of Aphrodite with contralateral standard nerve sparing. 33% of patients underwent a bilateral incremental nerve sparing operation. Patients undergoing bilateral veil of Aphrodite had significantly better return of potency than patients with conventional nerve sparing surgery (Figure 17). In patients with no pre-operative erectile dysfunction (SHIM>21), intercourse was reported in 70 and 100 percent of the patients undergoing bilateral veil nerve-sparing surgery at 12 and 48 month follow-up respectively, although only half of these patients attained normal SHIM score off medication. Post-operative potency rates in patients with no-, mild- and moderate erectile dysfunction preoperatively were analyzed. As expected, potency rates were higher in patients who had no erectile dysfunction pre-operatively. This trend was seen in patients undergoing both, standard or veil of Aphrodite (unilateral or bilateral) nerve-sparing procedures. Regardless of pre-operative erectile function, patients undergoing veil of Aphrodite (unilateral or bilateral) nerve-sparing had better potency outcomes than patients undergoing conventional nerve-sparing prostatectomy (Figure 18). Complications Our analysis of perioperative complications reveals a low incidence of complications. The mean hospital stay for patients undergoing VIP is 1.1 days with 97.6% of patients being discharged home within 48 hours. There were 5.8% unscheduled postoperative visits, mostly for urinary retention following early catheter removal. We have never had to transfuse any patient intraoperatively and our postoperative transfusion rate is 1.5%. The most disturbing complication in our series is symptomatic postoperative urinary leaks (1.8%). Because we use an intraperitoneal approach, these patients develop significant urinary peritonitis. Clinical presentation in such patients is very dramatic. Although half these patients were managed conservatively with nasogastric decompression and bowel rest, the other half needed CT guided drainage of urinomas and prolonged Foley catheterization. Only 0.8% patients had Clavien grade 2  postoperative complications requiring any intervention. Overall, VIP in our hands is a very safe procedure with a major complication rate of 1.5%. FIGURE 17. Erectile Function Postoperatively: Different Nerve Sparing Techniques. FIGURE 18. Comparison of Baseline Erectile Function and Postoperative Outcomes.
10 406 M. Bhandari and M. Menon. CONCLUSION Radical retropubic prostatectomy has evolved over the last three decades to a precise, sophisticated procedure with minimal mortality and excellent surgical outcomes. Our own experience suggests that equally good results can be obtained with robotic assistance. Our technique, Vattikuti Institute Prostatectomy (VIP) continues to evolve with experience, much as open radical prostatectomy does. In our hands, the veil nerve-sparing offers superior erectile function than conventional nerve-sparing surgery without compromising cancer control. It is our preferred technique in potent men with low-or moderately aggressive prostate cancer. ACKNOWLEDGMENTS We thank Alok Shrivastava for illustrations and Fred Muhletaler in preparation of the manuscript. REFERENCES AND RECOMMENDED READINGS (*of special interest, **of outstanding interest) BILL-AXELSON, A.; HOLMBERG, L.; RUT- TU, M. et al: Radical prostatectomy versus watchful waiting in early prostate cancer. N. Eng. J. Med., 352: 1977, WALSH, P.C.; LEPOR, H.; EGGLESTON, J.C.: Radical prostatectomy with preservation of sexual function: anatomical and pathological considerations. Prostate, 4: 473, WALSH, P.C.; MARSCHKE, P.; RICKER, D. et al: Patient-reported urinary continence and