PIONEERING BIG DATA IN RADIATION ONCOLOGY
|
|
- Marlene Powell
- 8 years ago
- Views:
Transcription
1 TM PIONEERING BIG DATA IN RADIATION ONCOLOGY Todd McNutt PhD Associate Professor Radiation Oncology Johns Hopkins University Presented at the Target Insight Toronto, CAN May 8 th, 2015
2 Disclosures This work has been partially funded with collaborations from: Philips Radiation Oncology Systems Elekta Oncology Systems Toshiba Medical Systems as well as Commonwealth Foundation Maritz Foundation 2
3 Problem Ability to advance radiotherapy is limited by our knowledge of which patients are at risk of high grade toxicity or of limited ability to cure. Knowledge from clinical trials is quite coarse and fails to consider all of the aspects of the individual patient. Big Data offers an opportunity to better predict treatment outcome and provide improved clinical decisions for individual patients.
4 Personalized care using database of prior patients How to best to treat individual patient? Pathology Diagnosis Performance Status Comorbidities Patient History Radiotherapy Surgery Chemotherapy CONSULT TREATMENT Survival FOLLOW-UP Quality of Life Clinical assessments Lab Values Toxicities Disease Status Prediction of complications for early intervention? Predicted response and toxicity?
5 Precision Radiotherapy Treatment Planning
6 Mucositis data collected at JHU # patients Toxicity grade 6
7 Promote Culture of Data Collection Data collected over entire treatment Consult Demographics Diagnosis Staging Baseline Tox Baseline QoL History Weekly On Treatment Toxicity QoL Patient status Symptom Mgmt End of Treatment Acute toxicity QoL Patient status Symptom mgmt Disease response Follow Up Late toxicity QoL Patient status Disease response Simulation Targets OARs OVH Planning Rx Dose DVH Image Guidance Motion Disease Response At what time point do we have enough data to make decision based on future prediction? Auto Plan Risk Based Symptom Mgmt Therapy Mgmt Input Variables => Prediction?
8 MOSAIQ Browser Departmental Analytics Framework Multi-Disciplinary Clinics RadOnc Users Security Certificate Johns Hopkins Enterprise Login SiteMinder Access Management Mobile Solutions Mosaiq Browser -IIS -ASP.NET -C# -SQL Data Access Layer SQL SQL Query Log Clinical Analytics IDE - Visual Studio - SVN repository MOSAIQ Security Rights MOSAIQ DB
9 Data Collection in Clinic Clinical Assessment Quality of life Disease Status 5/27/2015 9
10 Head and Neck Oncospace Landscape Home-based Assessment (FitNinja) Head and Neck Tissue Bank (Chung) SNP Genotyping Pre-Treatment Imaging (Kiess/Hobbs/Shen) On-Treatment Imaging (Lee/Shekhar) (Toshiba) Oncospace - On-Treatment Evaluation - RT dosimetry Swallow Function (Starmer et al) Toxicity PROs Oncologic Outcome Neck Function (Sweet) Ocular Function (Subramanian) Post-Treatment Oncologic and Toxicity (Ding/Fakhry/Murano/Prince/ Wasserman Ecological Momentary Assessments (EMAs)
11 Extract, Transform, Load DICO M MOSAIQ - SQL Query - Lab, Toxicity, Assessments Oncospace Pinnacle TPS - Scripts, Python, DICOM - DVH, OVH, Shapes
12 Oncospace tables and schema Patient Private Health Info (access restricted) Family History Social History Medical History Medications (chemo) Surgical Procedures Test Results (Labs) Assessments (Toxicities) Clinical Events Tumors Radiation Summary Patient Representations (CT based geometries) (m:n) Image Transform Image Feature Pathology Feature Organ DVH Data Organ Dose Summaries 1 : N multiple instances 1 : 1 single instance m : n relates m to n Organ DVH Feature ROI DVH Data Radiotherapy Sessions ROI Dose Summary ROI DVH Features Shape Descriptor Regions of Interest Data (m:n) Shape Relationship Features
13 Data inventory Toxicities (24var/pt) Quality of Life (64var/pt) Measured data (6 var/pt) Disease response(8var/pt) w 2-4w 4-6w 6w-3m 3m-6m 6m-1y 1-2y 2-3y 3-4y 4-5y 5-6y >6y 5/27/
14 Organs at risk with full dose 5/27/
15 Learning health system can t exist without data Decision Point Facts Controls Outcomes time Knowledge Database Facts Decisions Controls Presentation of Predictions Predictive Modeling Predicted Outcomes Data Feedback (Facts, Outcomes) 15
16 Oncospace Consortium Repository (It s all about the data) Johns Hopkins U. Washington U. Toronto Sunnybrook U. Virginia Institution X Knowledge Base Registry $/pt Quality Reporting Decision Support Research N
17 Toxicity trends during and after treatment detect outliers During Treatment Follow up Dysphagia Swallowing Worsens after Tx for many patients then improves long term Mucositis Inflammation Heals after Tx for most patients Xerostomia Dry Mouth Tends to be permanent #pts Toxicity grade (0-5)
18 Toxicity trends during and after treatment detect outliers During Treatment Follow up Dysgeusia Taste disturbance Worsens through Tx then improves long term Voice Change Worsens through Tx #pts Toxicity grade (0-5)
19 DVH, Toxicities and Grade distributions Voice Change Larynx 50% Volume Dysphagia Larynx_edema 30% Volume Toxicity Grade 0,1,2,3,4,5 Mean and stddev of DX% at grade Number of patients by grade at D50%
20 OVH: serial vs parallel Target OAR1 OAR2 r 70,1 r 70,2 For parallel organs, OAR2 is more easily spared. For serial organs, OAR1 is more easily spared.
