DUAL ANTIPLATELET THERAPY. Dr Robert S Mvungi, MD(Dar), Mmed (Wits) FCP(SA), Cert.Cardio(SA) Phy Tanzania Cardiac Society Dar es Salaam Tanzania

Size: px
Start display at page:

Download "DUAL ANTIPLATELET THERAPY. Dr Robert S Mvungi, MD(Dar), Mmed (Wits) FCP(SA), Cert.Cardio(SA) Phy Tanzania Cardiac Society Dar es Salaam Tanzania"

Transcription

1 DUAL ANTIPLATELET THERAPY Dr Robert S Mvungi, MD(Dar), Mmed (Wits) FCP(SA), Cert.Cardio(SA) Phy Tanzania Cardiac Society Dar es Salaam Tanzania

2

3 DUAL ANTIPLATELET THERAPY (DAPT) Dual antiplatelet regimen Acetylsalicylic acid (ASA) plus clopidogrel, Acetylsalicylic acid (ASA)Plus Prasugrel or Acetylsalicylic acid (ASA)Plus Ticagrelor. Guidelines recommend the indefinite use of ASA after an ACS event, Duration of clopidogrel, prasugrel or ticagrelor therapy varies based on patient characteristics.

4 DUAL ANTIPLATELET THERAPY CURRENT STANDARD OF CARE SECONDARY PREVENTION OF ACUTE CORONARY SYNDROME Thrombosis Bleeding

5 ASPIRIN /PLACEBO VS ASA/CLOPIDOGREL

6 Cumulative Hazard Rate PRIMARY END POINT - MI/STROKE/CV DEATH Placebo + ASA* 11.4% 9.3% ASA* * In combination with standard therapy The CURE Trial Investigators. N Engl J Med. 2001;345: Months of Follow-Up 20% RRR P < N = 12,562

7 Cumulative Hazard Rate MI/STROKE/CV DEATH WITHIN 30 DAYS Placebo + ASA* ASA* Days of Follow-Up * In combination with standard therapy The CURE Trial Investigators. N Engl J Med. 2001;345: % RRR P = N = 12,562

8 PCI-CURE Cumulative Hazard Rate OVERALL LONG-TERM RESULTS Composite of cardiovascular death or MI from randomization to end of follow-up 0.15 Placebo + ASA* 12.6% % + ASA* * In combination with standard therapy 31% RRR P = N = Days of follow-up Mehta, SR. et al for the CURE Trial Investigators. Lancet. August 2001.

9 PCI-CURE Cumulative Hazard Rate 30 DAY RESULTS Composite of cardiovascular death, MI, or urgent revascularization Placebo + ASA* 6.4% ASA* Days of follow-up 4.5% 30% RRR P = 0.03 N = 2658 * In combination with standard therapy Mehta, SR. et al for the CURE Trial Investigators. Lancet. August 2001;21:

10 ASPIRIN /PLACEBO VS ASA/CLOPIDOGREL

11 % Incidence ARMYDA-2 TRIAL: PRIMARY ENDPOINT 14% 12% 10% 8% 6% 4% 2% Primary Composite of death, MI, and target vessel revascularization p = % 12% The primary composite endpoint of death, MI, target vessel revascularization was significantly lower in the highdose clopidogrel group at 30 days There was one TVR in the high-dose group and no deaths in either arm 0% High-Dose Standard Dose Presented at ACC 2005

12 PUBLICATION OF PRIMARY RESULTS NEJM 357: , Slides and Full Listing of Trial Participants at

13 Primary Endpoint (%) 15 Primary Endpoint CV Death,MI,Stroke 12.1 (781) 10 5 HR 0.77 P= HR 0.80 P= Prasugrel 9.9 (643) HR 0.81 ( ) P= NNT= 46 0 ITT= 13,608 LTFU = 14 (0.1%) Days

14 Endpoint (%) Stent Thrombosis (ARC Definite + Probable) 3 2 Any Stent at Index PCI N= 12, (142) 1 Prasugrel 1.1 (68) HR 0.48 P < NNT= Days

15 Endpoint (%) Stent Thrombosis (ARC Definite + Probable) 3 2 Any Stent at Index PCI N= 12, (142) 1 Prasugrel 1.1 (68) HR 0.48 P < NNT= Days

16 Endpoint (%) Balance of Efficacy and Safety CV Death / MI / Stroke Prasugrel events HR 0.81 ( ) P= NNT = TIMI Major NonCABG Bleeds Days Prasugrel events HR 1.32 ( ) P=0.03 NNH = 167

17 Endpoint (%) Net Clinical Benefit Death, MI, Stroke, Major Bleed (non CABG) 15 ITT= 13, Prasugrel HR 0.87 P=0.004 Events per 1000 pts MI Days + 6 Major Bleed (non CABG) All Cause Mortality Clop 3.2% Pras 3.0 % P=0.64

18 Prior Stroke / TIA Yes No Net Clinical Benefit Bleeding Risk Subgroups Post-hoc analysis P int = Risk (%) Age >=75 < 75 P int = Wgt < 60 kg +3 >=60 kg P int = OVERALL Prasugrel Better HR Better

19 August 30, 2009 at CET

20 Cumulative Incidence (%) Days BRILINTA PLATO: Primary Efficacy Endpoint (Composite of CV Death, MI, or Stroke) 0 12 Months ARR=0.6% RRR=12% P=0.045 HR: 0.88 (95% CI, ) BRILINTA ARR=1.9% RRR=16% NNT=54* P<0.001 HR: 0.84 (95% CI, ) No. at risk Months After Randomization BRILINTA 9,333 8,628 8,460 8,219 6,743 5,161 4,147 9,291 8,521 8,362 8,124 6,650 5,096 4,047 Both groups included aspirin. *NNT at one year. Wallentin L, et al. N Engl J Med. 2009;361:

21 PLATO-defined Total Major Bleeding (%) PLATO: Primary Safety Endpoint BRILINTA 11.6% 11.2% P=NS 5 0 P=0.43 HR: 1.04 (95% CI, ) No. at risk Days From First Dose BRILINTA 9,235 7,246 6,826 6,545 5,129 3,783 3,433 9,186 7,305 6,930 6,670 5,209 3,841 3,479 Both groups included aspirin. Wallentin L, et al. N Engl J Med. 2009;361:

22 BRILINTA Indication By Diagnosis By Treatment UA/NSTEMI STEMI Medical management PCI CABG BRILINTA, co-administered with acetylsalicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with acute coronary syndromes (unstable angina, non ST-elevation myocardial infarction [NSTEMI] or ST-elevation myocardial infarction [STEMI]); including patients managed medically, and those who are managed with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) If clinically indicated, BRILINTA should be used with caution in the following patient groups: Patients with concomitant administration of medicinal products that may increase the risk of bleeding (eg, non-steroidal anti-inflammatory drugs (NSAIDs), oral anticoagulants and/or fibrinolytics) within 24 hours of BRILINTA dosing BRILINTA: Approved package insert.

