Drugs to consider prescribing by brand name or where brands should not be switched

Transcription

1 Index Page Index Page Adrenaline (epinephrine) prefilled syringes 2 Hormone replacement therapy oral 3 Alprostadil injection 4 Human papillomavirus vaccine 5 Aminophylline modified release 2 Insulins 3 Antacids containing simeticone 1 Interferon prefilled disposable injection devices 5 Antiepileptic medicines 3 Isosorbide mononitrate SR 60mg 1 Apomorphine prefilled syringe 3 Lithium 2 Azathioprine 4 Macrogols (polyethylene glycols) 1 Beclometasone and formoterol CFCfree metered dose inhalers 2 Mesalazine oral 1 Beclometasone dipropionate CFCfree pressurised metered dose inhalers 2 Methylphenidate modified release 2 Beclometasone dry powder inhalers 2 Midazolam buccal liquid 3 Botulinum toxin type A 3 Morphine oral modified release 2 Budesonide dry powder inhalers 2 Mycophenolate 4 Bulk forming laxatives 1 Nifedipine modified release 1 Buprenorphine patches 2 Oral rehydration salts 5 Calcium salts 5 Oxycodone 3 Ciclosporin 4 Pancreatin supplements 1 Combined oral contraceptives 4 Peginterferon prefilled disposable injection devices 5 Compound alginates and proprietary indigestion 1 Progestogen only oral contraceptives 4 Diltiazem modified release (MR) 1 Salbutamol dry powder inhalers 1 Duloxetine 2 Saliva replacement products 5 Erythropoietins 5 Skin and scalp conditionspreparations containing multiple ingredients 5 Estradiol transdermal patches 4 Somatropin injection cartridges 4 Fentanyl patches 3 Tacrolimus 4 Formoterol dry powder inhalers 1 Theophylline modified release 2 Granulocytecolony stimulating factors 5 Valproic acid 2 haemorrhoid compound 1 Verapamil SR 1

2 Chapter Antacids containing simeticone Compound alginates and proprietary indigestion To aid identification. Products contain multiple ingredients. To aid identification. Products contain multiple ingredients Mesalazine oral The delivery characteristics of oral mesalazine may vary and should not be considered interchangeable Bulk forming laxatives To aid identification. Products contain multiple ingredients Macrogols (polyethylene glycols) To aid identification. Products contain multiple ingredients Haemorrhoid compound To aid identification. Products contain multiple ingredients Pancreatin supplements To aid identification. Products contain multiple ingredients. Chapter Isosorbide mononitrate SR 60mg Generic may attract high pricesprescribe by brand e.g. Chemydur 60 XL ; Monomil XL 60mg. CCG Diltiazem modified release (MR) Nifedipine modified release MR have different release characteristics and are not interchangeable. MR have different release characteristics and are not interchangeable Verapamil SR Continuity of brand and cost Securon SR ; Univer ; Vertab SR CCG Chapter Formoterol dry powder inhalers Patient familiarity with one brand is important; instructions for use vary between Salbutamol dry powder inhalers Patient familiarity with one brand is important; instructions for use vary between. 1

3 3.1.3 Theophylline modified release MR have different release characteristics and are not interchangeable. Theophylline has a narrow therapeutic index Aminophylline modified release 3.2 Beclometasone dipropionate CFCfree pressurised metered dose inhalers MR have different release characteristics and are not interchangeable. Aminophyline has a narrow therapeutic index. The MHRA has advised that CFCfree beclometasone inhalers should be prescribed by brand name. This applies also to combination products. MHRA [8] 3.2 Beclometasone dry powder inhalers Patient familiarity with one brand is important; instructions for use vary between. 3.2 Beclometasone and formoterol CFCfree metered dose inhalers See beclometasone CFCfree metered dose inhalers, above. MHRA [8] 3.2 Budesonide dry powder inhalers Patient familiarity with one brand is important; instructions for use vary between Adrenaline (epinephrine) prefilled syringes Chapter 4 Patient familiarity with one brand is important; instructions for use vary between Lithium Preparations vary widely in bioavailability. Changing the preparation requires the same precautions as initiation of treatment. Lithium has a narrow therapeutic index Valproic acid Difference in licensed indications Duloxetine Different strengths and licenced indications 4.4 Methylphenidate modified release Morphine oral modified release MR contain different proportions of immediaterelease and modifiedrelease methylphenidate. MR have different release characteristics; Patient familiarity with one brand is PCF4 [9] Buprenorphine patches Patches have different release mechanisms and profiles 2

