1 HECHO RELEVANTE BIOORGANIC RESEARCH AND SERVICES, S.A 27 de mayo de 2015 De conformidad con lo dispuesto en la Circular 9/2010 del Mercado Alternativo Bursátil, por medio de la presente se pone a disposición del mercado la siguiente información relativa a Bioorganic Research and Services, S.A.: Con motivo de la participación de la Compañía en el 11º Foro Medcap de empresas de mediana capitalización, organizado por Bolsas y Mercados Españoles, se adjunta la presentación corporativa que será utilizada en dicho foro a celebrar los días 27 y 28 de mayo de 2015 en Madrid. En Jerez de la Frontera, Bioorganic Research and Services S.A. Victor Manuel Infante Viñolo Presidente del Consejo de Administración The next page translation of the above relevant fact is intended only for information purpose. In case of any discrepancies, the official Spanish version shall prevail.
2 Relevant fact release pursuant to section 9/2010 of the Mercado Alternativo Bursatil of Bioorganic Research and Services, S.A. ( Bionaturis o the Company ): It can be found attached the corporate presentation to be used by the Company in the 11th Forum Medcap on mid- cap size companies, organized by "Bolsas y Mercados Españoles" in Madrid on 27 th and 28 th, May Jerez de la Frontera, Bioorganic Research and Services S.A. Victor Manuel Infante Viñolo
3 GLOBAL ACCESS TO HEALTH
4 Disclaimer This presenta0on may contain forward- looking statements based on current assump0ons and forecasts made by Bionaturis Group or subgroup management. Various known and unknown risks, uncertain0es and other factors could lead to material differences between the actual future results, financial situa0on, development or performance of the company and the es0mates given here. These factors include those discussed in Bionaturis' public reports which are available on the Bionaturis website at The company assumes no liability whatsoever to update these forward- looking statements or to conform them to future events or developments.
5 Bionaturis Group at a glance (pu2ng health technologies at reach) 23 direct workers (45% PhDs) 1 company and 1 subsidiary in 2 different loca0ons IPO (January 2012): 0cker BNT 30- day Average volume shares Net sales CAGR ( ): 69% Market of medicines trends*: Economic trend: Global spending on medicines to increase 30% by 2018, to $1.3 trillion Technical trend: Biological drugs account for 26% of global spending, growing at double digit pace. 60% of new drug approvals Demographic trend: 38% of the market s0ll in the US but 50% of the global growth in the next 5 years will correspond to LATAM, Africa and Asia *IMS Health data
6 BIONATURIS GROUP offers outstanding products and services for human and animal applicanons by the following main divisions: Human and animal health division CRO division CDMO division New Target Consumer Products division
7 100% Bionaturis Group BBD BioPhenix S.L. is a Contract Research Organization (CRO) that Optimizes the Drug Discovery success rate using the zebra fish animal model*. BBD Biophenix operates in the pharmaceutical, veterinarian, cosmetics, nutraceutics, petrochemical and agrochemical, among others San Sebas4an (Spain) ü Toxicity assays: acute toxcitiy, cardiotoxicity, hepatoxiciy, ototoxicity and behavioural alterations ü Efficacy assays: devoted to several diseases such as cancer, Central Nervous System, metabolism and infection processes, among others ü Tailor-made solutions: customization of established assays, further development of ongoing research projects and development of new assays or applications. ROCHE SERVIER SANOFI ROYAL DUTCH SHELL *OECD guidelines
8 Develops and manufactures biological drugs for human and animal health. Bionaturis is working with top-level veterinarian and pharmaceutical multinationals in the world. Bionaturis doesn t register or commercialize medicines in a direct way but licenses its products in an early stage to veterinarian and pharmaceutical labs that are able to develop, register and commercialize them in the target market. Animal Health Swine: most prevalent infec0ous diseases Cadle: endo- parasi0cides, ovula0on hormone Poultry: infec0ous disease Fish: salmonids diseases Dogs: leishmaniosis, an0- tumor, TNF blockers Medical Feed Addi0ves: Poultry and Swine Jerez de la Frontera (Spain) Human Health Two new vaccine developments with US companies
9 Best features of the BEVS offseeng the "downsides of the tradi0onal fermenta0on process: Ø Lineal scaling- up. Faster development (minimizing shortage effect) Ø Flexibility and versa0lity Ø Reducing CoGs and investment needs Ø Reducing space demand (up to 15 0mes) Ø Higher yields Better adapted for: ü Recombinant multivalent vaccines ü Specialty market niches (fitting with a product diversification strategy and customized solutions) ü Changes in doses and delivery. Oral boosters ü Outbreaks and pandemics.