23 K-M Estimated Rate (% Per Year) PLATO: Bleeding NS P = BRILIQUE BRILINTA (n=9,235) (n=9,186) Major Bleeding 5.8 NS 5.8 Life-threatening/ Fatal Bleeding NS Fatal Bleeding Major and Minor Bleeding P = Non-CABG- Major Bleeding 7.4 NS 7.9 CABG-Major Bleeding All values presented by PLATO criteria. Both groups included aspirin. Wallentin L, et al. N Engl J Med. 2009;361:

24 Treated With an Initial Invasive or Ischemia-Guided Strategy (cont d) Recommendations COR LOE A P2Y 12 inhibitor (either clopidogrel or ticagrelor) in addition to aspirin should be administered for up to 12 months to all patients with NSTE-ACS without contraindications who are treated with either an early invasive or ischemia-guided strategy. Options include: I B : 300-mg or 600-mg loading dose, then 75 mg daily Ticagrelor : 180-mg loading dose, then 90 mg twice daily B The recommended maintenance dose of aspirin to be used with ticagrelor is 81 mg daily.

25 Antiplatelet Therapy to Support Primary PCI for STEMI I IIa IIb III A loading dose of a P2Y 12 receptor inhibitor should be given as early as possible or at time of primary PCI to patients with STEMI. Options include: 600 mg; or Prasugrel 60 mg; or Ticagrelor 180 mg

Duration of Dual Antiplatelet Therapy After Coronary Stenting

Duration of Dual Antiplatelet Therapy After Coronary Stenting Duration of Dual Antiplatelet Therapy After Coronary Stenting C. DEAN KATSAMAKIS, DO, FACC, FSCAI INTERVENTIONAL CARDIOLOGIST ADVOCATE LUTHERAN GENERAL HOSPITAL INTRODUCTION Coronary artery stents are

More information

Dual Antiplatelet Therapy. Stephen Monroe, MD FACC Chattanooga Heart Institute

Dual Antiplatelet Therapy. Stephen Monroe, MD FACC Chattanooga Heart Institute Dual Antiplatelet Therapy Stephen Monroe, MD FACC Chattanooga Heart Institute Scope of Talk Identify the antiplatelet drugs and their mechanisms of action Review dual antiplatelet therapy in: The medical

More information

Perspectives on the Selection and Duration of Dual Antiplatelet Therapy

Perspectives on the Selection and Duration of Dual Antiplatelet Therapy Perspectives on the Selection and Duration of Dual Antiplatelet Therapy Dominick J. Angiolillo, MD, PhD, FACC, FESC, FSCAI Director of Cardiovascular Research Associate Professor of Medicine University

More information

New Approaches to, and Indications for, Antiplatelet Therapy

New Approaches to, and Indications for, Antiplatelet Therapy New Approaches to, and Indications for, Antiplatelet Therapy Kenneth A. Bauer, MD Professor of Medicine, Harvard Medical School Chief, Hematology Section, VA Boston Healthcare System Director, Thrombosis

More information

NOAC in patients with Atrial Fibrillation and Acute Coronary Syndromes

NOAC in patients with Atrial Fibrillation and Acute Coronary Syndromes NOAC in patients with Atrial Fibrillation and Acute Coronary Syndromes Matteo Bertini, MD, PhD Department of Cardiology, Arcispedale S. Anna University of Ferrara Atrial fibrillation and PCI Among ACS

More information

WOEST TRIAL- NO ASPIRIN IN STENTED PATIENTS REQUIRING ANTICOAGULATION. Van Crisco, MD, FACC, FSCAI First Coast

WOEST TRIAL- NO ASPIRIN IN STENTED PATIENTS REQUIRING ANTICOAGULATION. Van Crisco, MD, FACC, FSCAI First Coast WOEST TRIAL- NO ASPIRIN IN STENTED PATIENTS REQUIRING ANTICOAGULATION Van Crisco, MD, FACC, FSCAI First Coast Conflicts of Interest I have been a paid consultant and speaker for AstraZeneca, makers of

More information

None. Dual Antiplatelet Therapy Plus Systemic Anticoagulation: Bleeding Risk and Management. 76 year old male LINGO 1/5/2015

None. Dual Antiplatelet Therapy Plus Systemic Anticoagulation: Bleeding Risk and Management. 76 year old male LINGO 1/5/2015 Financial Disclosure Information Dual Antiplatelet Therapy Plus Systemic Anticoagulation: Bleeding Risk and Management Robert D. McBane, M.D. Division of Cardiology Mayo Clinic Rochester Dual Antiplatelet

More information

Antiaggreganti. STEMI : cosa c è di nuovo? Heartline 2015. Genova 13 14 Novembre 2015

Antiaggreganti. STEMI : cosa c è di nuovo? Heartline 2015. Genova 13 14 Novembre 2015 Heartline 2015 Genova 13 14 Novembre 2015 STEMI : cosa c è di nuovo? Antiaggreganti Luigi Oltrona Visconti Divisione di Cardiologia IRCCS Fondazione Policlinico S. Matteo Pavia STEMI : cosa c è di nuovo?

