Paper PO03. A Case of Online Data Processing and Statistical Analysis via SAS/IntrNet. Sijian Zhang University of Alabama at Birmingham

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1 Paper PO03 A Case of Online Data Processing and Statistical Analysis via SAS/IntrNet Sijian Zhang University of Alabama at Birmingham BACKGROUND It is common to see that statisticians at the statistical center or unit get involved in many clinical trials or research projects. Usually, according to the investigators requests, the statisticians setup the statistical procedures, run them on the data from investigators, and generate analysis reports. However, in some studies the same statistical procedure need to run repeatedly on data from different time intervals or different batches of experiments. For example, in a proteomic experiment, a series of experiments will be conducted; the design of each experiment is based on the statistical analysis results of previous experiments. It is the same process every time that the investigator finishes an experiment and brings in the raw data; the statistician put the analysis request on his or her schedule, runs the same SAS procedures on the new data, and sends the results back to the investigator; then the investigator will conduct the next experiment according to the results. Since the investigator has the statistical knowledge, it will be not a problem for the investigator to interpret the SAS output. The problem is that the investigator has to wait for several days to see the analysis results. If the investigator can upload the data to a server, run the program, and get the results on the computer at the lab in real time, both the investigator and the statistician will be happy on the time saved. In another circumstance, different investigators need to use the same procedure with different options. For example, every randomized clinical trial needs a randomization list to allocate trail patients to different study groups. However, one trial uses simple randomization without block; another uses the stratified randomization with block. This can be done by customizing different options to the core procedures according to requirements. The essence is that the core procedures need to run repeatedly. It is what programmers like to see. In SAS programming, macro should be used for this kind of coding. For the repeated data and statistical services, the customized online application can be one of the choices, see Figure 1. In this model, the user only needs to know how to pass the requests through the browser interface. The computation will run on the server, and the output will be sent back to the user s browser. Web Server Interne SAS Server End User Web Server SAS Server Figure 1. Service model PROBLEM First, since different investigators need different services, each should see his / her customized interface. How does the system recognize different users and offer them what they need? Second, if the investigators have raw data, how do they process the data on the server and get the results? And third, how do they dynamically pass the optional parameters to the SAS programs on the server?

2 SOLUTION Before illustrating the solutions to the above problems, let s have a brief look at the requirements for this system to operate. First, we need a Web server to offer Web services to users and pass the requests from users to the SAS server. Then, we need the SAS server installed with SAS package, including SAS/IntrNet. All the SAS application codes are run on the SAS server. If the workload is not heavy, the two servers can be in one machine. Customized Services All the SAS codes can be stored on the server. However, an investigator may need only several of them. We can use the investigator s user name, which is need in logon process, to identify the specific web interface that contains only requested services, then to send it to the investigator. Through the hyper links on the page, the investigator runs the specific programs on the SAS server. For example, in Figure 2, an investigator Mark logs on in the Member Service page. If the password is verified, Mark will see the page with a list of services he requested in the Tasks column on the left. In another case, if someone else logs on, the other applications will be there. Figure 2. Customized interface Online Statistical Analysis Usually, investigators have their raw data in different file formats, such as Excel, Access, ASCII, and so on. There is no problem for SAS program to read in the data. And SAS program can also export the results in the requested file format. The issue is how to upload the data and download the result. There are many ways to do it. What we use is the ASP program, through which investigators can upload and download, meanwhile, browse their files on the server and delete the files if they will no longer use them. It is a simple file management system in the server-client environment. Let s take the investigator Mark for example. He first needs to upload his raw data from his hard drive to his folder on the server. He has the option to upload three data files in one time, see Figure 3 (a). Suppose he selects the raw data file genistien.xls and clicks on the Run button in Figure 2 (a). Then the SAS program will run on the server, and the uploaded file will be displayed on the browser. If Mark wants to save the output file In_Utero_TCDD.xls, he can download this file from the server to his hard drive, see Figure 3 (b). He can also browse the file in his server folder, and delete the file which he will no long use on the server, see Figure 3 (c, d).

3 Figure 3 (a). Upload interface Figure 3 (b). Download interface

4 Figure 3 (c). Browse and deletion interface Figure 3 (d). Browse and deletion interface After uploading the data onto the server, Mark goes to Run Analysis page, then 2D Gel Analysis interface is displayed as the default task. If he wants to use other tasks, he can click on the items listed in the left side Tasks column. Suppose, he wants to do some analyses on data genistien.xls, he clicks on the radio button beside it and presses Run button to run the SAS program, see Figure 4 (a). After SAS program running, Mark gets the results on his screen, see Figure 4 (b).

5 Figure 4 (a). Select data and run SAS program Figure 4 (b). SAS output display Online Data Processing The example I choose for online data processing is the WISC score conversion application. WISC instrument is popular in behavioral science surveys. It collects raw scores in the survey, but the raw scores need to be converted to scaled scores for reporting and analysis. The SAS conversion code is not complex, but tedious. One of the macros contains 1316 lines of statements. Suppose, the user BYVS has uploaded the raw data test2.sas7bdat onto the server, and selects it for the conversion program, see Figure 5 (a). After running the program, the user can view the results on the screen, see Figure 5 (b) ; meanwhile, a new dataset with the scaled scores has been generated, and is ready for the user to download on the Upload Data page.

6 Figure 5 (a). WISC score conversion interface Figure 5 (b). WISC score conversion results Customized Options It is important to write the SAS code in generic form, and leave the options for the uses to fill in. In the server-client environment, the options need to be passed from the user s browser to the SAS programs on the server. The Dispatcher in SAS/IntrNet is for this purpose. However, sometimes the process needs more than one step; some options may be based on the previous options. The process is dynamic. For example, in the clinical trial randomization application, if the randomization is stratified by the study site, the user needs to fill in first how many study sites in Figure 6 (a), then how many cases in each study site in Figure 6 (b). After these options are submitted to the SAS program on the server, the result will be generated and displayed on the screen, see Figure 6 (c).

7 Figure 6 (a). The first randomization interface figure Figure 6 (b). The second randomization interface figure

8 Figure 6 (c). Randomization result interface figure SUMMARY By taking the advantages of the server-client environment and SAS/IntrNet, the data management and analysis services can be massively and timely delivered. One SAS application can be run by many investigators in the same time, and each investigator can have a group of services tailored to his / her study projects. The programming is straightforward, and easy to maintain. If any situation is similar to what are described in the background section, considering the time and effects saved on both sides of investigators and statisticians, a system like this will generate the win-win output. Reference 1. SAS web tools: static and dynamic solutions using SAS/IntrNet software course notes. SAS Institute Inc. Contact Information Sijian Zhang, MS Statistician II Department of Biostatistics School of Public Health University of Alabama at Birmingham RPHB University Blvd. Birmingham, AL Phone: (205) Fax: (205) SAS and all other SAS Institute Inc. product or service names are registered trademark or trademarks of SAS Inc. in the USA and other countries. indicates USA registration. Other brand and product names are trademarks of their respective companies.

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