2011 GREETINGS. Our recognition to Dr. Enrique Graue Wiechers, Dean of the Faculty of Medicine, UNAM, and Honorary President of this Congress.

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1 GREETINGS On behalf of the Planning, Organizing and Scientific Committees of the International Congress of Pharmacology Mexico 2011, we welcome all attendees. The joint meeting of the XXXIV Congreso Anual de la Asociación Mexicana de Farmacología A. C. (AMEFAR), the 54 th Annual Meeting of the Western Pharmacology Society (WPS), and the 2 nd Latin American Meeting of the International Society of Pharmacoepidemiology (ISPE), is the sixth occasion since 1966, that Mexican and Northamerican Pharmacologists gather together to continue efforts for spreading and updating knowledge for continuous development of Pharmacology, as a basic science fundamental for therapeutic advances. The transition towards a more preventive Medicine in a scenario of complex diseases demands a personalized diagnostic and treatment approaches, particularly those related to the use of medicaments. The contribution of outstanding Clinical and Basic Pharmacology and Therapeutics Researchers in the academic program of the International Congress of Pharmacology Mexico 2011 highlights the key essence of 21 st Century Pharmacology as an integrated and integrative science. Sustainable development of Pharmacology and Therapeutics is a complex task that requires the cooperation of all parties involved. Hereby we acknowledge the enthusiastic participation of higher education institutions, health care institutions, academic associations, government regulatory agencies, editorial and pharmaceutical companies whose cooperation made this meeting possible. Special mention deserves the generosity of the Faculty of Medicine of the Universidad Nacional Autónoma de México (UNAM) by hosting the International Congress of Pharmacology Mexico 2011 in the splendid Palace of the School of Medicine in Mexico City. Our recognition to Dr. Enrique Graue Wiechers, Dean of the Faculty of Medicine, UNAM, and Honorary President of this Congress. María Dolores Ramírez-González, Ph.D. President of the Planning and Organizing Committees International Congress of Pharmacology Mexico 2011 May 16 th to the 20 th, 2011 Mexico City

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3 3 INTERNATIONAL CONGRESS OF PHARMACOLOGY MEXICO 2011 PLANNING COMMITTEE María Dolores Ramírez-González, Ph.D. AMEFAR President Laurence Brunton, Ph.D. WPS President Maribel Salas, Ph.D. ISPE Latin America Delegate ORGANIZING COMMITTEE María Dolores Ramírez-González, Ph.D. AMEFAR President Laurence Brunton, Ph.D. WPS President Claudia Gómez Acevedo, AMEFAR General Secretary Rosa Ventura Martínez, AMEFAR Treasurer Maribel Salas, Latin America Delegate of ISPE SCIENTIFIC COMMITTEE Enrique Hong Chong, AMEFAR Executive Secretary Marco Martínez Ríos María Elena Medina-Mora José Luis Reyes Angélica Ocampo Marcela López Cabrera Egbert Sánchez Van der Kast Agustín Rogelio Mosqueda Guadalupe Baños Marhaber Bertha Prieto Gómez Jesús Adolfo García Sáinz Aurora de la Peña Díaz Eduardo Anglés-Cano Gilberto Vargas-Alarcón

4 4 Germán Chamorro Cevallos María Teresa Espinosa Meléndez Oscar Presbítero Arriaga Jesús Antonio González Hermosillo Carlos M. Villalón Herrera Antonio Caso Marasco Elia Brosla Naranjo Rodríguez J. Moisés Álvarez Rueda Abraham Hartzema Stan Edlavitch Chirs Delaney Iain L. Buxton Augusto Bondani Guasti Alejandra Rosete Reyes Bruno Escalante Elena Guadalupe Ramírez López Andrés E. Castell Rodríguez Eduardo Calixto González Carlos Viesca Treviño Patricia Yahuaca Mendoza Susana Tera Ponce Georgina Araceli Torres Vargas Isabel Saad Villegas