More information

Rivaroxaban for acute coronary syndromes

Rivaroxaban for acute coronary syndromes Northern Treatment Advisory Group Rivaroxaban for acute coronary syndromes Lead author: Nancy Kane Regional Drug & Therapeutics Centre (Newcastle) May 2014 2014 Summary Current long-term management following

More information

Getting smart about dyspnea and life saving drug therapy in ACS patients. Kobi George Kaplan Medical Center Rehovot

Getting smart about dyspnea and life saving drug therapy in ACS patients. Kobi George Kaplan Medical Center Rehovot Getting smart about dyspnea and life saving drug therapy in ACS patients Kobi George Kaplan Medical Center Rehovot 78 year old female Case description Presented with resting chest pain and dyspnea Co morbidities:

More information

Antiplatelet drugs for the treatment and prevention of vascular disease: A review of recent clinical trials

Antiplatelet drugs for the treatment and prevention of vascular disease: A review of recent clinical trials Antiplatelet drugs for the treatment and prevention of vascular disease: A review of recent clinical trials Niteesh K. Choudhry, MD, PhD Nihar Desai, MD, MPH Michael Fischer, MD, MS Jerry Avorn, MD Eimir

More information

Apixaban Plus Mono vs. Dual Antiplatelet Therapy in Acute Coronary Syndromes: Insights from the APPRAISE-2 Trial

Apixaban Plus Mono vs. Dual Antiplatelet Therapy in Acute Coronary Syndromes: Insights from the APPRAISE-2 Trial Apixaban Plus Mono vs. Dual Antiplatelet Therapy in Acute Coronary Syndromes: Insights from the APPRAISE-2 Trial Connie N. Hess, MD, MHS, Stefan James, MD, PhD, Renato D. Lopes, MD, PhD, Daniel M. Wojdyla,

More information

Marco Ferlini Struttura Semplice di Emodinamica, UO Cardiologia Dipartimento Cardiotoracovascolare Fondazione IRCCS, Policlinico San Matteo

Marco Ferlini Struttura Semplice di Emodinamica, UO Cardiologia Dipartimento Cardiotoracovascolare Fondazione IRCCS, Policlinico San Matteo Marco Ferlini Struttura Semplice di Emodinamica, UO Cardiologia Dipartimento Cardiotoracovascolare Fondazione IRCCS, Policlinico San Matteo Acute Coronary Syndromes: oral antithrombotic therapy Focus on

More information

Antiplatelet Therapy in Elderly & Post-Stroke Patients Prof. Arthur Pollak Director, Acute Cardiac Care Center and Clinical research Heart Institute,

Antiplatelet Therapy in Elderly & Post-Stroke Patients Prof. Arthur Pollak Director, Acute Cardiac Care Center and Clinical research Heart Institute, Antiplatelet Therapy in Elderly & Post-Stroke Patients Prof. Arthur Pollak Director, Acute Cardiac Care Center and Clinical research Heart Institute, Hadassah University Hospital, Jerusalem Disclosures

More information

ACC/AHA 2009 STEMI Guideline Focused Update and What s New in 2012 Guideline

ACC/AHA 2009 STEMI Guideline Focused Update and What s New in 2012 Guideline ACC/AHA 2009 STEMI Guideline Focused Update and What s New in 2012 Guideline David Zhao, MD, FACC, FSCAI Professor of Medicine and Cardiac Surgery Harry and Shelley Page Professor in Interventional Cardiology

More information

Elderly Patients with renal insufficiency: Which anti-platelet/ Anti thrombin/minimizing Major bleeds

Elderly Patients with renal insufficiency: Which anti-platelet/ Anti thrombin/minimizing Major bleeds Elderly Patients with renal insufficiency: Which anti-platelet/ Anti thrombin/minimizing Major bleeds Blair J O Neill MD FRCPC FACC Text Professor of Medicine, University of Alberta Clinical Co-Director

More information

Antonio Colombo MD on behalf of the SECURITY Investigators

Antonio Colombo MD on behalf of the SECURITY Investigators Second Generation Drug-Eluting Stents Implantation Followed by Six Versus Twelve-Month - Dual Antiplatelet Therapy - The SECURITY Randomized Clinical Trial Antonio Colombo MD on behalf of the SECURITY

More information

Patients with Atrial Fibrillation and PCI or ACS Need Triple Therapy - Practical Guidance

Patients with Atrial Fibrillation and PCI or ACS Need Triple Therapy - Practical Guidance Patients with Atrial Fibrillation and PCI or ACS Need Triple Therapy - Practical Guidance Christopher P. Cannon, M.D. Executive Director, Cardiometabolic Trials, Harvard Clinical Research Institute Cardiovascular

More information

L'aspirina è diventata obsoleta nell'era dei nuovi inbitori P2Y12? Leonardo Bolognese MD, FESC, FACC Cardiovascular Department, Arezzo, Italy ISO 9001

L'aspirina è diventata obsoleta nell'era dei nuovi inbitori P2Y12? Leonardo Bolognese MD, FESC, FACC Cardiovascular Department, Arezzo, Italy ISO 9001 L'aspirina è diventata obsoleta nell'era dei nuovi inbitori P2Y12? Leonardo Bolognese MD, FESC, FACC Cardiovascular Department, Arezzo, Italy Scientific Advances and Cardiovascular Mortality Nabel and

More information

Antiplatelet and Antithrombotics From clinical trials to guidelines

Antiplatelet and Antithrombotics From clinical trials to guidelines Antiplatelet and Antithrombotics From clinical trials to guidelines Ashraf Reda, MD, FESC Prof and head of Cardiology Dep. Menofiya University Preisedent of EGYBAC Chairman of WGLVR One of the big stories

More information

University of Ulsan College of Medicine, Asan Medical Center on behalf of the REAL-LATE and the ZEST-LATE trial

University of Ulsan College of Medicine, Asan Medical Center on behalf of the REAL-LATE and the ZEST-LATE trial Duration of Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation A Pooled Analysis of the REAL-LATE and the ZEST-LATE Trial Seung-Jung Park MD PhD Seung-Jung Park, MD, PhD, University of Ulsan

More information

MANAGEMENT AKUTES KORONARSYNDROM: RISIKOSTRATIFIZIERUNG UND THERAPIE. Peter Wenaweser Universitätsklinik für Kardiologie

MANAGEMENT AKUTES KORONARSYNDROM: RISIKOSTRATIFIZIERUNG UND THERAPIE. Peter Wenaweser Universitätsklinik für Kardiologie MANAGEMENT AKUTES KORONARSYNDROM: RISIKOSTRATIFIZIERUNG UND THERAPIE Peter Wenaweser Universitätsklinik für Kardiologie Scientific Advances & Cardiovascular Mortality 1950 to 2010 Nabel EM and Braunwald

More information

NOAC s post Myocardial Infarction Peter Clemmensen MD, PhD, FESC, FSCAI Chief of Cardiology

NOAC s post Myocardial Infarction Peter Clemmensen MD, PhD, FESC, FSCAI Chief of Cardiology NOAC s post Myocardial Infarction Peter Clemmensen MD, PhD, FESC, FSCAI Chief of Cardiology Department of Medicine Division of Cardiology Nykøbing F Hospital Denmark Disclosure of Conflict of Interest

