AMC Advanced Moisture Complex NP

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1 AMC Advanced Moisture Complex NP

2 1 The Challenge 2 The Solution 3 Efficacy Data 4 Summary & Conclusion 2 BASF Personal Care

3 1 The Challenge 2 The Solution 3 Efficacy Data 4 Summary & Conclusion 3 BASF Personal Care

4 Challenges Skin Hydration Proper skin hydration helps to prevent aging, irritation, and damage, and is essential for healthy looking skin. Key elements include maintenance and strengthening of physiological barrier function, improvement of skin aesthetics, and reduction of dryness and flaking. Microphotograph BASF BCS Water is the essential component of the skin that determines its softness and flexibility, and the factors that influence the skin s state of hydration are as follows: 1. The rate at which water reaches the stratum corneum from the layers below 2. The ability of the stratum corneum to retain moisture 3. Prevention of water leaving 50 m the skin through evaporation E D 4 BASF Personal Care Source:

5 1 The Challenge 2 The Solution 3 Efficacy Data 4 Summary & Conclusion 5 BASF Personal Care

6 AMC Advanced Moisture Complex Triple Action Complex Triple Action Complex that immediately softens skin and offers 24 hour moisture and protection 50 m 6 BASF Personal Care

7 AMC Advanced Moisture Complex 1. Draws Moisture Glycerin and sodium PCA act in synergy to draw water into the stratum corneum. Glycerin is a water-soluble, extremely hygroscopic liquid. It is a humectant, so it Microphotograph BASF BCS attracts moisture to the skin, and it also draws moisture up through the skin layers. Sodium PCA, an amino acid derivative, is also a hygroscopic humectant and is naturally occurring ind the skin, attracting moisture to the 50 mstratum corneum for a softer, more hydrated appearance. 7 BASF Personal Care Source: E

8 AMC Advanced Moisture Complex 2. Retains Moisture Sodium hyaluronate and urea, two natural moisturizing factors, work together to hold water within the stratum corneum. Sodium hyaluronate, a water-binding polysaccharide, Microphotograph BASF provides BCS a water reservoir and fills up the space between the skin s connective fibers, keeping the ECM s components hydrated Eand the skin s structure intact. Urea is naturally found within the stratum D corneum, along with other physiological 50 m chemicals, and helps to soften skin and retain moisture. 8 BASF Personal Care Source:

9 AMC Advanced Moisture Complex 3. Prevents Evaporation The natural skin barrier is composed of intercellular lipids which help assemble the stacked formation of the stratum corneum, creating an impermeable barrier for the passage of water and natural moisturizing factors. Trehalose, a complex sugar, reinforces the lamellar Microphotograph structure BASF BCSof epidermal lipids, helping to maintain the stacked formation of the stratum corneum and thereby preventing water loss. Polyquaternium-51 is a known phospholipid copolymer that is a skin conditioning agent with film-forming properties. It plays an essential role in proper barrier function, improving moisture Dretention and helping prevent the evaporation of water. 50 m E 9 BASF Personal Care Source:

10 1 The Challenge 2 The Solution 3 Efficacy Data 4 Summary & Conclusion 10 BASF Personal Care

11 AMC Advanced Moisture Complex Ex Vivo Water Binding Capacity Microphotograph BASF BCS E D 50 m 11 BASF Personal Care Source:

12 AMC Advanced Moisture Complex In Vivo Comparison to HA Microphotograph BASF BCS E D 50 m 12 BASF Personal Care Source:

13 AMC Advanced Moisture Complex In Vivo - TEWL Microphotograph BASF BCS E D 50 m 13 BASF Personal Care Source:

14 AMC Advanced Moisture Complex In Vivo Immediate Moisturization Microphotograph BASF BCS E D 50 m 14 BASF Personal Care Source:

15 AMC Advanced Moisture Complex In Vivo 24 Hour Moisturization 24 Hour Intense Moisture % Change from Baseline E * * Untreated Placebo AMC 3% AMC 5% 5 14% 15% 22% 25% 15 BASF Personal Care Source: 0 D Untreated Placebo AMC 3% AMC 5% In vivo study -Tested on 20 subjects 50 m -Single application on forearm -Subjects completed a 3-day washout prior to test -Base, Base + 3% AMC, Base + 5% AMC -Hydration measured by Corneometer 24 hours after application *p<0.05 versus placebo

16 AMC Advanced Moisture Complex In Vivo Sustained Benefit Microphotograph BASF BCS E D 50 m 16 BASF Personal Care Source:

17 1 The Challenge 2 The Solution 3 Efficacy Data 4 Summary & Conclusion 17 BASF Personal Care

18 AMC NP R11016 Summary of Tests Ex vivo 70% increase in water-binding capacity (binds water to keep it in the skin) In vivo (quantitative measurements) More hydrating than hyaluronic acid (immediate effect within 30 minutes and up to 8 hours) Reinforces barrier function prevents TEWL (trans-epidermal waterloss) better than petrolatum Increases moisture up to 156% more than placebo (immediate effect within 30 minutes and up to 8 hours) Increases moisture for 24 hours Provides a sustained effect after 2 weeks of use 18 BASF Personal Care

19 AMC NP R11016 Triple Action Moisturizing Complex INCI: Glycerin, Water, Sodium PCA, Urea, Trehalose, Triacetin, Sodium Hyaluronate, Polyquaternium-51 Benefits & Unique Selling Points Triple Action Moisturizing Complex Draws moisture into the upper layers of the skin Binds water and creates a reservoir for structural support and long term hydration benefits Improves skin s natural barrier to prevent evaporation Product Properties Dose of use: 3-5% Solubility: water-soluble Shelf life: 12 months Preservatives: none Provides both immediate (within 30 minutes) and long term (24 hours) benefits Hydrates, softens, and protects for healthy skin Formula suggestion: Calming After Sun Gel CLG.NA-B Chinese Regulations INCI 2007 (1) INCI 2010 (2) IECSC (3) IECIC (4) (1) INCI name whether or not listed in "International Cosmetic ingredient standard Chinese name"(2007 version) (2) INCI name whether or not listed in "International Cosmetic ingredient standard Chinese name"(2010) (3) INCI name whether or not listed in "IECSC (Inventory of Existing Chemical Substances (October 2010) (4) INCI name whether or not listed in "IECSC (Inventory of Existing Chemical Substances ( , batch #1-3) 19 BASF Personal Care

20 Although all statements and information in this publication are believed to be accurate and reliable, they are presented gratis and for guidance only, and risks and liability for results obtained by use of the products or application of the suggestions described are assumed by the user. SELLER MAKES NO WARRANTY OF ANY KIND, EITHER EXPRESS OR IMPLIED, BY FACT OR LAW, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Statements or suggestions concerning possible use of the products are made without representation or warranty that any such use is free of patent infringement and are not recommendations to infringe any patent. The user should not assume that toxicity data and safety measures are indicated or that other measures may not be required. The claims and supporting data provided in this publication have not been evaluated for compliance with any jurisdiction s regulatory requirements and the results reported may not be generally true under other conditions or in other matrices. Users must evaluate what claims and information are appropriate and comply with a jurisdiction s regulatory requirements. Recipient of this publication agrees to (i) indemnify and hold harmless each entity of the BASF organization for any and all regulatory action arising from recipient s use of any claims or information in this publication, including, but not limited to, use in advertising and finished product label claims, and (ii) not present this publication as evidence of finished product claim substantiation to any regulatory authority. 20 BASF Personal Care

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