CURRICULUM VITAE. EDUCATION 10/ /2013 Ph.D. in Molecular Medicine (School of Medicine, University of Torino, Italy)

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1 PERSONAL INFORMATION CURRICULUM VITAE EDUCATION 10/ /2013 Ph.D. in Molecular Medicine (School of Medicine, University of Torino, Italy) 10/ /2006 B.Sc., M.Sc. in Biomedical Sciences, University of Torino, Italy RESEARCH AND PROFESSIONAL EXPERIENCES 01/11/2015 now 01/ /2015 Universitatsspital Basel, Basel, Switzerland Position: Post Doc, Laboratory of Cancer Immunotherapy Supervisor: Prof. Alfred Zippelius Washington University School of Medicine, St. Louis (MO), USA Position: Post Doc Research Associate Supervisor: Prof. Roberta Faccio Dickkopf-related protein 1 (Dkk1) regulates the expansion and function of myeloid derived suppressor cells in cancer. 06/ /2013 Washington University School of Medicine, St. Louis (MO), USA Position: PhD student (last year of PhD programme) Supervisor: Prof. Roberta Faccio 10/ /2013 University of Torino, School of Medicine, Molinette Hospital, Italy Position: PhD student Supervisor: Prof. Mirella Giovarelli, Dr. Riccardo Ferracini. Characterization of breast cancer stem-like cells ability to metastasize to bone: a human in mice model of bone metastasis (Ph.D. thesis title). 09/ /2009 CeRMS (Center for Research and Medical Studies), Molinette Hospital, Italy Position: Research Fellow Supervisor: Dr. Riccardo Ferracini Role of kidney, breast and lung cancer stem cells in promoting bone metastases 10/ /2006 Department of Molecular Biology, Molinette Hospital, University of Torino, Italy Position: M.Sc. student Supervisor: Prof. Enzo Ghigo. Prof. Alloatti Growth hormone-releasing hormone GHRH promotes surivival of cardiac myocytes in vitro and protect against ischaemia-reperfusion in rat heart (M.Sc. thesis title) Lucia D Amico, PhD 1

2 TEACHING AND SUPERVISION EXPERIENCE /2015 Supervisor of PhD students, Prof. Faccio R, Washington University School of Medicine, St. Louis (USA). TECHNICAL SKILLS More than 6 years of experience in animal tumor models (LTK1 and LTK2 certificates) Strong experience with mammalian cell culture, PBMC isolation/ handling, murine cell isolation, and establishment of primary cell cultures Strong experience in phenotypic and functional characterization of mouse and human immune cells by FACS, ELISA/ELISPOT. Strong experience with bead cell sorting (MACS or Auto-MACS) Good experience in Immunofluorescence and IHC analysis LANGUAGES Italian: native speaker English : excellent command / highly proficient in spoken and written English French: basic communication skills / working knowledge Lucia D Amico, PhD 2

3 SCIENTIFIC PUBLICATIONS 1. D Amico L, Capietto AH, Zamani Ali, Bumpass David, Weilbaecher K, Denardo D, Faccio R. Dickkopfrelated protein 1 (Dkk1) regulates the expansion and function of myeloid derived suppressor cells in cancer. J Exp Med. 2016, Apr 4. pii: jem Voena C, Menotti M, Mastini C, Di Giacomo F, Longo DL, Castella B, Merlo ME, Ambrogio C, Wang Q, Minero VG, Poggio T, Martinengo C, D'Amico L, Panizza E, Mologni L, Cavallo F, Altruda F, Butaney M, Capelletti M, Inghirami G, Jänne PA, Chiarle R. Efficacy of a Cancer Vaccine against ALK- Rearranged Lung Tumors. Cancer Immunol Res Dec;3(12): Bertolini G, D'Amico L, Moro M, Landoni E, Perego P, Miceli R, Gatti L, Andriani F, Wong D, Caserini R, Tortoreto M, Milione M, Ferracini R, Mariani L, Pastorino U, Roato I, Sozzi G, Roz L. Microenvironment modulated metastatic CD133+/CXCR4+/EpCAM- lung cancer initiating cells sustain tumor dissemination and correlate with poor prognosis. Cancer Res Sep 1;75(17): D'Amelio P, Sassi F, Buondonno I, Fornelli G, Spertino E, D'Amico L, Marchetti M, Lucchiari M, Roato I, Isaia GC. Treatment with intermittent PTH increases Wnt10b production by T cells in osteoporotic patients. Osteoporos Int Jun D'Amico L, Roato I. The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic tumors. JImmunol Res. 2015;2015: Voena C, Di Giacomo F, Panizza E, D'Amico L, Boccalatte FE, Pellegrino E, Todaro M, Recupero D, Tabbò F, Ambrogio C, Martinengo C, Bonello L, Pulito R, Hamm J, Chiarle R, Cheng M, Ruggeri B, Medico E, Inghirami G. The EGFR family members sustain the neoplastic phenotype of ALK+ lung adenocarcinoma via EGR1. Oncogenesis Apr 8;2:e43 7. D'Amico L, Patanè S, Grange C, Bussolati B, Isella C, Fontani L, Godio L, Cilli M, D'Amelio P, Isaia G, Medico E, Ferracini R, Roato I. Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature. Br J Cancer Jun 25;108(12): D'Amico L, Satolli MA, Mecca C, Castiglione A, Ceccarelli M, D'Amelio P, Garino M, De Giuli M, Sandrucci S, Ferracini R, Roato I. Bone metastases in gastric cancer follow a RANKL-independent mechanism. Oncol Rep Apr;29(4): D Amico L., Ruffini E., Ferracini R., Roato I. Low dose of IL-12 stimulates T cell response in cultures of PBMCs derived from Non Small Cell Lung Cancer patients. Journal of Cancer Therapy, 2012, 3, doi: /jct D Amico L., Roato I. Cross-talk between T cells and osteoclasts in bone resorption. BoneKEy Reports 2012 June 6;82(2012) doi: /bonekey D'Amelio P, Tamone C, Sassi F, D'Amico L, Roato I, Patanè S, Ravazzoli M, Veneziano L, Ferracini R, Pescarmona GP, Isaia GC. Teriparatide increases the maturation of circulating osteoblast precursors. Osteoporos Int Apr;23(4): D'Amelio P, Cristofaro MA, D'Amico L, Veneziano L, Roato I, Sassi F, Bisignano G, Saracco M, Pellerito R, Patane S, Ferracini R, Pescarmona GP, Isaia GC. Iloprost modulates the immune response in systemic sclerosis. BMC Immunol Dec 15;11(1): Roato I., Porta F., Mussa A., D'Amico L., Fiore L., Garelli D., Spada M., Ferracini R. Bone impairment in phenylketonuria is characterized by circulating osteoclast precursors and activated T cell increase. Plos One Lucia D Amico, PhD 3

