Claudio Pisano: Personal Data

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1 Date f Birth: May 16, 1954 Place: Benevent Citizenship: Italian Status: Married Hme Address: Via Cherubini,60 Aprilia (LT) Mb Mail: Claudi Pisan: Persnal Data EDUCATION 1984 Master Degree in Bilgy University Federic II, Naples, Italy. POSITIONS/CHRONOLOGY Frm 2013: Directr f Preclinical R&D (Bigem) Department This psitin gathered the fllwing respnsabilities/activities : Leading f the rerganitin f the Department by fcusing n: quality research, imprvement, self respnsibility in the verall team wrk, hiring new emplyees with innvative skills, increase f natinal and internatinal cllabratins. Inductin and investigatin n new research prjects Increase in revenue frm scientific cllabratins ffered as a service (CRO activities) t Academia and Cmpanies Frm 1998 t 2012: Directr f Onclgy Department, Sigma Tau, Pmezia, Italy This psitin gathered the fllwing respnsabilities/activities: Leading f the creatin and rganitin f the Department f Cellular Physipathlgy int Onclgy, by fcusing n: general gals, persnal and team milestnes, grup mtivatin, cllabratin, self respnsibility in the verall team wrk, hiring new emplyees with innvative skills and quality imprvement wrk plans. Inductin and investigatin f new targets/mlecules/therapeutic appraches The newly created Onclgy Department was cmpsed f 40 permanent staff members: 70% graduated (with a PhD degree) and 30% labratry technicians. Management f external research activities (mainly internatinal cllabratins in Academia, CRO) 1

2 Evaluatin f new therapeutic pprtunities (prjects/drug in licensing) Gathering f key data fr new patent applicatins. Prmting f research activities/results thrugh scientific meetings, scientific publicatins. Permanent member f the Scientific Cmmitee f Sigma Tau In this rle he administered a budget f apprximately 7 M /year Prmter and Leader f several research prjects c-funded by the Italian MIUR and by the Eurpean Cmmunity fr a ttal budget > 35 millin eur. Mre in detail the rles cvered in different Research Prject: Prgett PNR Onclgia Tema 12 " Svilupp di terapie antitumrali basate sul trasferiment genic" (Decret MIUR Respnsable sub-netwrk Prgett PNR Tema 13 Ricerca " Validazine di metdlgie e mdelli perterapie a lgica differenziativa reglativa della crescita" (Decret MIUR )- Prject Leader Prgett PNR Onclgia Tema 11 " Identificazine di mlecle cinvlte nella rispsta immunitaria e valutazine del lr ptenziale antitumrale" (Decret MIUR )- Respnsable sub-netwrk Prgett Angigenesi "Identificazine e svilupp di nuve mlecle farmaclgicamente attive nel cntrll dei prcessi di adesine inter-cellulari cinvlti nella reglazine dell'angigenesi, della crescita e metastatizzazine tumrale, della trmbsi e dell'infiammazine" (Decret MIUR 08/04/2002)- Prject Leader Prgett GPS Tumri cerebrali " Nuve strategie di ricerca e svilupp per ttenere farmaci efficaci nella cura dei tumri cerebrali e del pancreas" (Decret MIUR 11/10/2007)-Respnsable sub-netwrk Prgett GPS Bisint "Nuve terapie antitumrali basate sull'impieg di tecnlgie innvative (Decret MIUR 27/07/2007) Durata 14/07/ /07/2010 Respnsable sub-netwrk Prgett HEPARANASE- " Heparanase inhibitrs in antiangigenic and antimetastatic cancer therapy"eu Prject(QLK3-CT ) ( )- subnetwrk Leader Prgett PREDECT: Nvel cmplex mdels fr cancer- IMI Prject ( ) 60 Respnsable WP Frm 1997: Directr f the Cellular Physipathlgy Department, Sigma Tau, Pmezia, Italy 2

