Curriculum Vitae Lies Geboes Doctor in Medical Science

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1 Curriculum Vitae Lies Geboes Doctor in Medical Science Personalia Name: Birth: Addresse : Civil State: Lies Geboes 29/05/1982, Herentals Teunenpad 2, 2250 Olen, Belgium Married, mother of 2 children Studies Secundair Onderwijs Wetenschappen-Wiskunde Sint-Jozefscollege, Herentals Biomedical Sciences Catholic University of Leuven, Belgium e Bachelor Cum Laude e Bachelor Cum Laude e Master Magna Cum Laude e Master Magna Cum Laude Thesis: Importance of cellular and humoral immunity in the pathogenesis of collagen-induced arthritis: a study in interferon-gamma receptor knockout mice (IFN- R KO) and wild type mice. Promoter: Prof. Dr. P. Matthys Faculty of Medicine, Department of Microbiology en Immunobiology Rega Institute, Laboratory of Immunobiology Doctor in Medical Science Catholic University of Leuven, Belgium Thesis: Regulation of osteoclast differentiation and function in mouse arthritis models. Promoter: Prof. Dr. P. Matthys Faculty of Medicine, Department of Microbiology en Immunobiology Rega Institute, Laboratory of Immunobiology Work experience September 2004-oktober 2006: PhD student (IUAP), Catholic University of Leuven, Belgium, Rega Institute, Faculty of Medicine, Department of Microbiology and Immunology, Laboratory of Immunobiology

2 Oktober th of June 2009: PhD student, Aspirant FWO, Catholic University of Leuven, Belgium, Rega Institute, Faculty of Medicine, Department of Microbiology and Immunology, Laboratory of Immunobiology 23 th of June th of February 2010: Postdoctoral researcher, Catholic University of Leuven, Belgium, Rega Institute, Faculty of Medicine, Department of Microbiology and Immunology, Laboratory of Immunobiology 16 th of March 2010-at present: Postdoctoral researcher, Hasselt University, Department of Morphology & BIOMED Institute, Belgium Supervisor master students : : Merijn Vanhee, Bio-engineer Title: Inhibition of collagen-induced arthritis in IFN- R KO mice by administration of anti-mac-1 antibodies: analysis of the mechanism : Valerie Uyterhoeven, Master in Biomedical Sciences Title: The underlying pathogenesis of collagen type II specificity of CD11b + expansion in collagen-induced arthritis and synergy of cytokines in in vitro osteoclastogenesis : Wim Pierson, Master in Biomedical Sciences Title: The origine of osteoclastprecursors in a mice model of arthritis Supervisor PhD students : 2010-at present: Sofie Nelissen, Hasselt University 2010-at present: Ingrid Meex, Hasselt University 2011-at present: Tim Vangansewinkel, Hasselt University Supervisor of practical courses (Immunology): Students 2 e bachelor Biomedical Sciences Certificates Certificate Radioprotection: 2007 Certificate Expert laboratory animal leader : 2006

3 List of Publications Lies Geboes Articles in internationale journals B. De Klerk, Geboes L., Hatse S., Kelchtermans H., Meyvis Y., Vermeire K., Bridger G., Billiau A., Schols D. and Matthys P Pro-inflammatory properties of stromal cellderived factor-1 (CXCL12) in collagen-induced arthritis. Arthritis Res. Ther. 7: R1208-R1220 H. Kelchtermans, Struyf S., De Klerck B., Mitera T., Alen M., Geboes L., Van Balen M., Dillen C., Put W., Gysemans C., Van Damme J. and Matthys P Protective role of IFN- in collagen-induced arthritis conferred by inhibition of mycobacteria-induced granulocyte chemotactic protein-2 production. J. Leukocyt. Biol. 81(4): L. Geboes, De Klerck B., Van Balen M., Kelchtermans H., Mitera T., Boon L., De Wolf- Peeters C. and Matthys P Freund s complete adjuvant induces arthritis in mice lacking a functional interferon-gamma receptor by triggering tumor necrosis factor alpha-driven osteoclastogenesis. Arthritis Rheum. 56(8): L. Lenaerts, Kelchtermans H., Geboes L., Matthys P., Verbeken E., De Clercq E. and Naesens L Recovery of the humoral immunity is critical for successful antiviral therapy in disseminated mouse adenovirus type I infection. Antimicrob. Agents Chemother. 52(4): H. Kelchtermans*, L. Geboes*, Mitera T., Huskens D., Leclercq G. and Matthys P Activated CD4 + CD25 + regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis. Ann. Rheum. Dis. May 14 (*Kelchtermans and Geboes contributed equally) L. Geboes, Dumoutier L., Kelchtermans H., Schurgers E., Mitera T., Renauld JC and Matthys P The Th17 cytokine IL-22 plays a pro-inflammatory role in collagen-induced arthritis in C57Bl/6 mice. Arthritis Rheum. 60(2): H. Kelchtermans, Schurgers E., Geboes L., Mitera T., Van Damme J., Van Snick J., Uyttenhove C. and Matthys P Effector mechanisms of IL-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma. Arthritis Res. Ther. 11(4): R122 E. Schurgers, Kelchtermans H., Mitera T., Geboes L. and Matthys P Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T cell proliferation and collagen-induced arthritis. Arthritis Res Ther. 12(1):R31

