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1 Crprate Presentatin Bidegradable, Regenerative Plymer Technlgy Changing the Standard f Care Paul Brennan CEO

2 Disclaimer This presentatin has been prepared by PlyNv Limited and is prvided fr general infrmatin purpses nly. N party ther than PlyNv has authrised r caused the issue f this dcument, r takes respnsibility fr, r makes any statements, representatins r undertakings in this presentatin. This presentatin is nt intended t be relied upn as advice t investrs r ptential investrs and des nt take int accunt the investment bjectives, financial situatin r needs f any particular investr. PlyNv Limited makes n warranty r representatin (express r implied) as t the accuracy, reliability r cmpleteness f the infrmatin cntained in this presentatin. Specifically, several matters referred t in the presentatin remain under investigatin and are subject t change r even eliminatin, depending n further research and investigatin. Further, any pinins (including any frward lking statements) expressed in this presentatin are subject t change withut ntice. PlyNv and its directrs, fficers, emplyees, advisers and agents shall have n liability (including liability t any persn by reasn f negligence r negligent misstatement) fr any statements, pinins, infrmatin r matters (express r implied) arising ut f, r cntained in r derived frm, r fr any missins frm this presentatin, except liability under statute that cannt be excluded. This presentatin, including the infrmatin cntained in this disclaimer, des nt frm part f any ffer, invitatin r recmmendatin in respect f shares, r an ffer, invitatin r recmmendatin t sell, r a slicitatin f any ffer t buy, shares in the United States, r in any ther jurisdictin in which, r t any persn t whm, such an ffer wuld be illegal. This presentatin may include frward-lking statements. Frward-lking statements are nly predictins and are subject t knwn and unknwn risks, uncertainties and assumptins, many f which are utside the cntrl f PlyNv. Actual values, results r events may be materially different t thse expressed r implied in this presentatin depending n a range f factrs. Given these uncertainties, recipients are cautined nt t place reliance n frward-lking statements. N representatin r warranty (express r implied) is made by PlyNv r any f its directrs, fficers, emplyees, advisers r agents that any frecasts, prjectins, intentins, expectatins r plans set ut in this presentatin will be achieved. 2 PlyNv Limited

3 A Slutin t a Surgical Challenge PlyNv develps Regenerative Devices fr recnstructive surgery and tissue repair with ur patented bidegradable plymer technlgy, NvSrb TM Technlgy rigins frm CSIRO, patented and spun ut. NvSrb is a family f medical grade plymers used t frm medical devices that facilitate the recnstructin r repair f failed tissue. NvSrb can be tailred t a desired strength, elasticity r degradatin prfile. NvSrb has significant advantages in terms f safety, txiclgy prfile and strength. 2 PlyNv Limited

4 Repair f Surgical Wund - BTM Current Standard f Care BTM- Innvates the standard Nte the lack f cntracture and even tpgraphy with the BTM 3 PlyNv Limited

5 Tendn is free t mve 4 Cnfidential PlyNv Limited

6 BTM fr Burns BTM ffers a recnstructin which prduces a result similar t a full thickness graft When there is nt enugh dnr skin available it allws the wunds t be temprised, creating a nedermis while dnr sites recver fr the harvest f further skin grafts r whilst skin is cultured in the Lab. Day 6 These images demnstrate the integratin at Day 6 and the utcme f the finished tissue, nte the smthness and lack f cntractin. A Five (5) patient clinical trial in prgress at Ryal Adelaide Hspital by Principal Investigatr, Assciate Prfessr Jhn Greenwd AM. Three (3) patients cmpleted t date. Results utstanding Day 6 BTM Day 96 Graft 5 PlyNv Limited

7 Adelaide BTM Burns Trial Patient 6 PlyNv Limited

8 Delaminatin f BTM 7 Cnfidential PlyNv Limited

9 Bringing NvSrb BTM t market We anticipate cmmercial sales in US Market Early 2016 pst 510(k) Regulatry paths thrugh clinical trials 1. Achieve 510(k) apprval fr use in Surgical Wunds anticipated January Establish Clinical trials fr FDA PMA apprval in Burns, February 2016 ; Cntingent n BARDA funding 3. CE Mark trials cmmenced in Australia & France CE Mark anticipated Mid Priritising jurisdictins where access can be achieved with existing data Cmmercial executin We will initiate direct sales t establish market penetratin where we have regulatry apprval Establish cmmercial partnerships r licence agreements with KPIs arund sales perfrmance and revenue generatin 8 PlyNv Limited

10 BTM 2016 US Sales Opprtunity All surgically clean wunds Repair pst melanma, r tissue excisin Free Flap surgical repair Partial & full thickness burn skin recnstructin Diabetic Ft Ulcers Venus Leg Ulcers Pressure Injury Trauma Recnstructive Surgery 9 PlyNv Limited

