FILIPPO DE MARINIS EUROPEAN INSTITUTE OF ONCOLOGY (IEO), VIA RIPAMONTI 435, 20141, MILAN IT

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1 E U R O P E A N C U R R I C U L U M V I T A E F O R M A T PERSONAL INFORMATION Name Address FILIPPO DE MARINIS Phone Fax Mobile EUROPEAN INSTITUTE OF ONCOLOGY (IEO), VIA RIPAMONTI 435, 20141, MILAN IT Web site demarinis.filippo@virgilio.it filippo.demarinis@ieo.it demarinis.filippo@gmail.com Nationality Italian Date of birth 24/04/1952 WORK EXPERIENCE Dates (from to) FROM NOVEMBER 2013 AND AT PRESENT European Institute of Oncology (IEO), via Ripamonti 435, Milan IT Thoracic Oncology Division, DIRECTOR. FROM 2000 TO OCTOBER 2013 San Camillo & Forlanini Hospitals, Circonvallazione Gianicolense, Rome IT High Specialization Hospital Lung Disease Director 1 st Oncological Pulmonary Unit Page 1 - Curriculum vitae of

2 responsibilities Management, therapeutical decision, human resources coordination and financial budget building. The U.O.C. is consisting of: Ordinary stay in Hospital n.10 beds e n.10 beds in Day Hospital Staff with n. 4 MD of 1st level, n. 1 MD at contract, n.3 fellowships, n. 1 data-manager as fellowships, n. 2 ward sisters, n. 18 nurses and n.2 helpers plus Outpatients Dpt. Dates (from to) responsibilities From 2007 to 2012 and at present 1 st University of Rome La Sapienza, P.le Aldo Moro 5, Rome IT Postgraduate School Professor in Oncology Teaching, training and education Dates (from to) From 2007 to 2010 Private University of Rome Campus Biomedico, Via E. Longoni 83, Rome IT Postgraduate School Professor in Oncology Teaching, training and education responsibilities Page 2 - Curriculum vitae of

3 Date (from to) From January 30th 1998 to August 2000 Carlo Forlanini Hospital, P.le Carlo Forlanini 1, Rome IT Hospital Dpt. - 5 Operative Unit in Oncological Pulmonary Executive Manager Ordinary stay in Hospital n. 40 beds ande n. 10 beds in Day Hospital responsabilities Staff with n. 7 MD of 1st level, n. 1 ward sister, n. 18 nurses and n. 2 helpers Date (from to) From 1996 to 1998 Biomedical Sciences and Oncology Superior School Rome and Cagliari Parallel Courses Occupation or postion held Teacher Teaching, training and education responsabilities Date (from to) FROM APRIL 06 TH 1995 TO JANUARY 30 TH 1998 Carlo Forlanini Hospital, P.le Carlo Forlanini 1, Rome IT Hospital Dpt. - 3^ Pneumological Division Responsable of Modulo Funzionale A Sector - 1st level of Managing in health role responsabilities Activities of extremely high dose chemotherapy in thoracic tumors of functional area of medicine, new drugs testing. Responsibility of treatment and clinical course of patients hospital admission for pulmonary tumors with control of collateral effects. Dates (from to) From 1993 to 1996 Prof. J. P. Kleisbauer Marseille University - FR Clinical Studies Institute and Pneumopthisiological Researches Professor Teaching, training and education responsibilities Dates (from to) FROM FEBRUARY 16TH 1991 TO 1995 Carlo Forlanini Hospital, P.le Carlo Forlanini 1, Rome IT Hospital Dpt. 3^ Pneumological Division Special Assistant of Pneumology in role, competitive examination, in USL RM/10 responsibilities Oncological Day-Hospital and Home Care Service in patients with respiratory insufficiency in continuation oxygen-therapy. Responsable of n^ 6 beds for diagnostic-therapeutical activity and daily clinic of Hospital Stay Dates (from to) FROM 1990 Ministry of Health Forensic Medicine Office Consultant for Pneumology in medical colleges responsibilities Forensic Medicine advices Dates (from to) FROM 01/11/1987 TO 1991 Carlo Forlanini Hospital, P.le Carlo Forlanini 1, Rome Hospital Dpt. 3^ Pneumological Division Pneumological Assistant non in role, winner of internal announcement responsibilities Page 3 - Curriculum vitae of