4 4.7.2 Fentanyl patches Patches are available as matrix and reservoir formulations; Patient familiarity with one brand is Reservoir patches (e.g. Tilofyl) must not be cut because damage to the ratelimiting membrane can lead to a rapid release of fentanyl resulting in overdose. If the prescriber intends the patch to be cut (NB: unlicensed and not recommended by the MHRA) then the prescription must specify a brand of matrix formulation patch (e.g. Durogesic DTrans, Matrifen). PCF4 [9] Oxycodone Differentiate between plain and slow release versions Botulinum toxin type A Preparations are not interchangeable due to differences in potency Antiepileptic medicines Loss of seizure control has been reported in patients after switching brands of antiepileptic medicines. Continuity of the same brand, or the same generic preparation is recommended for patients taking: phenytoin, primidone, phenobarbital and carbamazepine For valproate, lamotrigine, retigabine, rufinamide, clobazam, clonazepam, oxycarazine, escarbazepine, zonisamide and topiramate Patients should be maintained on a specific manufacturer s product and not switched between different manufacturer s products, ensuring constancy of supply wherever possible. Changes should only be made after clinical assessment and consultation with the patient or carer. NICE [10] MHRA DSU Nov Midazolam buccal liquid Buccolam is the licensed preparation. Patient familiarity with one brand is important; instructions for use vary between Apomorphine prefilled syringe Patient familiarity with one brand is important; instructions for use vary between Botulinum toxin type A Preparations are not interchangeable due to differences in potency. Chapter Insulins Patient familiarity with the same brand is important; training is required in the use of specific devices for selfinjection Hormone replacement therapy oral Different brands of the same formulation are available. Patient familiarity with one brand is 3

5 6.4.1 Estradiol transdermal patches Different brands of the same formulation are available. Patient familiarity with one brand is Somatropin injection cartridges Patient familiarity with the same brand is important and training is required in the use of specific devices for selfinjection. Some somatropin are licensed as biosimilar medicines. Chapter Combined oral contraceptives Different brands of the same formulation are available. Patient familiarity with one brand is Progestogen only oral contraceptives Different brands of the same formulation are available. Patient familiarity with one brand is Alprostadil injection Patient familiarity with one brand is important; instructions for use vary between. Chapter Azathioprine Different formulations may vary in bioavailability; to avoid reduced effect or excessive side effects, it is important not to change formulation except on the advice of a transplant specialist Mycophenolate Generic and branded are considered bioequivalent but it may be prudent not to change formulation except on the advice of a transplant specialist. Mycophenolate mofetil and mycophenolic acid are not interchangeable Ciclosporin Preparations are not interchangeable and should be prescribed by brandname to avoid inadvertent switching. It is important not to change formulation except on the advice of a transplant specialist. Ciclosporin has a narrow therapeutic index Tacrolimus Preparations are not interchangeable; care should be taken to ensure the correct preparation is prescribed and dispensed. It is important not to change formulation except on the advice of a transplant specialist. Tacrolimus has a narrow therapeutic index. Eur Soc Org Trans [12] Eur Soc Org Trans [12] PJ [13] Eur Soc Org Trans [12] MHRA [14] MHRA [15] 4

6 8.2.4 Interferon prefilled disposable injection devices Chapter 9 Peginterferon prefilled disposable injection devices Patient familiarity with one brand is important; instructions for use vary between Erythropoietins Patient familiarity with the same brand is important and training is required in the use of specific devices for selfinjection. Some epoetin are licensed as biosimilar medicines Granulocytecolony stimulating factors Patient familiarity with the same brand is important and training is required in the use of specific devices for selfinjection. Filgrastim have been approved as biosimilar Oral rehydration salts To aid identification. Products contain multiple ingredients Calcium salts To aid identification. Products contain multiple ingredients. Chapter Saliva replacement products To aid identification. Products contain multiple ingredients. Chapter Skin and scalp conditions containing multiple ingredients To aid identification. Products contain multiple ingredients. Also, potency of topical corticosteroid is a result of the formulation as well as the corticosteroid. Chapter Human papillomavirus vaccine Cervarix (bivalent vaccine) and Gardasil (quadravalent vaccine) are not considered interchangeable. 5