11 Hw des the BTM wrk? Full Thickness Burns & Surgical Wunds: 2 stage clsure BTM in full thickness burn pst surgically debridement. The wund is physilgically clsed limiting cntractin and the risk f infectin BTM fully integrated The sealing membrane can be remved when dnr sites are available Sealing membrane remved when the wund is ready fr skin grafting. T date lngest 45days Wund clsed with split skin graft and the matrix bidegrades within 12 mnths. 10 PlyNv Limited

12 What makes NvSrb unique? Purely synthetic matrix. N rganic remnants, GAGS r ther prteins Cmpetitrs are bilgical based: Animal surced: Pig, Cws, Shark, Sheep, Cmbinatins Human: Cadaver skin, Placenta /Amnitic Cmplex manufacturing and expensive t scale up NvSrb advantage: Csmetic utcmes, lack f cntractin Fully regenerates the dermis Resilient against infectin Rbust prduct that is easy t handle, cut and apply Fat cells d grw within the matrix (O Brien institute study) Fully bidegraded in ~12 mnths Ease f manufacture, scalable and reduced cst Stable prduct with simple transprt and strage requirements 11 PlyNv Limited

13 Capabilities Key Staff 2 Full time Regulatry Managers 1 Full time Principal Scientist 1 Full time Quality Manager 2 Prductin Staff Office & Administrative supprt team Facilities Class 7 Cleanrm fr prductin and prduct cnversin Dedicated R&D Lab Dedicated Quality Cntrl lab with nsite testing facilities Accreditatin Standards TÜV-SÜD quality audit reapprved February 20 EN ISO (2012) ISO Bicmpatibility testing Prduct Frmats Plymer Fams Plymer Fam Laminates Thermplastic Plymers Thermset, Injectin mulding, Filament Extrusin Plymer slutins fr spray n r dipping applicatins Eluting Plymers 12 PlyNv Limited

14 The NvSrb Fam PlyNv s lead prducts are based arund the NvSrb TM bidegradable fam which has applicatins as a tissue scaffld in: Develped: Burn and wund repair Bidegradable Temprizing Matrix (BTM) Negative Pressure Wund Therapy NvPre negative pressure wund dressing In-Develpment: Hernia repair Pelvic Flr repair Breast Recnstructin Breast Augmentatin Breast Slings 13 PlyNv Limited

15 Barriers Bidegrades Prf f full degradatin. Clinically prven in free flaps and published in e-plasty paper. NvSrb / BTM delivers a better utcme than current standard f care Cmpared t bilgic prducts it is easier t handle, cut and apply It is resilient t infectin verses current matrix ptins The elasticity f the healed skin is cnsiderably better and the scar frmatin significantly reduced N crss species r antigen respnses due t n prteins cmpletely synthetic N ethical cncerns arund cadaver skin r placental harvest N cncerns fr sharks with shark fin harvest. Market access Initially targeting plastic surgens- defined grup In discussin with multinatinal device cmpanies Can scale sales frce with partnerships and gegraphical rights assignment. PlyNv Limited

16 Crprate Overview Bard ASX Cde PNV David Williams Chairman Share Price 11.5 cents Bruce Rathie Nn Exec. Issued Shares 418 millin David McQuillan Nn Exec. Market Cap. $48 millin Philip Pwell Nn Exec. Cash n Hand* $3.5 millin Max Jhnstn Nn Exec. Majr Sharehlders Merchant Funds 16% David Kenley 8% Management Paul Brennan Tim Mre Chris Mews Chief Executive Officer Principal Scientist CFO/Cmpany Secretary *As at 30 June 20

17 2 year Share Price Trend Year Share Price Jul 13 Aug 13 Sep 13 Oct 13 Nv 13 Dec 13 Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nv Dec Jan Feb Mar Apr May Jun Jul 16 PlyNv Limited

18 17

19 Develpment thrugh t Cmmercialisatin 2004 PlyNv incrprated ex-csiro 2005 Medtrnic licence (stent) 2006 BTA agreement (St Vincent, Binics Institute) NvSkin feasibility study 2007 Bimet licence (cartilage, CMF) 2008 S&N licence (fracture fixatin, bne vid filler) BTA agreement cancelled Prt Melburne facility established Metablic acquire 60% f PlyNv 2009 Medtrnic licence cancelled by PNV 2010 Bimet licence cancelled by PNV NvSkin is incrprated Bi Innvatin SA grant ($217K) Fcus n wund management 2011 KCI feasibility study n NvPre NPWT NvPre (NPWT) clinical trial (KCI prvide equipment) First human study (BTM in free flap Ryal Adelaide) Hernia feasibility study (TelaBi) Pelvic flr repair study (Clplast) Capital raise f $4.5m 20 NvPre regulatry apprval 510(k) and CE Mark Ryal Adelaide BTM Burn Trial 20 Divest Metablic fr $1.5M plus future 20% Ryalty stream New CEO & 2 full time Regulatry staff Factry expansin and higher vlume prductin equipment fit ut CE Trials cmmence BARDA agreement in discussin Final stages f FDA 510(k) apprval prcess App 1 PlyNv Limited