10 Animal Health market: business insight According to Vetnosis*: About $100 billion global market Medicines and vaccines $23 billion, with an expected growth of 6% CAGR driven by human popula0on growth and increasing standards of living Market dominated by: Zoe0s (about $4.5 B) Merck AH (about $3.6 B) Elanco (about $3.3 B) Merial (about $2.6 B) Bayer AH (about $1.7 B) Boehringer AH (about $1.4 B) Huge interest in higher profit products (biologics) and subs0tu0on of tradi0onal an0bio0cs * Vetnosis is a research and consul0ng firm specialising in global animal health and veterinary medicine
11 Animal Health market: business insight Animal Health main dis/nc/ons from Human Health R&D is faster, less expensive and more predictable and sustainable More diverse products porlolio Primarily self- pay. Non third parnes payers
12 Relevant team Emilio Moraleda Former president and former managing director of Pfizer Europe; President of Pfizer Founda0on in Spain; Former president of FARMAINDUSTRIA; Member of the Board of Bionaturis Group since 2012 Carmelo Angulo Former Ambassador of Spain in Mexico, Argen0na, Bolivia, and Colombia; Former resident coordinator of the United Na0ons in Nicaragua and Argen0na; Chairman of UNICEF Spain; Bionaturis Group adviser for LATAM Former Managing Director of Vetoquinol, Daichii Sankyo - Spain- and Nycomed Spain;Business Development Manager of Bionaturis Group since 2011 CEO and founder of Bionaturis Group since 2005; Named by FORBES Magazine as one of the young Spanish businessmen to track Javier Gallastegui Victor Infante
13 Business performance and trends Net Sales ( 000) P 2016P CAGR BIO ( P): 81% CAGR SECTOR ( P): 3.5% EBITDA M BIO (2014): 50% EBITDA M SECTOR (2014): 25%
14 Business performance and trends As a result of the new M&A transac0on Bionaturis Group will enhance its industrial branch, employing around 60 people and reaching a global revenue figure of 9.7 M in This presenta0on may contain forward- looking statements based on current assump0ons and forecasts made by Bionaturis Group or subgroup management. Various known and unknown risks, uncertain0es and other factors could lead to material differences between the actual future results, financial situa0on, development or performance of the company and the es0mates given here.
15 M&A transacnon Target company: CMO (Contract Manufacturing Organiza0on) of pharmaceu0cal OTC products and nutraceu0cals. Oral forms (liquid and solid). GMP cer0fied by EMA and FDA Buy- out scheme: Financial scheme: Total commitment: 9.7M 100% of the target Payment schedule: 60% at closing. Con0ngent payments of 20%, 20% in year 1 and 2, bond to business performance To keep key technical and execunve personnel at least 24 months at Bionaturis Group sole discre0on 4 M on EQUITY (Capital Increase) 6 M on debt financing. Approved to date linked to the Equity financing
16 M&A transacnon ü Strategic ra0onale for Bionaturis Group Diversifies products/clients/sectors. Less regulated, more de- risk sector Improving the integra0on in the value chain adding f&f GMP- cer0fied capabili0es for oral formula0ons Gets cri0cal mass and size. Size maders
17 Business performance and trends NEXT MILESTONES ü M&A closing ü Capital Increase closing ü Se2ng the Chinese subsidiary ü New BNTs development and licensing agreements ü BBD BIOPHENIX diversificanon ü LATAM, China and US expansion
19 Disclaimer This presenta0on may contain forward- looking statements based on current assump0ons and forecasts made by Bionaturis Group or subgroup management. Various known and unknown risks, uncertain0es and other factors could lead to material differences between the actual future results, financial situa0on, development or performance of the company and the es0mates given here. These factors include those discussed in Bionaturis' public reports which are available on the Bionaturis website at The company assumes no liability whatsoever to update these forward- looking statements or to conform them to future events or developments.
HECHO RELEVANTE AB-BIOTICS, S.A. 27 de Mayo de 2015 En cumplimiento de lo dispuesto en la Circular 9/2010 del Mercado Alternativo Bursátil y para su puesta a disposición del público como hecho relevante,
HECHO RELEVANTE CARBURES EUROPE, S.A. 27 de mayo de 2015 De conformidad con lo previsto en la Circular 9/2010 del Mercado Alternativo Bursátil, por medio de la presente, ponemos a disposición del mercado
HECHO RELEVANTE EBIOSS ENERGY, AD 22 de Mayo de 2015 De conformidad con lo previsto en la Circular 9/2010 del Mercado Alternativo Bursátil, por medio de la presente, ponemos a disposición del mercado la
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