3 This psitin gathered the fllwing respnsabilities/activities: Leading in the creatin/rganizatin f these new deparment: supervising and directing the research activities f 27 permanent staff members. Respnsible fr screening f small mlecules with activity n SNC and cardivascular receptrs; natural prducts acting as prtective agents against CNS/PNS prtein/drugs inducing txicity. Leading research n the prf f cncept/mechanism f actin f pharmaclgical targets/new mlecules. Prpser and Prject Leader f new discvery prjects including mlecules/targets in nclgy and in delivery systems (lipsmes, etc...). Permanent member f the Scientific Cmmitee f Sigma Tau Active member f Glbal Prject teams In this rle he administered a budget f apprximately 5 M /year Research cntract at Centr di Genetica Evluzinistica Natinal Research Cuncil (C.N.R.), Dept. f Genetics and Mlecular Bilgy - University f Rme La Sapienza Rme ( ) 09/ /1996 Staff research scientist at Centr di Genetica Evluzinistica Natinal Research Cuncil (C.N.R.), Dept. f Genetics and Mlecular Bilgy - University La Sapienza, Rme Including the fllwing research activities: develpment f new immun-histchemical techniques such as prtein purificatin and prductin f plyclnal and murine mnclnal antibdies directed against specific prteins f interest, clning and expressin f prteins aimed t study the mechanism f gene mdulatin. Inductin f genetic mutatin by transpsn in Drsphila and their phentypic and mlecular characterizatin. characterizatin f prteins assciated t highly hypermetylated human prmter genes. RESEARCH/RESULTS As the Directr f Preclinical R&D (Bigem) Department (2013) Main results: The department has reached an rganizatin in which everybdy has clear respnsibilities and in which all aspects f management have clear referents. The quality and prductivity f the research has been implemented 3

4 The revenue cming frm research service activities fr academia r pharmaceutical cmpanies has been increased by 6 times As the Directr f Onclgy Department Frm 1998 t Main results: ALC (acetylcarnitine) as an enhancer f gene expressin in transfected cell: PATENT GENERATION. ALC and their derivatives as prtective agents against peripheral neurpathy and bne marrw injury induced by antitumr drugs and characterizatin f their mechanism f actin (These studies have led t Clinical Investigatin: ALC is currently in Phase III f Clinical Trial in NSCLC in cmbinatin with cisplatin). Identificatin and develpment n new nanparticle as vehicle fr drugs and gene delivery (These studies have led t the Phase II f Clinical Trial fr tpic delivery f PG s). Screening and selectin f new mlecules fr their anti-tumr and/r antiangigenic activity.mlecular characterizatin f mechanism f actin and efficacy. These studies have led t investigate in several clinical trials the selected mlecules having the mst