5 5 INTERNATIONAL CONGRESS OF PHARMACOLOGY MEXICO 2011 JOINT MEETING OF: XXXIV CONGRESO ANUAL DE LA ASOCIACIÓN MEXICANA DE FARMACOLOGÍA 54th ANNUAL MEETING OF THE WESTERN PHARMACOLOGY SOCIETY 2 nd LATIN AMERICAN MEETING OF THE INTERNATIONAL SOCIETY OF PHARMACOEPIDEMIOLOGY May 16 th to the 20 th, 2011 MONDAY MAY THE 16 th, :00-08:00 h Registration 08:00-08:20 h Opening Ceremony MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Presidium: Dr. Enrique Graue Wiechers. Honorary President of the Meeting. Dean of the Faculty of Medicine, Universidad Nacional Autónoma de México. Dra. María Dolores Ramírez González, President of the Asociación Mexicana de Farmacología A. C. and President of the Organizing Committee Dr. Laurence Brunton, President of the Western Pharmacology Society. Vice- President of the Organizing Committee Guests of Honor: Dra. María Elena Medina Mora. General Director of the Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente Dr. Marco A. Martínez Ríos. General Director of the Instituto Nacional de Cardiología Dr. Ignacio Chávez (TO BE CONFIRMED) Dra. Marcela López Cabrera, General Director of the Instituto para la Atención y Prevención de las Adicciones de la Ciudad de México Rosa Amalia Bobadilla MD., PhD. Directora de la Escuela Superior de Medicina del Instituto Politecnico Nacional, Mexico (TO BE CONFIRMED) Dr. George Kunos, Scientific Director of NIAA, NIH Dr. Eduardo Anglés-Cano. Directeur de Recherche 1. Institut National de la Santé et de la Recherche Médicale (INSERM)

6 6 Dr. Enrique Hong Chong. Executive Secretary of the Asociación Mexicana de Farmacología A. C. and President of the Scientific Committee Dr. Augusto Bondani Guasti. Incoming President of the Asociación Mexicana de Farmacología A. C. Dra. Carolina Escobar. President of the Sociedad Mexicana de Ciencias Fisiológicas A.C. (TO BE CONFIRMED) Dra. Alejandra Rosete. Professor of Pharmacovigilance (UNAM, ULSA), President of Mexico Chapter International Society of Pharmacovigilance, member of ACSoMP- WHO Dr. Xavier Lozoya Legorreta, Vice-President of the Asociación Mexicana de Fitoterapia A.C. Dr. Antonio Caso Marasco, President of the Colegio Mexicano de Farmacoeconomía and of the Mexican Chapter of the International Society of Pharmacoeconomics Dr. Jorge González Antequera, Presidente de la Asociación Mexicana de Farmacovigilancia A.C. Dra. Patricia Yahuaca Mendoza, Regional Delegate of AMEFAR Dra. María Teresa Espinosa y Dr. Oscar Presbítero Arriaga. Founding Members of the Odontologists Chapter of AMEFAR Esp Adic. Lic. Angélica Ocampo, Head of the Clínica Contra el Tabaquismo. Hospital General de México, SS. Ing. Hugo Setzer Letsche, General Director of Editorial El Manual Moderno S.A. de C. V., Industrial Associate of the Asociación Mexicana de Farmacología A. C. Special Guests: Former AMEFAR Presidents: Dr. Andrés Navarrete Castro, Dr. Carlos Castilo Henkel, Dr. Gilberto Castañeda Hernández, Dr. J. Moisés Álvarez Rueda, Dr. Luis Antonio Barragán Díaz Infante, Dr. Horacio Vidrio López, Dr. José Antonio Rojas Ramírez, Dr. Miguel Cervantes, Dr. Rodolfo Rodríguez Carranza Former WPS President: Dr. Carlos M. Villalón Herrera ISPE Delegates: Abraham Hartzema, Stan Edlavitch, Chris Delaney Distinguished Members of the Scientific Committee: Symposia Organizers and Lecturers AMEFAR and WPS Associates 08:20-08:30 h Coffee break