More information

Il punto sulla terapia antitrombotica nelle sindromi coronariche acute

Il punto sulla terapia antitrombotica nelle sindromi coronariche acute Santa Margherita Ligure TIGULLIO CARDIOLOGIA 2012 16-17 Febbrajo 2012 Il trattamento dell infarto miocardico acuto ad ST spraslivellato: dal territorio al laboratorio di emodinamica Il punto sulla terapia

More information

The Anti coagulated Patient: The Cardiologist s View. February 28, 2015

The Anti coagulated Patient: The Cardiologist s View. February 28, 2015 The Anti coagulated Patient: The Cardiologist s View February 28, 2015 Conflicts Dr. McMurtry has no conflicts to disclose. CanMeds Medical Expert (as Medical Experts, physicians integrate all of the CanMEDS

More information

Optimal Duration of Dual Antiplatelet Therapy

Optimal Duration of Dual Antiplatelet Therapy Optimal Duration of Dual Antiplatelet Therapy Luis A Guzman, MD, FACC, FSCAI Associate Professor of Medicine Director, Cardiac and Vascular Cath Lab University of Florida College of Medicine - Jacksonville

More information

rivaroxaban 2.5mg film-coated tablets (Xarelto ) SMC No. (1062/15) Bayer plc.

rivaroxaban 2.5mg film-coated tablets (Xarelto ) SMC No. (1062/15) Bayer plc. rivaroxaban 2.5mg film-coated tablets (Xarelto ) SMC No. (1062/15) Bayer plc. 05 June 2015 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards

More information

Description of problem Description of proposed amendment Justification for amendment ERG response

Description of problem Description of proposed amendment Justification for amendment ERG response KEY INACCURACIES Issue 1 Distinguishing between groups of STEMI patients Key issue throughout the report The ERG distinguishes between groups of STEMI patients defining four patient groups: STEMI without

More information

o Antiplatelet therapy is used for both the management of acute o Meta analysis of 195 randomized controlled trials

o Antiplatelet therapy is used for both the management of acute o Meta analysis of 195 randomized controlled trials Introduction o Antiplatelet therapy is used for both the management of acute ischemic stroke and for the prevention of stroke o Antiplatelet therapy reduces the incidence of stroke in patients at high

More information

prodigy study: duration of dual antiplatelet therapy under review In BrIef In Brief NPS RADAR AuguSt 2012

prodigy study: duration of dual antiplatelet therapy under review In BrIef In Brief NPS RADAR AuguSt 2012 3 In BrIef A digest of news items about NPS RADAR, new drugs and changes to PBS listings prodigy study: duration of dual antiplatelet therapy under review Dual antiplatelet therapy with aspirin and clopidogrel

More information

Issues and Challenges in ACS Management. Dr.Nakul Sinha MD.DM, FACC. Sahara Hospital, LUCKNOW

Issues and Challenges in ACS Management. Dr.Nakul Sinha MD.DM, FACC. Sahara Hospital, LUCKNOW 1 Issues and Challenges in ACS Management Dr.Nakul Sinha MD.DM, FACC. Sahara Hospital, LUCKNOW 2 Disclaimer Presentation are intended for educational purposes only and do not replace independent professional

More information

Antiplatelet therapy:

Antiplatelet therapy: Balanced information for better care Antiplatelet therapy: Aggregating the latest evidence Evaluating the choices for a preventive therapy with impressive benefits and important risks Antiplatelet agents

More information

PRECOMBAT Trial. Seung-Whan Lee, MD, PhD On behalf of the PRECOMBAT Investigators

PRECOMBAT Trial. Seung-Whan Lee, MD, PhD On behalf of the PRECOMBAT Investigators Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease PRECOMBAT Trial Seung-Whan Lee, MD, PhD On behalf

More information

Single Antiplatelet Regimen after DES: already an Option?

Single Antiplatelet Regimen after DES: already an Option? Single Antiplatelet Regimen after DES: already an Option? Marco Valgimigli, MD, PhD University Hospital of Bern, Switzerland COI: Research grants from Astra Zeneca to ECRI and to Erasmus for the conduct

More information

Pretrattamento con Antiaggreganti Piastrinici nelle SCA. No, Sempre Necessario

Pretrattamento con Antiaggreganti Piastrinici nelle SCA. No, Sempre Necessario 9 MEETING CARDIOLUCCA CONTROVERSIA D AUTORE: PRETRATTAMENTO CON ANTIAGGREGANTI PIASTRINICI NELLE SCA Lucca, Auditorium S. Francesco 28-30 Novembre 2013 Pretrattamento con Antiaggreganti Piastrinici nelle

More information

Update in Acute Coronary Syndromes Hani Jneid, MD, FACC, FAHA Baylor College of Medicine Michael E. DeBakey VAMC

Update in Acute Coronary Syndromes Hani Jneid, MD, FACC, FAHA Baylor College of Medicine Michael E. DeBakey VAMC Update in Acute Coronary Syndromes Hani Jneid, MD, FACC, FAHA Baylor College of Medicine Michael E. DeBakey VAMC NAAMA 37 th National Medical Convention September 5 th, 2015 Atherosclerosis Coronary Heart

More information

Is There A LIfe for DES after discontinuation of Clopidogrel

Is There A LIfe for DES after discontinuation of Clopidogrel Chicago 2014 Is There A LIfe for DES after discontinuation of Clopidogrel Six-month versus 24-month dual antiplatelet therapy after implantation of drug eluting stents in patients non-resistant to aspirin:

More information

Como mejorar el manejo médico de los diabéticos con SCA

Como mejorar el manejo médico de los diabéticos con SCA DIABETES Y ENFERMEDAD CORONARIA EN 2011 Como mejorar el manejo médico de los diabéticos con SCA Antonio Fernández-Ortiz Jueves, 20 Octubre 2011 INSTITUTO CARDIOVASCULAR Conflicto de interés: Antonio Fernández-Ortiz

More information

Pooled RESOLUTE Clinical Program

Pooled RESOLUTE Clinical Program The Relationship Between Short and Long-term Antiplatelet Therapy Use and Stent Thrombosis Following Percutaneous Coronary Intervention With the Resolute Zotarolimus-eluting Stent Pooled RESOLUTE Clinical

More information

Rivaroxaban for preventing adverse outcomes after acute management of acute coronary syndrome

Rivaroxaban for preventing adverse outcomes after acute management of acute coronary syndrome Rivaroxaban for preventing adverse outcomes after acute management of acute coronary syndrome Issued: March 2015 guidance.nice.org.uk/ta335 NICE has accredited the process used by the Centre for Health

More information

Cardiovascular Drugs and Therapies ANTIPLATELET AGENTS (Oral)

