Årsmøde Hotel Helnan Marselis - Aarhus/Randers januar Medicinsk Endokrinologisk Afdeling MEA Aarhus Universitetshospital

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1 Årsmøde 2014 Hotel Helnan Marselis - Aarhus/Randers januar 2014 Medicinsk Endokrinologisk Afdeling MEA Medicinsk Afdeling Regionshospitalet Randers

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3 På vegne af Dansk Endokrinologisk Selskab vil årsmødets lokale organisationskomité gerne takke vore sponsorer og udstillere for godt samarbejde: Amgen Astra Zeneca Axellus Bayer BMS Brahms Danish Diabetes Academy Eli Lilly Ferring Ipsen Maribo Medtronic MSD Novartis Novo Nordisk Sanofi-Aventis Takeda Pharma Viropharma 1

4 Den lokale organisationskomité: Jens Melgaard Bruun (formand) Troels Krarup Hansen Morten Møller Poulsen Ulla Kampmann Esben Søndergaard Lene Ring Madsen Christian Kruse (webmaster) Regionshospitalet Randers Regionshospitalet Randers Aalborg Universitetshospital 2

5 Program Dansk Endokrinologisk Selskabs Årsmøde 2014 Hotel Helnan Marselis, Aarhus Fredag den 17. januar 2014 Registrering Kl Marselissalen Sal 8 Bøgesalen Velkomst Velkomst Velkomst T1DM Graviditet og endokrinologi Thyroidea Kardiovaskulært Inkretiner Pause Diabetiske komplikationer Frokost Prædiabetes og T2DM Kaffepause Blandet endokrinologi Omklædning Middag Kl Metabolisme Bariatri, anorexi og ernæring Knoglemetabolisme

6 Program Dansk Endokrinologisk Selskabs Årsmøde 2014 Hotel Helnan Marselis, Aarhus Lørdag den 18. januar 2014 Marselissalen Uddeling af abstract-priser Kl Uddeling af Niels Schwartz Sørensen prisen + foredrag Kl Kaffepause Nyt om de Nationale Behandlingsvejledninger Kl International Invited speaker: Professor Per-Henrik Groop, Helsinki, Finland Kl Frokost Kl

7 Abstract- og præsentationsoversigt T1DM Fredag 17. januar 2014, kl Marselissalen Abstract 1-9 Chairs: Ulrik Pedersen-Bjergaard og Peter Rossing 1 Genetic risk score modelling for disease progression in new-onset type 1 diabetes patients Evidence for TNFAIP3 and SKAP2 as modulators of β- cell apoptosis.b Caroline A. Brorsson, Lotte B. Nielsen, Anne M. Traulsen, Marie Louise Andersen, Tina Fløyel, Lukas A. Berchtold, Regine Bergholdt, Lars Hansen, Henrik B. Mortensen, Flemming Pociot and Joachim Størling. 2 Development of Anti-idiotypic Antibodies Against the Monoclonal Autoantibody IC2 in an Attempt to Normalize the Deficient Natural Killer T-cell Activity in Type-1 Diabetes. Jensen KL, Engmose CP, Engkilde K, Lermark Å, Brogren CH 3 Is TRAF3IP2 involved in the pathogenesis of type 1 diabetes and beta-cell apoptosis via induction of NFkB? Ann Bech Thomsen, Lise Wogensen Bach, Joachim Størling, Caroline Brorsson, Flemming Pociot. 4 Effect of insulin analogues on frequency of documented hypoglycaemia in patients with type 1 diabetes and recurrent severe hypoglycaemia Agesen RM, Kristensen PL, Beck-Nielsen H, Nørgaard K, Perrild H, Christiansen JS, Jensen T, Hougaard P, Parving H-H, Thorsteinsson B, Tarnow L, Pedersen-Bjergaard U 5 Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycaemia in type 1 diabetes Mikkel Christensen, Salvatore Calanna, Alexander Hovard Sparre-Ulrich, Peter Lommer Kristensen, Mette Marie Rosenkilde, Francesco Purrello, Gerrit van Hall, Jens Juul Holst, Tina Vilsbøll and Filip Krag Knop 6 Behandlingskvalitet hos patienter med type 1 diabetes i behandling med insulinpumpe Hans Jørgen Gjessing, Ulla Linding Jørgensen, Charlotte Chrois Møller, Jette Pedersen, Ellen Grodum, Karoline Schousboe 5