7 7 MONDAY MAY THE 16 th, :30 10:30 h Symposium 1: Addictions MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) 08:30 08:50 h Epidemiological overview of addictions. Dra. María Elena Medina-Mora. General Director of the Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente 08:50 09:10 How to understand addictions? Esp Adic. Lic. Angélica Ocampo, Head of the Clínica Contra el Tabaquismo. Hospital General de México, SS. 09:10 09:30 h From neurobiology to prevention of addictions. Dr. Luis Solis Rojas. Instituto para la Atención y Prevención de las Adicciones de la Ciudad de México. 09:30 09:40 h Questions and comments 09:40 10:20 h PLENARY LECTURE: From addictions to cardiovascular and metabolic diseases. MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Dr. George Kunos. Scientific Director NIAAA, National Institute of Health U.S. 10:20 10:30 h Questions and comments 10:30-10:40 h Coffee break 10:40-11:30 h PLENARY LECTURE: From neurobiology to public policies for attention and prevention of addictions MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Dra. Marcela López Cabrera. General Director of the Instituto para la Atención y Prevención de las Adicciones de la Ciudad de México. 11:30 11:40 h Questions and comments 11:40-12:50 h Lunch break 12:50-13:10 h PATIO DE PIEDRA Opening of the "Pavillion of the Pharmacology Book" Chairman: Ing. Hugo Setzer Letsche, General Director of Editorial El Manual Moderno S.A. de C. V., Industrial Associate of the Asociación Mexicana de Farmacología A. C. 13:10 13:20 h Coffee break

8 8 13:20-14:40 h Symposium 2: Current Trends in the retrieval of information on Pharmacology MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairman: Dr. Egbert Sánchez Vanderkast 13:20 13:35 h Licensing models for information retrieval and access to institutional repositories. Dr. Jesús Francisco García Pérez. Coordinador de la Biblioteca del Instituto de Investigaciones Sociales, Universidad Nacional Autónoma de México 13:35 14:00 h Specialized databases in Pharmacology. An approach to the current situation. Mtra. Isabel Margarita Lugo Hubp. Sub - directora de Servicios de Información Especializada de la Dirección General de Bibliotecas, Universidad Nacional Autónoma de México 14:00-14:15 h Access to medical information in a digital world: challenges for the librarian. Mtra. Alejandra Martínez del Prado. Biblioteca de la Facultad de Medicina, Universidad Nacional Autónoma de México y Coordinadora de la Sección de Bibliotecas en Ciencias de la Salud de la AMBAC 14:15 14:30 h The electronic book in the university environment. Mtro. Miguel Gama Ramírez. Coordinador de la Biblioteca Eduardo García Máynez of the Instituto de Investigaciones Filosóficas, Universidad Nacional Autónoma de México 14:30 14:40 h Questions and comments 14:40-14:50 h Coffee break 14:50-16:30 h Symposium 3: Obesity and diabetes MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairman: Dr. Agustín Rogelio Mosqueda-García Honorary Chairman: Dr. Carlos Posadas Romero. Head of the Departmento de Endocrinología, Instituto Nacional de Cardiología Dr. Ignacio Chávez 14:50 15:35 h Dr. Agustín Rogelio Mosqueda-García. New Pharmacological Approaches for Treating Type-2 Diabetes. Executive Director Clinical Pharmacology. Deputy HELC Chair & MSAG Lead. AstraZeneca LP 15:35 16:20 h Dr. Enrique Mendoza Pérez. Body fat disposition and cardiovascular risk. Departamento de Endocrinología. Instituto Nacional de Cardiología Dr. Ignacio Chávez 16:20 16:30 h Questions and comments 16:30-16:40 h Coffee break

9 9 16:40-18:00 h Symposium 4: Metabolic syndrome MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairwomen: Dra. Guadalupe Baños-Marhaber y Dra. Bertha Prieto Gómez 16:40 16:55 h Mechanisms of hyperinsulinemia in metabolic syndrome. Dra. Marcia Hiriart Urdanivia. Director of the Instituto de Fisiología Celular, Universidad Nacional Autónoma de México 16:55 17:25 h Metabolic syndrome in children. Dra. Yadira Eugenia Pastrana Fernández. Endocrinología Pediátrica, Hospital Ángeles Metropolitano 17:25 17:50 h Some characteristics of a model of metabolic syndrome. Dra. Guadalupe Baños Marhaber. Jefa de la Unidad de Biomedicina, Instituto Nacional de Cardiología Dr. Ignacio Chávez 17:50 18:00 h Questions and comments 18:00-18:50 h PLENARY LECTURE: From Himsworth to Syndrome X to the Metabolic Syndrome MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairwoman: Dra. Guadalupe Baños Marhaber Dr. Gerald Reaven. 18:50-19:00 h Coffee break Division of Cardiovascular Medicine, Falk CVRC, Stanford Medical Center 19:00-20:00 h Students gathering with Experts and Authors of Pharmacology Books 20:00-21:00 h Welcome reception