4 Dates (from to) FROM 1987 TO 1999 S.M.O.R.R.L. - Rome and Lazio Hospital Medical School Teacher responsibilities Teaching, training and education Dates (from to) FROM 1985 TO 1989 Professional Nurses School Carlo Forlanini Hospital in Rome Teacher responsibilities Teaching in Social Medicine Dates (from to responsibilities FROM 1984 TO 1991 Agreement between 1 University La Sapienza Rome and USL RM/10 3^ Pneumological Division of Carlo Forlanini Hospital At first, Assistant in Pulmonary and after Special Assistant MD for sanitary-organizing activities in assistance, teaching and research Dates (from to responsibilities Prof. F. Cavalli SAKK Ticinese Section Oncology Division San Giovanni Bellinzona Hospital Theoretical and pratical trainee Phase II clinical studies in antineoplastic new drugs From April 1st to April 30th 1982 Dates (from to) FROM APRIL 17 TH 1980 TO 1991 Winner of public announcement Employee with deliberation on 04/17/80 and from 09/01/1980 employeer in full time Monteverde Hosp-Sanitary Section Pneumology Assistant responsibilities MD for sanitary-organizing activities in assistance, teaching and research Dates (from to) FROM APRIL 1979 TO JULY 1980 Page 4 - Curriculum vitae of

5 responsibilities Due for call-up in Army 8^ ORME of Rome Sanitary Service Manager Voluntary worker in 3^ Division of Pneumology Forlanini Hospital Dates (from to) FROM 1977 TO 1978 Carlo Forlanini Hospital, Ple Forlanini 1, Rome IT 3 Division of Pneumology Trainee responsibilities EDUCATION AND TRAINING Dates (from to) From ^ European Conference on Clinical Oncology ESMO, London Oncology European Oncologist Dates (from to) From April 1989 Carlo Forlanini Hospital, P.le Carlo Forlanini 1, Rome IT Pneumology Pneumologist Director Dates (from to) From November 1983 to July nd University of Rome Cattolica del Sacro Cuore Specialization High School in Oncology Experimental thesis on Clinical aspects of bone metastasis from primitive lung carcinoma - edited for printing paper SPECIALIZATION in Oncology Dates (from to) From November 1978 to July st University of Rome La Sapienza Specialization High School in Lung Diseases Experimental thesis on Polichemotherapy in the treatment of primitive lung carcinoma at III stady not surgical operable: analysis of secondary toxicity immediate and delayed referring the response and the survival SPECIALIZATION in Pneumology Page 5 - Curriculum vitae of

6 Dates (from to) From April 14 th st University of Rome La Sapienza The Medical and Surgery Faculty Pthsiology Experimental graduation thesis on Chronic bronchitis and allergies Dates (from to) From 1969 Italian Secondary School Virgilio - Rome IT Classical Studies School Leaving taken after five years of Liceo Page 6 - Curriculum vitae of

7 PERSONAL SKILLS Acquired in the course of life and career but not necessarily covered by formal certificates and diplomas. MOTHER TONGUE ITALIAN LANGUAGE OTHER LANGUAGES ENGLISH AND FRENCH LANGUAGE Reading skills Good Good Writing skills Good Good Verbal skills Good Good SOCIAL SKILLS Living and working with other people, in multicultural environments, in positions where communication is important and situations where teamwork is essential (for example culture and sports), etc. ORGANISATIONAL SKILLS Coordination and administration of people, projects and budgets; at work, in voluntary work (for example culture and sports) and at home, etc. TECHNICAL SKILLS With computers, specific kinds of equipment, machinery, etc. ARTISTIC SKILLS Music, writing, design, etc. OTHER SKILLS Competences not mentioned above. DAILY CLINICAL ACTIVITY IN MULTIDISCIPLINARY EQUIPE PARTECIPATION IN WORKING NATIONAL AND INTERNATIONAL GROUPS (ADVISORY BOARD, INVESTIGATOR MEETING. ETC.) AT PRESENT MEMBER OF THE ETHICAL COMMITTEE OF SAN CAMILLO FORLANINI HOSPITALS. MEMBER OF THE ETHICAL COMMITTEE OF SANT'ANDREA HOSPITAL AND REGINA ELENA NATIONAL INSTITUTE AGAINST CANCER IN THE PAST ROME IT MEMBER OF SCIENTIFIC ITALIAN AND INTERNATIONAL ASSOCIATIONS WITH ACTIVE ROLES: AIOT, ITALIAN THORACIC ONCOLOGY (PRESIDENT 2007/2012 PAST PRESIDENT FROM 2012), ESMO (FACULTY MEMBER FOR CHEST TUMORS 2010/2014), ETOP, EUROPEAN ONCOLOGICAL RESEARCH (MEMBER OF WORKING GROUP ACTIVITIES IN THE WEB), ASCO AND IASLC (MEMBER) AIOM, ITALIAN MEDICAL ONCOLOGY (CONSELLOR OF BOARD OF DIRECTORS 2003/2005 E 2005/2007 REGIONAL CONSELLOR 1991/1995, SECRETARY- TREASURER 1995/2000, REGIONAL PRESIDENT 2001/2003), SIMER, ITALIAN RESPIRATORY MEDICINE (MEMBER AND RESPONSABLE FOR THORACIC ONCOLOGY GROUP 1994/1996), AIPO, ITALIAN HOSPITAL PNEUMOLOGISTS (PROMOTER 1990, SECRETARY-TREASURER 1990/1996, FONICAP (REGIONAL CONSELLOR 1991/1994), AIMAR (SCIENTIFIC COMMITTEE MEMBER OF ONCOLOGY OFFICIAL JOURNAL MRM) EXCELLENT CAPACITIES OF ORGANIZATION, COORDINATION, MANAGEMENT AND RUNNING OF HUMAN MEDICAL RESOURCES WARD ACTIVITIES, DAY HOSPITAL AND CLINICAL ACTIVITY. EXCELLENT ABILITY ABOUT FINANCIAL MANAGEMENT AND BALANCE&BUDGET DRAWING UP. SPECIFIC COMPETENCE IN SCIENTIFIC EVENTS ORGANIZATION AND IN BUILDING UP EDUCATIONAL PROGRAMMES AND IN OUTLINING AND COORDINATING PEOPLE AS SPEAKERS AND TEACHERS. EXCELLENT ABILITY IN THE USE OF COMPUTER FOR WORD PROGRAMME AND ABOVEALL SPECIFIC AND VERY HIGH COMPETENCE AND KNOLEDGE FOR USING POWER POINT PROGRAMME ALSO IN CREATIVE WAY. EXCELLENT ABILITY IN SURFING AND IN DISCOVERING ITS NEW ELEMENTS. A GOOD KNOWLEDGE AND COMPETENCE IN USING REPRODUCTION MUSICAL PROGRAMME AND BUILDING VIDEOS (WINDOWS MOVIE MAKER). THESE ACTIVITIES HAVE BEEN DOING BOTH IN PROFESSIONAL AND PRIVATE FIELD. GOOD ARTISTIC ABILITY IN PLAYING MUSIC WITH DRUMS AS AN AMATEUR. Excellent sports abilities and competences in sailing acquired in a competitive past during many races in Italian Country with the acquisition of Italian champion titles. Page 7 - Curriculum vitae of