8 7 Short-term effects of NPH insulin, insulin detemir and insulin glargine on the IGF-IGFBP-GH axis in patients with type 1 diabetes Zhulin Ma, Jens Sandahl Christiansen, Torben Laursen, Torsten Lauritzen, Jan Frystyk 8 Targeting intensive versus conventional glycemic control for type 1 diabetes mellitus: systematic review with meta-analyses and trial sequential analyses of randomized clinical trials Pernille Kähler, Berit Grevstad, Thomas Almdal, Christian Gluud, Jørn Wetterslev, Søren Søgaard Lund, Allan Vaag, Bianca Hemmingsen 9 Diabetes udløst af højdosis steroidbehandling hos kræftpatienter Schultz H, Kristensen PL, Engelholm SA, Harder E, Pedersen-Bjergaard U Ekstra Proteolytic fragmented and chimeric IC2 monoclonal autoantibody against the pancreatic beta-cell surface chemically labeled with the nearinfrared fluorochromes for near-infrared noninvasive imaging of the pancreatic beta-cell mass. Brogren CH, Al-Shamary N, Sefeld M, Briat A 6

9 Inkretiner Fredag 17. januar 2014, kl Sal 8 Abstract Chairs: Tina Vilsbøll og Jørgen Rungby 10 Weight reducing effects of liraglutide in mice are dependent on number of daily injections rather than dose Emilie Balk-Møller, Hannelouise Kissow 11 Glucagon-like peptide-1 (GLP-1) reduces mortality and improves lung function in a model of experimental obstructive lung disease in female mice. Niels-Erik Viby, Marie S. Isidor, Katrine B. Buggeskov, Steen S. Poulsen, Jacob B. Hansen and Hannelouise Kissow 12 Luminal glucose stimulates GLP-1 secretion from the isolated perfused rat small intestine by SGLT-1 and GLUT2 mediated uptake and L-type calcium channel activation Rune Ehrenreich Kuhre, Charlotte Rasmussen, Berit Svendsen, Jens Juul Holst 13 Activation of renal GLP-1 receptors located in the afferent arterioles causes an increase in renal blood flow Jensen, E.P., S.S. Poulsen, H.Kissow, C.Deacon, J.J. Holst and C.M. Sorensen 14 Targeting the L-cell Does G-protein Coupled Receptor 40 Activation Stimulate Glucagon-like-peptide-1 Secretion? Louise Wulff Christensen, Berit Svendsen, Jens Juul Holst 15 Impaired incretin effect and gastrointestinal-mediated glucose disposal in non-diabetic patients with cirrhosis Anders E. Junker, Lise L. Gluud, Jens J. Holst, Filip K. Knop, Tina Vilsbøll 16 The effects of liraglutide and ischemic postconditioning on myocardial salvage after ischemia-reperfusion injury in pigs. Ekström K, Dalsgaard M, Iversen KK, Pedersen-Bjergaard U, Vejlstrup NG, Diemar SS, Idorn M, Thorsteinsson B, Engstrøm T. 17 Liraglutide is associated with a decreased risk of acute myocardial infarction in type 2 diabetes mellitus patients. Søren Gregersen, Jakob Starup-Linde, Jan Scheel-Thomsen, Michael Gejl, Peter Vestergaard. 7

10 18 Near-normalization of glycaemic control with a glucagon-like peptide-1 receptor agonist in combination with physical exercise: a randomized double-blinded placebo-controlled clinical trial Pernille Mensberg, Signe Nyby, Peter G. Jørgensen, Heidi Storgaard, Jacob C. Sivertsen, Magnus T. Jensen, Bente Kiens, Erik A. Richter, Filip K. Knop and Tina Vilsbøll. 8

11 Metabolisme Fredag 17. januar 2014, kl Bøgesalen Abstract Chairs: Esben Søndergaard og Jens Otto Jørgensen 19 Persistent AS160 and TBC1D1 phosphorylation in human skeletal muscle 30 min after a single bout of exercise Mikkel H. Vendelbo, Andreas B. Møller, Jonas T. Treebak, Lars C Gormsen, Jørgen F. P. Wojtaszewski, Jens Otto L. Jørgensen, Niels Møller, Niels Jessen 20 Regulation of glycogen synthase during exercise and exercise recovery in skeletal muscle of overweight subjects with and without Type 2 diabetes: Effects of insulin. Andreas James Thestrup Pedersen, Janne Rasmus Hingst, Kurt Højlund, Martin Friedrichsen, Jonas Møller Kristensen, Jørgen F.P. Wojtaszewski 21 Molecular mechanisms of exercise-induced autophagy in human skeletal muscle effect of substrate availability A.B. Møller, M.H. Vendelbo, B. Christensen, B.F. Clasen, J.O. Jørgensen, N. Møller and N. Jessen 22 Growth Hormone (GH)-infusion and fasting both reduce mrna expression of G0/G1 Switch Gene 2 (G0S2) in human subjects Peter K. Brask-Thomsen, Birgitte Nellemann, Mikkel H. Vendelbo, Thomas S. Nielsen, Ann M. Bak, Steen B. Pedersen, Berthil F. F. Clasen, Niels Møller, Esben T. Vestergaard, Niels Jessen and Jens Otto L. Jørgensen. 23 Regulation of ANGPTL4 in human muscle- and adipose tissue Rikke Viggers, Ann Mosegaard Bak, Niels Møller, Jens Otto Lunde Jørgensen, Niels Jessen 24 Intravenous catheters, causes elevated IL-6 locally. Karen Fjeldborg, Steen Bønløkke Pedersen, Bjørn Richelsen 25 Impaired insulin-mediated VLDL-triglyceride Kinetics in Overweight/Obese men with Non-alcoholic Fatty Liver Disease Poulsen MK, Nellemann B, Pedersen SB, Grønbæk H, Nielsen S 9