21 Shape-dose relationship for radiation plan quality Shape relationship DB of prior patients Dose prediction parotids 0 PTV normalized volume Dose (Gy) Right parotid Left parotid For a selected Organ at Risk and %V, find the lowest dose achieved from all patients whose %V is closer to the selected target volume? Decisions: Plan quality assessment Automated planning IMRT objective selection Dosimetric trade-offs
22 Sample automated radiation planning result Original plan Automated plan 30% reduction in dose to parotids Auto plan Original Plan Dot: right No-dot: left Dose(Gy) brain (Gy) (max) Brainstem (Gy) (max) Cord4mm (Gy) (max) L inner ear (Gy)(mean) original re-plan R inner ear (Gy) (mean) mandible (Gy) (max) larynx for edema (V50) esophagus (Gy)(max) original % re-plan % 61
23 Toxicity and Dose Volume Histogram Scott Robertson PhD 23
24 Prevalence and prediction of treatment-related complications RISK STRUCTURES TOXICITIES / OUTCOMES 10%/Gy 5%/Gy MODELLED RISK May 27,
25 Voice Change
26 Bad DVH! DVH assumes that every sub-region of an OAR has the same radiosensitivity and functional importance to the related toxicity DVH assumes that each OAR is uniquely responsible for the overall human function related to the toxicity
27 Spatial dose analysis Method Voice dysfunction n=99, n + =8, n - =91 Xerostomia n=364, n + =275, n - =89 Bagged Naïve Bayes (1000 iterations) Bagged Linear Regression (1000 iterations) Naïve Bayes Linear Regression Random Forest (1000 trees) Hopkins NTCP inhealth LKB
28 Classification with correlated features: unreliability of feature ranking and solutions Simulation of 1, 10 and 20 variables with a correlation of 0.9 with variable 3 Genuer et al.
29 Weight loss prediction Endpoint: > 5kg loss at 3 months post RT Larynx salivary glands thyroid hypopharynx yes FALSE FALSE At planning Larynx D55 < 27.5Gy no Diagnostic ICD-9 Combo Parotid D50< 13.5Gy Distance: HD-PTV to Superior Constrictor Muscle >= 1.1cm Combo Masticatory Muscle D41 < 38.4Gy FALSE FALSE FALSE FALSE oropharynx tongue nasopharynx nasal cavities Larynx D80 < 23.0Gy TRUE Larynx salivary glands thyroid hypopharynx Nausea < 1 (CACAE) FALSE Skin Acute < 3 (CACAE) N stage < 2 Diagnostic ICD-9 At end of RT yes Combo Parotid D61< 7.5Gy Pain Intensity - Current < 5 Able to eat foods I like >= 3 (FACT) larynx D59 < 27.4Gy Distance: LD-PTV to Larynx >= -1.3cm Cricopharyngeal Muscle D100 < 38.1Gy oropharynx tongue nasopharynx nasal cavities Diagnostic ICD-9 tongue Esophagitis/ Pharyngitis < 3 (CACAE) Combo Parotid D96< 6.5Gy Larynx D10 < 42.3Gy FALSE TRUE TRUE FALSE FALSE TRUE FALSE TRUE FALSE TRUE FALSE TRUE FALSE TRUE no 5/27/
30 What can we do with the data? Shape based auto-planning Clinical (prostate, pancreas) Efficient high quality plan Weight loss prediction Improved symptom management Toxicity Risk DVH based Spatial dose based Disease response prediction Pancreas resectability Head and neck HPV dose de-escalation Shape relationship parotids PTV DB of prior patients normalized volume Dose prediction Right parotid Left parotid Dose (Gy) 30
31 Summary The Oncospace model can house RT data effectively and provides a model for sharing Data collection in the clinical environment has been demonstrated All patient on trial Data exploration and analysis across multiple institutions is possible Exploring models to stratify patients to improve the predictive power of the data Decision support to improve quality and safety has been demonstrated Personalized medicine has not been fully demonstrated, but remains a tenable goal
32 Acknowledgments JHU-RO Sierra Cheng MD Kim Evans MS Michael Bowers BS Joseph Moore PhD Scott Robertson PhD Wuyang Yang MS, MD John Wong PhD Theodore DeWeese MD GI Team Joseph Herman MD Amy Hacker-Prietz PA H&N Team Harry Quon MD Giuseppe Sanguineti MD Heather Starmer MD Ana Keiss MD Mysha Allen RN Sara Afonso RN JHU - CS Russ Taylor PhD Misha Kazhdan PhD Fumbeya Murango BS Philips PROS Karl Bzdusek BS Toshiba Minoru Nakatsugawa PhD Bobby Davey PhD Rachel-Louise Koktava John Haller Elekta
Automated Treatment Planning Using a Database of Prior Patient Treatment Plans