sexual function after anatomic radical prostatectomy. Urology, 55: 58, GRAEFEN, M.; WALZ, J.; HULAND, H.: Open retropubic nerve-sparing radical prostatectomy. Eur. Urol., 49: 38, ABBOU, C.C.; SALOMON, L.; HOZNEK, A. et al: Laparoscopic radical prostatectomy: preliminary results. Urology, 55: 630, GUILLONNEAU, B.; VALLANCIEN, G.: Laparoscopic radical prostatectomy: the Montsouris technique. J. Urol., 163: 1643, MENON, M.; SHRIVASTAVA, A.; TEWARI, A. et al: Laparoscopic and robot assisted radical prostatectomy: establishment of a structured program and preliminary analysis of outcomes. J. Urol., 168: 945, ** *12. * **15. ** MENON, M.; TEWARI, A.; PEABODY, J. et al: Vattikuti Institute prostatectomy: technique. J. Urol., 169: 2289, AHLERING, T.E.; SKARECKY, D.; LEE, D. et al: Successful transfer of open surgical skills to a laparoscopic environment using a robotic interface: initial experience with laparoscopic radical prostatectomy. J. Urol., 170: 1738, PATEL, V.R.; TULLY, A.S.; HOLMES, R. et al: Robotic radical prostatectomy in the community setting the learning curve and beyond: initial 200 cases. J. Urol., 174: 269, SMITH, J.A. Jr.: Robotically assisted laparoscopic prostatectomy: an assessment of its contemporary role in the surgical management of localized prostate cancer. Am. J. Surg., 188: 63, KAUL, S.; BHANDARI, A. et al: Robotic radical prostatectomy with preservation of the prostatic fascia: a feasibility study. Urology, 66: 1261, MENON, M.; KAUL, S. et al: Potency following robotic radical prostatectomy: a questionnaire based analysis of outcomes and conventional nerve sparing and prostatic fascia sparing technique. J. Urol., 174: 2291, SARANCHUK, J.W.; KATTAN, M.W.; ELKIN, E. et al: Achieving optimal outcomes after radical prostatectomy. J. Clin. Oncol., 23: 4146, MENON, M.; SHRIVASTAVA, A. et al: Vattikuti institute prostatectomy: contemporary technique an analysis of results. Euro. Urol., 51: 648, MYERS, R.P.: Detrusor apron, associated vascular plexus, and avascular plane: relevance to radical retropubic prostatectomy-anatomic and surgical commentary. Urology, 59: 472, TEWARI, A.; PEABODY, J.O.; FISCHER, M. et al: An operative and anatomic study to help in nerve sparing during laparoscopic and robotic radical prostatectomy. Eur. Urol., 43: 444, TAKENAKA, A.; MURAKAMI, G.; SOGA, H. et al: Anatomical analysis of the neurovascular bundle supplying penile cavernous tissue to ensure a reliable nerve graft after radical prostatectomy. J. Urol., 172: 1032, COSTELLO, A.J.; BROOKS, M.; COLE, O.J.: Anatomical studies of the neurovascular bundle and cavernosal nerves. BJU Int., 94: 1071, KIYOSHIMA, K.; YOKOMIZO, A.; YOSHIDA, T. et al: Anatomical features of periprostatic tissue and its surroundings: a histological analysis of 79 radical retropubic prostatectomy specimens. Jpn. J. Clin. Oncol., 34: 463, LUNACEK, A.; SCHWENTNER, C.; FRITSCH, H. et al: Anatomical radical retropubic prosta-
11 tectomy: curtain dissection of the neurovascular bundle. BJU Int., 95: 1226, VAN VELTHOVEN, R.F.; AHLERING, T.E.; PELTIER, A. et al: Technique for laparoscopic running urethrovesical anastomosis: the single knot method. Urology, 61: 699, MENON, M.; SHRIVASTAVA, A.; SARLE, R. et al: Vattikuti Institute Prostatectomy: a singleteam experience of 100 cases. J. Endourol., 17: 785, STEPHENSON, A.J.; KATTAN, M.W.; EAS- THAM, J.A. et al: Defining biochemical recurrence of prostate cancer after radical prostatectomy: a proposal for a standardized definition. J. Clin. Oncol., 24: 3973, CLAVIEN, P.A.; SANABRIA, J.R.; STRAS- BERG, S.M.: Proposed classification of complications of surgery with examples of utility in cholecystectomy. Surgery, 111: 518, 1992.