12 26 Gastrointestinal-mediated glucose disposal in total pancreatectomised patients Asger Lund, Jonatan I. Bagger, Mikkel Christensen, Magnus Grøndahl, Elisabeth R. Mathiesen, Carsten P. Hansen, Jan Storkholm, Steen Larsen, Jens J. Holst, Tina Vilsbøll and Filip K. Knop 27 Metabolic Effects of an Amino Acid infusion during LPS Exposure mimicking acute Infection in Humans N. Rittig, E. Bosjnak, HH. Thomsen, B. Richelsen, JO. Jørgensen, N. Møller 10

13 Graviditet og endokrinologi Fredag 17. januar 2014, kl Marselissalen Abstract Chairs: Birte Nygaard og Claus H. Gravholt 28 Adverse pregnancy outcome and mitochondrial dysfunction in women with subclinical hypothyroidism. Anne-Dorthe Feldthusen, Palle Lyngsie Pedersen, Jacob Larsen, Tina Toft Kristensen, Jan Kvetny. 29 Monitoring and evaluation of the Levothyroxin replacement therapy in pregnant women with hypothyroidism. Julia Hubaveshka, Luba Freja Liubov Michaelsson, Birte Nygaard. 30 Antithyroid behandling i tidlig graviditet giver betydende risiko for medfødte misdannelser. Et dansk nationalt studie af eksponerede børn. Stine Linding Andersen, Jørn Olsen, Chun Sen Wu og Peter Laurberg 31 Brug af antithyroid medicin bør begrænses i tidlig graviditet og ophøre før 6. graviditetsuge. Peter Laurberg & Stine Linding Andersen 32 Abdominal circumference is higher in children born of women with polycystic ovary syndrome than controls Hanne Mumm, Dorte Glintborg, Jens Aage Sørensen, Lise Lotte Torvin Andersen, Dorte Møller Jensen, Marianne Andersen 33 Lower levels of placental growth hormone in early pregnancy in type 1 diabetic women giving birth to large for gestational age infants Lene Ringholm, Anders Juul, Ulrik Pedersen-Bjergaard, Birger Thorsteinsson, Peter Damm, Elisabeth R. Mathiesen 34 Morbidity and mortality in offspring born to mothers with type 1 diabetes. Sine Knorr, Kirstine Stochholm, Zuzana Vlachova, Birgitte Bytoft, Tine Dalsgaard Clausen, Rikke Beck Jensen, Peter Damm, Henning Beck- Nielsen, Dorte M. Jensen, Claus Højbjerg Gravholt 11

14 Diabetiske komplikationer Fredag 17. januar 2014, kl Sal 8 Abstract Chairs: Lise Tarnow og Dan Hesse 35 Foot protection in bed in patients with diabetic pressure ulcers and serious comorbidity. Anne Rasmussen, Per Holstein, Kirsten Engelhard Nielsen, Martin Ridderstråle. 36 Effects of Leucopatch, an Autologous, Leucocytes and Platelet Rich Fibrin Patch, in Patients with Hard-to-Heal Diabetic Foot Ulcers. A pilot study. Magnus Löndahl, Lise Tarnow, Tonny Karlsmark, Rasmus Lundquist, Anna Marie Nielsen, Morten Michelsen, Anders Nilsson, Mariusz Zakrzewski, Bo Jörgensen. 37 Magnetic resonance imaging for volumetric evaluation of diabetic polyneuropathy: A methodological pilot study Michael Vaeggemose MSc PhD-stud, Steffen Ringgaard MSc PhD, Knud Yderstraede MD PhD, Niels Ejskjaer MD PhD, Henning Andersen MD PhD Prof 38 Soluble Urokinase Plasminogen Activator Receptor is associated with diabetes and diabetic complications in patients with type 1 diabetes S Theilade, S Lyngbæk, TW Hansen, J Eugen-Olsen, M Fenger, P Rossing and JL Jeppesen 39 Ficolin B in Diabetic Kidney Disease Charlotte Berg Holt, Jakob Appel Østergaard, Steffen Thiel, Troels Krarup Hansen 40 Circulating levels of mid regional pro-adrenomedullin (MR-proADM) are not associated with major cardiovascular events or renal failure in patients with type 1 diabetes Pernille Holmager, Ulrik Pedersen-Bjergaard, Anne-Sophie Sejling, Birger Thorsteinsson, Jens Faber, Caroline Kistorp. 41 Effect of Aldosterone Receptor Blockade on Galectin 3 in Patients with Diabetic Nephropathy Morten Lindhardt, Maria Lajer, Hiddo Jan Lambers Heerspink, Peter Rossing and Rudolf A. de Boer. 12