10 10 TUESDAY MAY THE 17 th, :00-08:00 h Registration 08:00-10:00 h Symposium 5: G protein coupled receptors IN HONOR OF DR. HORACIO VIDRIO LÓPEZ MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairman: Dr. J. Adolfo García Sáinz. Profesor Investigador del Instituto de Fisiología Celular, Universidad Nacional Autónoma de México 08:00 08:10 h Introduction. J. Adolfo García-Sáinz. 08:10 08:30 h Continuous Angiotensin II evokes cardiovascular effects inversely associated to alpha-1d-adrenoceptors expression in aorta of Wistar rats. Rafael Villalobos-Molina. Jefe de la Division de Investigacion y Posgrado. Unidad de Investigacion en Biomedicina. Facultad de Estudios Superiores Iztacala, UNAM 08:30 08:50 h Interactions of adrenergic receptors and the renin-angiotensin system during pregnancy and preclampsia. Pedro López- Sánchez. Jefe del Laboratorio de Farmacología Molecular.Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional 08:50 09:30 h Signaling by G-protein-coupled receptors: New results challenge old ideas. **Paul Insel. Professor, Pharmacology / Medicine Hematologic Malignancies Program. UC San Diego Moores Cancer Center 09:30 09:50 h Roles of paracrine/ autocrine communication in alpha-1- adrenoceptor phosphorylation/ desensitization. J. Adolfo García-Sáinz.. Profesor Investigador del Instituto de Fisiología Celular, Universidad Nacional Autónoma de México 09:50 10:00 h Questions and comments **SPONSORED BY INSTITUTO DE FISIOLOGÍA CELULAR, UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO 10:00 10:10 h Coffee break

11 11 10:10 A 12:10 h Symposium 6: Thrombosis MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairmen: Dr. Eduardo Anglés-Cano and Dra. Aurora de la Peña Díaz 10:10 10:35 h Physiopathology of thrombosis: procoagulant microparticles.dra. Aurora de la Peña Díaz. Profesor Titular A. Facultad de Medicina, Universidad Nacional Autónoma de México. Laboratorio de Trombosis y Fibrinólisis, Departamento de Biología Molecular. Instituto Nacional de Cardiología Dr. Ignacio Chávez. S.N.I. 10:35 11:00 h Thrombosis-novel drug targets: platelets. Dr. Abraham Majluf- Cruz. Jefe de la Clínica de Hemostasia y Trombosis del Hospital Mc Gregor del Instituto Mexicano del Seguro Social. S.N.I. 11:00 11:25 h Thrombosis: advances in new anticoagulant therapy. Dr. Carlos Martínez Murillo. Jefe de la Clínica de Hemostasia y Trombosis del Hospital General de México, Secretaría de Salud. Investigador en Ciencias Médicas de la Secretaría de Salud. Jefe de Programas Médicos. División de Excelencia Clínica. Dirección de Prestaciones Médicas, Jefe de UMAE. IMSS. S.N.I. Presidente de la Agrupación Mexicana para el Estudio de la Hematología, A.C. 11:25 11:50 h Fibrinolytic cross-talk: antithrombotic microparticles. Dr. Eduardo Anglés-Cano. Directeur de Recherche 1. Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 919. Serine Proteases et Pathologie Nerovasculaire. Cyceron, Caen, France. 11:50 12:10 h Questions and comments 10:10-12:10 h Symposium 7: Dental Pain GRAND HALL (PARANINFO DEL PALACIO DE LA ESCUELA DE MEDICINA) Chairmen: Dra. María Teresa Espinosa Meléndez and Dr. Oscar Presbítero Arriaga 10:10 10:25 h History of dental analgesia and anaesthesia. Dr. José Sanfilippo y Borras. Coordinador de Enseñanza del Departamento de Historia y Filosofía de la Medicina, Facultad de Medicina, Universidad Nacional Autónoma de México 10:25 11:05 h Physiopathology of dental pain. Dra. María Teresa Espinosa Meléndez. Profesora de la Facultad de Odontología, Universidad Nacional Autónoma de México 11:05-11:35 h Pain ATM: etiology, diagnosis and treatment. Dr. Adolfo Pérez Brignani. Benemérita Universidad Autónoma de Puebla