Robotic Radical Prostatectomy: What s s the Advantage? Matthew T. Gettman, M.D. Associate Professor Department of Urology Prostate Cancer Epidemiology: 2009 Estimated new cases: 230,000 Estimated deaths:
EUROPEAN UROLOGY 58 (2010) 457 461 available at www.sciencedirect.com journal homepage: www.europeanurology.com Case Series of the Month A New Anatomic Approach for Robot-Assisted Laparoscopic Prostatectomy:
Thomas A. Kollmorgen, M.D. Oregon Urology Institute None 240,000 new diagnosis per year, and an estimated 28,100 deaths (2012) 2 nd leading cause of death from cancer in U.S.A. Approximately 1 in 6 men
Robotic Assisted Laparoscopic Prostatectomy (RALP) A technical description of 11 steps of the procedure Author: John W. Davis, MD Assistant Professor, Urology The University of Texas M.D Anderson Cancer
Peninsula Urology Center, Inc. Dieter Bruno, M.D, F.A.C.S Chris Threat, M.D. 3351 El Camino. Real, Suite 101 Atherton, CA 94027 (650) 306-1016 email@example.com http://www.pucenter.com/ da Vinci Prostatectomy
Prostate Cancer OVERVIEW Prostate cancer is the second most common cancer diagnosed among American men, accounting for nearly 200,000 new cancer cases in the United States each year. Greater than 65% of
Prostatic Diseases Therapies for Prostate Cancer and Treatment Selection JMAJ 47(12): 555 560, 2004 Yoichi ARAI Professor and Chairman, Department of Urology, Tohoku University Graduate School of Medicine
2 Laparoscopic Anatomy of the Pelvis Intra-Abdominal Anatomy of the Male Pelvic Region Bladder Medial Umbilical Ligaments Lateral Umbilical Ligaments Spermatic Cords Iliac Vessels Ureters Seminal Vesicular
Prostate Cancer Treatment Comparison Treatment Comparative Data Outcome Comparison: Surgery vs. Radiotherapy Outcome Radical Prostatectomy* Radiation** Survival duration compared to conservative disease
Quality of Life After Radical Prostatectomy Bernard H. Bochner, MD FACS Attending Surgeon, Urology Service Vice Chairman, Department of Surgery Memorial Sloan-Kettering Cancer Center Quality of Life After
Precise, Minimally Invasive Prostate Cancer Removal Learn why da Vinci Surgery may be your best treatment option 1 Beyond Minimally Invasive For Prostate Cancer 1 Facing Prostate Cancer Prostate cancer
Disclaimer The following material has been reviewed and approved by a independent surgeon, who is not an Intuitive Surgical employee: Thomas E. Ahlering, M.D. Professor of Surgery Chief, Division of Urology
Oncological and functional outcomes of laparoscopic radical prostatectomy following fellowship training. Journal: BJU International Manuscript ID: Draft Manuscript Type: Original Article Date Submitted
HOW I DO IT Robot assisted radical prostatectomy: how I do it. Part II: surgical technique Roger F. Valdivieso, MD, Pierre-Alain Hueber, MD, Kevin C. Zorn, MD University of Montreal Hospital Center (CHUM)
Prostate Cancer Treatment Comparison Treatment Comparative Data Outcome Comparison: Surgery vs. Radiotherapy Outcome Radical Prostatectomy* Radiation** Survival duration compared to conservative disease
Robotic Assisted Laparoscopic Salvage Prostatectomy for Radiation Resistant Prostate Cancer Jonathan A. Eandi,* Brian A. Link, Rebecca A. Nelson, David Y. Josephson, Clayton Lau, Mark H. Kawachi and Timothy
Facing Prostate Cancer Surgery? Learn about minimally invasive da Vinci Surgery The Condition: Prostate Cancer Your prostate is a walnut-sized gland that is part of the male reproductive system. The prostate
Incidents and complications in our first 200 davinci radical prostatectomies II International Symposium Robotic Surgery and New technologies in Urology. Bilbao 5-65 March,, 2009 PATIENTS AND METHODS Period:
Management of Localized Prostate Cancer Surgery James A. Eastham, MD Chief, Urology Service Memorial lsloan Kettering Cancer Center Treatment Options 1. Active surveillance/watchful waiting 2. Focal therapy
RADICAL PROSTATECTOMY USING DAVINCI ROBOTIC SYSTEM HARTFORD HOSPITAL, HARTFORD, CT Broadcast May 17, 2004 NARRATOR Prostate cancer is the most common type of cancer, excluding skin cancer, among American
Comparison of Robotic-assisted versus Retropubic Radical Prostatectomy Performed by a Single Surgeon YEN-CHUAN OU 1, CHI-REI YANG 1, JOHN WANG 2, CHEN-LI CHENG 1 and VIPUL R. PATEL 3 1 Division of Urology,
East Lancashire Surgical Robot For ALL patients in Lancashire Prostate cancer claims the life of one man every hour and by 2030 will be the most common cancer; it is already the most common male cancer.