apprpriate and specific pharmaclgical prfile. In particular: Gimatecan (Phase III, varian cancer): Gimatecan has been the bject f a cmmercial agreement with Nvartis fr its Clinical Develpment. Namitecan (Phase II, cervix, H&N and neurblastma cancers ) Adartene (Phase I)- suggested indicatin in Phase II : Ovarian cancer in cmbinatin with Platins/taxanes SST0001 (Phase I-II, Multiple Myelma) New patents generatin Papers n these tpics have been published in peer reviewed Internatinal Jurnals As Directr f the Cellular Physipathlgy Department (1997) Main results: Characterizatin f mechanism at bases f gastrsparing effect f a new ST (NSAID) anti-inflammatry drug, named Eufans, launched in Italy in Carnitine as a natural smtic mlecule. Tw patents granted fr tissue preservatin and use in dialysis (These studies have suggested clinical investigatin studies that have led t the apprval by FDA fr its use in dialysis) 4

5 New patents generatin Papers n these tpics have been published in peer reviewed Internatinal Jurnals As a Investigatr at the Genetic and Mlecular Bilgy, Centr di Genetica Evluzinistica Natinal Research Cuncil (C.N.R.), Dept. f Genetics and Mlecular Bilgy - University f Rme La Sapienza Rme ( ) Studies n specific genes/mechanisms/prtein cntrlling the transictin between the transcribed euchrmatin and the trancriptinal inactive heterchrmatin in Drsphila melangaster. Characterizatin f multiple prtein-binding elements f muse CpG island. Papers n these tpics have been published in peer reviewed Internatinal Jurnals In a year f activities: ACADEMIC APPOINTMENTS AND ADDITIONAL PROFESSIONAL ACTIVITIES: In 2014, MIUR has granted t Dr. Pisan f Abilitazine Scientifica Nazinale di Prfessre I Fascia per gli insegnamenti di Bilgia Mleclare (05/E2) e Bichimica Generale e Bichimica Clinica (05/E1). Previusly: Annual Cntract as Prfessr fr teaching Pharmacgenmics at the University f Sanni, Faculty f Bilgy ( ) and Pharmaclgy at the University La Sapienza Rme, Faculty f Medicine ( ), Italy, Intrductin t Science and Genetic Technlgy at Bigem Campus (2014) (Faculty f Bilgy f Università degli Studi di Bari Ald Mr, Università degli Studi di Fggia, Università degli Studi di Napli Federic II, Università degli Studi del Sanni). In additin t his scientific activity, Dr. Pisan has been supervisr/tutr f students fr Degree and PhD Thesis. Invited speaker t several internatinal meetings; reviewer fr different scientific jurnals Cancer Research, Mlecular Cancer Therapeutics, Eurpean Jurnal f Cancer, Jurnal f Medicinal Chemistry, etc); Invited as scientific expert at Eurpean Cmmissin fr HEALTH Prjects (several times). Dr. Pisan as authr r c-authr has published mre than 130 peer reviewed publicatins in internatinal scientific jurnals and he is the authr f 31 internatinal patents 5