15 42 Low-density lipoprotein cholesterol is associated with fracture risk in diabetes patients - a nested case-control study Jakob Starup-Linde, Soeren Gregersen, Peter Vestergaard 13

16 Bariatri, anorexi og ernæring Fredag 17. januar 2014, kl Bøgesalen Abstract Chairs: Filip Knop og Jens Meldgaard Bruun 43 Changes in body weight, hormonal status, and physical activity during cannabinoid treatment in patients with severe, enduring anorexia nervosa: results from a randomised, controlled study Alin Andries, Bibi Gram, Jan Frystyk, Allan Flyvbjerg, René Klinkby Støving 44 Bone status in patients with anorexia nervosa and relationship with biochemical findings and findings at psychiatric interview Stine Aistrup Eriksen Msc, Hanne Prietzel MD, Jenna Rosenqvist Ibsen MD, Marlene Briciet Lauritsen MD DrMedSc, Peter Vestergaard MD PhD DrMedSc, Gry Kjærsdam Telléus Cand. Psych. 45 Whey, Casein, and Post-Prandial Lipaemia; a 12-week, randomized, parallel-controlled, human intervention study Bohl M., Gregersen S., and Hermansen K. 46 First report of cases treated with the EndoBarrier gastrointestinal liner in Denmark Ulrich Rohde, Ebbe Langholz, Peter Vilmann, Steffen U. Friis, Tina Vilsbøll and Filip K. Knop 47 Effect of gut-hormone inhibition on energy intake, glucose tolerance and pulse rate after Roux-en-Y Gastric Bypass surgery Maria Saur Svane, Kirstine Bojsen-Møller, Carsten Dirksen, Nils Bruun Jørgensen, Christoffer Martinussen, Jens Juul Holst, Sten Madsbad 48 Acute and long-term changes in leptin and ghrelin concentrations after Roux-en-Y gastric bypass Nils Bruun Jørgensen, Carsten Dirksen, Kirstine Bojsen-Møller, Siv Hesse Jacobsen, Maria Svane, Jens Juul Holst, Sten Madsbad, Trine Ryberg Clausen 49 Beta-cell function in response to oral and intravenous challenges after Roux-en-Y gastric bypass Kirstine N Bojsen-Møller, Carsten Dirksen, Nils B. Jørgensen, Siv H Jacobsen, Annette K Serup, Peter H Albers, Dorte L Hansen, Dorte Worm, Lars Naver, Viggo B Kristiansen, Jørgen FP Wojtaszewski, Bente Kiens, Jens J Holst, Erik A Richter, Sten Madsbad 14

17 Thyroidea Fredag 17. januar 2014, kl Marselissalen Abstract Chairs: Jesper Karmisholt og Thomas Brix 50 Autoreactivity and distribution between naïve and memory cell compartments of circulating Th17 cells and type-1 regulatory T cells in autoimmune thyroid disease. Birte Kristensen, Laszlo Hegedüs, Hans Madsen, Terry Smith, and Claus H. Nielsen. 51 Di-ethylhexyl-phthalate (DEHP) is metabolised by human thyroid cells and may influence thyroglobulin secretion Juliana Frohnert Hansen, Marianne Brorson, Marie-Louise Hartoft-Nielsen, Malene Boas Katharina M. Main, Hanne Frederiksen, Jacob Hofman-Bang, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen 52 Pendrin autoantibodies, using a radioligand binding assay, are detected with low frequency in patients with autoimmune thyroid disease and are undetectable in normal controls Brix TH, Hegedüs L, Weetman AP, Kemp EH 53 Psychiatric morbidity before and after the diagnosis of hyperthyroidism: A nationwide register-based study Frans Brandt, Marianne Thvilum, Dorthe Almind, Kaare Christensen, Anders Green, Thomas Heiberg Brix and Laszlo Hegedüs 54 Iodine fortification may influence the age-related change in thyroid volume a longitudinal population-based study (DanThyr). Anne Krejbjerg, Inge Pedersen, Lena Bjergved, Allan Carlé Torben Jørgensen, Hans Perrild, Lars Ovesen, Lone Rasmussen, Nils Knudsen og Peter Laurberg. 55 Increased psychiatric morbidity before and after the diagnosis of hypothyroidism: A nationwide register study Marianne Thvilum, Frans Brandt, Dorthe Almind, Kaare Christensen, Thomas H Brix, Laszlo Hegedüs 56 Reference change values for the Hospital Anxiety and Depression Scale, SF-36 and hypothyroid score in patients with stable subclinical hypothyroidism Jesper Karmisholt, Stig Andersen and Peter Laurberg 15