DISCUSSION ABOUT OPEN, LAPAROSCOPIC, AND ROBOTIC PROSTATECTOMIES MOUNT SINAI MEDICAL CENTER NEW YORK CITY, NEW YORK August 13, 2008 00:00:08 ANNOUNCER: Today, Mount Sinai Medical Center s leading urological
ROBOT-ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY: A REVIEW OF TECHNIQUE AND OUTCOMES Taner Kargi, 1 *Nevzat Can Sener 2 1. Department of Urology, Balikligol State Hospital, Sanliurfa, Turkey 2. Department
Associates: Dr Kim Pese Dr Kym Horsell Dr Michael Chong Dr Jason Lee The Tennyson Centre Suite 19, First Floor 520 South Road Kurralta Park SA 5037 Appointments: 08 8292 2399 Fax: 08 8292 2388 firstname.lastname@example.org
PROSTATE CANCER Get the facts, know your options Samay Jain, MD, Assistant Professor,The University of Toledo Chief, Division of Urologic Oncology i What is the Prostate? Unfortunately, you have prostate
X-Plain Prostatectomy Reference Summary Introduction Prostate cancer is a very common condition that affects men. The rate of occurrence of prostate cancer increases with age. Prostatectomy is a surgery
DOI 10.1007/s11701-011-0293-4 ORIGINAL ARTICLE Surgeon perception is not a good predictor of peri-operative outcomes in robot-assisted radical prostatectomy Joshua Stern Saurabh Sharma Pierre Mendoza Mary
UCLA Department Of Urology Information For Patients Radical Prostatectomy Background Prostate cancer affects the prostate gland which is located just below the urinary bladder and surrounds the urethra.
UROLOGY ROBOTIC SURGERY Arch. Esp. Urol., 60, 4 (375-382), 2007 ATHERMAL ROBOTIC TECHNIQUE OF RADICAL PROSTATECTOMY: AN ASSISTANT S PERSPECTIVE. Anil Mandhani, Roy Berryhill Jr. and Ash K. Tewari. Robotic
A. Decision to Insert a Urinary Catheter: 1. Before placing an indwelling catheter, please consider if these alternatives would be more appropriate: Bladder scanner: to assess and confirm urinary retention,
7. Prostate cancer in PSA relapse A patient with prostate cancer in PSA relapse is one who, having received a primary treatment with intent to cure, has a raised PSA (prostate-specific antigen) level defined
AMS Sphincter 800 Urinary Prosthesis AMS Sphincter 800 AMS Sphincter 800 AMS Sphincter 800 The device is implanted in the body and cannot be seen. The cuff can be placed at the bulbous urethra or at the
All men should know they are having a PSA test and be informed of the implications prior to testing. This booklet was created to help primary care providers offer men information about the risks and benefits
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution
JOURNAL OF ENDOUROLOGY Volume 22, Number 4, April 2008 Mary Ann Liebert, Inc. DOI: 10.1089/end.2007.9834 Overcoming Obstacles: Nerve-Sparing Issues in Radical Prostatectomy THOMAS E. AHLERING, M.D., ESEQUIEL
RADICAL CYSTECTOMY Procedure Guide RADICAL CYSTECTOMY Procedure Guide Disclaimer The following material has been reviewed and approved by the following independent surgeons, who are not Intuitive Surgical
Robotic radical prostatectomy: our bridge to the future Cesare Selli Cattedra e Scuola di Specializzazione in Urologia Università di Pisa Robotic RP: our bridge to the future New personal challenge: to
A Woman s Guide to Prostate Cancer Treatment Supporting the man in your life Providing prostate cancer support and resources for women and families WOMEN AGAINST PROSTATE CANCER A Woman s Guide to Prostate
CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Early Prostate Cancer:
DRAFT: Advice from Dr John Childs MoH advisor Summary of Harms from Screening and Treatment for Prostate Cancer There are minimal risks directly attributable to PSA testing or transrectal ultrasound (TRUS)
Laparoscopic extended right hemicolectomy for transverse colon cancer Elsa B. Valsdottir, MD Department of General Surgery University Hospital of Iceland Hringbraut 101 Reykjavik Iceland Phone +354 543
RADICAL HYSTERECTOMY IN ROBOTIC SURGERY FLORENCE BOCHU CENTRE OSCAR LAMBRET LILLE PATRICIA VARUMBEKE CENTRE OSCAR LAMBRET LILLE MELANIE FLAMENT CENTRE OSCAR LAMBRET LILLE More and more centers across the
Chapter 3. Treatment Options With contributions from Nancy L. Brown, Ph.D., Palo Alto Medical Foundation Research Institute; Patrick Swift, M.D., Alta Bates Comprehensive Cancer Program; D. Jeffrey Demanes,
Radical Prostatectomy Table of Contents Surgery Overview What To Expect After Surgery Why It Is Done How Well It Works Risks What To Think About References Credits Surgery Overview A radical prostatectomy
www.kjurology.org http://dx.doi.org/10.4111/kju.2013.54.9.598 Laparoscopy/Robotics Comparison of Continence Recovery Between Robot-Assisted Laparoscopic Prostatectomy and Open Radical Retropubic Prostatectomy:
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Goud JG et al. Int J Reprod Contracept Obstet Gynecol. 2014 Mar;3(1):34-39 www.ijrcog.org pissn 2320-1770 eissn 2320-1789
SILS Port Insertion By Homero Rivas, MD, MBA, FACS Single incision. Single port. Simple choice. SILS Port Insertion By Homero Rivas, MD, MBA, FACS For the last 20 years, there has given surgical procedure.