6 PUBBLICATIONS: (last 5 years) 1. Hiba El Hajj, Bariaa Khalil, Btheina Ghandur, Rihab Nasr, Sharif Shahine, Akram Ghantus, Rana Abdel-Samad, Ansam Sinjab, Hideki Hasegawa, Mark Jabbur, William W Hall, Ghazi Zaatari, Ghassan Dbaib, Claudi Pisan, Ali Bazarbachi, and Nadine DarwichePre-clinical efficacy f the synthetic retinid ST1926 fr treating adult T cell leukemia/lymphma (BLOOD/2014/accepted) 2. Taddei M, Ferrini S, Gianntti L, Crsi M, Manetti F, Giannini G, Vesci L, Milazz FM, Allatti D, Guglielmi MB, Castrina M, Cervni ML, Barbarin M, Fderà R, Carll V, Pisan C, Armarli S, Cabri W. Synthesis and evaluatin f new Hsp90 inhibitrs based n a 1,4,5-trisubstituted 1,2,3-triazle scaffld. J Med Chem Mar 27;57(6): Pisan C, Vldavsky I, Ilan N, Zunin F. The ptential f heparanase as a therapeutic target in cancer.bichem Pharmacl May 1;89(1): Cincinelli R, Muss L, Merlini L, Giannini G, Vesci L, Milazz FM, Carenini N, Pereg P, Penc S, Artali R, Zunin F, Pisan C, Dallavalle S.7-Azaindle-1- carbxamides as a new class f PARP-1 inhibitrs. Birg Med Chem Feb 1;22(3): De Cesare M1, Lauricella C, Vernese SM, Cminetti D, Pisan C, Zunin F, Zaffarni N, Zuc V.Synergistic antitumr activity f cetuximab and namitecan in human squamus cell carcinma mdels relies n cperative inhibitin f EGFR expressin and depends n high EGFR gene cpy number. Clin Cancer Res Feb 15;20(4): Crss-Knrr S, Lu S, Perez K, Guevara S, Brilliant K, Pisan C, Quesenberry PJ, Resnick MB, Chatterjee D. RKIP phsphrylatin and STAT3 activatin is inhibited by xaliplatin and camptthecin and are assciated with pr prgnsis in stage II cln cancer patients.bmc Cancer Oct 8;13:463. di: / PMID: Cassinelli G, Lanzi C, Trtret M, Cminetti D, Petranglini G, Favini E, Zaffarni N, Pisan C, Penc S, Vldavsky I, Zunin F.Antitumr efficacy f the heparanase inhibitr SST0001 alne and in cmbinatin with antiangigenic agents in the treatment f human pediatric sarcma mdels.bichem Pharmacl May 15;85(10): di: /j.bcp Dal Piaz F, Vassall A, Temraz A, Ctugn R, Belisari MA, Bifulc G, Chini MG, Pisan C, De Tmmasi N, Braca A.A chemical-bilgical study reveals C9-type iridids as nvel heat shck prtein 90 (Hsp90) inhibitrs.j Med Chem Feb 28;56(4): di: /jm301398y. Epub 2013 Feb Fratelli M, Fisher JN, Parni G, Di Francesc AM, Pierri F, Pisan C, Gdl K, Marx S, Tebbe A, Valli C, Gianni M, Stravalaci M, Gbbi M, Tera M, Garattini E. New insights int the mlecular mechanisms underlying sensitivity/resistance t the atypical retinid ST1926 in acute myelid leukaemia cells: the rle f histne H2A.Z, campdependent prtein kinase A and the prteasme.eur J Cancer Apr;49(6): di: /j.ejca

7 10. Mec D, Di Francesc AM, Cusan G, Bucci F, Pierri F, Patriarca V, Trella AR, Pisan C, Riccardi R. Preclinical evaluatin f the nvel 7-substituted camptthecin Namitecan (ST1968) in paediatric tumur mdels. Cancer Chemther Pharmacl Dec;70(6): di: /s PMID: Allatti D, Giannini G, Vesci L, Castrina M, Pisan C, Badalni E, Cabri W. Camptthecins in tumr hming via an RGD sequence mimetic.birg Med Chem Lett Oct 15;22(20): di: /j.bmcl PMID: Dal Piaz F, Vassall A, Chini MG, Crder FM, Cardna F, Pisan C, Bifulc G, De Tmmasi N, Brandi A.Natural iminsugar (+)-lentiginsine inhibits ATPase and chaperne activity f hsp90. PLS One. 2012;7(8):e Epub 2012 Aug Odrisi T, De Luca N, Vesci L, Luisi PL, Stan P, Zambrun G, Pisan C. The atypical retinid E-3-(3'-Adamantan-1-yl-4'-methxybiphenyl-4-yl)-2-prpenic acid (ST1898) displays cmedlytic activity in the rhin muse mdel. Eur J Dermatl Jul-Aug;22(4): Bargitti