12 12 11:35-12:00 h Dental emergencies management. Dr. Óscar Presbítero Arriaga. Professor of Pharmacology, Westhill University Mexico 12:00 12:10 h Questions and comments 12:10 12:20 h Coffee break 12:20-14:20 h Symposium 8: Pharmacogenetics of Cardiovascular Diseases MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairman: Dr. Gilberto Vargas Alarcón 12:20 12:45 h Pharmacogenetics: Why should it be studied in Mexico? Dr. Gilberto Vargas Alarcón 12:45 13:10 h Coronary intervencionism with Stents: restenosis and angiographic patterns. Dr. Marco Antonio Peña Duque 13:10 13:35 h Polymorphisms associated to restenosis deveopment. Dr. José Manuel Fragoso Lona 13:35 14:00 h Role of genetics in Clopidogrel response. Dra. Aurora de la Peña. 14:00 14:20 h Questions and comments 12:20 13:20 h Early presentation of the book Farmacología y Terapéutica para Odontólogos Editorial Médica Panamericana GRAND HALL (PARANINFO DEL PALACIO DE LA ESCUELA DE MEDICINA) Dra. María Teresa Espinosa Meléndez, Editora Compiladora de la obra. 13:20 14:20 h Many Changes: Goodman & Gilman and Medical Education in the U.S. GRAND HALL (PARANINFO DEL PALACIO DE LA ESCUELA DE MEDICINA) Dr. Laurence Brunton. Editor of the book 14:20 16:20 h CONGRESS COURSES

13 13 16:20-17:20 h PLENARY LECTURE : Hypertension MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairman: Dr. Enrique Hong Chong 17:20 17:30 h Coffee break Dr. Gerardo Gamba- Ayala Premio Nacional de Ciencias 2010 Head of the Departamento de Nefrología del Instituto Nacional de Cardiología Dr. Ignacio Chávez 17:30-18:30 h PANEL OF EXPERTS "Cardiovascular risk and metabolic syndrome" MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairman: Dr. Jesús A. González Hermosillo Honorary Chairman: Dr. Enrique Hong Chong Panelists: Dr. Gerald Reaven Dr. George Kunos Dr. Eduardo Anglés-Cano 16:20 18:20 h Symposium 9: Spirulina GRAND HALL (PARANINFO DE LA ESCUELA DE MEDICINA) Chairman Dr. Germán Chamorro Cevallos Honorary Chairman: Dr. Laurence Brunton 16:20 16:25 h Introducción: Dr. Germán Chamorro Cevallos, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional. 16:25 16:45 h Propiedades farmacológicas de la Spirulina: Dr. Marco Antonio Juárez Oropeza, Facultad de Medicina, Universidad Nacional Autónoma de México 16:45 17:05 h Actividad anti-hígado graso de Spirulina: Dra. Patricia Victoria Torres Durán, Facultad de Medicina, Universidad Nacional Autónoma de México 17:05 17:25 h Spirulina como un agente antiviral. Dra. Blanca Lilia Barrón. Departamento de Microbiología. Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional

14 14 17:25 17:45 h Capacidad antioxidante de Spirulina: Dr. Jorge Vázquez Sánchez, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional. 17:45 18:05 h Toxicología de la Spirulina. Dr. Germán Chamorro Cevallos, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional. 18:05 18:20 h Preguntas y comentarios 18:30-20:00 h POSTER SESSION MAIN SQUARE OF THE PALACE OF THE SCHOOL OF MEDICINE 19:30-20:00 h Business meeting of WPS AULA MAGNA OF THE PALACE OF THE SCHOOL OF MEDICINE 20:00 21:00 h Guided nocturnal visit to the Palace of Medicine