Automated Treatment Planning Using a Database of Prior Patient Treatment Plans Todd McNutt PhD, Binbin Wu PhD, Joseph Moore PhD, Steven Petit PhD, Misha Kazhdan PhD, Russell Taylor PhD Shape DB work funded
More informationEvolution of Head and Neck Treatment Using Protons. Mayank Amin, M.Sc,CMD
Evolution of Head and Neck Treatment Using Protons Mayank Amin, M.Sc,CMD Facility Layout Gantry Room 3 Fixed Beams Room 4 HEBT Gantry Room 2 Gantry Room 1 Synchrotron Linac Treatment Planning Imaging Area
More informationTHE DOSIMETRIC EFFECTS OF
THE DOSIMETRIC EFFECTS OF OPTIMIZATION TECHNIQUES IN IMRT/IGRT PLANNING 1 Multiple PTV Head and Neck Treatment Planning, Contouring, Data, Tips, Optimization Techniques, and algorithms AAMD 2013, San Antonio,
More informationProton Therapy Center Czech
Proton Therapy Center Czech The main goal of radiotherapy is to irreversibly damage tumor cells, whereas the cells of healthy tissue are damaged only reversibly or not at all. Proton therapy currently
More informationOur Facility. Advanced clinical center with the newest and highly exact technology for treatment of patients with cancer pencil beam
PTC Czech The main goal of radiotherapy is to irreversibly damage tumor cells, whereas the cells of healthy tissue are damaged only reversibly or not at all. Proton therapy currently comes closest to this
More informationCorporate Medical Policy
Corporate Medical Policy Intensity Modulated Radiation Therapy (IMRT) of Head and Neck File Name: Origination: Last CAP Review: Next CAP Review: Last Review: intensity_modulated_radiation_therapy_imrt_of_head_and_neck
More informationEvaluation of an automated knowledge based treatment planning system for head and neck
Krayenbuehl et al. Radiation Oncology (2015) 10:226 DOI 10.1186/s13014-015-0533-2 RESEARCH Open Access Evaluation of an automated knowledge based treatment planning system for head and neck Jerome Krayenbuehl
More informationLearning about Mouth Cancer
Learning about Mouth Cancer Creation of this material was made possible in part by a pioneering grant from CBCC-USA. Distributed by India Cancer Initiative What is mouth cancer? Our bodies are made up
More informationChapter 7. Accepted for publication in Acta Oncologica
Chapter 7 The potential of intensity-modulated proton radiotherapy to reduce swallowing dysfunction in the treatment of head and neck cancer: a planning comparative study Hans Paul van der Laan, Tara A.
More informationHead and Neck Treatment Planning: A Comparative Review of Static Field IMRT Rapid Arc Tomotherapy HD
Good Morning Head and Neck Treatment Planning: A Comparative Review of Static Field IMRT Rapid Arc Tomotherapy HD Barbara Agrimson, BS RT(T)(R), CMD Steve Rhodes, BS RT(T), CMD Disclaimer This presentation
More informationTHE SECRETS OF OUR SUCCESS
THE SECRETS OF OUR SUCCESS QUALITY OF LIFE STUDIES OF THE NCIC Andrea Bezjak, MDCM, MSc,, FRCPC Chair, NCIC CTG QOL Committee Outline of the Presentation Can we consider NCIC CTG QOL activities a success?
More informationClinical Education A comprehensive and specific training program. carry out effective treatments from day one
Proton Therapy Clinical Education A comprehensive and specific training program carry out effective treatments from day one Forewarned is forearmed Although over 100,000 patients have been treated in proton
More informationMedical Marijuana Use in Patients with History of SCCHN Treated with Radiotherapy
HEALTH SERVICES RESEARCH Assessment the Impact of Real-time Tumor Tracking & Reduced Planning Target Volume Margins on Quality-of-Life in Prostate Cancer Patients Treatment with Intensity Modulated Radiotherapy
More informationC a nc e r C e nter. Annual Registry Report
C a nc e r C e nter Annual Registry Report 214 214 Cancer Registry Report Larraine A. Tooker, CTR Please note that the 214 Cancer Registry Annual Report is created in 214, but it reflects data on cases
More informationPATIENT INFORMATION ABOUT ADJUVANT THERAPY AFTER THE WHIPPLE OPERATION FOR ADENOCARCINOMA ( CANCER ) OF THE PANCREAS AND RELATED SITES.