A, Muss L, Dallavalle S, Merlini L, Gall G, Ciacci A, Giannini G, Cabri W, Penc S, Vesci L, Castrina M, Milazz FM, Cervni ML, Barbarin M, Pisan C, Gimmarelli C, Zuc V, De Cesare M, Zunin F. Isxazl(aza)naphthquinnes: a new class f cyttxic Hsp90 inhibitrs. Eur J Med Chem Jul;53: Epub 2012 Mar Cassinelli G, Zuc V, Petranglini G, De Cesare M, Trtret M, Lanzi C, Cminetti D, Zaffarni N, Orlandi A, Passeri D, Mec D, Di Francesc AM, Riccardi R, Bucci F, Pisan C, Zunin F. The curative efficacy f namitecan (ST1968) in preclinical mdels f pediatric sarcma is assciated with antiangigenic effects. Bichem Pharmacl Jul 15;84(2): Epub 2012 Apr Giannini G, Brunetti T, Battistuzzi G, Allatti D, Quattrcicchi G, Cima MG, Merlini L, Dallavalle S, Cincinelli R, Nannei R, Vesci L, Bucci F, Fderà R, Guglielmi MB, Pisan C, Cabri W. New retinid derivatives as back-ups f Adartene. Birg Med Chem Apr 1;20(7): Epub 2012 Feb Piaz FD, Malafrnte N, Rman A, Galltta D, Belisari MA, Bifulc G, Gualtieri MJ, Sang R, Tmmasi ND, Pisan C. Structural characterizatin f tetranrtriterpenes frm Pseudrcedrela ktschyi and Trichilia emetica and study f their activity twards the chaperne Hsp90. Phytchemistry Mar;75: Epub 2012 Jan Gil N, Gldberg R, Neuman T, Garsen M, Zcharia E, Rubinstein AM, van Kuppevelt T, Meirvitz A, Pisan C, Li JP, van der Vlag J, Vldavsky I, Elkin M Heparanase is essential fr the develpment f diabetic nephrpathy in mice. Diabetes Jan;61(1): Epub 2011 Nv Zuc V, De Cesare M, Cincinelli R, Nannei R, Pisan C, Zaffarni N, Zunin F.PLS One. 2011;6(12):e Synergistic antitumr effects f nvel HDAC inhibitrs and paclitaxel in vitr and in viv.epub 2011 Dec Baruchell R, Simni D, Grislia G, Barbat G, Marchetti P, Rndanin R, Mangila S, Giannini G, Brunetti T, Allatti D, Gall G, Ciacci A, Vesci L, Castrina M, Milazz FM, Cervni ML, Guglielmi MB, Barbarin M, Fderà R, Pisan C, Cabri W. Nvel 7

8 3,4-isxazlediamides as ptent inhibitrs f chaperne heat shck prtein 90. J Med Chem Dec 22;54(24): Epub 2011 Nv Vldavsky I, Beckhve P, Lerner I, Pisan C, Meirvitz A, Ilan N, Elkin M. Significance f Heparanase in Cancer and Inflammatin. Cancer Micrenvirn Aug 3. [Epub ahead f print] 22. Purushthaman A, Hurst DR, Pisan C, Mizumt S, Sugahara K, Sandersn RD. Heparanase-mediated lss f nuclear syndecan-1 enhances histne acetyltransferase (HAT) activity t prmte expressin f genes that drive an aggressive tumr phentype. J Bil Chem Sep 2;286(35): Epub 2011 Jul Di Francesc AM, Ubezi P, Trella AR, Mec D, Pierri F, Barne G, Cusan G, Pisan C, D'Incalci M, Riccardi R. Enhanced cell cycle perturbatin and apptsis mediate the synergistic effects f ST1926 and ATRA in neurblastma preclinical mdels. Invest New Drugs Jun 3. [Epub ahead f print] 24. Tarall V, Lepre L, Marcellini M, Dal Piaz F, Tudisc L, Pnticelli S, Wendelbe Lund F, Repstrff P, Orlandi A, Pisan C, De Tmmasi N, De Falc S.The biflavnid Amentflavne inhibits nevascularizatin preventing the activity f prangigenic vascular endthelial grwth factrs. J Bil Chem Apr 6. [Epub ahead f print] 25. Meirvitz A, Herman E, Lerner I, Zcharia E, Pisan C, Peretz T, Elkin M. Rle f heparanase in radiatin-enhanced invasiveness f