15 15 WEDNESDAY MAY THE 18 th, :00-08:00 h Registration 8:00 10:00 h Symposium 10: Migraine MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairman: Dr. Carlos M. Villalón Herrera 08:00 08:40 h Migraine: from skull trepanation in the Neolithic period to the development of modern in vivo animal models for the development of antimigraine drugs. Dr. Carlos M. Villalón Herrera Departamento de Farmacobiología. CINVESTAV- Coapa 08:40 09:20 h The role of human in vitro and in situ models of migraine in the development of antimigraine drugs: building the bridge between animal experiments and patients. Dr. Antoinette Maassen van den Brink. Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands. 09:20 09:30 h Questions and comments 08:00 10:00 h Symposium 11: Pharmacoeconomy GRAND HALL (PARANINFO DE LA ESCUELA DE MEDICINA) Chairman: Dr. Antonio Caso Marasco. President of the Colegio Mexicano de Farmacoeconomía and President of the Mexican Chapter of the International Society of Pharmacoeconomy Honorary Chariman: 08:00 08:30 h Pharmacoeconomy in the globalized world. Dr. Antonio Caso Marasco. President of the Colegio Mexicano de Farmacoeconomía A.C. 08:30 09:15 h Models of pharmacoeconomy analysis and certainty of data. M. en C. Armando Nevarez Sida. Unidad de Economía de la Salud, IMSS 09:15 09:45 h Application of pharmacoeconomy criteria for constructing Formularies. Dr. Fernando García Contreras. Unidad de Economía de la Salud, IMSS 09:45 10:00 h Questions and comments 10:00-10:10 h Coffee break

16 16 10:10-12:10 h Plenary Lecture and Symposium 12: Advances in the Study of Melatonin: the 21 st century MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairwoman: Dra. Elia Brosla Naranjo Rodríguez, Profesora Investigadora de la Facultad de Química, Universidad Nacional Autónoma de México Honorary Chairman: Dr. J. Moisés Álvarez Rueda, Former President of AMEFAR 10:10 10:40 h PLENARY LECTURE: Actions of melatonin as an antioxidant and as a cytoskeletal modulator: Implications in therapeutics 10:40 12:10 h Symposium Dra. Gloria Benítez King. Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz 10:40 a 11:05 h Melatonin and its physiologic role in mmunomodulation. M. en C. Marcela Valdés Tovar.. Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz 11:05 11:30 h Design, synthesis and affinity binding of melatonin analogs. Dr. Alfonso Sebastián Lira Rocha, Facultad de Química, Universidad Nacional Autónoma de México 11:30 11:55 h Melatonin and analogues role in anxiety disorder. Dr. Elia Brosla Naranjo Rodríguez. Facultad de Química, Universidad Nacional Autónoma de México 11:55 12:10 h Questions and comments 12:10-12:20 h Coffee break 12:20-14:20 h Symposium 13: Pharmacoepidemiology MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairwoman: **Dra. Maribel Salas Ramírez 12:20 12:40 h Overview of Pharmacoepidemiology. **Dra. Maribel Salas. Latin America ISPE Delegate. Maribel Salas MD, DSc, MSc, FACP. Medical Director. CV Therapeutic Area. Safety Surveillance. US Patient Safety 12:40 13:10 h Importance of the pharmacoepidemiological study design. ** Stanley A. Edlavitch, PhD, MA, FACE. Professor of Epidemiology. Department of Psychiatry UMKC School of Medicine 13:10 13:35 h Data Sources in Pharmacoepidemiology for exposure, endpoints and covariates. **Dr. Abraham Hartzema, the Perry A. Foote Eminent Scholar. University of Florida College of Pharmacy

17 17 13:35 14:00 h Confounding and Biases in Pharmacoepidemiology. **Dr. Chris Delaney. University of Florida 14:00 14:20 h Questions and comments **SPONSORED BY THE INTERNATIONAL SOCIETY OF PHARMACOEPIDEMIOLOGY 12:20 14:20 h Symposium 14: Breast Cancer GRAND HALL (PARANINFO DE LA ESCUELA DE MEDICINA) Chairman: Dr. Sanford H. Barsky Honorary Chairman: Dr. Iain L. Buxton 12:20 12:55 h Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum. Iain L. O. Buxton, Professor of Pharmacology, University of Nevada School of Medicine, Reno, NV 12:55 13:00 h Questions and comments 13:00 13:35 h Semaphorin 3A potentiates metastatic disease by disrupting vascular barrier function. Lisette M. Acevedo, Project Scientist, Cheresh Laboratory, UCSD Moores Cancer Center, La Jolla, CA 13:35 13:40 h Questions and comments 13:40 14:15 h E-Cadherin and Its Proteolytic Fragments Function as Dominant Oncogenes and Provide a Therapeutic Target within the Lymphovascular Embolus of Human Breast Cancer. Sanford H. Barsky, Professor and Chair, Department of Pathology, University of Nevada School of Medicine, Reno, USA 14:15 14:20 h Questions and comments WESTERN PHARMACOLOGY SOCIETY SPONSORED SYMPOSIUM 14:20 16:20 h CONGRESS COURSES 16:20-18:20 h Symposium 15: Food Supplements MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairman: Dr. Augusto Bondani Guasti Honorary Chairman: Dr. Laurence Brunton 16:20 16:55 h Food Supplements or fraud supplements? Dr. Augusto Bondani Guasti. Incoming President of AMEFAR and Advisor of the Comisión Federal para la Protección de Riesgo Sanitario (COFEPRIS), Mexico

