E U R O P E A N ALESSANDRO AGOSTINO C U R R I C U L U M V I T A E F O R M A T PERSONAL INFORMATION WORK EXPERIENCE

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1 E U R O P E A N C U R R I C U L U M V I T A E F O R M A T PERSONAL INFORMATION Name and Surname Address ALESSANDRO AGOSTINO Telephone VIA RIVA DI RENO 60, 40122, BOLOGNA-BO, ITALY Nationality Italian Date of birth 02 SEPT 1973 WORK EXPERIENCE Jan 2010 today (5 years) Thermo Fisher Scientific (Life Sciences Solutions) & LifeTech, MONZA, Division Leader: Kent Davidson Senior Field Application Scientist HID (Human Identification) Europe Key Account Manager HID (Human identification) Italy PRODUCT DEVELOPMENT: LEADING GLOBAL PROJECTS FOR DEVELOPMENT, VALIDATION AND QC of NEW B2B PRODUCTS LINE. KEY ACCOUNT MANAGEMENT ITALY: MATERNITY LEAVE SUBSTITUTION ROLE FOR 1 YEAR AS KEY ACCOUNT MANAGER RESP. FORECAST AND SALES. SUPPORT ACTIVITY: TRAINING PROJECTS COORDINATOR, EMEA EXPERT ROLE NEXT GENERATION SEQUENCING. MARKETING ACTIVITY: DEFINING LOCAL ACTIVITIES SUCH AS SEMINARs AND USER MEETINGs, LOCAL MARKETING MATERIAL AND PROMOTIONS June 2008 Dec 2009 ( 1,5 years) Applied Biosystems part of life Technologies, MONZA, Division Leader: Marco Piccinini Support Specialist HID&QST (APM Europe), forensics and pharma-food SUPPORT ACTIVITY: PRE AND POST SALES ACTIVITIES, TRAINING PROGRAMS, TECHNICAL TROUBLESHOOTING, SHARING KNOWLEDGE WITHIN THE EUROPEAN SUPPORT TEAM, PLAYING MAYOR ROLE IN NEW PRODUCT TESTING, TRAINING OTHER SUPPORT TEAM MEMBERS ON NEW TECHNOLOGIES.. NEW PRODUCT TESTING AND IMPLEMENTATION. MARKETING ACTIVITY: GATHERING, ANALYZING AND DELIVERING INFORMATION FROM THE FIELD TO LOCAL AND EUROPEAN TEAMS ON COMPETITIVE ACTIVITY, MARKET CONDITIONS AND PRODUCTS. CUSTOMER SEGMENTATION AND MARKET ANALYSIS. DEFINING LOCAL BUSINESS STRATEGY IN CONJUNCTION WITH KEY ACCOUNT MANAGERS AND REGIONAL SALE REPS. PROACTIVELY DEVELOPING SALES OPPORTUNITIES, PROMOTIONS, DIRECT MARKETING. PREPARATION OF MARKETING AND TECH MATERIAL COOPERATING WITH USA PM AND EUROPEAN MARKETING MANAGER. May May (4 years) Miltenyi Biotec srl, BOLOGNA. Managing Dir.: Gianluca Tagliapietra Product-Marketing Specialist CliniMacs and Research, Italy Bussiness Develop. Specialist for microarray services, Italy SUPPORT ACTIVITY: PRE AND POST SALES CUSTOMERS TECH. SUPPORT, VISITS AT THE CUSTOMER SITE, DEMOS, SEMINARS, PARTECIPATION AND ORGANIZATION OF SYMPOSIA, TRAINING AND UPDATING SALE-REPS, KEEPING CONTACTS WITH PM, NEW PRODUCT RELEASES, FIELD MONITORING. MAIN RESPONSIBLE OF MACSMOLECULAR PRODUCTS DELIVERING SALES AND REVENUES. MONITORING AND COORDINATING SPECIAL PROJECTS SUCH AS TEST SITES, COOPERATIONS AND BETA TESTS. MARKETING ACTIVITY: MARKETING PLAN DEFINITION, RESPONSIBLE OF DIRECT MARKETING, ADVERTISING AND WRITING ARTICLES, COMPETITOR MONITORING, BACKUP ACTIVITY FOR THE GENERATION OF A NEW CRM SYSTEM, GENERATION OF PROMOTIONAL MATERIAL (FLYER, BROCHURES ETC), DEFINING PRICING POLICIES, COMPETITORS ANALYSIS, CUSTOMER SEGMENTATION. January 2004 May 2004 (5 months) S.I.S.M.E.R, Italian Society for Medical Reproduction, BOLOGNA. Lab. Director: Dr Cristina Magli Contractor Medical Reproduction