pancreatic carcinma. Cancer Res Apr 1;71(7): Bircci A, Prru M, Rizz A, Salvati E, D'Angel C, Orlandi A, Passeri D, Franceschin M, Stevens MF, Gilsn E, Beretta G, Zupi G, Pisan C, Zunin F, Lenetti C.DNA Damage Persistence as Determinant f Tumr Sensitivity t the Cmbinatin f Tp I Inhibitrs and Telmere-Targeting Agents. Clin Cancer Res Apr 15;17(8): Epub 2011 Feb Ritchie JP, Ramani VC, Ren Y, Naggi A, Trri G, Casu B, Penc S, Pisan C, Carminati P, Trtret M, Zunin F, Vldavsky I, Sandersn RD, Yang Y. SST0001, a chemically mdified heparin, inhibits myelma grwth and angigenesis via disruptin f the heparanase/syndecan-1 axis. Clin Cancer Res Mar 15;17(6): Epub 2011 Jan Auzzas L, Larssn A, Matera R, Baraldi A, Deschênes-Simard B, Giannini G, Cabri W, Battistuzzi G, Gall G, Ciacci A, Vesci L, Pisan C, Hanessian S. Nn-Natural Macrcyclic Inhibitrs f Histne Deacetylases: Design, Synthesis, and Activity. J Med Chem Nv Shafat I, Ben-Arush MW, Issakv J, Meller I, Narditsky I, Trttet M, Cassinelli G, Lanzi C, Pisan C, Ilan N, Vldavsky I, Zunin F. Preclinical and clinical significance f heparanase in Ewing's sarcma. J Cell Ml Med Oct 3. di: /j x. [Epub ahead f print] 30. Dal Pzz A, Espsit E, Ni M, Muzi L, Pisan C, Bucci F, Vesci L, Castrina M, Penc S. Cnjugates f a Nvel 7-Substituted Camptthecin with RGD-Peptides as α(v)β(3) Integrin Ligands: An Apprach t Tumr-Targeted Therapy. Bicnjug Chem Nv 17;21(11): Epub 2010 Oct 15. 8

9 31. Cngiu C, Onnis V, Vesci L, Castrina M, Pisan C. Synthesis and in vitr antitumr activity f new 4,5-dihydrpyrazle derivatives. Birg Med Chem Sep 1;18(17): Epub 2010 Aug Muss L, Dallavalle S, Merlini L, Bava A, Nasini G, Penc S, Giannini G, Gimmarelli C, De Cesare A, Zuc V, Vesci L, Pisan C, Dal Piaz F, De Tmmasi N, Zunin F. Natural and semisynthetic azaphilnes as a new scaffld fr Hsp90 inhibitrs. Birg Med Chem Aug 15;18(16): Epub 2010 Jul Pisan C, Vesci L, Milazz FM, Guglielmi MB, Fderà R, Barbarin M, D'Incalci M, Zucchetti M, Petranglini G, Trtret M, Pereg P, Zuc V, Orlandi A, Passeri D, Carminati P, Cavazza C, Zunin F. Metablic apprach t the enhancement f antitumr effect f chemtherapy: a key rle f acetyl-l-carnitine. Clin Cancer Res Aug 1;16(15): Epub 2010 Jun Dal Piaz F, Tsc A, Elett D, Piccinelli AL, Mlted O, Franceschelli S, Sbardella G, Remndelli P, Rastrelli L, Vesci L, Pisan C, De Tmmasi N. The identificatin f a nvel natural activatr f p300 histne acetyltranferase prvides new insights int the mdulatin mechanism f this enzyme. Chembichem Apr 12;11(6): Oussedik K, Françis JC, Halby L, Senamaud-Beaufrt C, Tutirais G, Dallavalle S, Pmmier Y, Pisan C, Arimnd PB. Sequence-specific targeting f IGF-I and IGF- IR genes by camptthecins. FASEB J Jul;24(7): Epub 2010 Feb Tarall V, Vesci L, Capass O, Espsit MT, Riccini T, Pastre L, Orlandi A, Pisan C, De Falc S. A Placental Grwth Factr Variant Unable t Recgnize Vascular Endthelial Grwth Factr (VEGF) Receptr-1 Inhibits VEGF-Dependent Tumr Angigenesis via Heterdimerizatin. Cancer Res Mar 1;70(5): Zuc V, Supin R, Favini E, Trtret M, Cincinelli R, Crce AC, Bucci F, Pisan C, Zunin F. Efficacy f ST1968 (namitecan) n a tptecan-resistant squamus cell carcinma. Bichem Pharmacl. 