PATIENT INFORMATION ABOUT ADJUVANT THERAPY AFTER THE WHIPPLE OPERATION FOR ADENOCARCINOMA ( CANCER ) OF THE PANCREAS AND RELATED SITES. Radiation Oncology Sidney Kimmel Cancer Center at Johns Hopkins Last
More informationRadiation Therapy for Prostate Cancer: Treatment options and future directions
Radiation Therapy for Prostate Cancer: Treatment options and future directions David Weksberg, M.D., Ph.D. PinnacleHealth Cancer Institute September 12, 2015 Radiation Therapy for Prostate Cancer: Treatment
More informationDosimetric impact of the 160 MLC on head and neck IMRT treatments
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 15, NUMBER 6, 2014 Dosimetric impact of the 160 MLC on head and neck IMRT treatments Prema Rassiah-Szegedi, a Martin Szegedi, Vikren Sarkar, Seth Streitmatter,
More informationHow To Know If You Have Cancer At Mercy Regional Medical Center
MERCY REGIONAL CANCER CENTER 2012 CANCER PROGRAM ANNUAL REPORT Using 2011 Data Mercy Regional Cancer Center When you have cancer, you might think first of treatments chemotherapy and radiation. You want
More informationDiagnosis and Treatment of Common Oral Lesions Causing Pain
Diagnosis and Treatment of Common Oral Lesions Causing Pain John D. McDowell, DDS, MS University of Colorado School of Dentistry Chair, Oral Diagnosis, Medicine and Radiology Director, Oral Medicine and
More informationVeterinary Oncology: The Lumps We Hate To Treat
Veterinary Oncology: The Lumps We Hate To Treat Michelle Turek, DVM, DACVIM (Oncology), DACVR (Radiation Oncology) College of Veterinary Medicine University of Georgia Athens, GA Veterinary Oncology Veterinary
More informationConcurrent Chemotherapy and Radiotherapy for Head and Neck Cancer
Concurrent Chemotherapy and Radiotherapy for Head and Neck Cancer Ryan J. Burri; Nancy Y. Lee Published: 03/23/2009 Abstract and Introduction Abstract Head and neck cancer is best managed in a multidisciplinary
More informationParticle Therapy for Lung Cancer. Bradford Hoppe MD, MPH Assistant Professor University of Florida bhoppe@floridaproton.org
Particle Therapy for Lung Cancer Bradford Hoppe MD, MPH Assistant Professor University of Florida bhoppe@floridaproton.org Content Rationale for Particle Therapy in Lung Cancer Proof of Principle Treatment
More informationAdvanced Radiation Therapy of Cancer by Proton Beam
March 20th, 2014 Advanced Radiation Therapy of Cancer by Proton Beam Fukui Prefectural Hospital Proton Therapy Center Yamamoto, Kazutaka Wave (electromagnetic wave) IR (Ionizing) Radiation 700 400 350~100
More informationGoals and Objectives: Breast Cancer Service Department of Radiation Oncology
Goals and Objectives: Breast Cancer Service Department of Radiation Oncology The breast cancer service provides training in the diagnosis, management, treatment, and follow-up of breast malignancies, including
More informationPrinciples of Radiation Therapy A Bapsi Chakravarthy, MD Associate e P rofessor Professor Radiation Oncology
Principles of Radiation Therapy A Bapsi Chakravarthy, MD Associate Professor Radiation Oncology Disclosure Information I have no financial relationships to disclose relevant to the conten of this presentation.
More informationRadiation Protection in Radiotherapy
Radiation Protection in Radiotherapy Albert Lisbona Medical Physics Department CLCC Nantes Atlantique 44805 Saint-Herblain France a-lisbona@nantes.fnclcc.fr Radiation therapy The lecture is oriented to
More informationManagement of Postmenopausal Women with T1 ER+ Tumors: Options and Tradeoffs. Case Study. Surgery. Lumpectomy and Radiation
Management of Postmenopausal Women with T1 ER+ Tumors: Options and Tradeoffs Michael Alvarado, MD Associate Professor of Surgery University of California San Francisco Case Study 59 yo woman with new palpable
More informationRadiotherapy in locally advanced & metastatic NSC lung cancer
Radiotherapy in locally advanced & metastatic NSC lung cancer Dr Raj Hegde. MD. FRANZCR Consultant Radiation Oncologist. William Buckland Radiotherapy Centre. Latrobe Regional Hospital. Locally advanced
More informationChapter 8. General discussion and conclusions - 153 -
Chapter 8 General discussion and conclusions - 153 - Chapter 8 General discussion and conclusions The aim of this thesis was (1) to investigate if irradiation with scanned intensity-modulated proton therapy
More informationCurrent Status and Perspectives of Radiation Therapy for Breast Cancer
Breast Cancer Current Status and Perspectives of Radiation Therapy for Breast Cancer JMAJ 45(10): 434 439, 2002 Masahiro HIRAOKA, Masaki KOKUBO, Chikako YAMAMOTO and Michihide MITSUMORI Department of Therapeutic
More informationThe Science behind Proton Beam Therapy
The Science behind Proton Beam Therapy Anthony Zietman MD Shipley Professor of Radiation Oncology Massachusetts General Hospital Harvard Medical School Principles underlying Radiotherapy Radiation related
More informationEsophageal Cancer Treatment
Scan for mobile link. Esophageal Cancer Treatment What is Esophageal Cancer? Esophageal cancer occurs when cancer cells develop in the esophagus, a long, tube-like structure that connects the throat and
More informationProstatectomy, pelvic lymphadenect. Med age 63 years Mean followup 53 months No other cancer related therapy before recurrence. Negative.