20 Markets USA will be the first market with Surgical Wund apprval, 510(k) Diabetic Ft Ulcers, Venus Leg Ulcers, Pressure Injuries, Trauma, Recnstructive Surgery (including Burn recnstructin- cntractures) Eurpe, Australia and thers that rely n CE Mark Certificatin as a regulatry basis Current trials are 12mnths recruitment & 12 mnths fllw thrugh Tuln, France and The Alfred, Melburne July 17 expected CE Certificatin India, China, Indnesia, Suth Africa and S.E.Asia are the next fcus pints fr regulatry apprval scping All cuntries have significant vlume f burn injuries BTM ffers significant shift in clinical utcme. Large scale will reduce prductin and in-market cst App 2 PlyNv Limited

21 Bard and Senir Executive David Williams Chairman David is an experienced Directr and Investment Banker with a prven track recrd in business develpment and strategy, as well as in crprate initiatives specialising in mergers and acquisitins and capital raising. He pssesses ver 25 years experience wrking with and advising ASX listed cmpanies in the fd, medical device and pharmaceutical sectrs. Dr. David McQuillan Nn Executive Directr Dr McQuillan was appinted a Directr f PlyNv n 6 August 2012 and Jint Acting Managing Directr n July 20. Dr McQuillan pssesses extensive technical, medical, scientific and regulatry knwledge, as well as merger and acquisitin expertise. Dr McQuillan was with LifeCell Inc/Kinetic Cncepts Inc fr 12 years, and served a number f rles f increasing respnsibility, including Vice-President fr Research and Develpment at LifeCell, and Senir Vice President f Advanced Research and Technlgy at KCI. Chief Science Officer fr TELA Bi, a VC-funded develpment-stage bitechnlgy cmpany frm 2013 t 20. He currently serves as an Operating Partner f 13 Capital, a private equity partnership that prvides capital t cmmercial-stage pharmaceutical, medical technlgy, and healthcare services cmpanies Max Jhnstn Nn Executive Directr Max held the psitin f President and Chief Executive Officer f Jhnsn & Jhnsn Pacific, the wrld s largest Medical, Pharmaceutical and Cnsumer Healthcare Cmpany fr 11 years. During his tenure he als served as Directr f Jhnsn & Jhnsn Research and was a member f their Research Review Cmmittee. Prir t jining Jhnsn & Jhnsn, Mr. Jhnstn s career als included senir rles with Diage and Unilever in Eurpe. Max has had extensive verseas experience during his career in leading businesses in bth Western and Central-Eastern Eurpe, Africa as well as Asia-Pacific. Bruce Rathie Nn Executive Directr Mr Rathie is an experienced cmpany directr and lawyer hlding degrees in law (LLB), cmmerce(bcmm) and business (MBA) having practised as a partner in a large legal firm and then as Senir in-huse Cunsel t Bell Resurces Limited frm 1980 t 1985 in aggregate. He studied fr his MBA in Geneva and then went int investment banking in Bruce was Head f the Industrial Franchise Grup at Salmn Smith Barney in the late 1990 s and led Salmn s rles in the Federal Gvernment s privatisatin f Qantas, Cmmnwealth Bank (CBA3) and Telstra (T1). He nw has ver years experience as a prfessinal nn-executive cmpany directr. He is currently Chairman f eftps Payments Australia Limited (6 years), Executive Chairman f DataDt Technlgy Limited (6 years) and a nn-executive directr f Capricrn Sciety Limited (7 years). In the medical device space, he was previusly a directr f Cmpumedics Limited (2 years) and USCOM Limited (5 years) and has been a nn-executive directr f PlyNv Limited since February 2010 (5 years). In additin, he was previusly Chairman f Ante Diagnstics Limited (3 years) App 3 21

22 Bard and Senir Executive (cntinued) Philip Pwell Nn Executive Directr Philip has ver years experience in investment banking specialising in capital raisings, IPOs, mergers and acquisitins and ther successful crprate finance assignments acrss a diverse range f sectrs including utilities, IT, financial services, fd and agriculture. He spent 10 years in senir financial rles at OAMPS Ltd, a frmer ASX listed financial services grup and 10 years in audit with Arthur Andersen & C. in Melburne, Sydney and Ls Angeles. Philip has been invlved in numerus IPO engagements, valuatins and venture capital related raisings Paul Brennan Chief Executive Officer Paul has extensive knwledge, expsure and understanding f the health system thrugh his clinical backgrund and cmmercial expsure with varius multinatinal cmpanies. He has c-rdinated the marketing, glbal strategy develpment, new prduct develpment and regulatry prcesses fr the Asia-Pacific regin fr industry leading rganisatins in relatin t medical prducts and devices. Paul has an intimate knwledge f the manufacturing / prductin prcesses. Previusly he was the Marketing Directr Australia and New Zealand and Sales Directr New Zealand fr Smith and Nephew Healthcare frm 2008 t his cmmencement with PlyNv in February 20. Paul hlds a Masters f Business Administratin (MBA) frm Swinburne University and a Bachelr f Science (Nursing) degree frm the University f New England in NSW, General Nursing and Midwifery Certificates. App 4 22

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