2010Feb 15; 79 (4): Stasi MA, Scili MG, Arcuri G, Mattera GG, Lmbard K, Marcellini M, Riccini T, De Falc S, Pisan C, Spagnli LG, Brsini F, Orlandi A. Prpinyl-L-Carnitine Imprves Pstischemic Bld Flw Recvery and Arterigenetic Revascularizatin and Reduces Endthelial NADPH-Oxidase 4-Mediated Superxide Prductin. Arteriscler Thrmb Vasc Bil Feb Fraplli R, Zucchetti M, Sessa C, Marsni S, Viganò L, Lcatelli A, Rulli E, Cmpagnni A, Bell E, Pisan C, Carminati P, D'Incalci M. Clinical pharmackinetics f the new ral camptthecin gimatecan: The inter-patient variability is related t alpha(1)-acid glycprtein plasma levels. Eur J Cancer Feb;46(3): Dal Pzz A, Ni MH, Espsit E, Dallavalle S, Muss L, Bargitti A, Pisan C, Vesci L, Bucci F, Castrina M, Fderà R, Giannini G, Aulicin C, Penc S. Nvel tumrtargeted RGD peptide-camptthecin cnjugates: synthesis and bilgical evaluatin. Birg Med Chem Jan 1;18(1):

10 41. Gimmarelli C, Zuc V, Favini E, Pisan C, Dal Piaz F, De Tmmasi N, Zunin F. The enhancement f antiprliferative and prappttic activity f HDAC inhibitrs by curcumin is mediated by Hsp90 inhibitin. Cell Ml Life Sci Mar;67(6): Zucchetti M, Mec D, Di Francesc AM, Servidei T, Patriarca V, Cusan G, D'Incalci M, Frestieri D, Pisan C, Riccardi R. Antitumr activity and pharmackinetics f ral gimatecan n pediatric cancer xengrafts. Cancer Chemther Pharmacl Dec 20. [Epub ahead f print] 43. G. Giannini, M. Marzi, M.D. Marz, G. Battistuzzi, R. Pezzi, T. Brunetti, W. Cabri, L. Vesci, C. Pisan. Explring bis-(indlyl)methane miety as an alternative and innvative CAP grup in the design f histne deacetylase (HDAC) inhibitrs. Birg & Med Chem Lett May 15;19(10): P. Vekhff; L. Halby; K. Oussedik; S. Dallavalle; L. Merlini; C. Mahieu; A. Lansiaux; C. Bailly; A. Butrine; G. Giannini; C. Pisan; P. B. Arimnd. Optimized synthesis and reinfrced efficacy f nvel triplex-frming camptthecin derivatives based n gimatecan. Bicnjug Chem Apr;20(4): Zinner RG, Barrett BL, Ppva E, Damien P, Vlgin AY, Gelvani JG, Ltan R, Tran HT, Pisan C, Mills GB, Ma L, Hng WK, Lippman SM, Miller JH. Algrithmic guided screening f drug cmbinatins f arbitrary size fr activity against cancer cells. Ml Cancer Ther Mar;8(3): Epub 2009 Mar Giannini G, Marzi M, Pezzi R, Brunetti T, Battistuzzi G, Marz MD, Cabri W, Vesci L, Pisan C. N-Hydrxy-(4-xime)-cinnamide: A versatile scaffld fr the synthesis f nvel histne deacetilase (HDAC) inhibitrs. Birg Med Chem Lett Feb Dallavalle S, Cincinelli R, Nannei R, Merlini L, Mrini G, Penc S, Pisan C, Vesci L, Barbarin M, Zuc V, De Cesare M, Zunin F. Design, synthesis, and evaluatin f biphenyl-4-yl-acrylhydrxamic acid derivatives as histne deacetylase (HDAC) inhibitrs. Eur J Med Chem Nv 19. chapter in bks: Drsphila: A Labratry Handbk, Cld Spring Harbr Labratry Press, New Yrk, Analysis f micrnuclei and micrtubule arrangement t identify aneuplidy-inducing agents in cultured mammalian cells. In: "Chrmsme segregatin and Aneuplidy" (Vig B.K., Ed.), Springer-Verlag, Berling Heidelberg: Mutagenesis, Vl. 6, 2001 granted patents: 31 and 20 new patent applicatin are under examinatin 10

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