prostate cancer: A Success Story Prostate cancer is the most common cancer in human beings. That is, even though prostate cancer occurs only in men, the number of men with prostate cancer exceeds the combined
O R I G I N A L A R T I C L E Short-term outcome of patients with robot-assisted versus open radical prostatectomy: for localised carcinoma of prostate KL Lo CF Ng Cleo NY Lam Simon SM Hou KF To Sidney
6 Pages, English Information sheet: Robotic-Assisted Laparoscopic Radical Prostatectomy This information sheet is to provide you and your family with information regarding your treatment and recovery from
Prostate Cancer For many older men, prostate cancer may be present but never cause symptoms or problems and many men will die with their prostate cancer rather than of their prostate cancer. Yet it remains
Minimally Invasive Surgical Treatment of Prostate Cancer: Robots, Microwaves, and Freezers Paul D. Maroni, MD Assistant Professor Department of Surgery/Urology Disclosures Relevant EDAP HIFU - investigator
Robotic Assisted Laparoscopic Radical Prostatectomy This leaflet is designed to give you information on why this procedure may be suitable for you, and what to expect from it. It outlines the advantages
Ventral Hernias Open Ventral Hernia Repair UCSF Postgraduate Course in General Surgery Maui, HI March 21, 2011 Hobart W. Harris, MD, MPH Ventral Hernias: National Experience Occur following 11-23% of laparotomies,
CLINICAL POLICY NERVE GRAFT TO RESTORE ERECTILE FUNCTION DURING RADICAL PROSTATECTOMY Policy Number: SURGERY 043.13 T Effective Date: October 1, 015 Table of Contents BENEFIT CONSIDERATIONS. APPLICABLE
PANCREATIC AND PERIAMPULLARY TUMORS: PANCREATICODUODENECTOMY Dr. Shailesh V. Shrikhande Associate Professor & Consultant Surgeon GI and HPB Surgical Oncology Tata Memorial Hospital, Mumbai INDIA HELICAL
0022-5347/01/1665-1729/0 THE JOURNAL OF UROLOGY Vol. 166, 1729 1733, November 2001 Copyright 2001 by AMERICAN UROLOGICAL ASSOCIATION, INC. Printed in U.S.A. INTRAOPERATIVE AND POSTOPERATIVE COMPLICATIONS
Foley Catheter Placement Indications for a Foley Catheter Retention of urine leading to urinary hesitancy, straining to urinate, decrease in size and force of the urinary stream, interruption of urinary
Beyond the PSA: Genomic Testing in Localized Prostate Cancer Kelvin A. Moses, MD, PhD Vanderbilt University Medical Center Wednesday, December 2, 2015 5:00 p.m. ET/2:00 p.m. PT About ZERO ZERO s mission
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at ChiaYi 嘉 義 長 庚 紀 念 醫 院 婦 產 科 Clinical Guideline Laparoscopic Assisted Vaginal Hysterectomy By Dr. CJ Tseng Laparoscopic assisted
Female Dog Urinary Catheterization 1 of 6 Placement of an indwelling urinary catheter in female dogs Bernie Hansen DVM MS North Carolina State University College of Veterinary Medicine Materials Needed
Robotic Assisted Radical Prostatectomy Department of Urology Information for patients i Introduction The prostate is a small gland, which is found only in men. It is found at the base of the bladder and
Management of Urinary Complications Prostate Cancer: Current Status & Future Directions March 27, 2010 Jaspreet S. Sandhu, MD Department of Surgery/Urology Memorial Sloan-Kettering Cancer Center Outline
Facing a Hysterectomy? If you ve been diagnosed with early stage gynecologic cancer, learn about minimally invasive da Vinci Surgery The Condition: Early Stage Gynecologic Cancer A variety of gynecologic
Oncology Annual Report: Prostate Cancer 25 Update By: John Konefal, MD, Radiation Oncology Prostate cancer is the most common cancer in men, with 232,9 new cases projected to be diagnosed in the U.S. in
The Whipple Procedure Sally Hodges, Ph.D.(c) Preoperative procedures Given the length and difficulty of the procedure, regardless of the diagnosis, certain assurances must occur prior to offering a patient