18 57 The impact of Graves disease and it s treatment on handwriting characteristics Giampaolo Papi, M.D. Ph.D., Cristina Botti, Salvatore Maria Corsello, M.D. Ph.D., Anna Vittoria Ciardullo, M.D., Alfredo Pontecorvi, M.D. Ph.D., and Laszlo Hegedüs 58 Randomised controlled trial of the effect of long-term selenium supplementation on serum thyrotropin concentrations in euthyroid Danish seniors Kristian Hillert Winther, Steen Bonnema, Frederik Cold, Søren Cold, Mads Nybo, Laszlo Hegedüs 59 The correlation between biochemically assessed thyroid disease and all cause-mortality - The Danish register-based OPENTHYRO study of 239,768 individuals- Anne Sofie Laulund, Mads Nybo, Thomas Heiberg Brix, Bo Abrahamsen, Henrik Løvendahl Jørgensen, Laszlo Hegedüs. 60 Development of autoimmune overt hypothyroidism is highly associated with childbirths and induced abortions but only in premenopausal women. Allan Carlé, Inge Bülow Pedersen, Nils Knudsen, Hans Perrild, Lars Ovesen, Lone Banke Rasmussen, Torben Jørgensen, and Peter Laurberg. 16

19 Prædiabetes og T2DM Fredag 17. januar 2014, kl Sal 8 Abstract Chairs: Ulla Kampmann og Søren Gregersen 61 Metabolic inflexibity in obese subjects: Unaltered insulin sensitivity after 72 h of fasting with and without acipimox Ann Mosegaard Bak, Mikkel Holm Vendelbo, Rikke Viggers, Jørgen Rungby, Jens Otto Lunde Jørgensen, Niels Jessen, Niels Møller 62 Effect of the primary human bile acid chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucose metabolism in patients with type 2 diabetes and in healthy control subjects Morten Hansen, Matthijs Scheltema, David P. Sonne, Jens J. Holst, Tina Vilsbøll and Filip K. Knop 63 High Intensity Interval Training Improves Insulin Mediated Glucose Clearance in Skeletal Muscle in Patients with Type 2 Diabetes and healthy controls Nielsen MB, Skaaby S, Andersen NB, Petersen HHH, Helge JW, Dela F 64 Incidence of diabetes and diabetes complications among migrants in Denmark Marit Eika Jørgensen, Zaza Kamper-Jørgensen, Bendix Carstensen, Marie Norredam, Ib Christian Bygbjerg, Gregers Stig Andersen 65 Insulintilfælde under behandling med sulfonylurinstof hos patienter med type 2-diabetes i Region Hovedstaden Sascha Pilemann-Lyberg, Birger Thorsteinsson, Ole Snorgaard, Mette Zander, Henrik Vestergaard og Michael E. Røder 66 Prescribing Patterns of Antidiabetic Drugs within the First Year following Diagnosis of Type 2 Diabetes: Results from the DD2 study Anil Mor, Klara Berencsi, Elisabeth Svensson, Jørgen Rungby, Jens Steen Nielsen, Søren Friborg, Ivan Brandslund, Jens Sandahl Christiansen, Allan Vaag, Henning Beck-Nielsen, Henrik Toft Sørensen, Reimar Wernich Thomsen 17

20 67 Family history of diabetes and the association with demographic and anthropometric characteristics among newly diagnosed diabetes type 2 patients: Results from the DD2 study Elisabeth Svensson, Klara Berencsi, Simone Sander, Anil Mor, Jørgen Rungby, Jens Steen Nielsen, Søren Friborg, Ivan Brandslund, Jens Sandahl Christiansen, Allan Vaag, Henning Beck-Nielsen, Henrik Toft Sørensen, Reimar Wernich Thomsen 68 Glucose lowering effects and low risk of hypoglycaemia in maturity onset diabetes of the young patients when treated with a glucagon-like peptide-1 receptor agonist a double-blind randomised cross-over trial Signe H. Østoft, Jonatan I. Bagger, Torben Hansen, Oluf B. Pedersen, Jens J. Holst, Filip K. Knop and Tina Vilsbøll 69 Pathophysiological phenotypes of clinically diagnosed type 2 diabetes Jacob Volmer Stidsen, Reimar W. Thomsen, Jens Steen Nielsen, Jørgen Rungby, Sinna Pilgaard Ulrichsen, Klara Berensci, Søren Friborg, Ivan Brandslund, Aneta A. Nielsen, Jens Sandahl Christiansen, Henrik Toft Sørensen, Jan Erik Henriksen, Henning Beck-Nielsen 70 Does intensive glycaemic control influence health-related quality of life in patients with type 2 diabetes? A systematic review with meta-analysis of randomised clinical trials Bianca Hemmingsen, Søren S Lund, Christian Gluud, Allan Vaag, Thomas Almdal, Christina Hemmingsen, Jørn Wetterslev 18