4 F. Boato, Rosenberger K., Nelissen S., Geboes L., Nitsch R. and Hendrix S Interleukin- 1 beta increases mortality and impairs axonal plasticity, functional recovery and lesion development after spinal cord injury (Resubmitted, JNEN) M. Matmati, Jacques P., Maelfait J., Sze E., Verheugen E., McGuire C., Vereecke L., Geboes L., Matthys P., Staelens S., Chu Y., Schmidt-Supprian M., Pasparakis M., Elewaut D., Beyaert R. and Van Loo G A20 deficiency in myeloid cells triggers murine erosive arthritis. (Submitted, Science) L. Geboes, Schurgers E., Maes C., Kelchtermans H., Mitera T., Vereecke L., Leclercq G., Carmeliet G., Beyaert R., Pasparakis M., Van Loo G., Matthys P. Increased collagen-induced arthritis and osteoclastogenesis in mice with a TRAF6 deficiency in the myeloid cell lineage. (in preparation, 2011) Poster presentations or oral presentations on national and international congresses and symposia, published as an abstract Geboes L. Freund's adjuvant induces osteoclastogenesis and arthritis in mice lacking a functional interferon-gamma receptor. 1 the Young Investigator Meeting Mons (Belgium), 21 september 2006 Geboes L., B. De Klerck, M. Van Balen, H. Kelchtermans, T. Mitera, C. De Wolf-Peeters, A. Billiau and P. Matthys Freund's adjuvant induces osteoclastogenesis and arthritis in mice lacking a functional interferon-gamma receptor. European Cytokine Network vol.17 supplement: p114 Kelchtermans H., S. Struyf, B. De Klerck, T. Mitera, M. Alen, L. Geboes, C. De Wolf- Peeters, A. Billiau and P. Matthys Protective role of interferon-gamma in collageninduced arthritis conferred by inhibition of granulocyte-chemotactic protein-2. European Cytokine Network vol.17 supplement: p77 Geboes L., B. De Klerck, M. Van Balen, H. Kelchtermans, T. Mitera, C. De Wolf-Peeters, A. Billiau and P. Matthys Freund s adjuvant induces osteoclasogenesis and arthritis in mice lacking a functional IFN receptor. Abstractbook, 10th Belgian Congress on Rheumatology, Mons, September, p.45 *Kelchtermans H., *Geboes L., T. Mitera, D. Huskens, G. Leclercq and P. Matthys. Activated CD4 + CD25 + regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis. Annual Meeting of the Belgian Immunological Society, november 2007, Gent. ( * Kelchtermans and Geboes contributed equally) Geboes L. Activated CD4 + CD25 + regulatory T cells inhibit osteoclastogenesis and collageninduced arthritis. 2 nd International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems. Rhodos (Greece), 8 th -13 th june, 2008 Evelien Schurgers, Hilde Kelchtermans, Tania Mitera, Lies Geboes and Patrick Matthys. The role of interferon-γ on the immunomodulatory properties of murine mesenchymal stem cells in

5 T cell proliferation and in collagen-induced arthritis. 2 nd European Congress of Immunology. September , Berlin, Germany. Hilde Kelchtermans, Evelien Schurgers, Lies Geboes, Tania Mitera, Jo Van Damme, Jacques Van Snick, Catherine Uyttenhove and Patrick Matthys. Effector functions of IL-17 in collagen-induced arthritis and the inhibition by IFN-γ. 2 nd European Congress of Immunology. September , Berlin, Germany. M. Matmati, Jacques P., Maelfait J., Sze E., Verheugen E., McGuire C., Vereecke L., Geboes L., Matthys P., Staelens S., Chu Y., Schmidt-Supprian M., Pasparakis M., Elewaut D., Beyaert R. and Van Loo G. A20 deficiency in myeloid cells triggers murine erosive arthritis. Eular meeting, 16 th -19 th of June, Rome, Italy Oral presentations Importance of osteoclastogenesis and innate immune aspects in experimental arthritis. Seminar in the framework of the PhD program, April 2008, Rega Institute, Leuven (Belgium) Osteoclasts: crucial cells in bone modeling and remodeling. Seminar in the framework of the PhD program, March 2009, Rega Institute, Leuven (Belgium) Regulation of osteoclast differentiation and function in mouse arthritis models. Public defence PhD, 22 th of June 2009, Universiteitshallen, Leuven (Belgium) Acute stress in spinal cord injury. BIOMED seminarie, 13 th of December 2010, Universiteit Hasselt, BIOMED Instituut, Diepenbeek Awards Winner of a Travel Award on the 2 th international congress on Osteoimmunology, June 2008, Rhodos (Greece)