Specialist, surgical room and lab analysis. IN VITRO FERTILIZATION, SEMEN ANALYSIS, OOCYTES PIC-KUP, ICSI AND FIVET; EMBRYO CULTURE AND QC, BASICS OF PRE-IMPLANTATION DIAGNOSIS. February 1999 December 2003 (5 years) Neurological Institute C.Besta, Molecular Neurogenetics Unit MILANO, Lab.Director: Dr. M.Zeviani PhD Student and Post Doc fellow RESEARCH PROJECTS LEADER/MANAGER FOR THE GENERATION OF GENETIC DISEASES ANIMAL MODELS AND CHARACTERIZATION OF NEW GENES&PROTEINS. Sept Dec 1998 (1,5 years) San Raffaele Institute, DIBIT-TIGET (TeletHon Institute for Gene Therapy) MILANO, Dept. Director: Dr. C.Bordignon Post Graduate Fellow HLA MOLECULAR TYPING FOR ALLELES FREQUENCIES STUDIES IN BONE MARROW TRANSPLANTATION Sept July 1997 (2 years) University of Pavia, Cytogenetics Laboratory.. Pavia, Lab Director: Prof. L. De Carli and E. Raimondi Under Graduate Fellow STUDY OF AN ARTIFICIAL HUMAN CHROMOSOME FOR GENE THERAPY PURPOSES. Page 1 - Curriculum vitae

2 WORK EXPERIENCES ABROAD Sept October 2014 (cumulative12 months) Thermo Fisher and Life Technologies EUROPE, England, Ireland, Scotland, Netherland, Finland, Germany, France, Spain, Portugal, South Africa, Botswana, Israel Dual visits, business development, customer training trainee STRATEGIC MEETING WITH KEY CUSTOMERS, ATTENDING INTERNATIONAL TRAININGS, WORKSHOPS, USER MEETINGS AND PERFORMING DUAL VISITS AND TRAININGS AT THE CUSTOMER SITES. EXTENSIVE AND ON FIELD EXPERIENCE LEADING TO EUROPEAN MARKET, PRODUCTS AND APPLICATION KNOWLEDGE. DEEP INTERACTION WITH EUROPEAN COLLEAGUES AND CUSTOMERS. May July 2008 (3 months) Miltenyi Biotec GmbH, Cologne, Germany Trainings participant ATTENDANT TO SEVERAL THEORETICAL AND PRACTICAL COURSES: BASIC AND ADVANCED TRAINING ON IMMUNOLOGY AND MACS TECHNOLOGY, BASIC AND ADVANCED TRAINING ON MACS MOLECULAR AND MICROARRAYS, BASIC CLINICAL TRAINING, BASIC AND ADVANCED TRAINING ON CLINIMACS CD34 E CD133 STEM CELLS AD CARDIO APPLICATIONS. TEAM WORK, PP PRESENTATIONS AND DISCUSSION OF THE ACTIVITIES FROM THE COURSE, MARKETING STRATEGY, COMPETITION ANALYSIS. Jun Jul 2003 (1.5 months) CSHL (Cold Spring Harbor Laboratories), NY, USA Training partecipant INTENSIVE THEORETICAL AND PRACTICAL COURSE ON MOLECULAR EMBRIOLOGY. TEAM WORK, PP PRESENTATIONS AND DISCUSSION OF THE ACTIVITIES FROM THE COURSE. Oct Nov 1999 (1,5 months) Neurologique Clinik, Wuerzburg, Germany Post-doc fellow RESEARCH ACTIVITY AND TRAINING TECHNIQUES FOR THE GENERATION OF MOUSE MODELS OF GENETIC DISEASES. EDUCATION, Institute Level in national classification Sept 1992 Jul 1997, Università degli Studi di Pavia Degree in Biological Sciences, Molecular Biology (5 years) Thesis title: Isolation and transfer of a human artificial mini-chromosome in in vitro cultured human cells 110/110 cum laude, Institute Sept 1999 Nov 2003, Università degli Studi di Pavia Specialization in Medical Genetics (PhD) 4 years Thesis title: Generation and characterization of animal models for Leigh Syndrome Level in national classification 44/50 Oct May 2007, Università degli Studi di Bologna ALMA Graduate School Distance Learning MBA Master in Business Administration (1,1/2 year) Main subjects/exams