21 Knoglemetabolisme Fredag 17. januar 2014, kl Bøgesalen Abstract Chairs: Bente Langdahl og Bo Abrahamsen 71 abmd at the hip measured by DXA overestimate cortical vbmd assesed by QCT scans Anne Kristine Amstrup, Tanja Sikjær, Leif Mosekilde, Lars Rejnmark 72 External auditory canal and middle ear diseases in bisphosphonatetreated osteoporosis patients. A Danish National Register Based Cohort Study Anne-Luise Thorsteinsson, Peter Vestergaard, Pia Eiken 73 Osteoporosis in male respiratory patients Rana Bibi, Peter Laurberg, Ulla Weinreich, Eigil Husted Nielsen 74 Frakturer og refrakturer fra et dansk perspektiv Louise Hansen, Stine Aistrup Eriksen, Bente Lomholt Langdahl, Pia A Eiken, Kim Brixen, Bo Abrahamsen, Jens-Erik Beck Jensen, Torben Harsløf og Peter Vestergaard 75 Risiko for infektioner og cancersygdom hos patienter med postoperativ hypoparathyreoidisme Line Underbjerg, Tanja Sikjaer, Leif Mosekilde, Lars Rejnmark Medicinsk-Endokrinologisk Afdeling, MEA,, Tage-Hansens Gade 76 Low thyrotropin levels as a predictor of major osteoporotic fractures The OPENTHYRO register cohort Abrahamsen Bo, Jørgensen Henrik L, Laulund Anne Sofie, Nybo Mads, Brix Thomas H, Hegedüs L 77 Hyponatremia and Bone Mineral Density: A Cross-Sectional Study Kruse C; Eiken P; Vestergaard P 78 Effekten af per oral mætningsdosis af vitamin D3 på serumkoncentration af vitamin D3 Cand.med. Rasmus Bo Jansen og ovl., klinisk lektor, dr.med. Ole Lander Svendsen 79 Resveratrol increases vbmd at the spine in obese men: A randomized controlled trial MJ Ornstrup, T Harsløf, T Kjær, SK Paulsen, BL Langdahl, SB Pedersen 19

22 80 Vitamin D treatment in primary hyperparathyroidism: a randomized placebo controlled trial Lars Rolighed, Lars Rejnmark, Tanja Sikjaer, Lene Heickendorff, Peter Vestergaard, Leif Mosekilde, and Peer Christiansen. 81 Biochemical markers of bone turnover in diabetes patients- a metaanalysis, and a methodological study on the effects of glucose on bone markers. Peter Vestergaard, Stine Aistrup Eriksen, Simon Lykkeboe, Aase Handberg, Jakob Starup-Linde 20

23 Kardiovaskulært Fredag 17. januar 2014, kl Marselissalen Abstract Chairs: Caroline Kistorp og Per Løgstrup Poulsen 82 Markedly Elevated 24-hour Ambulatory Blood Pressure in Healthy Male Carriers of Arg82Cys in CD300LG Identifies the Gene as a Possible Novel Regulator of Blood Pressure Julie Støy, Ulla Kampmann, Arne Hørlyck, Lotte Ibsen, Nils Magnusson, Jørgen Rungby, Per Løgstrup Poulsen,Ivan Brandslund, Cramer Christensen, Niels Grarup, Torben Hansen, Oluf Pedersen, Niels Møller 83 Treatment of subclinical hyperthyroidism with radioiodine: MRIevaluated effect on the heart Peter Dall Mark (stud. med.), Mikkel Andreasen, Claus Leth Petersen, and Jens Faber. 84 Cerebrovascular event rate after radioiodine therapy la Cour JL, Jensen LT, 2, Nygaard B 85 Associations between glycaemic deterioration and central haemodynamics in non-diabetic individuals. The ADDITION-PRO study Nanna B. Johansen, Signe S. Rasmussen, Niels Wiinberg, Dorte Vistisen, Marit E. Jørgensen, Erling B. Pedersen, Torsten Lauritzen, Annelli Sandbæk, Daniel R. Witte 86 Morning blood pressure surge is not associated with pulse wave velocity, cerebral white matter lesions or urinary albumin excretion in patients with newly diagnosed type II diabetes Lyhne J, Laugesen E, Høyem P, Christiansen JS, Knudsen ST, Hansen KW, Hansen TK, Poulsen PL. 87 Ambulant 24 timers besemmelse af pulsbølgehastighed og aorta blodtryk: et pilot projekt Christoffer Krogager, Niklas Rossen, Esben Laugesen, Søren Tang Knudsen, Per Løgstrup Poulsen, Klavs Würgler Hansen 88 Diabetes and stroke: Liraglutide is associated with a decreased risk of stroke in type 2 diabetes mellitus. A nested case-control study Jan Scheel-Thomsen, Jakob Starup-Linde, Michael Gejl, Soeren Gregersen, Peter Vestergaard 21