Cardiovascular Drugs and Therapies ANTIPLATELET AGENTS (Oral) Trade Name ASPIRIN, generics PLAVIX EFFIENT BRILINTA Dosage Forms Indication 81 mg, 325 mg enteric coated and non-enteric coated tablets 80 mg chewable tablet. ACS treatment. Secondary prevention of cardiovascular

More information

Investor science conference call: American College of Cardiology 2015

Investor science conference call: American College of Cardiology 2015 Investor science conference call: American College of Cardiology 2015 San Diego, California, USA 16 March 2015 Cautionary statement regarding forward-looking statements In order, among other things, to

More information

Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation (ISAR-TRIPLE Trial)

Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation (ISAR-TRIPLE Trial) Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation (ISAR-TRIPLE Trial) Katrin A. Fiedler, Michael Maeng, Julinda Mehilli, Stefanie Schulz, Robert

More information

Issues with Antithrombotic Agents in Acute Stroke. Al Jin MD PhD FRCPC November 24, 2015

Issues with Antithrombotic Agents in Acute Stroke. Al Jin MD PhD FRCPC November 24, 2015 Issues with Antithrombotic Agents in Acute Stroke Al Jin MD PhD FRCPC November 24, 2015 Disclosures No commercial interests No conflicts of interest Antiplatelet Issues Dual vs single antiplatelet therapy

More information

Presenter: Marco Valgimigli, MD PhD, FESC Erasmus MC, Thoraxcenter Rotterdam The Netherlands

Presenter: Marco Valgimigli, MD PhD, FESC Erasmus MC, Thoraxcenter Rotterdam The Netherlands Comparing zotarolimus-eluting and bare-metal stent efficacy in selected high bleeding risk patients treated with a short dual antiplatelet therapy duration. A pre-specified analysis from the The Zotarolimuseluting

More information

Secondary Stroke Prevention. Lawrence R. Wechsler, M.D.

Secondary Stroke Prevention. Lawrence R. Wechsler, M.D. Secondary Stroke Prevention Lawrence R. Wechsler, M.D. Outline Risk factor modification Antiplatelet therapy Anticoagulation Intracranial stenosis PFO and stroke Risk Factor Control Hypertension - < 140/90,

More information

Postoperative Myocardial Infarction: Diagnosis and Management

Postoperative Myocardial Infarction: Diagnosis and Management Postoperative Myocardial Infarction: Diagnosis and Management Todd M. Brown, MD, MSPH Chief Fellow Division of Cardiovascular Diseases December 9, 2008 CHEST PAIN NON-ANGINAL UNSURE ANGINAL STABLE ANGINA

More information

Triple thérapie anti-thrombotique chez le coronarien. Y Cottin Dijon

Triple thérapie anti-thrombotique chez le coronarien. Y Cottin Dijon Triple thérapie anti-thrombotique chez le coronarien Y Cottin Dijon «Dans la vie, rien n est à craindre, tout est à comprendre» Marie Curie Epidémiologie Aspirine/Clopidogrel/Ticagrelor/Prasugrel Durée?

More information

No conflict of interest

No conflict of interest Anthony Fung Presenter Disclosure The BRIEF-PCI Trial No conflict of interest Brief Infusion of Eptifibatide Following PCI The BRIEF-PCI Trial AY Fung, J Saw, A Starovoytov, C Densem, P Jokhi, SJ Walsh,

More information

ΠΟΙΟ ΑΝΤΙΠΗΚΤΙΚΟ ΓΙΑ ΤΟΝ ΑΣΘΕΝΗ ΜΟΥ? ΚΛΙΝΙΚΑ ΠΑΡΑΔΕΙΓΜΑΤΑ. Σωκράτης Παστρωμάς Καρδιολόγος Νοσοκομείο Ερρίκος Ντυνάν

ΠΟΙΟ ΑΝΤΙΠΗΚΤΙΚΟ ΓΙΑ ΤΟΝ ΑΣΘΕΝΗ ΜΟΥ? ΚΛΙΝΙΚΑ ΠΑΡΑΔΕΙΓΜΑΤΑ. Σωκράτης Παστρωμάς Καρδιολόγος Νοσοκομείο Ερρίκος Ντυνάν ΠΟΙΟ ΑΝΤΙΠΗΚΤΙΚΟ ΓΙΑ ΤΟΝ ΑΣΘΕΝΗ ΜΟΥ? ΚΛΙΝΙΚΑ ΠΑΡΑΔΕΙΓΜΑΤΑ Σωκράτης Παστρωμάς Καρδιολόγος Νοσοκομείο Ερρίκος Ντυνάν The AF epidemic Mayo Clinic data (assuming a continued increase in the AF incidence) Mayo

More information

Guidelines for Use of Clopidogrel (Plavix )

Guidelines for Use of Clopidogrel (Plavix ) East Lancashire Medicines Management Board representing East Lancashire Hospitals NHS Trust, Lancashire Care Trust, Blackburn with Darwen PCT, East Lancs PCT Licensed Indications Guidelines for Use of

More information

Cilostazol versus Clopidogrel after Coronary Stenting

Cilostazol versus Clopidogrel after Coronary Stenting Cilostazol versus Clopidogrel after Coronary Stenting Seong-Wook Park, MD, PhD, FACC Division of Cardiology, Asan Medical Center University of Ulsan College of Medicine Seoul, Korea AMC, 2004 Background

More information

RR 0.88 (95% CI: 0.77 1.00) P=0.051 (superiority) 3.75

RR 0.88 (95% CI: 0.77 1.00) P=0.051 (superiority) 3.75 ALL-CAUSE MORTALITY RR 0.88 (95% CI: 0.77 1.00) P=0.051 (superiority) Rate per year (%) 5.0 4.0 3.0 2.0 1.0 0 3.64 D150 mg BID 3.75 D110 mg BID RR 0.91 (95% CI: 0.80 1.03) P=0.13 (superiority) 4.13 Warfarin

More information

2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease

2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease Accepted Manuscript 2016 ACC/AHA Guideline in Patients With Coronary Artery Disease Glenn N. Levine, MD, FACC, FAHA, Chair, Eric R. Bates, MD, FACC, FAHA, FSCAI, John A. Bittl, MD, FACC, Ralph G. Brindis,

More information

Update on Antiplatelet Therapy for Non-Cardioembolic Ischemic Stroke

Update on Antiplatelet Therapy for Non-Cardioembolic Ischemic Stroke Update on Antiplatelet Therapy for Non-Cardioembolic Ischemic Stroke Eric M. Bershad, M.D. Assistant Professor of Neurology Vascular Neurologist and Neurointensivist Baylor College of Medicine Houston,