Business Strategy, Corporate Strategy, Marketing management, Control and Administration, Logistics and Production, Financial management, Information Technology management, People Management Level in national classification 27/30 Project Work: Use of stem cells for cardiac regeneration:: analysis of the potential market and business plan of a new therapeutic approach, Institute June 2009, Life Technology Project Management, Institute Sept- Dec Gustav Kaeser Sales and communication FOREING LANGUAGES SKILLS Reading skills Writing skills Verbal skills ENGLISH Page 2 - Curriculum vitae

3 . SOCIAL SKILLS ORGANISATIONAL SKILLS TECHNICAL SKILLS ARTISTIC SKILLS OTHER SKILLS COMMUNICATION IS CRUCIAL FOR THE GENERATION OF GOOD RELATIONSHIPS. I HAVE DEVELOPED GOOD TEAM WORK SKILLS THANKS TO THE ATTENDANCE TO TECHNICAL AND THEORETICAL COURSES AT INTERNATIONAL LEVEL WHERE I COULD IMPROVE MY SKILLS IN MANAGING DIFFERENT CULTURES AND BEHAVIOURAL STYLES. WORKING IN MANY DIFFERENT TEAMS HELPED ME TO IMPROVE MY TEAM ATTITUDE. EXPERIENCES ACQUIRED BY INTERACTING DIRECTLY WITH CUSTOMERS MADE ME LEARN TO COPE WITH DIFFERENT KINDS OF PEOPLE. TEACHING EXPERIENCE AT UNIVERSITY LEVEL (MASTER FORENSIC SCIENCES ) COORDINATION OF SOME COWORKERS DURING THE RESEARCH EXPERIENCE IN THE LAB ALLOW ME TO DEVELOP SKILLS SUCH AS AVAILABILITY, COMUNICATION, ACCURACY AND EFFECTIVENESS FOR THE OPTIMIZATION OF THE SOURCES AND STRENGHTS IN ORDER TO REACH THE GOALS GOOD LEVEL OF INDEPENDENT THINKING AND ACTING HAVEBEEN DEVELOPED. I AUTONOMOUSLY BROUGHT TO TERM SEVERAL PROJECTS DURING MY STUDIES, DURING THE LAB-WORK AND IN MY PRESENT JOB. I HAVE ALSO ACQUIRED SOME BASIC SKILLS IN THE COORDINATION OF SMALL TEAMS. I GENERALLY PLAN MY ACTIVITIES ACCORDING TO DEADLINES, PRIORITY ALWAYS TRYING TO DO MY BEST AND LOOKING DIRECTLY AT THE RESULTS WITHOUT WASTING TIME IN USELESS DETAILS. GOOD PROBLEM SOLVING AND TIME MANAGEMENT CAPABILITIES. DEEP EXPERIENCE IN LAB TECNIQUES (MOLECULAR BIOLOGY, EMBRYOLOGY, CELL BIOLOGY, IMMUNOLOGY, CELL CULTURE, STEM CELL CULTURE, MURINE ANIMAL MODELS, PROTEIN STUDY, SANGER SEQUENCING, REAL TIME PCR, NEXT GENERATION SEQUENCING WITH PGM PLATFORM) PROJECT MANAGEMENT, DATA ANALYSIS. PC SKILLS: USE OF DATABASE MANAGEMENT SYSTEMS, CRM (MAXIMIZER, SIEBEL, E1, SAP), OFFICE, GRAPHICS SOFTWARES, MINITAB, INTERNET, GENETIC DATABASE QUERY, USE OF SOCIAL MEDIA. MUSIC: I LOVE IT BOTH PLAYING AND LISTENING TO EVERY KIND OF MUSIC. I CAN PLAY SOME GUITAR AND PIANO DRAWING: I LIKE DRAWING HUMAN BODY AND OIL PAINTING ON CANVAS WRITING: I LIKE WRITING FLEXIBLE AND ADABTABLE IN DIFFERENT SITUATIONS, ALWAYS LOOOKING FOR NEW AND CHALLENGING OPPORTUNITIES. I M CURIOUS FOR EVERY NEW INITIATIVE AND TECHNOLOGY, FAST IN LEARNING, HONEST AND RESPECTFUL, POLITE AND OPEN WITH FRANK OPEN AND GOOD PEOPLE ESPECIALLY WITH THOSE WHO SHOW TO BE SPECIAL AND CAN TEACH ME SOMETHING GOOD. I EXPECT THE SAME FROM OTHERS. I LOVE SPORTS AND FITNESS, GYM AND GOOD QUALITY LIFE STYLE DRIVING LICENCE(S) SINCE 1992, INTERNATIONAL DRIVING LICENCE FROM ADDITIONAL INFORMATION ANNEXES AVAILABLE TO TRAVEL BOTH ON NATIONAL AND INTERNATIONAL LEVEL UP TO 50% OF THE TIME. LIST OF SCIENTIFIC PUBBLICATIONS PARTECIPATION TO CONGRESSES Page 3 - Curriculum vitae