24 89 Vitamin D and carotid intima media thickness in 416 Danish patients with type 2 diabetes mellitus (T2D) at entry into the CIMT trial K. Winckler, T. W. Boesgaard, L. Tarnow, H. Vestergaard, T. Almdal, L. Lundby-Christensen, A. Vaag, S. Madsbad, C. Gluud, 90 Risk Stratification with Plasma-NT-proBNP and Coronary Calcium Score Predicts All-Cause Mortality in Microalbuminuric Type 2 Diabetic Patients. Bernt Johan Illum von Scholten, Henrik Reinhard, Peter Godsk Jørgensen, Simone Theilade, Peter Riis Hansen, Niels Wiinberg, Andreas Kjær, Claus L Petersen, Kaj Winther, Hans-Henrik Parving, Jan Skov Jensen, Peter K Jacobsen, Peter Rossing Ekstra Assessment of Central Blood Pressure in Patients with Type 2 Diabetes: A Comparison Between Sphygmocor and Invasively Measured Values E. LAUGESEN, N.B. ROSSEN, C.D. PETERS, M. MÆNG, E. EBBEHØJ, S.T. KNUDSEN, K.W. HANSEN, H.E.BØTKER, P.L. POULSEN 22

25 Blandet endokrinologi Fredag 17. januar 2014, kl Bøgesalen Abstract Chairs: Kirstine Stochholm og Peter Vestergaard 91 Environmentally-Induced Epigenetic Changes in Gametes Does Our Lifestyle Affect the Next Generation? Ida Donkin, Soetkin versteyhe, Thais de Castro Barbosa, Kui Quan, Lars Ingerslev, Juleen Zierath, Romain Barrès 92 Glucocorticoid-induced adrenal insufficiency in prednisolone treated patients and how it relates to glucocorticoid dose and the duration of treatment Stina Dinsen, Bo Baslund, Marianne Klose, Åse Krogh Rasmussen, Lennart Friis-Hansec, Linda Hilsted, Henning Locht, Annette Hansen, Ulla Feldt- Rasmussen. 93 Anthropometrics in Klinefelter syndrome and the influence of genetic and hypothalamic-pituitary-gonadal markers Simon Chang, Anne Skakkebæk, Anders Bojesen, Jens Michael Hertz, Arieh Cohen, David Michael Hougaard, Mikkel Wallentin, Anders Degn Pedersen, John Rosendahl Østergaard, Claus Højbjerg Gravholt 94 Copeptin in polycystic ovary syndrome Signe Frøssing, Mubeena Aziz, Sven O. Skouby, Caroline Kistorp, Jens Faber 95 Determinants of non-alcoholic fatty liver disease in women with previous gestational diabetes mellitus Signe Foghsgaard, Louise Vedtofte, Camilla Andersen, Emilie S. Andersen1, Lise L. Gluud, Charlotte Strandberg, Thora Buhl, Elisabeth R. Mathiesen, Peter Damm, Jens Svare, Filip K. Knop and Tina Vilsbøll 96 Prevalence of sleep apnea in Danish Type 1 Diabetes patients Henriette Holst Hansen, Lise Tarnow, Ulrik Pedersen-Bjergaard, Brynjulf Mortensen, Michael Laub og Birger Thorsteinsson 97 Obstruktiv søvnapnø hos diabetes patienter henvist til søvnklinik. Freja Eriksen, Anne Roed Jacobsen, Line Thorup, Lykke Bennedsen, Jonas Peter Yde Holm, Klavs Würgler Hansen 23

26 98 The metabolic effects of lipopolysaccharide depend on intact pituitary stress hormone responses studies of glucose, lipid and amino acid metabolism in hypopituitary patients and healthy volunteers Ermina Bach, Andreas B. Møller, Jens O. L. Jørgensen, Mikkel H. Vendelbo, Niels Jessen, Jonas F. Olesen, Steen B. Pedersen, Niels Møller 99 Incidence and late prognosis of Acromegaly in Denmark: Preliminary data Jakob Dal, Ulla Feldt-Rasmussen, Marianne Andersen, Lars Ø. Kristensen, Peter Laurberg, Henrik Toft Sørensen, and Jens Otto L. Jørgensen 24