More information

Indicazione, efficacia e sicurezza dello switching tra terapie antiaggreganti piastiniche

Indicazione, efficacia e sicurezza dello switching tra terapie antiaggreganti piastiniche Indicazione, efficacia e sicurezza dello switching tra terapie antiaggreganti piastiniche Guido Parodi Dipartimento CardioToracoVascolare Azienda Ospedaliero-Universitaria Careggi Firenze CardioLucca Lucca,

More information

A Patient s Guide to Primary and Secondary Prevention of Cardiovascular Disease Using Blood-Thinning (Anticoagulant) Drugs

A Patient s Guide to Primary and Secondary Prevention of Cardiovascular Disease Using Blood-Thinning (Anticoagulant) Drugs A Patient s Guide to Primary and Secondary Prevention of PATIENT EDUCATION GUIDE What Is Cardiovascular Disease? Cardiovascular disease (CVD) is a broad term that covers any disease of the heart and circulatory

More information

Rivaroxaban in SPAF: Efficacy, safety and cardio-vascular profile. Hans Rickli, St.Gallen

Rivaroxaban in SPAF: Efficacy, safety and cardio-vascular profile. Hans Rickli, St.Gallen Rivaroxaban in SPAF: Efficacy, safety and cardio-vascular profile Hans Rickli, St.Gallen HADS 2 Distribution Across SPAF Trials % HADS 2 Score Dabigatran and apixaban: evaluated across a spectrum of stroke

More information

Dual Antiplatelet Therapy Beyond One Year in Patients Receiving Coronary Stents for Treatment of Acute Coronary Syndromes

Dual Antiplatelet Therapy Beyond One Year in Patients Receiving Coronary Stents for Treatment of Acute Coronary Syndromes Dual Antiplatelet Therapy Beyond One Year in Patients Receiving Coronary Stents for Treatment of Acute Coronary Syndromes Robert W. Yeh, Dean J. Kereiakes, P. Gabriel Steg, Stephan Windecker, Michael J.

More information

Goals 6/6/2014. Stroke Prevention in Atrial Fibrillation: New Oral Anti-Coagulants No More INRs. Ashkan Babaie, MD

Goals 6/6/2014. Stroke Prevention in Atrial Fibrillation: New Oral Anti-Coagulants No More INRs. Ashkan Babaie, MD Stroke Prevention in Atrial Fibrillation: New Oral Anti-Coagulants No More INRs Ashkan Babaie, MD Arrhythmia Service Providence Heart Clinic June 8 th, 2014 Goals Discuss the data behind approval of NOACs

More information

Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation

Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation George D. Dangas MD, PhD Professor of Medicine Icahn School of Medicine at Mount Sinai Summary Predictors of restenosis such diabetes, small

More information

ABOUT XARELTO CLINICAL STUDIES

ABOUT XARELTO CLINICAL STUDIES ABOUT XARELTO CLINICAL STUDIES FAST FACTS Xarelto (rivaroxaban) is a novel, oral direct Factor Xa inhibitor. On September 30, 2008, the European Commission granted marketing approval for Xarelto for the

More information

Clinical Study Synopsis

Clinical Study Synopsis Clinical Study Synopsis This Clinical Study Synopsis is provided for patients and healthcare professionals to increase the transparency of Bayer's clinical research. This document is not intended to replace

More information

BRIGHT Trial. Bivalirudin versus Heparin and Heparin plus Tirofiban in Patients with AMI Undergoing PCI. Thirty-Day and One-Year Outcomes of the

BRIGHT Trial. Bivalirudin versus Heparin and Heparin plus Tirofiban in Patients with AMI Undergoing PCI. Thirty-Day and One-Year Outcomes of the Bivalirudin versus Heparin and Heparin plus Tirofiban in Patients with AMI Undergoing PCI Thirty-Day and One-Year Outcomes of the BRIGHT Trial Yaling Han, MD, FACC On behalf of the BRIGHT investigators

More information

Platelet Function Testing vs Genotyping : Focus on Pharmacogenomics of Clopidogrel. Kiyuk Chang, M.D., Ph.D.

Platelet Function Testing vs Genotyping : Focus on Pharmacogenomics of Clopidogrel. Kiyuk Chang, M.D., Ph.D. Platelet Function Testing vs Genotyping : Focus on Pharmacogenomics of Clopidogrel Kiyuk Chang, M.D., Ph.D. Cardiovascular Center & Cardiology Division Seoul St. Mary s Hospital The Catholic University

More information

Antiplatelet and anticoagulation treatment of patients undergoing carotid and peripheral artery angioplasty

Antiplatelet and anticoagulation treatment of patients undergoing carotid and peripheral artery angioplasty Round Table: Antithrombotic therapy beyond ACS Antiplatelet and anticoagulation treatment of patients undergoing carotid and peripheral artery angioplasty M. Matsagkas, MD, PhD, EBSQ-Vasc Associate Professor

More information

FDA Briefing Document for the Cardiovascular and Renal Drugs Advisory Committee (CRDAC)

FDA Briefing Document for the Cardiovascular and Renal Drugs Advisory Committee (CRDAC) FDA Briefing Document for the Cardiovascular and Renal Drugs Advisory Committee (CRDAC) Meeting Date: 23 May 2012 NDA: Sponsor: Drug: Indication for Use: 202439/S-002 Janssen Pharmaceuticals, Inc. Xarelto

More information

Bayer Extends Clinical Investigation of Rivaroxaban into Important Areas of Unmet Medical Need in Arterial Thromboembolism

Bayer Extends Clinical Investigation of Rivaroxaban into Important Areas of Unmet Medical Need in Arterial Thromboembolism Investor News Not intended for U.S. and UK Media Bayer AG Investor Relations 51368 Leverkusen Germany www.investor.bayer.com Bayer Extends Clinical Investigation of Rivaroxaban into Important Areas of

More information

Endoscopy & ACS. 8/1/2014 Dr. Whang

Endoscopy & ACS. 8/1/2014 Dr. Whang Endoscopy & ACS 8/1/2014 Dr. Whang Outline I. Antiplatelets II. Coronary Artery Disease in U.S. III. GI Bleeding in ACS IV. ACC/AHA guidelines: Dual Antiplatelet Therapy in CAD V. PPI and Plavix Controversy