Adjuvante und Salvage Radiotherapie Ludwig Plasswilm Klinik für Radio-Onkologie, KSSG CANCER CONTROL WITH RADICAL PROSTATECTOMY ALONE IN 1,000 CONSECUTIVE PATIENTS 1983 1998 Clinical stage T1 and T2 Mean
More informationCurrent Status and Future Direction of Proton Beam Therapy
Current Status and Future Direction of Proton Beam Therapy National Cancer Center Hospital East Division of Radiation Oncology and Particle Therapy Tetsuo Akimoto Comparison of status of particle therapy
More informationNon-Small Cell Lung Cancer Treatment Comparison to NCCN Guidelines
Non-Small Cell Lung Cancer Treatment Comparison to NCCN Guidelines April 2008 (presented at 6/12/08 cancer committee meeting) By Shelly Smits, RHIT, CCS, CTR Conclusions by Dr. Ian Thompson, MD Dr. James
More informationDepartment of Radiation Oncology
Department of Radiation Oncology Welcome to Radiation Oncology at Emory Clinic Every member of Emory Clinic Department of Radiation Oncology strives to provide the highest quality of care for you as our
More informationEvaluation of complexity and deliverability of IMRT- treatment plans. Author: Elin Svensson Supervisors: Anna Bäck and Anna Karlsson Hauer
Evaluation of complexity and deliverability of IMRT- treatment plans Author: Elin Svensson Supervisors: Anna Bäck and Anna Karlsson Hauer June 11 Abstract Background: Intensity modulated beams are used
More informationStomach (Gastric) Cancer. Prof. M K Mahajan ACDT & RC Bathinda
Stomach (Gastric) Cancer Prof. M K Mahajan ACDT & RC Bathinda Gastric Cancer Role of Radiation Layers of the Stomach Mucosa Submucosa Muscularis Serosa Stomach and Regional Lymph Nodes Stomach and Regional
More informationProton Therapy for Pediatric Cancers
Proton Therapy for Pediatric Cancers Christine Hill- Kayser, MD Editor- in- Chief, OncoLink Assistant Professor of Radiation Oncology, Pediatrics Service, University of Pennsylvania Melanie Eisenhower,
More informationThe Canadian National System for Incident Reporting in Radiation Treatment (NSIR-RT) Taxonomy March 2, 2015 V2
The Canadian National System for Incident Reporting in Radiation Treatment (NSIR-RT) Taxonomy March 2, 2015 V2 Taxonomy Data Category Number Description Data Fields and Menu Choices 1. Impact 1.1 Incident
More informationBasic Radiation Therapy Terms
Basic Radiation Therapy Terms accelerated radiation: radiation schedule in which the total dose is given over a shorter period of time. (Compare to hyperfractionated radiation.) adjuvant therapy (add-joo-vunt):
More informationPediatric Oncology for Otolaryngologists
Pediatric Oncology for Otolaryngologists Frederick S. Huang, M.D. Division of Hematology/Oncology Department of Pediatrics The University of Texas Medical Branch Grand Rounds Presentation to Department
More informationBrain Tumor Treatment
Scan for mobile link. Brain Tumor Treatment Brain Tumors Overview A brain tumor is a group of abnormal cells that grows in or around the brain. Tumors can directly destroy healthy brain cells. They can
More informationAndre Konski, MD, MBA, MA, FACR Professor & Chair Department of Radiation Oncology Wayne State University School of Medicine Barbara Ann Karmanos
Andre Konski, MD, MBA, MA, FACR Professor & Chair Department of Radiation Oncology Wayne State University School of Medicine Barbara Ann Karmanos Cancer Center Financial None The views that I will be going
More informationSCD Case Study. Most malignant lesions of the tonsil are either lymphosarcoma or carcinoma.
SCD Case Study Dry Mouth This case study details a patient who has experienced xerostomia as a result of treatment for squamous cell carcinoma of the left tonsil involving surgery followed by deep x-ray
More informationRadiation therapy involves using many terms you may have never heard before. Below is a list of words you could hear during your treatment.