4 ANNEX 1 LIST OF MAIN SCIENTIFIC PAPERS ON INTERNATIONAL JOURNALS 1) Revealing the challenges of low template DNA analysis with the prototype Ion AmpliSeq Identity panel v2.3 on the PGM Sequencer. Agostino A, Salata E., Watson, Berti Forensic Science International: Genetics under review 2) Quantifiler Trio kit and forensic samples management: a matter of degradation." Vernarecci S, Agostino A, Mei E., Calandro L, Montagna P. Forensic Science International: Genetics 16 (2015) ) Preliminary assessment of the prototype Yfiler Plus kit in a population study of Northern Italian males Ottaviani E., Vernarecci S., Asili P., Agostino A. Internation Journal of Legal Medicine, 2014 Sept (6) 4) Allele frequencies of the new European Standard Set (ESS) loci in a population of Southern Italy A. Barbaro, P. Cormaci and A.Agostino Forensic Science International: Genetics, 2012, Jan (6) 5) Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice. Dell'agnello C, Agostino A, Szabadkai G, Tiveron C, Zulian A, Prelle A, Roubertoux P, Rizzuto R, Zeviani M. Hum Mol Genet Feb 15;16(4): Epub 2007 Jan 8. 6) Post Transcriptional Silencing and Functional Characterization of the Drosophila melanogaster Homolog of HumanSurf1. Zordan MA, Benna C, Agostino A, Rizzo G, Piccin A, Pegoraro M, Sandrelli F, Perini G, Tognon G, De Caro R, Peron S, Te Kronnie' T, Megighian A, Reggiani C, Zeviani M, Costa R. Genetics Sep 19 7) Constitutive knocked out of Surf1 is associated with high embrionic lethality, mitochondrial disease and cytochrome c oxidase deficiency in mice" Agostino A., Invernizzi F., Tiveron C., Prelle A., Lamantea E., Giavazzi A., Battaglia G., Tiranti V., Zeviani M. Human Molecular Genetics, 2003 Feb 15;12(4): )"Mutations of ANT1, twinkle and POLG1 in asporadic progressive external ophthalmoplegia (PEO)" Agostino A., Valletta L, Chinnery P., G. Ferrari, Carrara F, Taylor G., Tiranti V. and Zeviani M Neurology, 2003 April 69, ) A novel heteroplasmic mtdna mutation in a family with heterogeneous clinical presentations Corona P., Lamantea E., Greco M., Carrara F., Agostino A., Guidetti D., Dotti MT., Mariotti C., Zeviani M. Annals of neurology, 2002 Jan, 51(1), ) New splicing-site mutations in the SURF 1 gene in Leigh sindrome patients Pequignot MO, Desguerre I, Dey R, Tartari M, Zeviani M, Agostino A, Benelli C, Fouque F, Prip-Buus C, Marchant D, Abitbol M, Marsac C. J. Biol Chem, 2001 May 4, 276 (18); ) Molecular characterization of HLA class I in Colombians carrying HLA-A2: high allelic diversity and frequency of heterozygotes at the HLA-B locus. Fleischhauer K, Agostino A, Zino E, Mazzi B, Benazzi E, Arevalo-Herrera M, Herrera S, Bordignon C Tissue Antigens Jun;53(6): ARTICLES ON ITALIAN BIOTECH MEGAZINES 1) Innovazione nell analisi della regolazione dell espressione genica: mirna e mirxplore Microarray. Biotecnologie 2000, sept ) La biologia molecolare e l isolamento di macromolecole: separazione immunomagnetica molecolare Biotecnologie 2000, june ) Soluzioni innovative per l analisi genomica: a-hyb Hibridization station e CGH service" e Silvia Guenzi Biotecnologie 2000, oct