More information

STROKE PREVENTION IN ATRIAL FIBRILLATION. TARGET AUDIENCE: All Canadian health care professionals. OBJECTIVE: ABBREVIATIONS: BACKGROUND:

STROKE PREVENTION IN ATRIAL FIBRILLATION. TARGET AUDIENCE: All Canadian health care professionals. OBJECTIVE: ABBREVIATIONS: BACKGROUND: STROKE PREVENTION IN ATRIAL FIBRILLATION TARGET AUDIENCE: All Canadian health care professionals. OBJECTIVE: To guide clinicians in the selection of antithrombotic therapy for the secondary prevention

More information

How to manage a patient who needs thrombolysis in acute stroke, ablation or angioplasty/stenting? Janet M McComb Freeman Hospital Newcastle upon Tyne

How to manage a patient who needs thrombolysis in acute stroke, ablation or angioplasty/stenting? Janet M McComb Freeman Hospital Newcastle upon Tyne How to manage a patient who needs thrombolysis in acute stroke, ablation or angioplasty/stenting? Janet M McComb Freeman Hospital Newcastle upon Tyne What do the guidelines say? What happens with warfarin

More information

Copenhagen University Hospital Rigshospitalet Aarhus University Hospital Skejby Denmark

Copenhagen University Hospital Rigshospitalet Aarhus University Hospital Skejby Denmark Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-elevation myocardial infarction 3 year follow-up of the randomised trial Peter Clemmensen, Henning Kelbæk,

More information

Newcastle, North Tyneside and Northumberland Guidelines on Antiplatelet Therapy

Newcastle, North Tyneside and Northumberland Guidelines on Antiplatelet Therapy Clinical Guidelines Guideline Number: NoT 14 (1 of 2) Newcastle, North Tyneside and Northumberland Guidelines on Antiplatelet Therapy Ratified by: NHS North of Tyne Commissioning Integrated Governance

More information

Addendum to Clinical Review for NDA 22-512

Addendum to Clinical Review for NDA 22-512 Addendum to Clinical Review for DA 22-512 Drug: Sponsor: Indication: Division: Reviewers: dabigatran (Pradaxa) Boehringer Ingelheim Prevention of stroke and systemic embolism in atrial fibrillation Division

More information

Is there a role for aspirin in stroke prevention in AF 2015?

Is there a role for aspirin in stroke prevention in AF 2015? Is there a role for aspirin in stroke prevention in AF 2015? Jonas Oldgren Associate professor of cardiology Uppsala Clinical Research Center and Dept of Medical Sciences, Uppsala University Sweden MY

More information

Pearls and Perils of Anti-platelet therapy. Van Hellerslia, PharmD, BCPS October 10, 2014 Abington Memorial Hospital

Pearls and Perils of Anti-platelet therapy. Van Hellerslia, PharmD, BCPS October 10, 2014 Abington Memorial Hospital Pearls and Perils of Anti-platelet therapy Van Hellerslia, PharmD, BCPS October 10, 2014 Abington Memorial Hospital Role of Platelets in vascular ischemia Mechanism of action Clopidogrel Ticlopidine Prasugrel

More information

New Oral Anticoagulants

New Oral Anticoagulants New Oral Anticoagulants Tracy Minichiello, MD Associate Professor of Medicine Chief, San FranciscoVA Anticoagulation and Thrombosis Service Ansell, J. Hematology Copyright 2010 American Society of Hematology.

More information

Bayer Initiates Rivaroxaban Phase III Study to Support Dose Selection According to Individual Benefit-Risk Profile in Long- Term VTE Prevention

Bayer Initiates Rivaroxaban Phase III Study to Support Dose Selection According to Individual Benefit-Risk Profile in Long- Term VTE Prevention Investor News Not intended for U.S. and UK Media Bayer AG Investor Relations 51368 Leverkusen Germany www.investor.bayer.com Long-term prevention of venous blood clots (VTE): Bayer Initiates Rivaroxaban

More information

LEADERS: 5-Year Follow-up

LEADERS: 5-Year Follow-up LEADERS: -Year Follow-up from a Prospective, Randomized Trial of Biolimus A9-eluting Stents with a Biodegradable Polymer vs. Sirolimus-eluting Stents with a Durable Polymer : Final Report of the LEADERS

More information

Rivaroxaban (XARELTO )

Rivaroxaban (XARELTO ) Rivaroxaban (XARELTO ) Cardiovascular and Renal Drugs Advisory Committee January 16, 2014 CC-1 Introduction Paul Burton, MD, PhD, FACC Vice President, Janssen Research & Development, L.L.C. CC-2 Rivaroxaban

More information

Bayer Pharma AG 13342 Berlin Germany Tel. +49 30 468-1111 www.bayerpharma.com. News Release. Not intended for U.S. and UK Media

Bayer Pharma AG 13342 Berlin Germany Tel. +49 30 468-1111 www.bayerpharma.com. News Release. Not intended for U.S. and UK Media News Release Not intended for U.S. and UK Media Bayer Pharma AG 13342 Berlin Germany Tel. +49 30 468-1111 www.bayerpharma.com Bayer Forms Collaboration with Academic and Governmental Institutions for Rivaroxaban

More information

Direct oral anticoagulants in daily care: what do we know today and what are the remaining issues?

Direct oral anticoagulants in daily care: what do we know today and what are the remaining issues? De afbeelding kan niet worden weergegeven. Mogelijk is er onvoldoende geheugen beschikbaar om de afbeelding te openen of is de afbeelding beschadigd. Start de computer opnieuw op en open het bestand opnieuw.