Dictionary Radiation therapy involves using many terms you may have never heard before. Below is a list of words you could hear during your treatment. Applicator A device used to hold a radioactive source
More informationDental health following cancer treatment
Dental health following cancer treatment Treatment for cancer often increases the risk for dental problems. As a cancer survivor, it is important for you to understand the reasons why dental care is especially
More informationM D Anderson Cancer Center Orlando TomoTherapy s Implementation of Image-guided Adaptive Radiation Therapy
M D Anderson Cancer Center Orlando TomoTherapy s Implementation of Image-guided Adaptive Radiation Therapy Katja Langen, PhD Research supported by TomoTherapy Inc. Today s Lecture Introduction to helical
More informationPrincipal Investigator: Valerie W. Rusch, MD, FACS, Chief, Thoracic Surgery Memorial Sloan-Kettering Cancer Center
Protocol 1101-1088 Phase I study of intra-pleural administration of GL-ONC1 in patients with malignant pleural effusion: primary, metastases and mesothelioma Principal Investigator: Valerie W. Rusch, MD,
More informationClinical Trials and Radiation Treatment. Gerard Morton Odette Cancer Centre Sunnybrook Research Institute University of Toronto
Clinical Trials and Radiation Treatment Gerard Morton Odette Cancer Centre Sunnybrook Research Institute University of Toronto What I will cover.. A little about radiation treatment The clinical trials
More informationNew strategies in anticancer therapy
癌 症 診 療 指 引 簡 介 及 臨 床 應 用 New strategies in anticancer therapy 中 山 醫 學 大 學 附 設 醫 院 腫 瘤 內 科 蔡 明 宏 醫 師 2014/3/29 Anti-Cancer Therapy Surgical Treatment Radiotherapy Chemotherapy Target Therapy Supportive
More informationProstate Cancer Guide. A resource to help answer your questions about prostate cancer
Prostate Cancer Guide A resource to help answer your questions about prostate cancer Thank you for downloading this guide to prostate cancer treatment. We know that all the information provided online
More informationOropharyngeal carcinoma State of the Art
Oropharyngeal carcinoma State of the Art Pr. Jean Bourhis Institute Gustave Roussy Ville juif, France - Among HNSCC what are the specificities of the oropharyngeal sub site? - Frequent among HNSCC - More
More informationProtons vs. CyberKnife. Protons vs. CyberKnife. Page 1 UC SF. What are. Alexander R. Gottschalk, M.D., Ph.D.
Protons vs. CyberKnife UC SF Protons vs. CyberKnife UC SF Alexander R. Gottschalk, M.D., Ph.D. Associate Professor and Director of the CyberKnife Radiosurgery Program Department of Radiation Oncology University
More informationRadioterapia panencefalica. Umberto Ricardi
Radioterapia panencefalica Umberto Ricardi Background Systemic disease to the brain is unfortunately a quite common event Radiotherapy, especially with the great technical development during the past decades,
More informationKINGS COUNTY HOSPITAL CENTER EXECUTIVE SUMMARY. Always Here When You Need Us
KINGS COUNTY HOSPITAL CENTER EXECUTIVE SUMMARY Always Here When You Need Us Kings County Hospital Center Cancer Care Program ANNUAL REPORT 2013: EXECUTIVE SUMMARY The Kings County Hospital Center Cancer
More informationTransition from 2D to 3D Brachytherapy in Cervical Cancers: The Vienna Experience. Richard Pötter MD. BrachyNext, Miami, 2014.
Transition from 2D to 3D Brachytherapy in Cervical Cancers: The Vienna Experience Richard Pötter MD BrachyNext, Miami, 2014 Disclosures Richard Pötter, MD, does not have any financial relationships or
More informationTricia Cox on 7/18/2012 at Oncology Center. Sarah Randolf. Female
SAMPLE This Survivorship Care Plan will facilitate cancer care following active treatment. It may include important contact information, a treatment summary, recommendations for follow-up care testing,
More informationEnhancing the Child s Voice in Clinical Care and Research
Enhancing the Child s Voice in Clinical Care and Research Bryce B. Reeve, Ph.D. Associate Professor, Health Policy and Management Member, Lineberger Comprehensive Cancer Center bbreeve@email.unc.edu Standardized,
More informationRadiation Oncology Nursing Care. Helen Lusby Radiation Oncology Nurse BAROC 2012
Radiation Oncology Nursing Care Helen Lusby Radiation Oncology Nurse BAROC 2012 Definitions Radiation Therapy: Treatment of cancer using x- ray particles that cause ionisation within the cells. External
More informationAnalysis of Population Cancer Risk Factors in National Information System SVOD
Analysis of Population Cancer Risk Factors in National Information System SVOD Mužík J. 1, Dušek L. 1,2, Pavliš P. 1, Koptíková J. 1, Žaloudík J. 3, Vyzula R. 3 Abstract Human risk assessment requires
More informationPost Treatment Log File Based QA Varian. Krishni Wijesooriya, PhD University of Virginia. D e p a r t m e n t of R a d i a t i o n O n c o l o g y
Post Treatment Log File Based QA Varian Krishni Wijesooriya, PhD University of Virginia Learning Objectives What information could be accessed via log files Scenarios where Log files could be used. How
More informationThe evolution of rectal cancer therapy. Objectives
The evolution of rectal cancer therapy Hagen Kennecke MD MHA FRCPC Western Canada Consensus Conference September 5, 2014 Objectives Identify standard therapy: stage II/III rectal cancer Update recent adjuvant
More information2011 ANNUAL REPORT C.H. Chub O Reilly Cancer Center. The cancer journey
2011 ANNUAL REPORT C.H. Chub O Reilly Cancer Center The cancer journey The C.H. Chub O Reilly Cancer Center is home to the latest technology and treatments, including davinci surgery, the region s only
More informationTechnology Assisting Cancer Outcomes: Automated Biomarker Abstraction Overcoming Textual Data-Silos
Technology Assisting Cancer Outcomes: Automated Biomarker Abstraction Overcoming Textual Data-Silos Patrick Mergler, MBA PMP CPHIMS DISCLAIMER: The views and opinions expressed in this presentation are
More informationProton Therapy for Head & Neck Cancers
Proton Therapy for Head & Neck Cancers Robert S Malyapa, MD, PhD and William M Mendenhall, MD University of Florida Proton Therapy Institute, Jacksonville, USA Carmen Ares, MD and Ralf Schneider, MD Paul
More information2014Cancer Annual Report
2014Cancer Annual Report Cancer doesn, t care but we do. Letter from Cancer Committee Chair and Cancer Liaison Accredited by the American College of Surgeons Commission on Cancer, CHRISTUS St. Patrick
More informationALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials)
ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) 3 Integrated Trials Testing Targeted Therapy in Early Stage Lung Cancer Part of NCI s Precision Medicine Effort in
More informationProstate cancer is the most common cause of death from cancer in men over age 75. Prostate cancer is rarely found in men younger than 40.