8 DRIVING LICENCE(S) A and B ADDITIONAL INFORMATION In the past Scientific Consultant of many Pharmaceutical Companies: Eli Lilly, Astrazeneca, Sanofi-Aventis. At the present for Roche, and Boehringer Ingelheim In the last 5 years ( ) Invited Speaker in more than 300 scientific meetings (80% as Speaker and 20% as Chair), whose in 20% of cases took part in Scientific Committee (60 meetings/year). Participation in 40 Advisory Boards and in 17 Investigator Meetings as Speaker. About scientific international activities in the last 5 years ( ) invited Speaker in 50 International Meetings (10% as chair). Expert in Good Clinical Practice Trials on New Antineoplastic Drugs in Lung Cancer (phase I, II, III) and developer trials in Lung Cancer with Vinorelbine, Paclitaxel, Docetaxel, Gemcitabine, Topotecan, Pemetrexed, Affinitak, MMPI, SR 48692, Gefitinib, Erlotinib, Cetuximab, BMS , Bevacizumab, Sorafenib, Sunitinib, ASA 404, Zoledronic Acid, Bortezomib, Vandetanib, Vargatef, Amrubicin, Vorinostat, Panobinostat, CPT-751, Talactoferrin, Eribulin Mesylate, MAGE-3, Stimuvax, Afatinib, Onartuzumab, Ramucirumab, Crizotinib, Dacomitinib, Tivantinib, etc. In the last 5 years ( ) participation in more than 80 clinical studies controlled in phase I-II-III as Principal Investigators (20 new studies/year) recruiting about 80 patients/year (20% Annual casistic) Authors of more than 250 printed scientific publications (14 books/monographers and 125 papers in International Indexed Reviews on PUB MED) Impact Factor di: cp=re214_x_p2&ch=reg&login=demarinis.filippo@virgilio.it&pli=1 Citation Index of: 8444 on 100 pubblications (Hirsch s Index: 37) Page 8 - Curriculum vitae of

9 Associate Editor in Lung Cancer for a term of two years (1 June 2011/2013) Reviewer in charge of more than 36 Scientific National and International Journals: Annals of Oncology, Aging Health, Cancer Therapy, Cancer Chemotherapy and Pharmacology, Lung Cancer, Current Pharmacogenomics, Clinical Medicine Insights: Oncology, Clinical Revue in Oncology and Hematology, Clinical Lung Cancer, Cancer Treatment Revue, Chemotherapy, Cancer Investigation, Cancer Therapy, Current Pharmacogenomics, Journal of Medical Economics, CML Lung Cancer, Current Gerontology & Geriatrics Research, Current Opinion in Oncology, Current Stem Cell Research, European Oncology, Expert Review of Anticancer Therapy, Expert Review of Clinical Pharmacology, Frontiers in Drugs Design and Discovery, Future Oncology, International Journal of Biomedical Sciences, Journal of chinese Clinical Medicine, Lung Cancer Target and Therapy, Oncology, The Oncologist, Respiration, Therapeutics and Clinical Risk Management, Therapeutic Advances in Medical Oncology. ANNEXES About publications please look up website pointed here below http// Milan, November 11 th 2013 Page 9 - Curriculum vitae of