27 1. Genetic risk score modelling for disease progression in new-onset type 1 diabetes patients Evidence for TNFAIP3 and SKAP2 as modulators of β-cell apoptosis. Caroline A. Brorsson, Lotte B. Nielsen, Anne M. Traulsen, Marie Louise Andersen, Tina Fløyel, Lukas A. Berchtold, Regine Bergholdt, Lars Hansen, Henrik B. Mortensen, Flemming Pociot and Joachim Størling. Herlev Hospital, Herlev, Danmark Genome-wide association studies (GWAS) have identified over 40 type 1 diabetes risk loci. The clinical impact of these loci on β-cell function during disease progression is unknown. We hypothesized that genetic variation in type 1 diabetes candidate genes that are expressed within the β-cells could be involved in disease mechanisms by modulating the β-cells sensitivity to immune attack. In the current study we therefore considered genes expressed and transcriptionally regulated by cytokines in human islets to perform genetic risk score modelling for prediction of β-cell function in children with newly-diagnosed type 1 diabetes. Expression profiles for candidate genes within associated risk loci were investigated in nine human islet preparations ± cytokine stimulation (TNF-α, IFN-γ, IL-1β) for 48h. SNPs from the corresponding GWAS loci were genotyped in 257 children (126 girls and 131 boys) with mean age at clinical onset 9.1 ± 3.7 years, in an international prospective cohort of newly-diagnosed children followed for one year after diagnosis. A genetic risk score was constructed based on the cumulative number of risk alleles carried by each child. Using linear regression the risk score was tested for association with HbA1c and insulin-dose adjusted HbA1c (IDAA1C; a surrogate marker of β-cell function). Individual SNPs were analysed for effect on stimulated C-peptide, HbA1c and IDAA1c in linear regression models. The effect on β-cell apoptosis of selected candidate genes was tested by transcriptional knock-down using specific sirnas in a rat INS-1E cell line. Eleven candidate genes were significantly regulated by cytokines in human islets. The genetic risk score constructed from these genes was positively associated with HbA1c and IDAA1c levels after three and six months and throughout the study period, respectively. This suggests poorer glycaemic control and residual β-cell function with increasing genetic risk score. Individual SNP analysis revealed that rs of TNFAIP3 and rs of SKAP2 predicted glycaemic control as assessed by HbA1c and IDAA1C 12 months after onset. Functional knock-down of TNFAIP3, SKAP2, or both, in INS-1E cells demonstrated involvement in cytokine-mediated cell death. Our results may help predict disease progression in children at type 1 diabetes onset and provide novel information about genes involved in regulating β-cell apoptosis. 25

28 2. Development of Anti-idiotypic Antibodies Against the Monoclonal Autoantibody IC2 in an Attempt to Normalize the Deficient Natural Killer T-cell Activity in Type-1 Diabetes. Jensen KL1, Engmose CP1, Engkilde K1, Lermark Å2, Brogren CH1 The Bartholin Institute, Rigshospitalet, Copenhagen N, Denmark, 2University Hospital Malmö, Malmö, Sweden. A major objective in diabetes research is to identify factors that can prevent β-cell death. Natural Killer T cells (NKT cells) receive stimulatory signals from CD1d-lipid complexes, and are part of the regulatory control of the autoimmune T cells. An inhibition of this regulation is thought to be the reason for the β-cell destruction in Type 1 Diabetes (T1D). The monoclonal autoantibody IC2 that was raised in the BB rat binds specifically to functional pancreatic β-cells. The autoantigen on the β-cell to which it binds has only been partially determined. IC2 has been shown to inhibit the IL-2 secretion of NKT cells, which is why development of an anti-idiotypic antibody (anti-id Ab) against the paratope of IC2 is interesting. This anti-id Ab could prevent the inhibitory role of IC2, which would lead to maintenance of the normal regulatory functions of the NKT cells and thereby have preventive effects on T1D. Our aim is therefore to develop an anti-idiotypic antibody binding the paratope of IC2. A modified functional NKT-hybridoma assay with CD1d lipid complexes was used to measure NKT cell IL-2 secretion on a sandwich enzyme-linked immunosorbent assay (ELISA). A modified direct ELISA coated with IC2-F(ab )2 fragments was used to measure presence of Anti-Id Ab against IC2 and hybridoma formation was used to develop the IC2-specific Anti-Id Ab. Rat hybridomas were raised by PEG mediated fusion of splenocytes from IC2 immunized diabetes resistant BBDR+/+ rats with the rat HAT-sensitive YB2/0 cell line as fusion partner. Successful immunizations of BBDR+/+ rats show the syngenic idiotype immunogenic capabilities of IC2. The amount of anti-id in the sera of the immunized rats depends on the amount of IC2 injected during the immunizations. Initial ELISA screening of fusions showed that supernatants from 201 out of 720 wells were positive of IC2-anti-Id Ab to more or less degree. Successful subcloning have been made and currently six of them are ready to be propagated, recloned and further investigated. A majority of the subcloned hybridoma anti-idiotypic antibodies showed inhibition in IC2 binding assays indicating their potential used for in vivo treatment in preventive studies using diabetic prone BBDP+/+ rats. Similarly, binding to IC2 VH- CDR3 synthetic peptide was observed in ELISA with most of the antibodies tested, which also is the expected location of the IC2 specific idiotype. Hereby we conclude that development of anti-id Ab against IC2 can be done in a syngeneic system by immunization of rats with IC2 without carrier conjugation. Selected monoclonal Abs from this fusion will be further investigated for prevention of diabetes of the diabetes prone BBDR-/- rat in vivo. 26

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