A.D.A.M. Medical Encyclopedia. Prostate cancer Cancer - prostate; Biopsy - prostate; Prostate biopsy; Gleason score Last reviewed: October 2, 2013. Prostate cancer is cancer that starts in the prostate
More informationRadiotherapy in Plasmacytoma and Myeloma. David Cutter Multiple Myeloma NSSG Annual Meeting 14 th September 2015
Radiotherapy in Plasmacytoma and Myeloma David Cutter Multiple Myeloma NSSG Annual Meeting 14 th September 2015 Contents Indications for radiotherapy: Palliation in Multiple Myeloma Solitary Bone Plasmacytoma
More informationRadiation Fibrosis Fact Sheet
Radiation Fibrosis Fact Sheet What is Radiation Fibrosis Syndrome (RFS), and when can it occur? Radiation Fibrosis Syndrome (RFS) is a term used to describe the multiple clinical symptoms associated with
More informationYour Certified Professional Cancer Coach. An Integrative Answer to Cancer Exclusive Professional Program for Patients with Cancer
Your Certified Professional Cancer Coach An Integrative Answer to Cancer Exclusive Professional Program for Patients with Cancer The CPCC Patient Program Nutrition & Lifestyle Oncology A Cancer Diagnosis
More informationRadiation Therapy in Prostate Cancer Current Status and New Advances
Radiation Therapy in Prostate Cancer Current Status and New Advances Arno J. Mundt MD Professor and Chairman Dept Radiation Oncology Moores Cancer Center UCSD Presentation Welcome Overview of UCSD, Moores
More informationContemporary Orthopedic Care: The O.R. Through Rehabilitation
Session Descriptions and Objectives: The Impact of Orthopaedic Care, Michael West, CPA, MBA, CEO, Rothman Institute This session will provide an overview of the Health Care Reform. Conference participants
More informationIntensity-Modulated Radiation Therapy (IMRT)
Scan for mobile link. Intensity-Modulated Radiation Therapy (IMRT) Intensity-modulated radiotherapy (IMRT) uses linear accelerators to safely and painlessly deliver precise radiation doses to a tumor while
More informationOral Complications of Cancer Treatment: What the Oncology Team Can Do
Oral Complications of Cancer Treatment: What the Oncology Team Can Do Radiation to the head and neck and chemotherapy for any malignancy can cause oral side effects so debilitating that patients may tolerate
More informationChapter I Overview Chapter Contents
Chapter I Overview Chapter Contents Table Number Contents I-1 Estimated New Cancer Cases and Deaths for 2005 I-2 53-Year Trends in US Cancer Death Rates I-3 Summary of Changes in Cancer Incidence and Mortality
More informationCentralizing image and data management in radiation oncology with MOSAIQ Data Director
White Paper Centralizing image and data management in radiation oncology with MOSAIQ Data Director Authors: Laura Francis, Global Product Marketing, Elekta Software, UK and Erdal Sipahi, Information Technology,
More informationOur Department: structure and organization
EORTC meeting for Radiation Therapy Technologists: RTT s role in the modernization of radiotherapy 10th October 2014, Villejuif (Grand Paris), France Elekta Stereotactic Body Frame: transmission modelled
More informationPancreatic Cancer: FDA Approved Treatments and Clinical Trials
Pancreatic Cancer: FDA Approved Treatments and Clinical Trials Vincent J Picozzi MD MMM Virginia Mason Medical Center Seattle WA 1 Pancreatic cancer is the hardest cancer of all to treat 2 Pancreatic cancer:
More informationSeton Medical Center Hepatocellular Carcinoma Patterns of Care Study Rate of Treatment with Chemoembolization 2007 2012 N = 50
General Data Seton Medical Center Hepatocellular Carcinoma Patterns of Care Study Rate of Treatment with Chemoembolization 2007 2012 N = 50 The vast majority of the patients in this study were diagnosed
More informationIntensity Modulated Radiation Therapy (IMRT) for Thyroid Cancer
Thyroid Science 5(1):CLS1-8, 2010 www.thyroidscience.com Clinical and Laboratory Studies Intensity Modulated Radiation Therapy (IMRT) for Thyroid Cancer 1 2 5 Aruna Turaka, MD, Tianyu Li, MS, Jian Q. Yu,
More informationCase Number: RT2009-124(M) Potential Audiences: Intent Doctor, Oncology Special Nurse, Resident Doctor
Renal Cell Carcinoma of the Left Kidney Post Radical Surgery with pt4 Classification with Multiple Lung and Single Brain Metastases: the Role and Treatment Consideration of Radiotherapy Case Number: RT2009-124(M)
More informationManagement of low grade glioma s: update on recent trials
Management of low grade glioma s: update on recent trials M.J. van den Bent The Brain Tumor Center at Erasmus MC Cancer Center Rotterdam, the Netherlands Low grades Female, born 1976 1 st seizure 2005,
More informationRadiation Therapy for Cancer Treatment
Radiation Therapy for Cancer Treatment Guest Expert: Kenneth, MD Associate Professor of Therapeutic Radiology www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center Answers with Dr. Ed and
More informationThe Cancer Center of Chester County Annual Report 2006 With statistical data from 2005
06 The Cancer Center of Chester County Annual Report 2006 With statistical data from 2005 2005 Statistical Report Community Screenings Screening Participants Normal Results Referred for Follow-up Colon
More informationIn 1946 Harvard physicist Robert Wilson (1914-2000) suggested:
In 1946 Harvard physicist Robert Wilson (1914-2000) suggested: Protons can be used clinically Accelerators are available Maximum radiation dose can be placed into the tumor Proton therapy provides sparing
More informationThere must be an appropriate administrative structure for each residency program.
