Course Syllabus Bioactive Compounds from Natural Origins

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1 Course Syllabus Bioactive Compounds from Natural Origins Course title Bioactive Compounds from Natural Origins สารออกฤทธ ทางช วภาพจากธรรมชาต Code Credits 3(3-0) Prerequisite - Day/time/place Friday/ hr Course Description occurrence, isolation, characterization, identification, biosynthesis and activity profile of biologically active compounds from natural origin แหล งท มา การสก ดแยก การหาค ณสมบ ต การพ ส จน เอกล กษณ การช วส งเคราะห และ ฤทธ ของสารออกฤทธ ทางช วภาพจากธรรมชาต Objectives After completing this course, students will know the occurrence, isolation, characterization, identification, biosynthesis and activity profile of biologically active compounds from natural origin. Student Evaluation Procedures Students performance will be evaluated by midterm & final examinations: Scores from lecture 100%, i.e., 7.7% for each topic* * Depends on each lecturer. The lecturer may evaluate the students by midterm/final exam and/or class assignments. Grading: 80% up A B B C C D D <50% F References 1. Evans, W.C. Trease and Evans Pharmacognosy. 15th ed. London: Harcourt Publishers; Robbers, J.E., Speedie, M.K., Tyler, V.E. Pharmacognosy and Pharmacobiotechnology. Baltimore: William & Wilkins; Samuelsson, G. Drugs of Natural Origin. Stockholm: Swedish Pharmaceutical Press;

2 Instructors Associate Professor Dr. Ingkaninan Assistant Professor Dr. Ampawan Sriwilai Assistant Professor Sirinthorn Pisutthanan Assistant Professor Dr. Anan Ounaroon Associate Professor Dr. Anuchit Plubrukarn* Dr. Dumrongsak Pektong Assistant Professor Dr. Supaporn Lamlertthon** Acharn Nuntika Prommee*** * Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, PSU ** Department of Microbiology, Faculty of Medical Sciences *** Department of Thai Traditional Medicines, Faculty of Public Health Course director: Ingkaninan: Contacting number 3618 or k_ingkaninan@yahoo.com 2

3 Class Schedule Friday Room 2103 Date Topic Content Instructor 1 (Jan 8) hr Class Introduction Drug Production Introduction Nomenclature Cultivation of medicinal plants Collecting and harvesting medicinal plants Quality control of crude drug 2 (Jan 11, Mon) ) 3 (Jan 18, Mon) ) 4 (Jan 29) Formation of pharmacologically active compounds in plants- Biosynthesis (1hr) /primary metabolites (2 hours) deriving from shikimic acid deriving from Photosynthesis Biosynthetic pathway Classification of natural products Research in biosynthesis pathways of natural products Primary metabolites Monosaccharide/disaccharides/ polysaccharides Gums and mucilages Sugar alcohols closely related to carbohydrates Peptides and proteins Fats/waxes Biosynthesis of shikimic acid Gallic acid and tannins Volatile oils Substances formed from phenylpropanes by shortening of sidechain Coumarins and furanocoumarins The acylpolymalonate pathway Flavonoids Macrolides ( )/ (2.6%) Ampanwan ( ) (5.1%) Ampawan ( ) (5.1%) ( ) (2.6%) Ampawan ( ) (5.1%) 3

4 5 (Feb 12) acetate anthraquinones ( ) (2.6%) deriving from acetate (continued) The mevalonic acid pathway Monoterpenes Sesquiterpenes Diterpenes Triterpenes Steroids Cardiac glycosides Tetraterpenes 6 (Feb 12) ) 7 (Feb 19) Thai traditional medicines Herbal drugs in Thailand Principle of Thai traditional medicines Thai traditional pharmacy (เภส ชกรรมแผน ไทย) Research in Thai traditional pharmacy Herbal drugs in National list of essential Medicines Herbal drugs in the Primary Health Cares Midterm Exam (Feb 23-27) Nuntika Sirinthorn 4

5 Date Topic Content Instructor 8 4) Plant Tissue and cell culture Callus cultures, Suspension cultures, Organ cultures and regeneration of plants Environmental factors of importance for plant tissue and cell culture Tissue and cell culture in plant bleeding Micropropogation of plants Industrial production of natural products by plant and cell culture Methods for increasing the production Anan 9 18) deriving from amino acids of secondary metabolites glycosides Antibiotics Cyanogenetic glycosides and glucosinolates Amino alkaloids Pyridine and piperidine alkaloids Tropane alkaloids Pyrolizidine alkaloids Anuchit 10 19/ ) 11 19/ ) Alkaloids (continued) Marine Natural products Quinolizidine alkaloids Isoquinoline alkaloids Bisbenzylisoquinoline alkaloids Indole alkaloids Quinoline alkaloids Imidazole alkaloids Overview of marine natural products Drugs from the sea Some interesting marine natural products Anuchit Anuchit 5

6 12 (April 1) 13 (April 1, )) 14 (April 8) 15 (April 22) Antimicrobials from natural origins Herb-drug interaction and synergistic effect of phytomedicines Self study/tutorials Self study/tutorials Antimicrobials Antimicrobials from natural origins Applications of natural products for antimicrobial purpose: drugs, cosmetics, natural food preservatives Examples of some interesting antimicrobial from natural products Herb-drug interaction Synergy and other interaction in phytomedicines Self study/tutorials on bioactive compounds from Natural Origins Self study/tutorials on bioactive compounds from Natural Origins Final Exam April, 23 May 8 Supaporn Dumrongsak 6

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