18 18 16:55 17:30 h The charm of pseudoscience Ing.Mario Mendez Acosta. President of the Sociedad Mexicana para la Investigación Escéptica 17:30 18:05 h Miraculous medicaments and COFEPRIS. TO BE CONFIRMED 18:05 18:20 h Questions and comments 16:20 18:20 h Symposium 16: Developing Passive Pharmacovigilance GRAND HALL (PARANINFO DE LA ESCUELA DE MEDICINA) Chairwoman: Alejandra Rosete Reyes. MD, MSHCA Honorary Chairman: Gilberto Castañeda BSBIO, PhD 16:20 16:45 h Gaps in Latin American Region and Transitioning to Excellence in National Pharmacovigilance Systems. Dra. Alejandra Rosete Reyes 16:45 17:10 h Good Practices in Pharmacoepidemiology and Pharmacovigilance development. ** Stanley A. Edlavitch, PhD, MA, FACE. Professor of Epidemiology. Department of Psychiatry. UMKC School of Medicine 17:10 17:35 h Passive pharmacovigilance in pharmaceutical industry. Achievements and challenges for Mexico. Dr. Luis Felipe Cortes. Member of the Asociaci n Mexicana de Farmacovigilancia 17:35 18:00 h Beyond passive pharmacovigilance: research and education. Dr. Gilberto Castañeda Hernández. Former AMEFAR President 18:00 18:20 h Questions and comments **SPONSORED BY THE INTERNATIONAL SOCIETY OF PHARMACOEPIDEMIOLOGY 18:20-18:30 h Coffee break 18:30-20:00 h POSTER SESSION 20:00 22:00 h Play at the Palace 20:00-21:00 h Business meeting of AMEFAR AULA MAGNA OF THE PALACE OF THE SCHOOL OF MEDICINE

19 19 THURSDAY MAY THE 19 th, :00-08:00 h Registration 08:00-10:00 h Symposium 17: Arachidonic Acid Metabolism IN HONOR OF DR. JOHN McGIFF MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairmen: Dr. Carlos Castillo Henkel and Dr Pedro López Sánchez 08:00 08:10 h Introduction. Bruno Escalante, M.D., Ph.D. 08:10-08:30 h PPARa and Proline Hydroxylase Binding Domains in the regulation of renal function and blood pressure Adebayo Oyekan DVM, PhD. Interim Associate Provost/Associate Vice President for Research. Professor and Director, Center for Cardiovascular Diseases. College of Pharmacy and Health Sciences,Texas Southern 08:30 08:50 h Nox Inhibitor Discovery: A Multidisciplinary Approach to Taming the Adventitia Patrick J. Pagano, Ph.D., F.A.H.A. Professor & Graduate Program Director. Department of Pharmacology and Chemical Biology & Vascular Medicine Institute. University of Pittsburgh School of Medicine 08:50 09:10 h Experimental Models to study pregnancy pathology. Rosa Amalia Bobadilla MD., PhD. Directora de la Escuela Superior de Medicina del IPN. Instituto Politecnico Nacional, Mexico D.F. 09:10 09:50 h Five Decades related to Arachidonic Acid Metabolism. John McGiff MD. New York Medical College. Valhalla NY 09:50 10:00 h Questions and comments 08:00 10:00 h Symposium 18: Academy - Industry Relationships IN MEMORY OF DR. ROBERTO VARGAS ECHEVERRÍA GRAND HALL (PARANINFO DE LA ESCUELA DE MEDICINA) Chairwoman: Dr. María Dolores Ramírez González, AMEFAR President 08:00 08:40 h La vinculación tecnológica en la UNAM. M. en C. Carlos Maynor Salinas Santano. Coordinador del Sistema de Incubadoras INNOVAUNAM 08:40 09:10 h Semblanza del Dr. Roberto Vargas Echeverría. Dr. Horacio Vidrio López. Former AMEFAR President 09:10 09:50 h Regulación sanitaria para biotecnológicos. Dr. Augusto Bondani Guasti. Incoming President of AMEFAR