Specific Standards of Accreditation for Residency Programs in Radiation Oncology 2015 VERSION 3.0 INTRODUCTION The purpose of this document is to provide program directors and surveyors with an interpretation
More informationHealth Information. Technology and Cancer Information Management. Health Information Technology & Cancer Information Management 363
Health Information Technology & 363 Health Information Technology and Cancer Information Management Opportunities in the health information field have expanded with changes in health care delivery, utilization
More informationGUIDELINES FOR THE MANAGEMENT OF LUNG CANCER
GUIDELINES FOR THE MANAGEMENT OF LUNG CANCER BY Ali Shamseddine, MD (Coordinator); as04@aub.edu.lb Fady Geara, MD Bassem Shabb, MD Ghassan Jamaleddine, MD CLINICAL PRACTICE GUIDELINES FOR THE TREATMENT
More informationFoundations of Oncology Nursing Practice
Foundations of Oncology Nursing Practice Course Syllabus Course Lead:, RN, MN, BScN, CON(C) Associate Faculty:, RN, CON(C) Last updated January 27, 2011 Course Description: This online course will introduce
More informationThomas A. Kollmorgen, M.D. Oregon Urology Institute
Thomas A. Kollmorgen, M.D. Oregon Urology Institute None 240,000 new diagnosis per year, and an estimated 28,100 deaths (2012) 2 nd leading cause of death from cancer in U.S.A. Approximately 1 in 6 men
More informationBig Data and Oncology Care Quality Improvement in the United States
Big Data and Oncology Care Quality Improvement in the United States Peter P. Yu, MD, FACP, FASCO President, American Society of Clinical Oncology Director of Cancer Research, Palo Alto Medical Foundation
More informationMultidisciplinary Head and Neck Cancer Clinic and Adherence with Speech Pathology
The Laryngoscope VC 2011 The American Laryngological, Rhinological and Otological Society, Inc. Multidisciplinary Head and Neck Cancer Clinic and Adherence with Speech Pathology Heather Starmer, MA, CCC-SLP;
More informationIBA Proton Therapy. Biomed days 2015. Vincent Bossier. System Architect Vincent.bossier@iba-group.com. Protect, Enhance and Save Lives
Vincent Bossier System Architect Vincent.bossier@iba-group.com IBA Proton Therapy Biomed days 2015 Protect, Enhance and Save Lives 1 Agenda AN INTRODUCTION TO IBA WHY PROTON THERAPY CLINICAL WORKFLOW TREATMENT
More informationHow TARGIT Intra-operative Radiotherapy can help Older Patients with Breast cancer
How TARGIT Intra-operative Radiotherapy can help Older Patients with Breast cancer Jeffrey S Tobias, Jayant S Vaidya, Frederik Wenz and Michael Baum, University College Hospital, London, UK - on behalf
More informationClinical Trial Design. Sponsored by Center for Cancer Research National Cancer Institute
Clinical Trial Design Sponsored by Center for Cancer Research National Cancer Institute Overview Clinical research is research conducted on human beings (or on material of human origin such as tissues,
More informationBreast Health Program
Breast Health Program Working together, for your health. Breast Health Program The Breast Health Program at The University of Arizona Cancer Center offers patients a personalized approach to breast cancer,
More informationR E X C A N C E R C E N T E R. Annual Report 2012. Rex Cancer Care Committee 2012 On behalf of the Rex Cancer Center & Rex Health Care
R E X C A N C E R C E N T E R Annual Report 2012 Rex Cancer Care Committee 2012 On behalf of the Rex Cancer Center & Rex Health Care An American College of Surgeons Commission on Cancer Accredited Comprehensive
More informationDental Health Following Childhood Cancer Treatment
Following Childhood Cancer Treatment Treatment for cancer during childhood often increases the risk for dental problems. As a childhood cancer survivor, it is important for you to understand the reasons
More information