4 2010 Nov 30;5(11):e D Amelio P, Roato I, D Amico L. Veneziano L, Suman E, Sassi F, Bisignano G, Ferracini R, Gargiulo G, Castoldi F, Pescarmona GP, Isaia GC. Bone and bone-marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures. Osteoporos Int., 2010 Nov 30, I. Roato, D. Caldo, L. D Amico, P. D Amelio, L. Godio, S. Patanè, F. Astore, G Grappiolo, M.Boggio, R. Scagnelli, L. Molfetta, R. Ferracini. Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues. Biomaterials 2010 Oct;31(29): Roato I, Caldo D, Godio L, D'Amico L, Giannoni P, Morello E, Quarto R, Molfetta L, Buracco P, Mussa A, Ferracini R. Bone invading NSCLC cells produce IL-7: mice model and human histologic data. BMC Cancer Jan 12;10(1): Boccalatte FE, Voena C, Riganti C, Bosia A, D'Amico L, Riera L, Cheng M, Ruggeri B, Jensen ON, Goss VL, Lee K, Nardone J, Rush J, Polakiewicz RD, Comb MJ, Chiarle R, Inghirami G. The enzymatic activity of 5- aminoimidazole-4-carboxamide ribonucleotide formyltransferase/imp cyclohydrolase (ATIC) is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALC. Blood. 2009,Mar 19;113(12): PROCEEDINGS: Satolli M., Roato I., D amico L, Mecca C., Ferracini R., Bussolati G., De Giuli M., Garetto M., Ciuffreda L., Mussa A. Mechanisms of bone metastases in gastric carcinoma (GC): preliminary results of a biological and clinical study. Annals of Oncology 2010, 21:1-132 BOOK CHAPTER: Lucia D Amico, Ilaria Roato. Osteoclasts: Morphology, Functions and Clinical Implications. Edited by: Alexander J. Brown and Johanna S. Walker Nova Science Publishers. AWARDS 10/ / / American Society for Bone and Mineral Research (ASBMR),Young Investigator Award 2015, Seattle,USA Musculoskeletal Research Center, Washington University St. Louis, MO, USA ASBMR Travel Award, Houston, USA Best Italian Project, National Congress of Italian Society of Osteoncology (ISO) Selected posters presented by the author: L. D Amico, Roberta Faccio. Musculoskeletal Symphosium, Washington University School of Medicine, St. Louis, Travel Award. L. D Amico, Capietto Aude Helene, Zamani Ali, Roberta Faccio. American Society of Bone and Mineral Research, Annual Meeting 2014, Houston, Texas, USA. Plennary poster presentation. ASBMR Young Investigator Travel Award. Lucia D Amico, PhD 4

5 L. D Amico, Patanè S., Grange C., Bussolati B., Cilli M. D Amelio P., Isaia GC., Ferracini R., Roato I. Breast cancer stem cells metastatize to bone in a human in mice model. American Society of Bone and Mineral Research, Annual Meeting, 2011, San Diego, California, USA. L. D Amico, I. Roato, S. Patanè, G. Bertolini, B. Bussolati, R. Ferracini. Cancer stem cells promote bone metastasis in osteotropic tumors. 3 rd Joint meeting of ECTS and IBMS, May , Athene, Greece. I. Roato, L. D'Amico, F. Porta, A. Mussa,.R. Ferracini. Role of T cells in the activation of osteoclastogenesis in phenylketonuria patients. American Society of Bone and Mineral Research, Annual Meeting, October , Toronto, Canada. Oral presentation (invited speaker) 11/10/2015 American Society for Bone and Mineral Research (ASBMR), Seattle, USA Lucia D Amico, PhD 5

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