ARTICLES ON MARKETING MATERIAL 1) Technical Focus - Direct PCR Amplification of Blood Samples on Copan NUCLEIC-CARDTM Systems Using the AmpF STR Identifiler Direct PCR Amplification Kit Nicola Oldroyd, Jennifer Schroeder, Dennis Wang, FORENSIC NEWS Life Technologies Corporation 2) Technical Focus Direct PCR Amplification of Buccal Samples on the NUCLEIC-CARDCOLOR With the AmpFlSTR Identifiler Direct PCR Amplification Kit -1Life Technologies Corporation, Annalisa Gervasoni, Alice Squassina, Jill Muehling FORENSIC NEWS Life Technologies Corporation Page 4 - Curriculum vitae

5 ANNEX 2 LIST OF THE MOST RELEVANT SCIENTIFIC CONGRESSES AND MEETING ATTENDED 1) XXV Convegno Nazionale GE.F.I Genetisti Forensi Italiani, Iseo October ) Ion World Tour, Bologna, September ) ESBB Bio-banking 2013 Conference, Verona, 8-11 October ) XXIV Convegno Nazionale GE.F.I Genetisti Forensi Italiani, Pavia September ) XXIII Convegno Nazionale GE.F.I Genetisti Forensi Italiani, Assisi September ) Immune-Related Gene Polymorphism in Health and Disease, XXIV European Immunogen and Histocompatibility Conf. EFI, Firenze May ) 49 C Simposio Afi, Rimini June 2009, Oral comunication and Poster presentation 8) La biologia molecolare nel moderno laboratiorio di controllo di qualità microbiologico, Monza 10 Mar 2009, Oral comunication 9) MGM Microbiology goes Molecular workshop, Monza, 11 Mar 2009, Oral comunication 10) Workshop di Scienze Forensi, Parma 15 Nov ) MGM Microbiology goes Molecular workshop, Dublin, 4 Oct ) XXII Convegno Nazionale Genetisti Forensi Italiani GeFi, Sept ) Scuola Dottorato Silenziamento Genico, Ferrara, Jun ) X Congresso SIGU, Montecatini, nov ) Congresso SINS (società italiana neuroscienze), Verona, sept ) Mesenchimal Stem Cells (MSCs) for Regenerative medicine and Immune Regulation, Verona (VR), may ) FISV (Italian Society for Life Science), Riva del Garda (TN), 28 sept-1 oct ) AINI (Italian Association of Neuro Immunology), Ostuni (BR), sept ) V National Symposia Stem Cell and Circulating hematopoietic Progenitor, Roma, May ) VIII International Congress of the Cell Transplantation Society, Milano May ) Riunione nazionale GITMO, Bologna, May ) Focus sulle Biotecnologie, Milano, December 2005, Oral comunication 23) XXII Conferenza Nazionale di Citometria, S.Benedetto (AP), 4-8 October ) VIII Congresso SIGU, Chia Laguna (CA), Sept ) Congresso Annuale SIDE, Grado (GO), 7-10 Jun ) Riunione nazionale GITMO, Bologna, May ) Miteuro 2003, european workshop, Padova, Oct 2003, Oral comunication 28) MitEURO 2003 first plenary conference, Saariselka (Finland), apr. 2003, 2 Posters, Oral comunication 29) XI Telethon Scientific Convention, Riva del Garda, nov. 2002, Poster 30) Miteuro 2002, European Workshop, Milano, sept. 2002, Oral comunication 31) IV Congresso SIGU, Orvieto, nov. 2001, Poster 32) Euromit V, Venezia, sept ) EMBO Workshop on Mitochondrial (dys)-function, Aussois (France), may ) IX Telethon Scientific Convention, Rimini, nov. 2000, Poster 35) Mithocondrial meeting, Jaca (Spain), 9-12 jun. 2000, Oral comunication Bologna, January 30th, 2015 Page 5 - Curriculum vitae

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