More information

Recent and Ongoing Cardiovascular Outcomes Trials with Diabetes Drugs

Recent and Ongoing Cardiovascular Outcomes Trials with Diabetes Drugs Recent and Ongoing Cardiovascular Outcomes Trials with Diabetes Drugs Jay S. Skyler, MD, MACP Division of Endocrinology, Diabetes, and Metabolism and Diabetes Research Institute University of Miami Miller

More information

Antiplatelet Therapy Update Aspirin, Plavix, Effient, Ticagrelor, Etc. Garrett Wong, MD May 14, 2011

Antiplatelet Therapy Update Aspirin, Plavix, Effient, Ticagrelor, Etc. Garrett Wong, MD May 14, 2011 Antiplatelet Therapy Update Aspirin, Plavix, Effient, Ticagrelor, Etc. Garrett Wong, MD May 14, 2011 Faculty Disclosures Speaker Panel Boehringer Ingelheim Bristol-Myers Squibb/Sanofi Aventis Daiichi Sankyo/Eli

More information

East Kent Prescribing Group

East Kent Prescribing Group East Kent Prescribing Group Rivaroxaban (Xarelto ) Safety Information Approved by the East Kent Prescribing Group. Approved by: East Kent Prescribing Group (Representing Ashford CCG, Canterbury and Coastal

More information

ADVANCE: a factorial randomised trial of blood pressure lowering and intensive glucose control in 11,140 patients with type 2 diabetes

ADVANCE: a factorial randomised trial of blood pressure lowering and intensive glucose control in 11,140 patients with type 2 diabetes ADVANCE: a factorial randomised trial of blood pressure lowering and intensive glucose control in 11,140 patients with type 2 diabetes Effects of a fixed combination of the ACE inhibitor, perindopril,

More information

Addendum to Commission A09-02 (Prasugrel for acute coronary syndrome) 1

Addendum to Commission A09-02 (Prasugrel for acute coronary syndrome) 1 IQWiG Reports Commission No. A11-21 Addendum to Commission A09-02 (Prasugrel for acute coronary syndrome) 1 Addendum Commission: A11-21 Version: 1.0 Status: 07.11.2011 1 Translation of addendum A11-21

More information

WOEST. NOAC, OAC and PCI: An update ' W.Dewilde, MD,PhD. Amphia Hospital, Breda, The Netherlands

WOEST. NOAC, OAC and PCI: An update ' W.Dewilde, MD,PhD. Amphia Hospital, Breda, The Netherlands NOAC, OAC and PCI: An update ' W.Dewilde, MD,PhD Amphia Hospital, Breda, The Netherlands DRES, Hart van Nijkerk, June 2015 Disclosure belangen spreker (potentiële) belangenverstrengeling Voor bijeenkomst

More information

9/5/14. Objectives. Atrial Fibrillation (AF)

9/5/14. Objectives. Atrial Fibrillation (AF) Novel Anticoagulation for Prevention of Stroke in Patients with Atrial Fibrillation Objectives 1. Review current evidence on use of warfarin in individuals with atrial fibrillation 2. Compare the three

More information

RESEARCH. Eliano Pio Navarese, 1, 2 Felicita Andreotti, 2, 3 Volker Schulze, 1, 2 Michalina Kołodziejczak,

RESEARCH. Eliano Pio Navarese, 1, 2 Felicita Andreotti, 2, 3 Volker Schulze, 1, 2 Michalina Kołodziejczak, open access Optimal duration of dual antiplatelet therapy after percutaneous coronary intervention with drug eluting stents: meta-analysis of randomised controlled trials Eliano Pio Navarese, 1, 2 Felicita

More information

EXAMINATION trial. Manel Sabaté Hospital Clínic, Barcelona (On behalf of the Examination Investigators)

EXAMINATION trial. Manel Sabaté Hospital Clínic, Barcelona (On behalf of the Examination Investigators) EXAMINATION trial Manel Sabaté Hospital Clínic, Barcelona (On behalf of the Examination Investigators) EXAMINATION trial Background and Rationale (I) Acute coronary syndromes repeatedly appear as independent

More information

ANESTHESIA FOR PATIENTS WITH CORONARY STENTS FOR NON CARDIAC SURGERY. Dr. Mahesh Vakamudi. Professor and Head

ANESTHESIA FOR PATIENTS WITH CORONARY STENTS FOR NON CARDIAC SURGERY. Dr. Mahesh Vakamudi. Professor and Head ANESTHESIA FOR PATIENTS WITH CORONARY STENTS FOR NON CARDIAC SURGERY Dr. Mahesh Vakamudi Professor and Head Department of Anesthesiology, Critical Care and Pain Medicine Sri Ramachandra University INTRODUCTION

More information

4/9/2015. Risk Stratify Our Patients. Stroke Risk in AF: CHADS2 Scoring system JAMA 2001; 285: 2864-71

4/9/2015. Risk Stratify Our Patients. Stroke Risk in AF: CHADS2 Scoring system JAMA 2001; 285: 2864-71 Anticoagulation in the 21 st Century Adam Karpman, D.O. Saint Francis Medical Center/Oklahoma State University Medical Center Disclosures: None Atrial Fibrillation Most common arrhythmia in clinical practice.

More information

The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines

The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines Canadian Journal of Cardiology 27 (2011) S1 S59 Society Guidelines The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines Alan D. Bell, MD, CCFP, a André

More information

Therapeutic Approach in Patients with Diabetes and Coronary Artery Disease

Therapeutic Approach in Patients with Diabetes and Coronary Artery Disease Home SVCC Area: English - Español - Português Therapeutic Approach in Patients with Diabetes and Coronary Artery Disease Martial G. Bourassa, MD Research Center, Montreal Heart Institute, Montreal, Quebec,

More information

Scelte Antitrombotiche nelle SCA delle UTIC Italiane: Nuovi Dati dal Registro EYESHOT

Scelte Antitrombotiche nelle SCA delle UTIC Italiane: Nuovi Dati dal Registro EYESHOT CARDIOLUCCA 2014 HEART CELEBRATION Lucca, palazzo Ducale Sala Ademollo 27-29 Novembre 2014 Scelte Antitrombotiche nelle SCA delle UTIC Italiane: Nuovi Dati dal Registro EYESHOT Leonardo De Luca, MD, PhD,

More information

What s New in Stroke?

What s New in Stroke? 5 th McMaster University Review Course in INTERNAL MEDICINE What s New in Stroke? Robert Hart, M.D. HHS / McMaster Stroke Program Department of Medicine (Neurology) McMaster University Hamilton, Ontario

More information

New Anticoagulants and GI bleeding

New Anticoagulants and GI bleeding New Anticoagulants and GI bleeding DR DANNY MYERS MD FRCP(C) CLINICAL ASSISTANT PROFESSOR OF MEDICINE, UBC Conflicts of Interest None I am unbiased in the use of NOAC s vs Warfarin based on risk benefit

More information

The largest clinical study of Bayer's Xarelto (rivaroxaban) Wednesday, 14 November 2012 07:38

The largest clinical study of Bayer's Xarelto (rivaroxaban) Wednesday, 14 November 2012 07:38 Bayer HealthCare has announced the initiation of the COMPASS study, the largest clinical study of its oral anticoagulant Xarelto (rivaroxaban) to date, investigating the prevention of major adverse cardiac

More information

A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines Duration of Dual Antiplatelet Therapy: A Systematic Review for the 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease A Report of the

More information