20 20 09:50 10:00 h Questions and comments 10:00-10:10 h Coffee break 10:10-12:10 h Symposium 19: Nanotechnology in Biomedicine MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairman: Dr. Laurence Brunton 10:10 10:45 h Logic Gate Nanoparticles: a stable and selective strategy for the delivery of therapeutics. Adah Almutairi, Ph.D. Assistant Professor UCSD School of Pharmacy and Pharmaceutical Sciences 10:45 10:50 h Questions 10:50 11:25 h Designing degradable MRI contrast agents for enhanced contrast and clearance. Eric Schopf, Ph.D. Postdoctoral Scholar, UCSD School of Pharmacy and Pharmaceutical Sciences 11:25 11:30 h Questions 11:30 11:55 h Lab-on-a-chip cell sorter for biomedical applications. Jose Morachis, Ph.D. Postdoctoral Scholar, UCSD School of Pharmacy and Pharmaceutical Sciences 11:55 12:00 h Questions WESTERN PHARMACOLOGY SOCIETY SPONSORED SYMPOSIUM 10:10 12:10 h Symposium 20: New approaches for drug development IN HONOR OF DR. EUGENE BRATOEFF GRAND HALL (PARANINFO DE LA ESCUELA DE MEDICINA) Chairwoman: Dra. Elena Guadalupe Ramírez López, Facultad de Química, Universidad Nacional Autónoma de México Honorary Chairwoman: Dra. María Dolores Ramírez González 10:10 10:20 h Remembrance of Eugene Bratoeff. By Dra. Elena Guadalupe Ramírez López. Departamento de Farmacia, Facultad de Química. Universidad Nacional Autónoma de México 10:20-11:00 h Synthesis of progesterone derivatives for bening prostate hyperplasia and prostate cancer treatment. Dr. Eugene Bratoeff. Departamento de Farmacia, Facultad de Química. Universidad Nacional Autónoma de México 11:00 11:30 h Current therapeutic options for anxiety treatment. Dra. Elia Brosla Naranjo Rodríguez, Facultad de Química. Universidad Nacional Autónoma de México

21 21 11:30 12:00 h Medicinal plants and propoleos as sources of active principles. Dr. José Fausto Rivera Cruz. Departamento de Farmacia, Facultad de Química. Universidad Nacional Autónoma de México 12:00 12:10 h Questions and comments 12:10-12:20 h Coffee break 12:20-14:20 h Symposium 21: Immunotherapy of neoplastic diseases MAIN HALL (AUDITORIO DR. GUSTAVO BAZ PRADA ) Chairman: Dr. Andrés E. Castell Rodríguez, Jefe del Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México Honorary Chairman: Dr. Iain L. Buxton 12:20-13:00 h Inmunoterapia: principios y aplicaciones. Dr. Luis Felipe Montaño, Facultad de Medicina, Universidad Nacional Autónoma de México 13: h Inmunoterapia contra células madre tumorales: Dr. Alejandro García Carrancá, 13:40-14:20 h Inmunoterapia con células dendríticas contra melanoma: Dr. Andrés Castell Rodríguez, Jefe del Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México 12:20-14:20 h Symposium 21: Muscular dystrophy GRAND HALL (PARANINFO DEL PALACIO DE LA ESCUELA DE MEDICINA) IN MEMORY OF DR. HUGO GONZÁLEZ-SERRATOS Chairman: Dr. Alicia Ortega. Biochemistry Professor, Facultad de Medicina, Universidad Nacional Autónoma de México Honorary Chairman: Dr. Iain L. Buxton 12:20-12:30 h Remembrance of Dr. Hugo González Serratos. Dr. Alicia Ortega. Department of Biochemistry. Facultad de Medicina, Universidad Nacional Autónoma de México 12:30 13:10 h Muscular dystrophy: a disease with several pathways towards cell mechanical failure. Dr. Alicia Ortega. Departamento de Bioquímica. Facultad de Medicina. UNAM 13:10-13:50 h Muscular Dystrophy. A molecular point of view. Dr. Ramón Coral. Department of Biochemistry. Escuela Superior de Medicina, Instituto Politécnico Nacional 13:50-14:00 h Questions and comments

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