Recovery of Erectile Function After Radical Prostatectomy Vanderbilt University Department of Urologic Surgery Postoperative erectile dysfunction is a potential risk of surgery for prostate cancer, whether
Radiation Therapy for Prostate Cancer: Treatment options and future directions David Weksberg, M.D., Ph.D. PinnacleHealth Cancer Institute September 12, 2015 Radiation Therapy for Prostate Cancer: Treatment
INFORMATION LEAFLET ON TOTAL LAPAROSCOPIC RADICAL HYSTERECTOMY (TLRH) FOR EARLY STAGE CERVICAL CANCER (TREATING EARLY STAGE CERVICAL CANCER BY RADICAL HYSTERECTOMY THROUGH KEYHOLE SURGERY) Aim of the leaflet
FAQ About Prostate Cancer Treatment and SpaceOAR System P. 4 Prostate Cancer Background SpaceOAR Frequently Asked Questions (FAQ) 1. What is prostate cancer? The vast majority of prostate cancers develop
ASERNIP S Australian Safety and Efficacy Register of New Interventional Procedures Surgical Consumer summary Minimally invasive techniques for the relief of stress urinary incontinence (Adapted from the
Radiation Therapy for Prostate Cancer Introduction Cancer of the prostate is the most common form of cancer that affects men. About 240,000 American men are diagnosed with prostate cancer every year. Your
EUROPEAN UROLOGY 65 (2014) 610 619 available at www.sciencedirect.com journal homepage: www.europeanurology.com Prostate Cancer Comparisons of the Perioperative, Functional, and Oncologic Outcomes After
(ALIF) Anterior In human anatomy, referring to the front surface of the body or the position of one structure relative to another Lumbar Relating to the loins or the section of the back and sides between
9 Urinary tract and perineum Key Points 9.1 9.1 THE URINARY BLADDER URINARY RETENTION Acute retention of urine is an indication for emergency drainage of the bladder The common causes of acute retention
Evidence-Based Series 17-3 IN REVIEW A Quality Initiative of the Program in Evidence-based Care (PEBC), Cancer Care Ontario (CCO) Guideline for Optimization of Surgical and Pathological Quality Performance
MANAGEMENT OF SLING COMPLICATIONS IN FEMALES Jorge L. Lockhart M.D. Program Director Division of Urology University of South Florida INTRODUCTION The traditional gold standard treatments for stress urinary
Laparoscopic Inguinal Hernia Repair Surgery Patient Information from SAGES About Your Inguinal Hernia and Laparoscopic Repair: Approximately 600,000 inguinal or groin hernia repair operations are performed
Prostate Cancer What Are the Outcomes of Radical Prostatectomy for High-risk Prostate Cancer? Stacy Loeb, Edward M. Schaeffer, Bruce J. Trock, Jonathan I. Epstein, Elizabeth B. Humphreys, and Patrick C.
Surgical learning curve for open radical prostatectomy: Is there an end to the learning curve? Alexander Kretschmer, Philipp Mandel, Alexander Buchner, Christian G. Stief & Derya Tilki World Journal of
Prostate Cancer ACTION PLAN Choosing the treatment that s right for you Video Series Guidebook View videos at kpactionplans.org Endorsed by Kaiser Permanente Inter-regional Chiefs of Urology 2015 Kaiser
Laparoscopic Repair of Hernias A simple guide to help answer your questions What is a hernia? A hernia is defined as a hole or defect in the abdominal (belly) wall. A hernia can either be congenital (a
Clinical Practice Assessment Robotic surgery Background: Surgery is by nature invasive. Efforts have been made over time to reduce complications and the trauma inherently associated with surgery through
Understanding Your Diagnosis of Endometrial Cancer A STEP-BY-STEP GUIDE Introduction This guide is designed to help you clarify and understand the decisions that need to be made about your care for the